As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
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inquirySorafenib Intermediates Cas no. 284462-37-9 4-(4-Aminophenoxy)-N-methylpicolinamide Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manuf
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inquiryItems Standard Result Appearance light brown to brown crystalline solid brown crystalline solid Assay, on dry base
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/557.html Product Name 4-(4-Aminophenoxy)-N-methylpicolinamide
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo
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inquiry4-(4-Aminophenoxy)-N-methylpicolinamide CAS No.:284462-37-9 Name: 4-(4-Aminophenoxy)-N-methylpicolinamide Molecular Structure Molecular Formula: C13H13N3O2 Molecular Weight: 243.26
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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inquiryName:4-(4-Aminophenoxy)-N-methylpicolinamide CAS NO: 284462-37-9 Grade:Medical chemicals and exports Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerabil
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inquiryHigh purity CAS 284462-37-9 4-(4-Aminophenoxy)-N-methylpicolinamide in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryChemical Name: 4-(4-Aminophenoxy)-N-methylpicolinamide Cas No.: 284462-37-9 Molecular Formula: C13H13N3O2 Molecular Weight: 243.26 Molecular Structure: Appearance:White powder Sto
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:284462-37-9
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:Light yellow to brown powder / Refer to COA Pac
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inquiryBeluga chemical professional supply 4-Chloro-6-ethyl-5-fluoropyrimidine CAS 284462-37-9 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryProduct Detail Minimum Order Qty. 10 Gram
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inquiryWe are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates Storage:Refrigerator Application:Pharmaceutical intermediate Port:Chinese main port
Cas:284462-37-9
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inquiry4-(4-Aminophenoxy)-N-methylpicolinamide CAS: 284462-37-9 Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years Storage should
Cas:284462-37-9
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Type:Other
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
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inquiry4-amino-phenol
4-chloro-N-methylpicolinamide
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
With potassium tert-butylate In N,N-dimethyl-formamide at 25℃; for 1h; | 97% |
Stage #1: 4-amino-phenol With potassium hydroxide for 0.166667h; Stage #2: 4-chloro-N-methylpicolinamide for 1.5h; | 97.3% |
With 18-crown-6 ether In acetonitrile for 1.5h; Reagent/catalyst; Solvent; Temperature; Reflux; | 92.5% |
4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
With hydrogen; nickel In tetrahydrofuran; methanol at 20℃; Product distribution / selectivity; | 97% |
With palladium 10% on activated carbon; hydrogen In methanol at 35℃; under 2068.65 Torr; for 2h; | 95% |
With palladium 10% on activated carbon; hydrogen In methanol at 40 - 50℃; under 7500.75 Torr; Solvent; Autoclave; | 92.5% |
Stage #1: 4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine With iron(III) chloride hexahydrate; pyrographite In ethanol at 90℃; for 0.5h; Sonication; Stage #2: With hydrazine hydrate In ethanol Sonication; | 70% |
With ammonia; tetra(n-butyl)ammonium hydrogensulfate; iron | 20.1 g |
4-nitro-phenol
4-chloro-N-methylpicolinamide
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 4-nitro-phenol; 4-chloro-N-methylpicolinamide With potassium carbonate for 4h; Reflux; Stage #2: With iron(III) chloride; hydrazine hydrate; FeCl3/C In ethanol for 3h; Concentration; Reflux; | 94.6% |
Stage #1: 4-nitro-phenol With potassium hydroxide for 0.166667h; Heating; Green chemistry; Stage #2: 4-chloro-N-methylpicolinamide for 1.5h; Green chemistry; Stage #3: With iron(III) chloride; pyrographite; hydrazine hydrate In ethanol; 1,2-dichloro-ethane for 3h; Reflux; Green chemistry; | 94.5% |
Conditions | Yield |
---|---|
With potassium carbonate In water; N,N-dimethyl-formamide at -5 - 10℃; for 1.5h; Large scale; | 84.1% |
4-chloropyridine-2-carbohydrazide
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Stage #2: 4-chloropyridine-2-carbohydrazide With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere; | 80% |
4-chloro-N-methylpicolinamide
