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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Yangzhou Qinyuan Pharmatech Co.,Ltd

Sorafenib Intermediates Cas no. 284462-37-9 4-(4-Aminophenoxy)-N-methylpicolinamide Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manuf

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance light brown to brown crystalline solid brown crystalline solid Assay, on dry base

High purity Various Specifications 4-(4-Aminophenoxy)-N-methylpicolinamide CAS:284462-37-9

Cas:284462-37-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/557.html Product Name 4-(4-Aminophenoxy)-N-methylpicolinamide

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:1 Gram

FOB Price: $35.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo

Manufacturer high quality 4-(4-Aminophenoxy)-N-methylpicolinamide Cas 284462-37-9 with good price

Cas:284462-37-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

4-(4-Aminophenoxy)-N-methylpicolinamide CAS No.:284462-37-9 Name: 4-(4-Aminophenoxy)-N-methylpicolinamide Molecular Structure Molecular Formula: C13H13N3O2 Molecular Weight: 243.26

High purity 4-(4-Aminophenoxy)-N-methylpicolinamide CAS No.:284462-37-9

Cas:284462-37-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Cas:284462-37-9

Min.Order:1

Negotiable

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide

Cas:284462-37-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:4-(4-Aminophenoxy)-N-methylpicolinamide CAS NO: 284462-37-9 Grade:Medical chemicals and exports Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerabil

4-(4-Aminophenoxy)-N-methylpicolinamide CAS:284462-37-9 Chinese manufacturers high-quality

Cas:284462-37-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

High purity CAS 284462-37-9 4-(4-Aminophenoxy)-N-methylpicolinamide in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

High purity CAS 284462-37-9 4-(4-Aminophenoxy)-N-methylpicolinamide in stock

Cas:284462-37-9

Min.Order:1 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

4- (4-Aminophenoxy) -N-Methylpicolinamide CAS 284462-37-9

Cas:284462-37-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New arrival CAS 284462-37-9 with best price

Cas:284462-37-9

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Chinese supplier suppliers manufacturer factory of 4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Chemical Name: 4-(4-Aminophenoxy)-N-methylpicolinamide Cas No.: 284462-37-9 Molecular Formula: C13H13N3O2 Molecular Weight: 243.26 Molecular Structure: Appearance:White powder Sto

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

4-(4-Aminophenoxy)-N-methylpicolinamideCAS NO.: 284462-37-9

Cas:284462-37-9

Min.Order:1 Gram

FOB Price: $4.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

4-(4-Aminophenoxy)-N- methylpicolinamide

Cas:284462-37-9

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Sorafenib intermediate, 4-(4-Aminophenoxy)-N-methylpicolinamide CAS:284462-37-9

Cas:284462-37-9

Min.Order:1 Kilogram

FOB Price: $35.0 / 38.0

Type:Trading Company

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:Light yellow to brown powder / Refer to COA Pac

4-AMino-5-iMidazolecarboxaMide hydrochloride

Cas:284462-37-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 4-Chloro-6-ethyl-5-fluoropyrimidine CAS 284462-37-9 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made

4-Chloro-6-ethyl-5-fluoropyrimidine CAS 284462-37-9

Cas:284462-37-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-(4-Aminophenoxy)-N-methylpicolinamide/ LIDE PHARMA- Factory supply / Best price

Cas:284462-37-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

4-(4-Aminophenoxy)-N-methylpicolinamide CAS NO.284462-37-9 CAS NO.284462-37-9

Cas:284462-37-9

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates Storage:Refrigerator Application:Pharmaceutical intermediate Port:Chinese main port

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

4-(4-Aminophenoxy)-N-methylpicolinamide CAS: 284462-37-9 Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years Storage should

Factory supply 4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

Sell high quality Sorafenib intermediate 98%min

Cas:284462-37-9

Min.Order:10 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-(4-Aminophenoxy)-N-methylpicolinamide

Cas:284462-37-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-amino-phenol
123-30-8

4-amino-phenol

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 25℃; for 1h;97%
Stage #1: 4-amino-phenol With potassium hydroxide for 0.166667h;
Stage #2: 4-chloro-N-methylpicolinamide for 1.5h;
97.3%
With 18-crown-6 ether In acetonitrile for 1.5h; Reagent/catalyst; Solvent; Temperature; Reflux;92.5%
4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine
864272-34-4

