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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6-Methyl Prednisolone supplier in China

Cas:83-43-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

English name: Methylprednisolone Molecular Formula:C22H30O5 Molecular Weight:374.4706 CAS Registry Number:83-43-2 EINECS:201-476-4 Quality:BP/CP Density:1.28g/cm3 Melting point:228-237°C (dec.) Boiling point:571.8°C

CAS:83-43-2 Methylprednisolone

Cas:83-43-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Methylprednisolone CAS NO.83-43-2

Cas:83-43-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers

6alpha-methylprednisolone 83-43-2

Cas:83-43-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Lab grade 99% Methylprednisolone powder supplier CAS:83-43-2

Cas:83-43-2

Min.Order:50 Gram

FOB Price: $1.6 / 1.8

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Methylprednisolone

Cas:83-43-2

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Methylprednisolone 83-43-2 GMP Manufacturer

Cas:83-43-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Methylprednisolone

Cas:83-43-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6α-Methylprednisolone

Cas:83-43-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

top Methylprednisolone

Cas:83-43-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Methylprednisolone / LIDE PHARMA- Factory supply / Best price

Cas:83-43-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Methylprednisolone

Cas:83-43-2

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Methylprednisolone cas83-43-2

Cas:83-43-2

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white crystalline powder Storage:ln stock Package:25kg/Carton drums Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

Methylprednisolone USP grade

Cas:83-43-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Methylprednisolone CAS NO83-43-2

Cas:83-43-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

API-Methylprednisolone, hot sale high quality 99% pure CAS NO: 83-43-2 Methylprednisolone

Cas:83-43-2

Min.Order:1 Kilogram

FOB Price: $260.0 / 300.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methylprednisolone 83-43-2

Cas:83-43-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. A

Methylprednisolone Adrenal corticosteroids

Cas:83-43-2

Min.Order:1 Kilogram

FOB Price: $40.0 / 60.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Methylprednisolone CAS:83-43-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi

Methylprednisolone CAS:83-43-2

Cas:83-43-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methylprednisolone

Cas:83-43-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers

High Purity Powder Methylprednisolone // Medrone

Cas:83-43-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available;

Glucocorticoid Steroid Methylprednisolon E CAS 83-43-2

Cas:83-43-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Methylprednisolone

Cas:83-43-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Methylprednisolone CAS NO.83-43-2

Cas:83-43-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

6alpha-methylprednisolone

Cas:83-43-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, Nuevo Laredo, Mexico, Vancouver, Canada, Amsterdam, The Netherlands and Melbourne, Australia. Overseas warehouses can provide some of the best selling products. We look forward to cooperating with strong loc

Secure delivery CAS 83-43-2 Methylprednisolone

Cas:83-43-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

99% Methylprednisolone CAS 83-43-2 with Best Price

Cas:83-43-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

6a-Methyl Prednisolone

Cas:83-43-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Methylprednisolone CAS 83-43-2 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control

Methylprednisolone CAS 83-43-2

Cas:83-43-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Methylprednisolone

Cas:83-43-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Hydrolysis;
With potassium hydroxide In methanol; dichloromethane at 10 - 15℃; for 0.333333h; Inert atmosphere;
(20Ξ)-11β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-pregna-1,4-dien-3-one
117888-35-4

(20Ξ)-11β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-pregna-1,4-dien-3-one

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
With formic acid
methylprednisolone acetate
53-36-1

methylprednisolone acetate

A

Methylprednisolone
83-43-2

Methylprednisolone

B

17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
86401-94-7

17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With aq. buffer In N,N-dimethyl-formamide at 25℃; Rate constant; Mechanism; pH dependence;
17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
86401-94-7

17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

A

Methylprednisolone
83-43-2

Methylprednisolone

B

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
With aq. buffer In N,N-dimethyl-formamide at 25℃; Rate constant; Mechanism; pH dependence;
6α-methylprednisolone-21-hydrogen succinate
2921-57-5

6α-methylprednisolone-21-hydrogen succinate

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
With tetramethyl ammoniumhydroxide; tetrazolium blue In ethanol Rate constant; Ambient temperature; reaction of corticosteroids and their hemisuccinate esters with blue tetrazolium under USP assay conditions, hydrolysis of esters, effect of water content, kinetic study by HPLC;
With water In acetonitrile at 25℃; Rate constant;
In water at 25℃; Rate constant; rate constants for hydrolysis;
6α-methylprednisolone-21-hydrogen succinate
2921-57-5

