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Yangzhou Qinyuan Pharmatech Co.,Ltd

Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.Track record of quality, Lot to lot consistency. 4.Zero

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:0 Metric Ton

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Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:1 Kilogram

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or off-white solid White solid Assay,HPLC 99%min

High purity Various Specifications 4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS:327-78-6

Cas:327-78-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Chloro-3-(Trifluoromethyl)Phenylisocyanate supplier in China

Cas:327-78-6

Min.Order:0 Metric Ton

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/506.html Product Name 4-Chloro-3-(trifluoromethyl)phenyl isocyanate

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to yellow powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermedia

Hangzhou Think Chemical Co. Ltd

4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS No.:327-78-6 Name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Molecular Structure Molecular Formula: C8H3ClF3NO

High purity 4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS No.:327-78-6

Cas:327-78-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Chloro-3-(Trifluoromethyl)Phenylisocyanate

Cas:327-78-6

Min.Order:1

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Type:Other

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% 5. Chi

4-Chloro-3-(trifluoromethyl)phenyl isocyanate(327-78-6)

Cas:327-78-6

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:0

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-5-isocyanatobenzotrifluoride

Cas:327-78-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

1-chloro-4-isocyanato-2-(trifluoromethyl)benzene

Cas:327-78-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

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Hubei DiBo chemical co., LTD

Name: 4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE CAS NO: 327-78-6 Grade:Medical chemicals and exports Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulner

4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE CAS:327-78-6 Chinese manufacturers high-quality

Cas:327-78-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Product Name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Synonyms: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate,98%;Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)-;4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 98% 5GR;4-chloro-a,a,a-trifl

4-Chloro-3-(trifluoromethyl)phenyl isocyanate 327-78-6

Cas:327-78-6

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

High quality 4-Chloro-3-(Trifluoromethyl)Phenylisocyanate supplier in China

Cas:327-78-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 327-78-6 with best quality

Cas:327-78-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzene,1-chloro-4-isocyanato-2-(trifluoromethyl)- 327-78-6

Cas:327-78-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

4-Chloro-3-(trifluoro methyl)phenyl isocyanate

Cas:327-78-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

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Qingdao Beluga Import and Export Co., LTD

4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS:327-78-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hi

4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS:327-78-6

Cas:327-78-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzene,1-chloro-4-isocyanato-2-(trifluoromethyl)-

Cas:327-78-6

Min.Order:1 Kilogram

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:327-78-6

Cas:327-78-6

Min.Order:0

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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates Application:Pharmaceutical intermediate Port:Chinese main port

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:1 Kilogram

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Lonwin Chemical Group Limited

4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS:327-78-6 Specification Items Specification Product name 4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS# 327-78-6

Factory Supply 4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:1 Kilogram

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Type:Other

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

4-Chloro-3-(trifluoromethyl)phenylisocyanate CAS327-78-6

Cas:327-78-6

Min.Order:10 Kilogram

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Chloro-3-(Trifluoromethyl)Phenylisocyanate

Cas:327-78-6

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Nanjing Fred Technology Co.,Ltd.

4-Chloro-3-(trifluoromethyl)phenyl isocyanate is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to off-white solid Storage:Room temperature, Keep in Dark Place. Package:Accordi

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:1 Kilogram

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

4-chloro-3-trifluromethyl)phenyl isocyanate

Cas:327-78-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloro-5-isocyanatobenzotrifluoride

Cas:327-78-6

Min.Order:0

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Type:Lab/Research institutions

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Synthetic route

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
In ethyl acetate at 80℃; for 1h;99.2%
In ethyl acetate at -5 - 80℃; for 3h; Solvent;95%
phosgene
75-44-5

phosgene

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

Conditions
ConditionsYield
In benzene for 12h; Product distribution / selectivity; Reflux;
for 12h; Reflux;
In benzene for 12h; Reflux;
1-chloro-2-(trifluoromethyl)benzene
88-16-4

