KDMF would be available soon! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the re
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inquiryItem Specification Test Result Appearance Colourless to brown viscous liquid Conform Identification by GC
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryItems Standard Result Appearance Light yellow or yellow powder or crystals,slightly hygroscopic Complies Solub
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inquirySpecifications CAS No.: 186826-86-8 Other Names: Moxifloxacin Hcl powder MF: C21H25ClFN3O4 EINECS No.: 186826-86-8 Place of Origin:
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Crystalline Powder Storage:2-8°C Package:1kg/foil b
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:186826-86-8
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inquiryCASNumber: 186826-86-8 Name: Moxifloxacinhydrochloride Appearance:white Storage:c Package:durm Application:api Transportation:by sea or by air Port:Shanghai
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inquiryName:Moxifloxacin hydrochloride CAS:186826-86-8 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vul
Cas:186826-86-8
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inquiryTIANFUCHEM--186826-86-8-- Moxifloxacin hydrochloride factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable busi
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiryProduct Name: Moxifloxacin hydrochloride Synonyms: AVALOX;BAY-12-8039;(1's,6's)-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydr
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Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:186826-86-8
Min.Order:10 Gram
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Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
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Min.Order:1 Kilogram
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Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:white powder Storage:dry and cool pl
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Min.Order:100 Gram
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Min.Order:10 Gram
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inquiryMoxifloxacin hydrochloride CAS: 186826-86-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga
Cas:186826-86-8
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inquirybest price,best quality and fast delivery assurance available in sample product and customization with years of export experience along with excellent quality, advanced services and competitive prices the quality of products conform u
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Min.Order:10 Gram
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inquiryMoxifloxacin hydrochloride CAS: 186826-86-8 Specification testing item specification result appearance lypc lypc identification comply with
Cas:186826-86-8
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquirymoxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 0 - 8℃; for 0.333333h; Temperature; | 96.2% |
With hydrogenchloride In methanol at -5 - 20℃; for 2h; pH=1; Temperature; | 93.1% |
With sodium hydroxide In acetone for 1h; Large scale; | 89.8% |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 20℃; for 2h; pH=3; pH-value; | 92.9% |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water at 60℃; for 6h; Solvent; | 92.1% |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With titanium(IV) isopropylate; triethylamine In isopropyl alcohol at 100℃; Inert atmosphere; Stage #2: With hydrogenchloride In methanol at 20℃; for 1h; pH=1; Solvent; Reagent/catalyst; | 90% |
Multi-step reaction with 2 steps 1: Alkaline conditions 2: hydrogenchloride View Scheme | |
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20 - 85℃; for 36h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 15℃; for 1h; pH=1.4 - 1.8; Inert atmosphere; | 3.3 g |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boric acid; acetic anhydride at 90 - 100℃; for 3h; Stage #2: With triethylamine In acetonitrile at 20℃; for 0.5h; Stage #3: (1S,6S)-2,8-diazabicyclo[4.3.0]nonane Temperature; Solvent; Reagent/catalyst; Further stages; | 89.78% |
1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With triethylamine In acetonitrile at 15℃; Stage #2: With hydrogenchloride In water pH=0.5; Temperature; | 89.1% |
Conditions | Yield |
---|---|
With tetrabutyl-ammonium chloride In N-methyl-acetamide; hydrogenchloride; ethanol; water | A n/a B 89% |
L(+)-moxifloxacin tartrate
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 25 - 30℃; for 1h; | 88.3% |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water at 10℃; for 1h; Temperature; | 81% |
moxifloxacin
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 0 - 5℃; for 1h; pH=1.0 - 2.0; Product distribution / selectivity; | 77% |
With hydrogenchloride; edetate disodium In methanol; water at 0 - 38℃; for 2h; | 54.84% |
With hydrogenchloride In ethanol at 0 - 10℃; for 2h; Product distribution / selectivity; |
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: C20H22BF2NO8; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With triethylamine In acetonitrile at 80 - 90℃; for 5h; Large scale; Stage #2: With hydrogenchloride In methanol at 0 - 20℃; for 3h; pH=Ca. 0.5; Large scale; | 76.3% |
1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O3,O4-bis(propyloxy-O)borate
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline-carboxylic acid O3,O4-bis(propyloxy-O)borate; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane In butan-1-ol at 10 - 100℃; for 3h; Stage #2: With hydrogenchloride In methanol; butan-1-ol at 25 - 30℃; for 2h; pH=1.0 - 2.0; Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages; | 75% |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol at 30 - 40℃; Temperature; Solvent; Inert atmosphere; Industrial scale; | 75% |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: (1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-(oxo-κO3)-3-quinolinecarboxylato-κO3)difluoroboron With triethylamine In methanol at 60 - 65℃; for 6 - 24h; Heating / reflux; Stage #2: With hydrogenchloride In methanol; water; acetonitrile at 0 - 25℃; for 1 - 2.5h; Product distribution / selectivity; | 55% |
Conditions | Yield |
---|---|