4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
With hydrogen; nickel In tetrahydrofuran; methanol at 20℃; Product distribution / selectivity;97%
With palladium 10% on activated carbon; hydrogen In methanol at 35℃; under 2068.65 Torr; for 2h;95%
With palladium 10% on activated carbon; hydrogen In methanol at 40 - 50℃; under 7500.75 Torr; Solvent; Autoclave;92.5%
Stage #1: 4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine With iron(III) chloride hexahydrate; pyrographite In ethanol at 90℃; for 0.5h; Sonication;
Stage #2: With hydrazine hydrate In ethanol Sonication;
70%
With ammonia; tetra(n-butyl)ammonium hydrogensulfate; iron20.1 g
4-nitro-phenol
100-02-7

4-nitro-phenol

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 4-nitro-phenol; 4-chloro-N-methylpicolinamide With potassium carbonate for 4h; Reflux;
Stage #2: With iron(III) chloride; hydrazine hydrate; FeCl3/C In ethanol for 3h; Concentration; Reflux;
94.6%
Stage #1: 4-nitro-phenol With potassium hydroxide for 0.166667h; Heating; Green chemistry;
Stage #2: 4-chloro-N-methylpicolinamide for 1.5h; Green chemistry;
Stage #3: With iron(III) chloride; pyrographite; hydrazine hydrate In ethanol; 1,2-dichloro-ethane for 3h; Reflux; Green chemistry;
94.5%
C12H9ClN2O2

C12H9ClN2O2

methylamine
74-89-5

methylamine

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at -5 - 10℃; for 1.5h; Large scale;84.1%
4-chloropyridine-2-carbohydrazide
73771-11-6

4-chloropyridine-2-carbohydrazide

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Stage #1: With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;
Stage #2: 4-chloropyridine-2-carbohydrazide With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere;
80%
4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 4-amino-phenol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h;
71%
With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 10h; Product distribution / selectivity;
Multi-step reaction with 2 steps
1: ethyl acetate
2: ammonia; iron; tetra(n-butyl)ammonium hydrogensulfate
View Scheme
4-chloro-N,N-dimethylpyridine-2-carboxamide
114780-06-2

4-chloro-N,N-dimethylpyridine-2-carboxamide

4-amino-phenol
123-30-8

4-amino-phenol

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

A

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

B

4-(4-aminophenoxy)-N,N-dimethylpicolinamide
284462-86-8

4-(4-aminophenoxy)-N,N-dimethylpicolinamide

Conditions
ConditionsYield
Stage #1: 4-amino-phenol With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 4-chloro-N,N-dimethylpyridine-2-carboxamide; 4-chloro-N-methylpicolinamide With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; Inert atmosphere;
A 70%
B 69%
4-(3-aminophenoxy)-N-methylpicolinamide
284462-78-8

4-(3-aminophenoxy)-N-methylpicolinamide

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-amino-3-methoxynaphthalene
67291-63-8

2-amino-3-methoxynaphthalene

A

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

B

5-tert-Butyl-2-(2,5-dimethylpyrrolyl)-aniline

5-tert-Butyl-2-(2,5-dimethylpyrrolyl)-aniline

3-(4-aminophenoxy)-N-methylbenzamide
284462-56-2

3-(4-aminophenoxy)-N-methylbenzamide

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

of4-aminophenol

of4-aminophenol

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

A

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

B

of4-(2-(N-methylcarbamoyl)-4-pyridyloxy)aniline

of4-(2-(N-methylcarbamoyl)-4-pyridyloxy)aniline

Conditions
ConditionsYield
With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide
2-Picolinic acid
98-98-6

2-Picolinic acid

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 17.5 h / 50 °C / Inert atmosphere; Reflux
2.1: tetrahydrofuran; methanol / 0 - 20 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C
3.2: 6 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 72 °C
2: 5 h / 3 °C
3: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 50 °C / Inert atmosphere; Reflux
2.1: tetrahydrofuran; methanol / 2 h / 0 - 20 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C
3.2: 6 h / 80 °C / Inert atmosphere
View Scheme
4-chloro-pyridine-2-carbonyl chloride
53750-66-6

