Sorafenib Cas no. 284461-73-0 API or Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.
We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Sorafenib from Wuhan, Hubei, China. I
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:284461-73-0
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryAnalysis tests Standard Results Appearance Pale Yellow or almost white crystalline powder Conforms Solubility
Cas:284461-73-0
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryDescription: English name:Sorafenib Synonyms:BAY43-9006;N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Specification: 98% CAS N
Cas:284461-73-0
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:284461-73-0
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryHebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ
Cas:284461-73-0
Min.Order:100 Gram
FOB Price: $2.0
Type:Manufacturers
inquiryUnique advantages for Sorafenib tosylate Cas 284461-73-0 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Off white to white crystalline powder Storage:-20°C Freezer Package:1
Cas:284461-73-0
Min.Order:1 Kilogram
FOB Price: $670.0 / 696.0
Type:Trading Company
inquirySorafenib CAS No:284461-73-0 Name: Sorafenib Synonyms: 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide Molecular Structure Molecular Formula: C21H
Cas:284461-73-0
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:284461-73-0
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:284461-73-0
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:284461-73-0
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Sorafenib CAS NO:284461-73-0 Grade:Medical chemicals and exports Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Product Technology Str
Cas:284461-73-0
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
Cas:284461-73-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name Sorafenib Tosylate Appearance White powder Assay 99%min, 98.0% --101.0% Test HPLC Certificate ISO 9001 CA
Cas:284461-73-0
Min.Order:1 Kilogram
FOB Price: $15.0 / 50.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:284461-73-0
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:284461-73-0
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryEnglish name:Sorafenib Synonyms:BAY43-9006;N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Specification: 99% CAS NO.:284461-73-0 Appearance: White crystalline powder Mo
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Light Yellow Solid Storage:Store in sealed containers at coo
Cas:284461-73-0
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:284461-73-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:284461-73-0
Min.Order:25 Kilogram
FOB Price: $625.0 / 704.0
Type:Trading Company
inquirySorafenib tosylate CAS: 284461-73-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte
Cas:284461-73-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:284461-73-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
4-chloro-3-trifluoromethylphenylurea
[4-(4-bromophenoxy)(2-pyridyl)]-N-methylcarboxamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: [4-(4-bromophenoxy)(2-pyridyl)]-N-methylcarboxamide With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 20℃; for 0.5h; Stage #2: 4-chloro-3-trifluoromethylphenylurea In 1,4-dioxane at 80 - 100℃; for 1h; Solvent; Reagent/catalyst; | 97.9% |
With t-BuBrettPhos; palladium diacetate; caesium carbonate In tetrahydrofuran; water at 75℃; for 5h; Inert atmosphere; | 206 mg |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
sorafenib
Conditions | Yield |
---|---|
With 1-Methylpyrrolidine In dichloromethane at 30℃; for 24h; Solvent; Temperature; | 97.6% |
4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol
4-bromo-pyridine-2-carboxylic acid methyl amide
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol With 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride In 1-methyl-pyrrolidin-2-one at 50 - 60℃; for 0.5h; Stage #2: 4-bromo-pyridine-2-carboxylic acid methyl amide In 1-methyl-pyrrolidin-2-one for 2h; Reagent/catalyst; Reflux; | 96.7% |
4-hydroxy-N-methylpyridine-2-carboxamide
4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol
sorafenib
Conditions | Yield |
---|---|
at 132℃; | 96.3% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-(trifluoromethyl)phenyl isocyanate
sorafenib
Conditions | Yield |
---|---|
With zirconia grinding balls In acetonitrile for 4h; Milling; | 96% |
In ethyl acetate at 20 - 30℃; Large scale; | 94.2% |
In dichloromethane | 93% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide
sorafenib
Conditions | Yield |
---|---|
In chlorobenzene at 70 - 75℃; for 0.25h; Product distribution / selectivity; | 95% |
In ethyl acetate at 20 - 50℃; for 2.75h; | 77% |
With potassium carbonate In dichloromethane for 8h; Milling; | 72% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-(trifluoromethyl)benzoic acid
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-chloro-3-(trifluoromethyl)benzoic acid; 2,2,2,-trichloroethoxycarbonyl azide With dmap; copper diacetate In dimethyl sulfoxide at 100℃; for 6h; Curtius Rearrangement; Inert atmosphere; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 100℃; for 24h; Inert atmosphere; | 93% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-trifluoromethyl-aniline
1,1'-carbonyldiimidazole
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-chloro-3-trifluoromethyl-aniline; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 16h; Inert atmosphere; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In dichloromethane Inert atmosphere; | 91% |
Stage #1: 4-chloro-3-trifluoromethyl-aniline; 1,1'-carbonyldiimidazole In dichloromethane at 25 - 35℃; for 18h; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In dichloromethane at 25 - 35℃; for 48.75h; | 90 g |
4-amino-phenol
4-chloro-3-(trifluoromethyl)phenyl isocyanate
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-amino-phenol; 4-chloro-3-(trifluoromethyl)phenyl isocyanate; 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 80℃; Solvent; Reagent/catalyst; Temperature; | 90.6% |
4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
With potassium carbonate In toluene Heating; | 90% |