Stage #1: (1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With triethylamine In methanol at 30℃; for 32h; Heating / reflux; Stage #2: With hydrogenchloride In methanol; water; acetonitrile at 0 - 25℃; for 3h; pH=~ 7; Product distribution / selectivity; |
1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid monohydrochloride monohydrate
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
In toluene Heating / reflux; |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 75 - 80℃; for 1.5h; Stage #2: With hydrogenchloride; water In methanol at 25℃; pH=1.0 - 2.0; | |
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With triethylamine In methanol Reflux; Stage #2: With hydrogenchloride In ethanol; water Acidic conditions; | |
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With triethylamine In ethanol at 70℃; for 4h; Stage #2: With hydrogenchloride In water at 30℃; for 1h; pH=1; Solvent; Temperature; Heating; | 45 g |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 25 - 30℃; for 2h; pH=1 - 2; |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: magnesium hydroxide / acetonitrile / 1 h / 78 °C 1.2: 5 h / Reflux 2.1: hydrogenchloride / water; ethanol / 6 h / 20 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: magnesium hydroxide / acetonitrile / 1 h / 78 °C 1.2: 5 h / Reflux 2.1: hydrogenchloride / water; ethanol / 10 h / 20 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: boric acid / 80 - 90 °C 1.2: 1 h / 80 - 90 °C 2.1: triethylamine / water; acetonitrile / 10 - 20 °C 3.1: hydrogenchloride / water / 6 h / 10 - 15 °C / pH 1.0 - 2.0 View Scheme | |
Multi-step reaction with 3 steps 1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 10 - 35 °C / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 35 h / 20 - 85 °C / Inert atmosphere 3.1: sodium hydroxide; water / ethylene glycol / 115 °C / Inert atmosphere 3.2: 1 h / 15 °C / pH 1.4 - 1.8 / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: toluene / 105 - 115 °C / Inert atmosphere; Industrial scale 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 5 - 80 °C / Inert atmosphere; Industrial scale 3: hydrogenchloride / ethanol / 30 - 40 °C / Inert atmosphere; Industrial scale View Scheme |
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: magnesium hydroxide / acetonitrile / 1 h / 78 °C 1.2: 5 h / Reflux 2.1: hydrogenchloride / water; ethanol / 6 h / 20 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: magnesium hydroxide / acetonitrile / 1 h / 78 °C 1.2: 5 h / Reflux 2.1: hydrogenchloride / water; ethanol / 10 h / 20 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1: diethylamine / acetonitrile / 80 °C 2: sodium hydroxide / 2.5 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: aluminum (III) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 60 °C 2: 2 h 3: hydrogenchloride / water / 6 h / 60 °C View Scheme |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; dichloromethane; isopropyl alcohol / 1 h / 30 - 35 °C 2: hydrogenchloride / water; ethanol / 10 h / 20 - 60 °C View Scheme |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: lithium aluminium tetrahydride 2: Resolution of racemate 3: palladium on activated charcoal; hydrogen 4: Alkaline conditions 5: hydrogenchloride View Scheme |
(S,S)-8-benzyl-2,8-diazabicyclo[4.3.0]nonane-D-tartrate
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium on activated charcoal; hydrogen 2: Alkaline conditions 3: hydrogenchloride View Scheme |
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium fluoride / N,N-dimethyl-formamide 2: Alkaline conditions 3: hydrogenchloride View Scheme |
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Resolution of racemate 2: palladium on activated charcoal; hydrogen 3: Alkaline conditions 4: hydrogenchloride View Scheme |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 2 h / 75 - 140 °C 1.2: 3 h / 55 - 120 °C 2.1: diethylamine / acetonitrile / 80 °C 3.1: sodium hydroxide / 2.5 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: glycine / 2.5 h / 80 - 98 °C / Inert atmosphere 2: 4-methyl-morpholine / acetonitrile / 2 h / 75 °C 3: hydrogenchloride / methanol / 2 h / 20 °C / pH 3 View Scheme | |
Multi-step reaction with 3 steps 1.1: 1 h / Reflux 1.2: 1 h / 70 - 105 °C 2.1: triethylamine / acetonitrile / 4 h / 50 °C 3.1: hydrogenchloride / ethanol; water / 1 h / 25 °C / pH 1 View Scheme |
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diethylamine / acetonitrile / 80 °C 2: sodium hydroxide / 2.5 h / 80 °C View Scheme |
ethyl 1-cyclopropyl-6-fluoro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water at -5℃; for 2h; pH=2; Temperature; | |
With hydrogenchloride In water at 25℃; for 3h; pH=2; Temperature; |
C25H33FN4O3
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: C25H33FN4O3 With water; sodium hydroxide In ethylene glycol at 115℃; Inert atmosphere; Stage #2: With hydrogenchloride In water at 15℃; for 1h; pH=1.4 - 1.8; Inert atmosphere; | 6.4 g |
2-iodoacetanilide
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 100℃; for 24h; | 90% |
With triethylamine In acetonitrile at 100℃; for 24h; | 90% |
[2,2]bipyridinyl
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 3h; Reflux; | 88.71% |
[2,2]bipyridinyl
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 3h; Reflux; | 85.57% |
2-(bromomethyl)naphthalene
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: moxifloxacin hydrochloride With potassium carbonate In water; acetonitrile at 20℃; for 0.0833333h; Stage #2: 2-(bromomethyl)naphthalene In water; acetonitrile at 20℃; for 25h; | 84.6% |
[2,2]bipyridinyl
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 3h; Reflux; | 80.81% |
[2,2]bipyridinyl
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 3h; Reflux; | 77.37% |
[2,2]bipyridinyl
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 3h; Reflux; | 75.6% |
water
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
With triethylamine at 20℃; for 48h; pH=7.5 - 8; pH-value; Solvent; | 65% |
moxifloxacin hydrochloride
moxifloxacin
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetone at 25 - 60℃; for 0.666667h; Product distribution / selectivity; | |
With sodium hydroxide In cyclohexane; water; acetone at 25 - 60℃; for 13.1667 - 15.1667h; Product distribution / selectivity; Heating / reflux; |
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