1-chloro-2-(trifluoromethyl)benzene

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic anhydride; nitric acid / 3 h / 10 - 12 °C
2: iron(III) chloride hexahydrate; hydrazine hydrate / ethanol / 3 h / Reflux
3: dmap / 1,2-dichloro-ethane / -5 - 5 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid / water / 18 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2: iron; ammonium chloride; hydrogenchloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Schlenk technique
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

Conditions
ConditionsYield
In dichloromethane at 50℃; for 16h;
4-chloro-3-(trifluoromethyl)nitrobenzene
777-37-7

4-chloro-3-(trifluoromethyl)nitrobenzene

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iron; ammonium chloride; hydrogenchloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Schlenk technique
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
2-aminomethyl-3-(4-fluoro-phenyl)-3H-quinazolin-4-one
330796-23-1

2-aminomethyl-3-(4-fluoro-phenyl)-3H-quinazolin-4-one

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(4-chloro-3-trifluoromethylphenyl)-3-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-ylmethyl]urea
330796-24-2

1-(4-chloro-3-trifluoromethylphenyl)-3-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-ylmethyl]urea

Conditions
ConditionsYield
In dichloromethane at 20℃;100%
In chloroform98%
4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

3-aminophenylboronic acid pinacolate
210907-84-9

3-aminophenylboronic acid pinacolate

1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea
1258961-70-4

1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea

Conditions
ConditionsYield
In dichloromethane100%
In dichloromethane for 0.333333h;
4-(4-amino-3-(trifluoromethyl)phenoxy)-3-nitropyridin-2-amine
884339-72-4

4-(4-amino-3-(trifluoromethyl)phenoxy)-3-nitropyridin-2-amine

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(4-(2-amino-3-nitropyridin-4-yloxy)-2-(trifluoromethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
884340-04-9

1-(4-(2-amino-3-nitropyridin-4-yloxy)-2-(trifluoromethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Conditions
ConditionsYield
at 20℃; for 20h; Inert atmosphere;99%
N-(4-amino-2-methylphenyl)-5-methylisoxazole-4-carboxamide

N-(4-amino-2-methylphenyl)-5-methylisoxazole-4-carboxamide

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

5-methylisoxazole-4-carboxylic acid {4-[3-(4-chloro-3-(trifluoromethyl)phenyl)ureido]-2-methylphenyl}amide

5-methylisoxazole-4-carboxylic acid {4-[3-(4-chloro-3-(trifluoromethyl)phenyl)ureido]-2-methylphenyl}amide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;99%
In tetrahydrofuran at 20℃;49%
1H-imidazole
288-32-4

1H-imidazole

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide
1187086-96-9

N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide

Conditions
ConditionsYield
In chloroform at 0 - 20℃; for 2h;98%
7-(4-amino-2-methoxyphenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one
1160825-66-0

7-(4-amino-2-methoxyphenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-3-methoxyphenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
1160825-37-5

1-(4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-3-methoxyphenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 14h;98%
4-(4-aminophenoxy)-N-cyclopentylpyridine-2-carboxamide

4-(4-aminophenoxy)-N-cyclopentylpyridine-2-carboxamide

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-cyclopentylpyridine-2-carboxamide

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-cyclopentylpyridine-2-carboxamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 16h; Inert atmosphere;98%
3-bromobenzylamine hydrochloride
39959-54-1

3-bromobenzylamine hydrochloride

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(3-bromo-benzyl)-3-(4-chloro-3-trifluoromethyl-phenyl)-urea
847606-86-4

1-(3-bromo-benzyl)-3-(4-chloro-3-trifluoromethyl-phenyl)-urea

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 20℃; for 3h;97.8%
3-nitrobenzylamine hydrochloride
26177-43-5

3-nitrobenzylamine hydrochloride

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(4-chloro-3-trifluoromethyl-phenyl)-3-(3-nitro-benzyl)-urea
847606-82-0

1-(4-chloro-3-trifluoromethyl-phenyl)-3-(3-nitro-benzyl)-urea

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 2h;97%
1,2-benzisothiazolin-3-one
2634-33-5