With tetrabutylammomium bromide; potassium iodide; potassium hydroxide In tetrahydrofuran at 80℃; for 10h; Solvent; Reagent/catalyst; | 89.4% |
Stage #1: 4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol With potassium tert-butylate In N,N-dimethyl-formamide for 2h; Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate at 80℃; for 6h; | 50% |
4-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoic acid
4-chloro-3-trifluoromethyl-aniline
sorafenib
Conditions | Yield |
---|---|
With diphenyl phosphoryl azide; triethylamine In water at 30 - 100℃; | 90% |
N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide
4-amino-phenol
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide; 4-amino-phenol; 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 20℃; for 3h; Stage #2: With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 80℃; | 88.5% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-(trifluoromethyl)benzoic acid
sorafenib
Conditions | Yield |
---|---|
With diphenyl phosphoryl azide; triethylamine In water at 30 - 100℃; | 88% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
sorafenib
Conditions | Yield |
---|---|
With sodium acetate In methanol at 60℃; for 2h; | 86% |
N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride
4-amino-phenol
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride; 4-amino-phenol; 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 80℃; | 85.5% |
4-amino-phenol
(4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-amino-phenol; (4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester; 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 20℃; for 3h; Stage #2: With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 80℃; | 85.4% |
Conditions | Yield |
---|---|
In dichloromethane at 0℃; for 0.25h; Inert atmosphere; | 85% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
sorafenib
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide; acetonitrile at 100℃; for 24h; Schlenk technique; Sealed tube; Inert atmosphere; | 80% |
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxylic acid
methylamine hydrochloride
sorafenib
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; | 63.2% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
(4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester
sorafenib
Conditions | Yield |
---|---|
With pyridine at 80℃; for 3h; | 48.2% |
In N,N-dimethyl-formamide at 40 - 45℃; for 2 - 3h; Product distribution / selectivity; | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 40 - 45℃; |
sorafenib
Conditions | Yield |
---|---|
at 200℃; |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-trifluoromethylphenylurea
sorafenib
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 110 - 120℃; for 12 - 18h; Product distribution / selectivity; | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 110 - 120℃; |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxyurea
sorafenib
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 125℃; for 96h; Product distribution / selectivity; | |
With triethylamine In N,N-dimethyl-formamide at 125℃; for 96h; |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
2,2,2-trichloro-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide
sorafenib
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 24h; Product distribution / selectivity; Heating / reflux; | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 24h; Reflux; |
N-methyl-4-(4-ureidophenoxy)picolinamide
4-chloro-3-trifluoromethyl-aniline
sorafenib
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 24h; Product distribution / selectivity; Heating / reflux; | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 24h; Reflux; |
phenyl 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate
4-chloro-3-trifluoromethyl-aniline
sorafenib
Conditions | Yield |
---|---|
In acetonitrile for 24h; Product distribution / selectivity; Heating / reflux; | |
In acetonitrile for 24h; Reflux; |
N-methyl-4-(4-(2,2,2-trichloroacetamido)phenoxy)picolinamide
4-chloro-3-trifluoromethyl-aniline
sorafenib
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 110℃; for 8 - 9h; Product distribution / selectivity; | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 110℃; |
sorafenib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride; water / 1 h / 40 °C / Inert atmosphere 2: t-BuBrettPhos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / 5 h / 75 °C / Inert atmosphere View Scheme |
5-bromo-2-chlorobenzotrifluoride
sorafenib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: t-BuBrettPhos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / 2 h / 85 °C / Inert atmosphere 2: hydrogenchloride; water / 1 h / 40 °C / Inert atmosphere 3: t-BuBrettPhos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / 5 h / 75 °C / Inert atmosphere View Scheme |
(1S)-10-camphorsulfonic acid
sorafenib
Conditions | Yield |
---|---|
In tert-butyl methyl ether at 15 - 50℃; Solvent; Temperature; | 99.4% |
cis-dichlorobis(dimethylsulfoxide)platinum(II)
sorafenib
Conditions | Yield |
---|---|
In methanol; acetone at 45℃; for 28h; Solvent; Temperature; | 98% |
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 75℃; for 3h; Solvent; Temperature; | 97.9% |
sorafenib
Conditions | Yield |
---|---|
With sulfuric acid In butanone at 26℃; for 5h; Product distribution / selectivity; | 90.9% |
sorafenib
4-(4-{3-[4-chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N-methylpyridine-2-carboxamide sulphate
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; water at 20 - 60℃; for 12h; | 89% |
ethanesulfonic acid
sorafenib
Conditions | Yield |
---|---|
In butanone at 26℃; for 3h; | 88.9% |
toluene-4-sulfonic acid
sorafenib
Conditions | Yield |
---|---|
In water; acetonitrile Reflux; | 87.6% |
In methanol at 40 - 65℃; | 84.5% |
In acetonitrile at 26℃; for 2h; | 78.2% |
sorafenib
Conditions | Yield |
---|---|
With hydrogenchloride In water; butanone at -10 - -5℃; for 3.16667h; Product distribution / selectivity; | 85.84% |
methanesulfonic acid
sorafenib
Conditions | Yield |
---|---|
In ethanol at 26 - 78℃; for 11h; Product distribution / selectivity; | 85.08% |
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