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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6-Methyl Prednisolone Acetate supplier in China

Cas:53-36-1

Min.Order:1 Metric Ton

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Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Methylprednisolone acetate CAS NO.53-36-1

Cas:53-36-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

99% Methylprednisolone acetate Supplier Methylprednisolone acetate Powder cas:53-36-1

Cas:53-36-1

Min.Order:100 Gram

FOB Price: $0.48 / 0.58

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Methylprednisolone 21-acetate

Cas:53-36-1

Min.Order:1

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

CAS RN.: 53-36-1 EINECS: 200-171-3 Molecular Weight:

Methylprednisolone acetate 53-36-1

Cas:53-36-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Methylprednisolone acetate 53-36-1 GMP Manufacturer

Cas:53-36-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Methylprednisolone acetate

Cas:53-36-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6α-Methylprednisolone 21-acetate

Cas:53-36-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

top Methylprednisolone acetate

Cas:53-36-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

53-36-1 Methylprednisolone acetate

Cas:53-36-1

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 53-36-1 with competitive price

Cas:53-36-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

DMF GMP are all available! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the resea

Methylprednisolone acetate DMF GMP

Cas:53-36-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 53-36-1 Methylprednisolone acetate with best price

Cas:53-36-1

Min.Order:10 Gram

Negotiable

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:R.T Package:25kg/drum Application:Methylprednisolone acetate has a strong anti-inflammatory effect and a weak effect on sodium retention, and the effect is the same as that of prednisone. Methylprednisolone acetate su

Factory price high quality Methylprednisolone acetate

Cas:53-36-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methylprednisolone acetate 53-36-1

Cas:53-36-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Methylprednisolone Acetate CAS 53-36-1 For research Use only

Cas:53-36-1

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Methylprednisolone acetate CAS:53-36-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

Methylprednisolone acetate CAS:53-36-1

Cas:53-36-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methylprednisolone acetate

Cas:53-36-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Methylprednisolone acetate

Cas:53-36-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Methylprednisolone Acetate

Cas:53-36-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Methylprednisolone Acetate

Cas:53-36-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hefei Zhaobo Technology Co., Ltd.

Methylprednisolone acetate cas 53-36-1 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality

Methylprednisolone acetate cas 53-36-1

Cas:53-36-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Methylprednisolone acetate

Cas:53-36-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

buy-METHYLPREDNISOLONE ACETATE

Cas:53-36-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Miheng Trading Co., Ltd.

Methylprednisolone acetate CAS 53-36-1 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to ass

Methylprednisolone acetate CAS 53-36-1

Cas:53-36-1

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

1H-Pyrazolo[3,4-c]pyridine-5-carboxylic acid

Cas:53-36-1

Min.Order:1 Gram

Negotiable

Type:Other

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Wuhan Xinhao Biotechnology Co., Ltd.

Our service We have our own research and development team, laboratory, pilot workshop and production plant. Factory produc

High quality 6-Methyl Prednisolone Acetate supplier in China

Cas:53-36-1

Min.Order:1 Kilogram

FOB Price: $0.54

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 6-Methyl Prednisolone Acetate

Cas:53-36-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr

Methylprednisolone acetate

Cas:53-36-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Methylprednisolone acetate

Cas:53-36-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

21-acetoxy-11β-hydroxy-6α-methyl-pregna-1,4,17(20)c-trien-3-one
1968-76-9

21-acetoxy-11β-hydroxy-6α-methyl-pregna-1,4,17(20)c-trien-3-one

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
With osmium(VIII) oxide; [bis(acetoxy)iodo]benzene; tert-butyl alcohol Reagens 4: Pyridin;
Methylprednisolone
83-43-2

Methylprednisolone

acetic anhydride
108-24-7

acetic anhydride

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
With pyridine
17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
86401-94-7

17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

A

Methylprednisolone
83-43-2

Methylprednisolone

B

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
With aq. buffer In N,N-dimethyl-formamide at 25℃; Rate constant; Mechanism; pH dependence;
17,21-dihydroxy-pregn-4-ene-3,11,20-trione
53-06-5, 10007-36-0, 15779-07-4, 35446-72-1, 104713-00-0

17,21-dihydroxy-pregn-4-ene-3,11,20-trione

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: aqueous hydrochloric acid; chloroform
2: benzene; toluene-4-sulfonic acid
3: peroxybenzoic acid; benzene / Behandeln unter Ausschluss von Licht, Behandeln des Reaktionsprodukts mit Ameisensaeure und Erwaermen des danach isolierten Reaktionsprodukts mit wss.-methanol. Kalilauge
4: toluene-4-sulfonic acid
5: benzene; diethyl ether
6: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
7: acetone; toluene-4-sulfonic acid
8: acetic acid; tert-butyl alcohol; selenium dioxide
9: aqueous formic acid
10: pyridine
View Scheme
11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one
3386-04-7, 14423-17-7