6α-methylprednisolone-21-hydrogen succinate

A

Methylprednisolone
83-43-2

Methylprednisolone

B

6α-methylprednisolone 17-hemisuccinate
77074-42-1

6α-methylprednisolone 17-hemisuccinate

Conditions
ConditionsYield
With aq. buffer In N,N-dimethyl-formamide at 25℃; Rate constant; Mechanism; pH dependence;
6α-methylprednisolone 17-hemisuccinate
77074-42-1

6α-methylprednisolone 17-hemisuccinate

A

Methylprednisolone
83-43-2

Methylprednisolone

B

6α-methylprednisolone-21-hydrogen succinate
2921-57-5

6α-methylprednisolone-21-hydrogen succinate

Conditions
ConditionsYield
With aq. buffer In N,N-dimethyl-formamide at 25℃; Rate constant; Mechanism; pH dependence;
6α-methylprednisolone 21-hemiadipate
85847-50-3

6α-methylprednisolone 21-hemiadipate

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
With water In acetonitrile at 25℃; Rate constant;
6α-methylprednisolone 21-hemisuberate
85847-51-4

6α-methylprednisolone 21-hemisuberate

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
With water In acetonitrile at 25℃; Rate constant;
17,21-dihydroxy-pregn-4-ene-3,11,20-trione
53-06-5, 10007-36-0, 15779-07-4, 35446-72-1, 104713-00-0

17,21-dihydroxy-pregn-4-ene-3,11,20-trione

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: aqueous hydrochloric acid; chloroform
2: benzene; toluene-4-sulfonic acid
3: peroxybenzoic acid; benzene / Behandeln unter Ausschluss von Licht, Behandeln des Reaktionsprodukts mit Ameisensaeure und Erwaermen des danach isolierten Reaktionsprodukts mit wss.-methanol. Kalilauge
4: toluene-4-sulfonic acid
5: benzene; diethyl ether
6: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
7: acetone; toluene-4-sulfonic acid
8: acetic acid; tert-butyl alcohol; selenium dioxide
9: aqueous formic acid
View Scheme
11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one
3386-04-7, 14423-17-7

11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Dehydrierung durch Septomyxa affinis und anschliessende Acetylierung
2: diacetoxy-phenyl-iodan; OsO4; tert-butyl alcohol / Reagens 4: Pyridin
3: Hydrolysis
View Scheme
21-acetoxy-11β-hydroxy-6α-methyl-pregna-1,4,17(20)c-trien-3-one
1968-76-9

21-acetoxy-11β-hydroxy-6α-methyl-pregna-1,4,17(20)c-trien-3-one

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diacetoxy-phenyl-iodan; OsO4; tert-butyl alcohol / Reagens 4: Pyridin
2: Hydrolysis
View Scheme
(20Ξ)-11β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-pregn-4-en-3-one
123292-91-1

(20Ξ)-11β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-pregn-4-en-3-one

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; tert-butyl alcohol; selenium dioxide
2: aqueous formic acid
View Scheme
17α,20;20,21-bismethylenedioxypregn-4-ene-3,11-dione
3607-68-9

17α,20;20,21-bismethylenedioxypregn-4-ene-3,11-dione

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: benzene; toluene-4-sulfonic acid
2: peroxybenzoic acid; benzene / Behandeln unter Ausschluss von Licht, Behandeln des Reaktionsprodukts mit Ameisensaeure und Erwaermen des danach isolierten Reaktionsprodukts mit wss.-methanol. Kalilauge
3: toluene-4-sulfonic acid
4: benzene; diethyl ether
5: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
6: acetone; toluene-4-sulfonic acid
7: acetic acid; tert-butyl alcohol; selenium dioxide
8: aqueous formic acid
View Scheme
(20Ξ)-17,20;20,21-bis-methylenedioxy-5α-pregnane-3,6,11-trione
55701-21-8

(20Ξ)-17,20;20,21-bis-methylenedioxy-5α-pregnane-3,6,11-trione

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: toluene-4-sulfonic acid
2: benzene; diethyl ether
3: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
4: acetone; toluene-4-sulfonic acid
5: acetic acid; tert-butyl alcohol; selenium dioxide
6: aqueous formic acid
View Scheme
(20Ξ)-3,3-ethanediyldioxy-6-methyl-17,20;20,21-bis-methylenedioxy-pregn-5-en-11β-ol

(20Ξ)-3,3-ethanediyldioxy-6-methyl-17,20;20,21-bis-methylenedioxy-pregn-5-en-11β-ol