4-chloro-pyridine-2-carbonyl chloride

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; methanol / 0 - 20 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C
2.2: 6 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; methanol / 2 h / 0 - 20 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C
2.2: 6 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: 2 h / 30 °C
2.1: tetrahydrofuran; methanol / 3 h / 2 - 20 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
3.2: 10 h / 80 - 85 °C
View Scheme
4-chloro-2-pyridine carboxylic acid chloride hydrochloride

4-chloro-2-pyridine carboxylic acid chloride hydrochloride

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5 h / 3 °C
2: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; methanol / 4 h / 0 - 3 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C
2.2: 8 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere
2.2: 4 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; methanol / 4 h / 0 - 3 °C
2.1: potassium tert-butylate / DMF (N,N-dimethyl-formamide) / 2 h / 20 °C
2.2: 8 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: water; tetrahydrofuran
2: sodium hydride / dimethyl sulfoxide / 3 h / 100 °C
View Scheme
4-Chloro-pyridine-2-carboxylic acid methyl ester
24484-93-3

4-Chloro-pyridine-2-carboxylic acid methyl ester

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; methanol / 3 h / 2 - 20 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
2.2: 10 h / 80 - 85 °C
View Scheme
Multi-step reaction with 2 steps
1: water / 3 h / 20 °C
2: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: water; tetrahydrofuran / 3 h / 20 °C
2: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / 100 °C
View Scheme
4-chloropicolinamide
99586-65-9

4-chloropicolinamide

4-amino-phenol
123-30-8

4-amino-phenol

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 4-amino-phenol With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;
Stage #2: 4-chloropicolinamide With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere;
4‐(4‐aminophenoxy)‐2‐pyridine carboxylic acid
1012058-77-3

4‐(4‐aminophenoxy)‐2‐pyridine carboxylic acid

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / chloroform / 1.5 h / Reflux; Large scale
2: potassium carbonate / water; N,N-dimethyl-formamide / 1.5 h / -5 - 10 °C / Large scale
View Scheme
4-bromo-2-cyanopyridine
62150-45-2

4-bromo-2-cyanopyridine

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / tetrahydrofuran; water / 5.5 h / Reflux; Large scale
2: thionyl chloride / chloroform / 1.5 h / Reflux; Large scale
3: potassium carbonate / water; N,N-dimethyl-formamide / 1.5 h / -5 - 10 °C / Large scale
View Scheme
4-amino-phenol
123-30-8

4-amino-phenol

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / tetrahydrofuran; water / 5.5 h / Reflux; Large scale
2: thionyl chloride / chloroform / 1.5 h / Reflux; Large scale
3: potassium carbonate / water; N,N-dimethyl-formamide / 1.5 h / -5 - 10 °C / Large scale
View Scheme
sorafenib
284461-73-0

sorafenib

A

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

B

4-amino-phenol
123-30-8

4-amino-phenol

Conditions
ConditionsYield
With hydrogenchloride; water; sodium chloride at 0℃; for 3h; pH=1.5; pH-value;
4-chloropicolinic acid
5470-22-4

4-chloropicolinic acid

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 15.5 h / 0 - 20 °C / Inert atmosphere
2.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere
3.2: 4 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / ethanol; water / 4 h / 120 °C
2: ethyl acetate
3: ammonia; iron; tetra(n-butyl)ammonium hydrogensulfate
View Scheme
N-methylpyridine-2-carboxamide
6144-78-1