11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Dehydrierung durch Septomyxa affinis und anschliessende Acetylierung
2: diacetoxy-phenyl-iodan; OsO4; tert-butyl alcohol / Reagens 4: Pyridin
View Scheme
(20Ξ)-11β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-pregna-1,4-dien-3-one
117888-35-4

(20Ξ)-11β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-pregna-1,4-dien-3-one

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous formic acid
2: pyridine
View Scheme
(20Ξ)-11β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-pregn-4-en-3-one
123292-91-1

(20Ξ)-11β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-pregn-4-en-3-one

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; tert-butyl alcohol; selenium dioxide
2: aqueous formic acid
3: pyridine
View Scheme
17α,20;20,21-bismethylenedioxypregn-4-ene-3,11-dione
3607-68-9

17α,20;20,21-bismethylenedioxypregn-4-ene-3,11-dione

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: benzene; toluene-4-sulfonic acid
2: peroxybenzoic acid; benzene / Behandeln unter Ausschluss von Licht, Behandeln des Reaktionsprodukts mit Ameisensaeure und Erwaermen des danach isolierten Reaktionsprodukts mit wss.-methanol. Kalilauge
3: toluene-4-sulfonic acid
4: benzene; diethyl ether
5: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
6: acetone; toluene-4-sulfonic acid
7: acetic acid; tert-butyl alcohol; selenium dioxide
8: aqueous formic acid
9: pyridine
View Scheme
(20Ξ)-17,20;20,21-bis-methylenedioxy-5α-pregnane-3,6,11-trione
55701-21-8

(20Ξ)-17,20;20,21-bis-methylenedioxy-5α-pregnane-3,6,11-trione

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: toluene-4-sulfonic acid
2: benzene; diethyl ether
3: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
4: acetone; toluene-4-sulfonic acid
5: acetic acid; tert-butyl alcohol; selenium dioxide
6: aqueous formic acid
7: pyridine
View Scheme
(20Ξ)-3,3-ethanediyldioxy-6-methyl-17,20;20,21-bis-methylenedioxy-pregn-5-en-11β-ol

(20Ξ)-3,3-ethanediyldioxy-6-methyl-17,20;20,21-bis-methylenedioxy-pregn-5-en-11β-ol

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetone; toluene-4-sulfonic acid
2: acetic acid; tert-butyl alcohol; selenium dioxide
3: aqueous formic acid
4: pyridine
View Scheme
6-methyl-11-oxo-3-pyrrolidino-pregna-3,5,17(20)c-trien-21-oic acid methyl ester
1968-77-0

6-methyl-11-oxo-3-pyrrolidino-pregna-3,5,17(20)c-trien-21-oic acid methyl ester

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: LiAlH4; diethyl ether / Behandeln des Reaktionsprodukts mit wss.-methanol.Alkalilauge
2: Dehydrierung durch Septomyxa affinis und anschliessende Acetylierung
3: diacetoxy-phenyl-iodan; OsO4; tert-butyl alcohol / Reagens 4: Pyridin
View Scheme
(8′S,9′S,10′R,13′S,14′S,17′R)-10′,13′-dimethyl-1′,2′,4′,7′,8′,9′,10′,12′,13′,14′,15′,16′-dodecahydro-11′H-trispiro[[1,3]dioxolane-2,3′-cyclopenta[a]phenanthrene-17′,4''-[1,3]dioxolane-5'',4'''-[1,3]dioxolan]-11′-one
52248-40-5

(8′S,9′S,10′R,13′S,14′S,17′R)-10′,13′-dimethyl-1′,2′,4′,7′,8′,9′,10′,12′,13′,14′,15′,16′-dodecahydro-11′H-trispiro[[1,3]dioxolane-2,3′-cyclopenta[a]phenanthrene-17′,4''-[1,3]dioxolane-5'',4'''-[1,3]dioxolan]-11′-one

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: peroxybenzoic acid; benzene / Behandeln unter Ausschluss von Licht, Behandeln des Reaktionsprodukts mit Ameisensaeure und Erwaermen des danach isolierten Reaktionsprodukts mit wss.-methanol. Kalilauge
2: toluene-4-sulfonic acid
3: benzene; diethyl ether
4: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
5: acetone; toluene-4-sulfonic acid
6: acetic acid; tert-butyl alcohol; selenium dioxide
7: aqueous formic acid
8: pyridine
View Scheme
(20Ξ)-3,3-ethanediyldioxy-6β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-5α-pregnan-11-one
123885-50-7

(20Ξ)-3,3-ethanediyldioxy-6β-hydroxy-6α-methyl-17,20;20,21-bis-methylenedioxy-5α-pregnan-11-one