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 4-amino-phenol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h; | 71% |
With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 10h; Product distribution / selectivity; | |
Multi-step reaction with 2 steps 1: ethyl acetate 2: ammonia; iron; tetra(n-butyl)ammonium hydrogensulfate View Scheme |
4-chloro-N,N-dimethylpyridine-2-carboxamide
4-amino-phenol
4-chloro-N-methylpicolinamide
A
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
B
4-(4-aminophenoxy)-N,N-dimethylpicolinamide
Conditions | Yield |
---|---|
Stage #1: 4-amino-phenol With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 4-chloro-N,N-dimethylpyridine-2-carboxamide; 4-chloro-N-methylpicolinamide With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; Inert atmosphere; | A 70% B 69% |
4-(3-aminophenoxy)-N-methylpicolinamide
bis(trichloromethyl) carbonate
2-amino-3-methoxynaphthalene
A
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
3-(4-aminophenoxy)-N-methylbenzamide
4-chloro-3-trifluoromethyl-aniline
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-N-methylpicolinamide
A
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide |
2-Picolinic acid
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 17.5 h / 50 °C / Inert atmosphere; Reflux 2.1: tetrahydrofuran; methanol / 0 - 20 °C 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 3.2: 6 h / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 72 °C 2: 5 h / 3 °C 3: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide View Scheme | |
Multi-step reaction with 3 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 50 °C / Inert atmosphere; Reflux 2.1: tetrahydrofuran; methanol / 2 h / 0 - 20 °C 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 3.2: 6 h / 80 °C / Inert atmosphere View Scheme |
4-chloro-pyridine-2-carbonyl chloride
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrahydrofuran; methanol / 0 - 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 6 h / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran; methanol / 2 h / 0 - 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 6 h / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: 2 h / 30 °C 2.1: tetrahydrofuran; methanol / 3 h / 2 - 20 °C 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 3.2: 10 h / 80 - 85 °C View Scheme |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 5 h / 3 °C 2: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran; methanol / 4 h / 0 - 3 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 8 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere 2.2: 4 h / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran; methanol / 4 h / 0 - 3 °C 2.1: potassium tert-butylate / DMF (N,N-dimethyl-formamide) / 2 h / 20 °C 2.2: 8 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: water; tetrahydrofuran 2: sodium hydride / dimethyl sulfoxide / 3 h / 100 °C View Scheme |
4-Chloro-pyridine-2-carboxylic acid methyl ester
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetrahydrofuran; methanol / 3 h / 2 - 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 2.2: 10 h / 80 - 85 °C View Scheme | |
Multi-step reaction with 2 steps 1: water / 3 h / 20 °C 2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: water; tetrahydrofuran / 3 h / 20 °C 2: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / 100 °C View Scheme |
4-chloropicolinamide
4-amino-phenol
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 4-amino-phenol With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Stage #2: 4-chloropicolinamide With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere; |
4‐(4‐aminophenoxy)‐2‐pyridine carboxylic acid
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / chloroform / 1.5 h / Reflux; Large scale 2: potassium carbonate / water; N,N-dimethyl-formamide / 1.5 h / -5 - 10 °C / Large scale View Scheme |
4-bromo-2-cyanopyridine
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / tetrahydrofuran; water / 5.5 h / Reflux; Large scale 2: thionyl chloride / chloroform / 1.5 h / Reflux; Large scale 3: potassium carbonate / water; N,N-dimethyl-formamide / 1.5 h / -5 - 10 °C / Large scale View Scheme |
4-amino-phenol
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / tetrahydrofuran; water / 5.5 h / Reflux; Large scale 2: thionyl chloride / chloroform / 1.5 h / Reflux; Large scale 3: potassium carbonate / water; N,N-dimethyl-formamide / 1.5 h / -5 - 10 °C / Large scale View Scheme |
sorafenib
A
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