N-methylpyridine-2-carboxamide

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: fluorine; sulfuric acid / 25 °C
2: caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 35 °C / 2068.65 Torr
View Scheme
ethyl 4-chloropyridine-2-carboxylate
64064-56-8

ethyl 4-chloropyridine-2-carboxylate

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: chlorobenzene / 4 h / 130 °C / UV-irradiation
2.1: ethanol; sodium hydroxide / 1 h / 20 °C
3.1: thionyl chloride / 0.17 h / 85 °C / Sonication
4.1: triethylamine / dichloromethane; water / 0.33 h / Cooling with ice
4.2: 0.5 h / Cooling with ice
5.1: iron(III) chloride hexahydrate; pyrographite / ethanol / 0.5 h / 90 °C / Sonication
5.2: Sonication
View Scheme
ethyl 4-(4-nitrophenoxy)picolinate

ethyl 4-(4-nitrophenoxy)picolinate

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethanol; sodium hydroxide / 1 h / 20 °C
2.1: thionyl chloride / 0.17 h / 85 °C / Sonication
3.1: triethylamine / dichloromethane; water / 0.33 h / Cooling with ice
3.2: 0.5 h / Cooling with ice
4.1: iron(III) chloride hexahydrate; pyrographite / ethanol / 0.5 h / 90 °C / Sonication
4.2: Sonication
View Scheme
4-(4-nitrophenoxy)picolinic acid

4-(4-nitrophenoxy)picolinic acid

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / 0.17 h / 85 °C / Sonication
2.1: triethylamine / dichloromethane; water / 0.33 h / Cooling with ice
2.2: 0.5 h / Cooling with ice
3.1: iron(III) chloride hexahydrate; pyrographite / ethanol / 0.5 h / 90 °C / Sonication
3.2: Sonication
View Scheme
4-(4-nitrophenoxy)pyridine-2-carbonyl chloride

4-(4-nitrophenoxy)pyridine-2-carbonyl chloride

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane; water / 0.33 h / Cooling with ice
1.2: 0.5 h / Cooling with ice
2.1: iron(III) chloride hexahydrate; pyrographite / ethanol / 0.5 h / 90 °C / Sonication
2.2: Sonication
View Scheme
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

(4-chloro-3-trifluoromethyl aniline)carboxylic acid allyl ester

(4-chloro-3-trifluoromethyl aniline)carboxylic acid allyl ester

sorafenib
284461-73-0

sorafenib

Conditions
ConditionsYield
With 1-Methylpyrrolidine In dichloromethane at 30℃; for 24h; Solvent; Temperature;97.6%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

2-fluoro-5-(trifluoromethyl)benzoic acid
115029-23-7

2-fluoro-5-(trifluoromethyl)benzoic acid

4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide
1313019-74-7

4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

Conditions
ConditionsYield
Stage #1: 2-fluoro-5-(trifluoromethyl)benzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide for 0.516667h;
Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In N,N-dimethyl-formamide for 12h;
97%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

1-fluoro-3-isocyanatobenzene
404-71-7

1-fluoro-3-isocyanatobenzene

4-(4-(3-(3-fluorophenyl)ureido)phenoxy)-N-methylpicolinamide

4-(4-(3-(3-fluorophenyl)ureido)phenoxy)-N-methylpicolinamide

Conditions
ConditionsYield
In dichloromethane for 48h;97%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

sorafenib
284461-73-0

sorafenib

Conditions
ConditionsYield
With zirconia grinding balls In acetonitrile for 4h; Milling;96%
In ethyl acetate at 20 - 30℃; Large scale;94.2%
In dichloromethane93%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

sorafenib tosylate

sorafenib tosylate

Conditions
ConditionsYield
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In ethyl acetate at 40 - 71℃; for 0.5h;
Stage #2: toluene-4-sulfonic acid In water; ethyl acetate at 71℃; for 0.666667h; Product distribution / selectivity;
96%
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In butanone at 20 - 85℃;
Stage #2: toluene-4-sulfonic acid In butanone at 20℃;
88%
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In tetrahydrofuran at 25 - 64℃; for 0.5h;
Stage #2: toluene-4-sulfonic acid In tetrahydrofuran at 64℃; Product distribution / selectivity;
81.6%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

para-fluorophenyl isocyanate
1195-45-5

para-fluorophenyl isocyanate

4-[4-[[[[4-fluorophenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2-carboxamide
1285533-80-3

4-[4-[[[[4-fluorophenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
In dichloromethane for 48h;96%
In acetone at 20 - 40℃;
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-chloro-3-(trifluoromethyl)benzoic acid
1737-36-6

4-chloro-3-(trifluoromethyl)benzoic acid

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

4-(4-(4-chloro-3-(trifluoromethyl)phenylamido)phenoxy)-N-methylpyridine-2-carboxamide