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
2: acetone; toluene-4-sulfonic acid
3: acetic acid; tert-butyl alcohol; selenium dioxide
4: aqueous formic acid
5: pyridine
View Scheme
(20Ξ)-3,3-ethanediyldioxy-17,20;20,21-bis-methylenedioxy-5α-pregnane-6,11-dione
107157-45-9

(20Ξ)-3,3-ethanediyldioxy-17,20;20,21-bis-methylenedioxy-5α-pregnane-6,11-dione

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: benzene; diethyl ether
2: pyridine; thionyl chloride / Erwaermen des Reaktionsprodukts mit Lithiumalanat in Aether und Benzol
3: acetone; toluene-4-sulfonic acid
4: acetic acid; tert-butyl alcohol; selenium dioxide
5: aqueous formic acid
6: pyridine
View Scheme
21-acetoxy-9-bromo-11β,17-dihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione
93052-90-5

21-acetoxy-9-bromo-11β,17-dihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione

methylprednisolone acetate
53-36-1

methylprednisolone acetate

9α-chloro-11β,17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate

9α-chloro-11β,17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate

methylprednisolone acetate
53-36-1

methylprednisolone acetate

C26H42O6

C26H42O6

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
2.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
3.1: iodine; calcium oxide / methanol; dichloromethane
3.2: 2 h / 45 - 50 °C
View Scheme
11β,17-dihydroxy-6α-methyl-pregn-4-ene-3,20-dione
7055-53-0

11β,17-dihydroxy-6α-methyl-pregn-4-ene-3,20-dione

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
2.1: iodine; calcium oxide / methanol; dichloromethane
2.2: 2 h / 45 - 50 °C
View Scheme
11β,17α-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
6870-94-6

11β,17α-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

acetic acid
64-19-7

acetic acid

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Stage #1: 11β,17α-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione With iodine; calcium oxide In methanol; dichloromethane
Stage #2: acetic acid With potassium acetate In acetone at 45 - 50℃; for 2h;
17-hydroxy-pregn-4-ene-3,11,20-trione
1882-82-2

17-hydroxy-pregn-4-ene-3,11,20-trione

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: trimethyloxosulfonium bromide; orthoformic acid triethyl ester / 5 h
2.1: sodium tetrahydroborate / tetrahydrofuran / 12 h
3.1: phthalic anhydride; dihydrogen peroxide / ethyl acetate / 6 h
4.1: magnesium / tetrahydrofuran / 4 h
5.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
6.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
7.1: iodine; calcium oxide / methanol; dichloromethane
7.2: 2 h / 45 - 50 °C
View Scheme
3,3;20,20-bis-ethanediyldioxy-17-hydroxy-pregn-5-en-11-one
74332-34-6

3,3;20,20-bis-ethanediyldioxy-17-hydroxy-pregn-5-en-11-one

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 12 h
2.1: phthalic anhydride; dihydrogen peroxide / ethyl acetate / 6 h
3.1: magnesium / tetrahydrofuran / 4 h
4.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
5.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
6.1: iodine; calcium oxide / methanol; dichloromethane
6.2: 2 h / 45 - 50 °C
View Scheme
3,3;20,20-bis-ethanediyldioxy-pregn-5-ene-11β,17-diol
41870-77-3

3,3;20,20-bis-ethanediyldioxy-pregn-5-ene-11β,17-diol

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: phthalic anhydride; dihydrogen peroxide / ethyl acetate / 6 h
2.1: magnesium / tetrahydrofuran / 4 h
3.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
4.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
5.1: iodine; calcium oxide / methanol; dichloromethane
5.2: 2 h / 45 - 50 °C
View Scheme
C25H38O7

C25H38O7

methylprednisolone acetate
53-36-1

methylprednisolone acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: magnesium / tetrahydrofuran / 4 h
2.1: sulfuric acid / tetrahydrofuran / pH 2 - 3
3.1: D-glucose; potassium dihydrogenphosphate / water; methanol / 50 h
4.1: iodine; calcium oxide / methanol; dichloromethane
4.2: 2 h / 45 - 50 °C
View Scheme
methylprednisolone acetate
53-36-1

methylprednisolone acetate

Methylprednisolone
83-43-2

Methylprednisolone

Conditions
ConditionsYield
Hydrolysis;
With potassium hydroxide In methanol; dichloromethane at 10 - 15℃; for 0.333333h; Inert atmosphere;
methylprednisolone acetate
53-36-1

methylprednisolone acetate

2-((6S,10R,13S)-17-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
93239-37-3