B
4-amino-phenol
Conditions | Yield |
---|---|
With hydrogenchloride; water; sodium chloride at 0℃; for 3h; pH=1.5; pH-value; |
4-chloropicolinic acid
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 15.5 h / 0 - 20 °C / Inert atmosphere 2.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere 3.2: 4 h / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / ethanol; water / 4 h / 120 °C 2: ethyl acetate 3: ammonia; iron; tetra(n-butyl)ammonium hydrogensulfate View Scheme |
N-methylpyridine-2-carboxamide
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: fluorine; sulfuric acid / 25 °C 2: caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 35 °C / 2068.65 Torr View Scheme |
ethyl 4-chloropyridine-2-carboxylate
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: chlorobenzene / 4 h / 130 °C / UV-irradiation 2.1: ethanol; sodium hydroxide / 1 h / 20 °C 3.1: thionyl chloride / 0.17 h / 85 °C / Sonication 4.1: triethylamine / dichloromethane; water / 0.33 h / Cooling with ice 4.2: 0.5 h / Cooling with ice 5.1: iron(III) chloride hexahydrate; pyrographite / ethanol / 0.5 h / 90 °C / Sonication 5.2: Sonication View Scheme |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: ethanol; sodium hydroxide / 1 h / 20 °C 2.1: thionyl chloride / 0.17 h / 85 °C / Sonication 3.1: triethylamine / dichloromethane; water / 0.33 h / Cooling with ice 3.2: 0.5 h / Cooling with ice 4.1: iron(III) chloride hexahydrate; pyrographite / ethanol / 0.5 h / 90 °C / Sonication 4.2: Sonication View Scheme |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride / 0.17 h / 85 °C / Sonication 2.1: triethylamine / dichloromethane; water / 0.33 h / Cooling with ice 2.2: 0.5 h / Cooling with ice 3.1: iron(III) chloride hexahydrate; pyrographite / ethanol / 0.5 h / 90 °C / Sonication 3.2: Sonication View Scheme |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane; water / 0.33 h / Cooling with ice 1.2: 0.5 h / Cooling with ice 2.1: iron(III) chloride hexahydrate; pyrographite / ethanol / 0.5 h / 90 °C / Sonication 2.2: Sonication View Scheme |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
sorafenib
Conditions | Yield |
---|---|
With 1-Methylpyrrolidine In dichloromethane at 30℃; for 24h; Solvent; Temperature; | 97.6% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
2-fluoro-5-(trifluoromethyl)benzoic acid
4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide
Conditions | Yield |
---|---|
Stage #1: 2-fluoro-5-(trifluoromethyl)benzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide for 0.516667h; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In N,N-dimethyl-formamide for 12h; | 97% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
1-fluoro-3-isocyanatobenzene
Conditions | Yield |
---|---|
In dichloromethane for 48h; | 97% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-(trifluoromethyl)phenyl isocyanate
sorafenib
Conditions | Yield |
---|---|
With zirconia grinding balls In acetonitrile for 4h; Milling; | 96% |
In ethyl acetate at 20 - 30℃; Large scale; | 94.2% |
In dichloromethane | 93% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
toluene-4-sulfonic acid
4-chloro-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In ethyl acetate at 40 - 71℃; for 0.5h; Stage #2: toluene-4-sulfonic acid In water; ethyl acetate at 71℃; for 0.666667h; Product distribution / selectivity; | 96% |
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In butanone at 20 - 85℃; Stage #2: toluene-4-sulfonic acid In butanone at 20℃; | 88% |
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In tetrahydrofuran at 25 - 64℃; for 0.5h; Stage #2: toluene-4-sulfonic acid In tetrahydrofuran at 64℃; Product distribution / selectivity; | 81.6% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
para-fluorophenyl isocyanate
4-[4-[[[[4-fluorophenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
In dichloromethane for 48h; | 96% |
In acetone at 20 - 40℃; |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-(trifluoromethyl)benzoic acid
1,1'-carbonyldiimidazole
Conditions | Yield |
---|---|
Stage #1: 4-chloro-3-(trifluoromethyl)benzoic acid; 1,1'-carbonyldiimidazole In tetrahydrofuran at 45℃; for 3h; Inert atmosphere; Enzymatic reaction; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In tetrahydrofuran at 20℃; for 2h; | 96% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene
4-(4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
In dichloromethane for 72h; | 96% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
1-Fluoro-2-isocyanato-benzene