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetone; toluene-4-sulfonic acid
2: acetic acid; tert-butyl alcohol; selenium dioxide
3: aqueous formic acid
View Scheme
6-methyl-11-oxo-3-pyrrolidino-pregna-3,5,17(20)c-trien-21-oic acid methyl ester
1968-77-0

6-methyl-11-oxo-3-pyrrolidino-pregna-3,5,17(20)c-trien-21-oic acid methyl ester

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: LiAlH4; diethyl ether / Behandeln des Reaktionsprodukts mit wss.-methanol.Alkalilauge
2: Dehydrierung durch Septomyxa affinis und anschliessende Acetylierung
3: diacetoxy-phenyl-iodan; OsO4; tert-butyl alcohol / Reagens 4: Pyridin
4: Hydrolysis
View Scheme
(8′S,9′S,10′R,13′S,14′S,17′R)-10′,13′-dimethyl-1′,2′,4′,7′,8′,9′,10′,12′,13′,14′,15′,16′-dodecahydro-11′H-trispiro[[1,3]dioxolane-2,3′-cyclopenta[a]phenanthrene-17′,4''-[1,3]dioxolane-5'',4'''-[1,3]dioxolan]-11′-one
52248-40-5

(8′S,9′S,10′R,13′S,14′S,17′R)-10′,13′-dimethyl-1′,2′,4′,7′,8′,9′,10′,12′,13′,14′,15′,16′-dodecahydro-11′H-trispiro[[1,3]dioxolane-2,3′-cyclopenta[a]phenanthrene-17′,4''-[1,3]dioxolane-5'',4'''-[1,3]dioxolan]-11′-one

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: peroxybenzoic acid; benzene / Behandeln unter Ausschluss von Licht, Behandeln des Reaktionsprodukts mit Ameisensaeure und Erwaermen des danach isolierten Reaktionsprodukts mit wss.-methanol. Kalilauge
2: toluene-4-sulfonic acid
3: benzene; diethyl ether
4: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
5: acetone; toluene-4-sulfonic acid
6: acetic acid; tert-butyl alcohol; selenium dioxide
7: aqueous formic acid
View Scheme
(20Ξ)-3,3-ethanediyldioxy-6β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-5α-pregnan-11-one
123885-50-7

(20Ξ)-3,3-ethanediyldioxy-6β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-5α-pregnan-11-one

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
2: acetone; toluene-4-sulfonic acid
3: acetic acid; tert-butyl alcohol; selenium dioxide
4: aqueous formic acid
View Scheme
(20Ξ)-3,3-ethanediyldioxy-17,20;20,21-bis-methylenedioxy-5α-pregnane-6,11-dione
107157-45-9

(20Ξ)-3,3-ethanediyldioxy-17,20;20,21-bis-methylenedioxy-5α-pregnane-6,11-dione

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: benzene; diethyl ether
2: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
3: acetone; toluene-4-sulfonic acid
4: acetic acid; tert-butyl alcohol; selenium dioxide
5: aqueous formic acid
View Scheme
HYCp45

HYCp45

A

C16H27NO11

C16H27NO11

B

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
With sodium hydroxide In water-d2 at 37℃; pH=7.0;
C26H42O6

C26H42O6

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
2.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
3.1: iodine; calcium oxide / methanol; dichloromethane
3.2: 2 h / 45 - 50 °C
4.1: potassium hydroxide / methanol; dichloromethane / 0.33 h / 10 - 15 °C / Inert atmosphere
View Scheme
11β,17-dihydroxy-6α-methyl-pregn-4-ene-3,20-dione
7055-53-0

11β,17-dihydroxy-6α-methyl-pregn-4-ene-3,20-dione

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
2.1: iodine; calcium oxide / methanol; dichloromethane
2.2: 2 h / 45 - 50 °C
3.1: potassium hydroxide / methanol; dichloromethane / 0.33 h / 10 - 15 °C / Inert atmosphere
View Scheme
17-hydroxy-pregn-4-ene-3,11,20-trione
1882-82-2

17-hydroxy-pregn-4-ene-3,11,20-trione

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: trimethyloxosulfonium bromide; orthoformic acid triethyl ester / 5 h
2.1: sodium tetrahydroborate / tetrahydrofuran / 12 h
3.1: phthalic anhydride; dihydrogen peroxide / ethyl acetate / 6 h
4.1: magnesium / tetrahydrofuran / 4 h
5.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
6.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
7.1: iodine; calcium oxide / methanol; dichloromethane
7.2: 2 h / 45 - 50 °C
8.1: potassium hydroxide / methanol; dichloromethane / 0.33 h / 10 - 15 °C / Inert atmosphere
View Scheme
3,3;20,20-bis-ethanediyldioxy-17-hydroxy-pregn-5-en-11-one
74332-34-6