4-(4-(4-chloro-3-(trifluoromethyl)phenylamido)phenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 4-chloro-3-(trifluoromethyl)benzoic acid; 1,1'-carbonyldiimidazole In tetrahydrofuran at 45℃; for 3h; Inert atmosphere; Enzymatic reaction;
Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In tetrahydrofuran at 20℃; for 2h;
96%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene
69922-27-6

1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene

4-(4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpyridine-2-carboxamide
847054-10-8

4-(4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpyridine-2-carboxamide

Conditions
ConditionsYield
In dichloromethane for 72h;96%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

1-Fluoro-2-isocyanato-benzene
16744-98-2

1-Fluoro-2-isocyanato-benzene

4-(4-(3-(2-fluorophenyl)ureido)phenoxy)-N-methylpicolinamide

4-(4-(3-(2-fluorophenyl)ureido)phenoxy)-N-methylpicolinamide

Conditions
ConditionsYield
In dichloromethane for 48h;96%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide
1187086-96-9

N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide

sorafenib
284461-73-0

sorafenib

Conditions
ConditionsYield
In chlorobenzene at 70 - 75℃; for 0.25h; Product distribution / selectivity;95%
In ethyl acetate at 20 - 50℃; for 2.75h;77%
With potassium carbonate In dichloromethane for 8h; Milling;72%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

p-trifluoromethyl-phenylisocyanate
1548-13-6

p-trifluoromethyl-phenylisocyanate

N-methyl-4-(4-(3-(4-(trifluoromethyl)phenyl)ureido)phenoxy)pyridine-2-carboxamide

N-methyl-4-(4-(3-(4-(trifluoromethyl)phenyl)ureido)phenoxy)pyridine-2-carboxamide

Conditions
ConditionsYield
In dichloromethane for 48h;95%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

3-(Trifluoromethyl)benzoyl chloride
2251-65-2

3-(Trifluoromethyl)benzoyl chloride

N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide

N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 20℃; for 2h;95%
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 3-(Trifluoromethyl)benzoyl chloride With pyridine In dichloromethane for 14h; Inert atmosphere;
Stage #2: With pyridine
74%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

2,5-difluorophenyl isocyanate
39718-32-6

2,5-difluorophenyl isocyanate

4-(4-(3-(2,5-difluorophenyl)ureido)phenoxy)-N-methylpicolinamide

4-(4-(3-(2,5-difluorophenyl)ureido)phenoxy)-N-methylpicolinamide

Conditions
ConditionsYield
In dichloromethane for 24h;94%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-trifluoromethyl-phenyl acetyl chloride
329-15-7

4-trifluoromethyl-phenyl acetyl chloride

N-methyl-4-(4-(4-(trifluoromethyl)benzamido)phenoxy)picolinamide
1125780-43-9

N-methyl-4-(4-(4-(trifluoromethyl)benzamido)phenoxy)picolinamide

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 20℃; for 2h;93.2%
With pyridine In tetrahydrofuran at 20℃; for 2h;
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

2,6-difluorophenyl isocyanate

2,6-difluorophenyl isocyanate

4-(4-(3-(2,6-difluorophenyl)ureido)phenoxy)-N-methylpicolinamide

4-(4-(3-(2,6-difluorophenyl)ureido)phenoxy)-N-methylpicolinamide

Conditions
ConditionsYield
In dichloromethane for 48h;93%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

1-isothiocyanato-4-(methylthio)benzene
15863-41-9

1-isothiocyanato-4-(methylthio)benzene

N-methyl-4-(4-(3-(4-(methylthio)phenyl)thioureido)phenoxy)picolinamide

N-methyl-4-(4-(3-(4-(methylthio)phenyl)thioureido)phenoxy)picolinamide

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 25℃; for 2h;93%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-chloro-3-(trifluoromethyl)benzoic acid
1737-36-6