Conditions | Yield |
---|---|
In dichloromethane for 48h; | 96% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide
sorafenib
Conditions | Yield |
---|---|
In chlorobenzene at 70 - 75℃; for 0.25h; Product distribution / selectivity; | 95% |
In ethyl acetate at 20 - 50℃; for 2.75h; | 77% |
With potassium carbonate In dichloromethane for 8h; Milling; | 72% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
p-trifluoromethyl-phenylisocyanate
Conditions | Yield |
---|---|
In dichloromethane for 48h; | 95% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
3-(Trifluoromethyl)benzoyl chloride
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran at 20℃; for 2h; | 95% |
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 3-(Trifluoromethyl)benzoyl chloride With pyridine In dichloromethane for 14h; Inert atmosphere; Stage #2: With pyridine | 74% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
2,5-difluorophenyl isocyanate
Conditions | Yield |
---|---|
In dichloromethane for 24h; | 94% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-trifluoromethyl-phenyl acetyl chloride
N-methyl-4-(4-(4-(trifluoromethyl)benzamido)phenoxy)picolinamide
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran at 20℃; for 2h; | 93.2% |
With pyridine In tetrahydrofuran at 20℃; for 2h; |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
In dichloromethane for 48h; | 93% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
1-isothiocyanato-4-(methylthio)benzene
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 25℃; for 2h; | 93% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-(trifluoromethyl)benzoic acid
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-chloro-3-(trifluoromethyl)benzoic acid; 2,2,2,-trichloroethoxycarbonyl azide With dmap; copper diacetate In dimethyl sulfoxide at 100℃; for 6h; Curtius Rearrangement; Inert atmosphere; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 100℃; for 24h; Inert atmosphere; | 93% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-fluorophenyl isothiocyanate
4-(4-(3-(4-fluorophenyl)thioureido)phenoxy)-N-methylpicolinamide
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 25℃; for 2h; | 92% |
In dichloromethane at 0 - 20℃; for 20h; Inert atmosphere; | 70.3% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
3-nitrophenyl isothiocyanate
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 25℃; for 2h; | 92% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
3-ethoxycarbonylphenyl isothiocyanate
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 25℃; for 2h; | 92% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-(tert-butylbenzyl)isothiocyanate
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 25℃; for 2h; | 92% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
2-trifluoromethylbenzoyl chloride
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran at 20℃; for 2h; | 92% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-3-trifluoromethyl-aniline
1,1'-carbonyldiimidazole
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-chloro-3-trifluoromethyl-aniline; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 16h; Inert atmosphere; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In dichloromethane Inert atmosphere; | 91% |
Stage #1: 4-chloro-3-trifluoromethyl-aniline; 1,1'-carbonyldiimidazole In dichloromethane at 25 - 35℃; for 18h; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In dichloromethane at 25 - 35℃; for 48.75h; | 90 g |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
phenyl isothiocyanate
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 25℃; for 2h; | 91% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-Bromophenyl isothiocyanate
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 25℃; for 2h; | 91% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-bromo-3-(trifluoromethyl)phenyl isocyanate
Conditions | Yield |
---|---|
In dichloromethane | 90% |
In dichloromethane | 90% |
In dichloromethane | 90% |
In dichloromethane | 90% |
In dichloromethane at 0 - 20℃; for 16h; | 90% |
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4‐(4‐aminophenoxy)‐2‐pyridine carboxylic acid
Conditions | Yield |
---|---|
Reflux; Alkaline conditions; | 90% |
With potassium carbonate In water at 100℃; for 2h; | 90% |
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide With potassium hydroxide; water at 100℃; for 2h; Stage #2: With water pH=5; | 80% |
With water; potassium hydroxide at 100℃; | 18.9 g |
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