1,2-benzisothiazolin-3-one

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

N-[4-chloro-3-(trifluoromethyl)phenyl]benzisothiazol-3-one-2-amide
1437999-63-7

N-[4-chloro-3-(trifluoromethyl)phenyl]benzisothiazol-3-one-2-amide

Conditions
ConditionsYield
In tetrahydrofuran; dichloromethane for 0.5h; Reflux;97%
C11H14BrN5

C11H14BrN5

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

C19H17BrClF3N6O

C19H17BrClF3N6O

Conditions
ConditionsYield
In dichloromethane at 20℃; for 3h;96.5%
3-(4-pyridinyloxy)benzylamine
685533-75-9

3-(4-pyridinyloxy)benzylamine

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(4-chloro-3-trifluoromethylphenyl)-3-[3-(4-pyridinyloxy)benzyl]urea
685533-66-8

1-(4-chloro-3-trifluoromethylphenyl)-3-[3-(4-pyridinyloxy)benzyl]urea

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;96%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

sorafenib
284461-73-0

sorafenib

Conditions
ConditionsYield
With zirconia grinding balls In acetonitrile for 4h; Milling;96%
In ethyl acetate at 20 - 30℃; Large scale;94.2%
In dichloromethane93%
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
284462-37-9

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

sorafenib tosylate

sorafenib tosylate

Conditions
ConditionsYield
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In ethyl acetate at 40 - 71℃; for 0.5h;
Stage #2: toluene-4-sulfonic acid In water; ethyl acetate at 71℃; for 0.666667h; Product distribution / selectivity;
96%
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In butanone at 20 - 85℃;
Stage #2: toluene-4-sulfonic acid In butanone at 20℃;
88%
Stage #1: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; 4-chloro-3-(trifluoromethyl)phenyl isocyanate In tetrahydrofuran at 25 - 64℃; for 0.5h;
Stage #2: toluene-4-sulfonic acid In tetrahydrofuran at 64℃; Product distribution / selectivity;
81.6%
4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

tert-butyl 4-(3-methoxy-4-(1H-pyrazol-4-yl)benzoyl)-3-phenylpiperazine-1-carboxylate
502649-25-4

tert-butyl 4-(3-methoxy-4-(1H-pyrazol-4-yl)benzoyl)-3-phenylpiperazine-1-carboxylate

4-tert-butoxycarbonyl-1-[(4-chloro-3-trifluoromethylphenyl)-aminocarbonyl]-2-phenylpiperazine

4-tert-butoxycarbonyl-1-[(4-chloro-3-trifluoromethylphenyl)-aminocarbonyl]-2-phenylpiperazine

Conditions
ConditionsYield
In dichloromethane at 20℃;96%
4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

3-methyl-piperazine-1-carboxylic acid tert-butyl ester
120737-59-9

3-methyl-piperazine-1-carboxylic acid tert-butyl ester

4-tert-Butoxycarbonyl-1-[(4-chloro-3-trifluoromethylphenyl)-aminocarbonyl]-2-methylpiperazine

4-tert-Butoxycarbonyl-1-[(4-chloro-3-trifluoromethylphenyl)-aminocarbonyl]-2-methylpiperazine

Conditions
ConditionsYield
In dichloromethane at 20℃;96%
Tropone
539-80-0

Tropone

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1,3-bis(4-chloro-3-(trifluoromethyl)phenyl)-3,6-dihydrocyclohepta[d]imidazol-2(1H)-one

1,3-bis(4-chloro-3-(trifluoromethyl)phenyl)-3,6-dihydrocyclohepta[d]imidazol-2(1H)-one

Conditions
ConditionsYield
In Triethylene glycol dimethyl ether at 180℃; for 1h;96%
In Triethylene glycol dimethyl ether at 180℃; for 1h;96%
In Triethylene glycol dimethyl ether at 20 - 180℃; for 1h; Sealed tube; Green chemistry;70%
4-nitro-aniline
100-01-6

4-nitro-aniline

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-nitrophenyl)urea
370-52-5

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-nitrophenyl)urea

Conditions
ConditionsYield
In dichloromethane at 20℃; for 24h;96%
In dichloromethane at 20℃; for 48h;90%
In dichloromethane at 20℃; for 24h;73%
In tetrahydrofuran at 20℃; for 2h;
4-(4-aminophenoxy)-2-pyridine-(N-(methyl-d3))carboxamide
1189975-18-5