2-((6S,10R,13S)-17-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Conditions
ConditionsYield
With pyridine; thionyl chloride
With pyridine; N-bromoacetamide
With sulfur dioxide; methanesulfonyl chloride In tetrahydrofuran; N,N-dimethyl-formamide Cooling with ice;
methylprednisolone acetate
53-36-1

methylprednisolone acetate

A

Methylprednisolone
83-43-2

Methylprednisolone

B

17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
86401-94-7

17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With aq. buffer In N,N-dimethyl-formamide at 25℃; Rate constant; Mechanism; pH dependence;
methylprednisolone acetate
53-36-1

methylprednisolone acetate

A

11β,17α-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
6870-94-6

11β,17α-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

B

11β-hydroxy-6α-methyl-1,4-androstadiene-3,17-dione
61919-52-6

11β-hydroxy-6α-methyl-1,4-androstadiene-3,17-dione

C

6α-methylprednisone acetate

6α-methylprednisone acetate

Conditions
ConditionsYield
Product distribution; Rate constant; Irradiation; radiolytic degradation;
methylprednisolone acetate
53-36-1

methylprednisolone acetate

9-fluoro-11β,17,21-trihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione
382-52-5

9-fluoro-11β,17,21-trihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-bromo-acetamide; pyridine
2: CH2Cl2; tert-butyl alcohol; aqueous HClO4
3: acetone; potassium acetate
4: CH2Cl2; water; HF
5: aqueous methanol. KHCO3
View Scheme
methylprednisolone acetate
53-36-1

methylprednisolone acetate

9,21-difluoro-11β,17-dihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione
359-80-8

9,21-difluoro-11β,17-dihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-bromo-acetamide; pyridine
2: CH2Cl2; tert-butyl alcohol; aqueous HClO4
3: acetone; potassium acetate
4: CH2Cl2; water; HF
5: aqueous methanol. KHCO3
6: ueber mehrere Stufen
View Scheme
methylprednisolone acetate
53-36-1

methylprednisolone acetate

21-acetoxy-9-fluoro-11β,17-dihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione
432-33-7

21-acetoxy-9-fluoro-11β,17-dihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-bromo-acetamide; pyridine
2: CH2Cl2; tert-butyl alcohol; aqueous HClO4
3: acetone; potassium acetate
4: CH2Cl2; water; HF
View Scheme
methylprednisolone acetate
53-36-1

methylprednisolone acetate

21-acetoxy-9-bromo-11β,17-dihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione
93052-90-5

21-acetoxy-9-bromo-11β,17-dihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-bromo-acetamide; pyridine
2: CH2Cl2; tert-butyl alcohol; aqueous HClO4
View Scheme
methylprednisolone acetate
53-36-1

methylprednisolone acetate

21-acetoxy-9,11β-epoxy-17-hydroxy-6α-methyl-9β-pregna-1,4-diene-3,20-dione
115322-26-4

21-acetoxy-9,11β-epoxy-17-hydroxy-6α-methyl-9β-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-bromo-acetamide; pyridine
2: CH2Cl2; tert-butyl alcohol; aqueous HClO4
3: acetone; potassium acetate
View Scheme
methylprednisolone acetate
53-36-1

methylprednisolone acetate

17α,21-dihydroxy-6α-methylpregna-1,4-diene-3,11,20-trione
111264-84-7, 91523-05-6

17α,21-dihydroxy-6α-methylpregna-1,4-diene-3,11,20-trione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Hydrolysis
2: N-bromo-acetamide; pyridine
View Scheme
methylprednisolone acetate
53-36-1

methylprednisolone acetate

21-acetoxy-17-hydroxy-6α-methyl-11β-trifluoroacetoxy-1,4-pregnadiene-3,20-dione
86413-46-9

21-acetoxy-17-hydroxy-6α-methyl-11β-trifluoroacetoxy-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With trifluoroacetic anhydride In pyridine; dichloromethane
methylprednisolone acetate
53-36-1

methylprednisolone acetate

2-oxo-2-((6S,10R,13S)-6,10,13-trimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)ethyl acetate
52212-12-1

2-oxo-2-((6S,10R,13S)-6,10,13-trimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)ethyl acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfur dioxide; methanesulfonyl chloride / N,N-dimethyl-formamide; tetrahydrofuran / Cooling with ice
2: pyridine hydrochloride / toluene / Heating
3: hydrogenchloride; water / tetrahydrofuran
4: potassium carbonate / N,N-dimethyl-formamide / Heating
View Scheme
Multi-step reaction with 4 steps
1: sulfur dioxide / N,N-dimethyl-formamide; tetrahydrofuran / Cooling with ice
2: pyridine hydrochloride / toluene / Heating
3: hydrogenchloride / tetrahydrofuran
4: potassium carbonate / N,N-dimethyl-formamide / Heating
View Scheme

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