4-chloro-3-(trifluoromethyl)benzoic acid

2,2,2,-trichloroethoxycarbonyl azide

2,2,2,-trichloroethoxycarbonyl azide

sorafenib
284461-73-0

sorafenib

Conditions
ConditionsYield
Stage #1: 4-chloro-3-(trifluoromethyl)benzoic acid; 2,2,2,-trichloroethoxycarbonyl azide With dmap; copper diacetate In dimethyl sulfoxide at 100℃; for 6h; Curtius Rearrangement; Inert atmosphere;
Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 100℃; for 24h; Inert atmosphere;
93%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-fluorophenyl isothiocyanate
1544-68-9

4-fluorophenyl isothiocyanate

4-(4-(3-(4-fluorophenyl)thioureido)phenoxy)-N-methylpicolinamide
1229611-42-0

4-(4-(3-(4-fluorophenyl)thioureido)phenoxy)-N-methylpicolinamide

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 25℃; for 2h;92%
In dichloromethane at 0 - 20℃; for 20h; Inert atmosphere;70.3%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

3-nitrophenyl isothiocyanate
3529-82-6

3-nitrophenyl isothiocyanate

N-methyl-4-(4-(3-(3-nitrophenyl)thioureido)phenoxy)picolinamide

N-methyl-4-(4-(3-(3-nitrophenyl)thioureido)phenoxy)picolinamide

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 25℃; for 2h;92%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

3-ethoxycarbonylphenyl isothiocyanate
3137-84-6

3-ethoxycarbonylphenyl isothiocyanate

ethyl 3-(3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)thioureido)benzoate

ethyl 3-(3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)thioureido)benzoate

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 25℃; for 2h;92%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-(tert-butylbenzyl)isothiocyanate
19241-24-8

4-(tert-butylbenzyl)isothiocyanate

4-(4-(3-(4-(tert-butyl)phenyl)thioureido)phenoxy)-N-methylpicolinamide

4-(4-(3-(4-(tert-butyl)phenyl)thioureido)phenoxy)-N-methylpicolinamide

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 25℃; for 2h;92%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

2-trifluoromethylbenzoyl chloride
312-94-7

2-trifluoromethylbenzoyl chloride

N-methyl-4-(4-(2-(trifluoromethyl)benzamido)phenoxy)picolinamide

N-methyl-4-(4-(2-(trifluoromethyl)benzamido)phenoxy)picolinamide

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 20℃; for 2h;92%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

sorafenib
284461-73-0

sorafenib

Conditions
ConditionsYield
Stage #1: 4-chloro-3-trifluoromethyl-aniline; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 16h; Inert atmosphere;
Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In dichloromethane Inert atmosphere;
91%
Stage #1: 4-chloro-3-trifluoromethyl-aniline; 1,1'-carbonyldiimidazole In dichloromethane at 25 - 35℃; for 18h;
Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In dichloromethane at 25 - 35℃; for 48.75h;
90 g
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

N-methyl-4-(4-(3-phenylthioureido)phenoxy)picolinamide

N-methyl-4-(4-(3-phenylthioureido)phenoxy)picolinamide

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 25℃; for 2h;91%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-Bromophenyl isothiocyanate
1985-12-2

4-Bromophenyl isothiocyanate

4-(4-(3-(4-bromophenyl)thioureido)phenoxy)-N-methylpicolinamide

4-(4-(3-(4-bromophenyl)thioureido)phenoxy)-N-methylpicolinamide

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 25℃; for 2h;91%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-bromo-3-(trifluoromethyl)phenyl isocyanate
41513-02-4

4-bromo-3-(trifluoromethyl)phenyl isocyanate

4-{4-[({[4-bromo-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methyl-2-pyridine carboxamide

4-{4-[({[4-bromo-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methyl-2-pyridine carboxamide

Conditions
ConditionsYield
In dichloromethane90%
In dichloromethane90%
In dichloromethane90%
In dichloromethane90%
In dichloromethane at 0 - 20℃; for 16h;90%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4‐(4‐aminophenoxy)‐2‐pyridine carboxylic acid
1012058-77-3

4‐(4‐aminophenoxy)‐2‐pyridine carboxylic acid

Conditions
ConditionsYield
Reflux; Alkaline conditions;90%
With potassium carbonate In water at 100℃; for 2h;90%
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide With potassium hydroxide; water at 100℃; for 2h;
Stage #2: With water pH=5;
80%
With water; potassium hydroxide at 100℃;18.9 g

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