3,3;20,20-bis-ethanediyldioxy-17-hydroxy-pregn-5-en-11-one

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 12 h
2.1: phthalic anhydride; dihydrogen peroxide / ethyl acetate / 6 h
3.1: magnesium / tetrahydrofuran / 4 h
4.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
5.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
6.1: iodine; calcium oxide / methanol; dichloromethane
6.2: 2 h / 45 - 50 °C
7.1: potassium hydroxide / methanol; dichloromethane / 0.33 h / 10 - 15 °C / Inert atmosphere
View Scheme
3,3;20,20-bis-ethanediyldioxy-pregn-5-ene-11β,17-diol
41870-77-3

3,3;20,20-bis-ethanediyldioxy-pregn-5-ene-11β,17-diol

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: phthalic anhydride; dihydrogen peroxide / ethyl acetate / 6 h
2.1: magnesium / tetrahydrofuran / 4 h
3.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
4.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
5.1: iodine; calcium oxide / methanol; dichloromethane
5.2: 2 h / 45 - 50 °C
6.1: potassium hydroxide / methanol; dichloromethane / 0.33 h / 10 - 15 °C / Inert atmosphere
View Scheme
C25H38O7

C25H38O7

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: magnesium / tetrahydrofuran / 4 h
2.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
3.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
4.1: iodine; calcium oxide / methanol; dichloromethane
4.2: 2 h / 45 - 50 °C
5.1: potassium hydroxide / methanol; dichloromethane / 0.33 h / 10 - 15 °C / Inert atmosphere
View Scheme
Methylprednisolone
83-43-2

Methylprednisolone

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

2-((6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl methanesulfonate
51474-81-8

2-((6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl methanesulfonate

Conditions
ConditionsYield
With pyridine at 0 - 10℃;95%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;81%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
ethyl orthoacetate
58924-88-2

ethyl orthoacetate

Methylprednisolone
83-43-2

Methylprednisolone

A

6α-methylprednisolone 17α,21-ethyl orthoacetate

6α-methylprednisolone 17α,21-ethyl orthoacetate

B

17α,21-diacetoxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
86413-24-3

17α,21-diacetoxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With sodium carbonate; toluene-4-sulfonic acid In N-methyl-acetamide; water; ethyl acetateA 92.5%
B n/a
methyl orthovalerate
856317-97-0

methyl orthovalerate

Methylprednisolone
83-43-2

Methylprednisolone

A

6α-methylprednisolone 17α,21-methyl orthovalerate

6α-methylprednisolone 17α,21-methyl orthovalerate

B

11β,21-dihydroxy-6α-methyl-17α-valeroyloxy-1,4-pregnadiene-3,20-dione
86413-38-9

11β,21-dihydroxy-6α-methyl-17α-valeroyloxy-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With sodium carbonate; toluene-4-sulfonic acid In N-methyl-acetamide; water; ethyl acetateA n/a
B 91.7%
methyl orthoisovalerate

methyl orthoisovalerate

Methylprednisolone
83-43-2

Methylprednisolone

A

6α-methylprednisolone 17α,21-methyl orthoisovalerate

6α-methylprednisolone 17α,21-methyl orthoisovalerate

B

11β,21-dihydroxy-17α-isovaleryloxy-6α-methyl-1,4-pregnadiene-3,20-dione
86413-32-3

11β,21-dihydroxy-17α-isovaleryloxy-6α-methyl-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With sodium carbonate; toluene-4-sulfonic acid In N-methyl-acetamide; water; ethyl acetateA 82.8%
B n/a
3-sulfopropanoic acid
44826-45-1

3-sulfopropanoic acid

Methylprednisolone
83-43-2

Methylprednisolone

21-<<3-sulfo-1-oxopropyl>oxy>-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione

21-<<3-sulfo-1-oxopropyl>oxy>-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With pyridine; dicyclohexyl-carbodiimide for 16h;70%
Methylprednisolone
83-43-2

Methylprednisolone

17α,21-dihydroxy-6α-methylpregna-1,4-diene-3,11,20-trione
111264-84-7, 91523-05-6

17α,21-dihydroxy-6α-methylpregna-1,4-diene-3,11,20-trione

Conditions
ConditionsYield
With pyridine; N-bromoacetamide
Methylprednisolone
83-43-2

Methylprednisolone

11β,17α-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
6870-94-6

11β,17α-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
ueber mehrere Stufen;
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