4-(4-aminophenoxy)-2-pyridine-(N-(methyl-d3))carboxamide

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d3)aminoformyl)-4-pyridyloxy)phenyl)urea
1130115-44-4

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d3)aminoformyl)-4-pyridyloxy)phenyl)urea

Conditions
ConditionsYield
In dichloromethane; dimethyl sulfoxide at 20℃; for 0.333333h; Inert atmosphere;95.4%
In dichloromethane; dimethyl sulfoxide at 20℃; for 0.333333h; Inert atmosphere;95.4%
In dichloromethane; dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere; Large scale;95.4%
C18H18N2O2S
1474012-29-7

C18H18N2O2S

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

N-[(+/-)-1-phenylethyl]-{6-[3-(4-chloro-3-(trifluoromethyl)phenyl)urea]naphthalen-2-yl}sulfonamide
1474012-34-4

N-[(+/-)-1-phenylethyl]-{6-[3-(4-chloro-3-(trifluoromethyl)phenyl)urea]naphthalen-2-yl}sulfonamide

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 0.2h; Inert atmosphere;95.4%
methyl 4‐(4‐aminophenoxy)picolinate
757251-59-5

methyl 4‐(4‐aminophenoxy)picolinate

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

methyl 4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinate
573673-43-5

methyl 4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinate

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃; Inert atmosphere;95%
In dichloromethane at 0 - 20℃; for 22h;85%
In dichloromethane at 20℃; for 2h;76%
In dichloromethane at 0 - 20℃;5.9 g
4-amino-phenol
123-30-8

4-amino-phenol

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol
1129683-83-5

4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol

Conditions
ConditionsYield
In acetonitrile at 20℃; for 3h;95%
In acetonitrile95%
In dichloromethane at 20℃; for 16h;94%
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 1.5h;94.5%
In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;90%
In dichloromethane for 24h;87%
Boc-tryptophan

Boc-tryptophan

piperonal
120-57-0

piperonal

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

C27H17ClN3O4F3

C27H17ClN3O4F3

Conditions
ConditionsYield
Multistep reaction.;94%
C12H11FN2O

C12H11FN2O

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

C20H14ClF4N3O2

C20H14ClF4N3O2

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1h;94%
4-(4-amino-3-(methylthio)phenoxy)-3-nitropyridin-2-amine
884340-41-4

4-(4-amino-3-(methylthio)phenoxy)-3-nitropyridin-2-amine

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-[4-(2-amino-3-nitropyridin-4-yloxy)-2-(methylthio)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea
884340-42-5

1-[4-(2-amino-3-nitropyridin-4-yloxy)-2-(methylthio)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea

Conditions
ConditionsYield
at 20℃; for 20h; Inert atmosphere;93%
4-(4-aminophenyl)-1H-thieno[3,4-b][1,4]diazepine-2(3H)-one

4-(4-aminophenyl)-1H-thieno[3,4-b][1,4]diazepine-2(3H)-one

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-2,3-dihydro-1H-thieno[3,4-b][1,4]diazepin-4-yl)-phenyl)urea

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-2,3-dihydro-1H-thieno[3,4-b][1,4]diazepin-4-yl)-phenyl)urea

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 12h;93%
In tetrahydrofuran at 20℃;93%
N‐(2‐(tritylthio)ethyl)‐4‐(4‐aminophenoxy)picolinamide

N‐(2‐(tritylthio)ethyl)‐4‐(4‐aminophenoxy)picolinamide

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

N‐(2‐(tritylthio)ethyl)‐4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide

N‐(2‐(tritylthio)ethyl)‐4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h;93%
C37H31N3O2S

C37H31N3O2S

4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

N‐(2‐(tritylthio)ethyl)‐4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide

N‐(2‐(tritylthio)ethyl)‐4‐(4‐(3‐(4‐chloro‐3‐(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h; Cooling with ice;93%

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