Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:32780-32-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent out in 24 ho
Cas:32780-32-8
Min.Order:1 box
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:32780-32-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquirySuperiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 100.0
Type:Other
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:32780-32-8
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryReason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1g/foil bag Application:medicine raw material Transportation:by couri
Cas:32780-32-8
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
TIANFUCHEM-- 32780-32-8--High purity Validamine in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business re
Cas:32780-32-8
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua
Cas:32780-32-8
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:32780-32-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates We strive to provide world-class service for every cl
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Trading Company
inquiryPT-141 Acetate CAS:32780-32-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
Cas:32780-32-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $80.0 / 100.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
We have overseas warehouses in California, Nuevo Laredo, Mexico, Vancouver, Canada, Amsterdam, The Netherlands and Melbourne, Australia. Overseas warehouses can provide some of the best selling products. We look forward to cooperating with strong loc
Cas:32780-32-8
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:32780-32-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Validamine CAS 32780-32-8 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Pr
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryValidamine CAS 32780-32-8 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality
Cas:32780-32-8
Min.Order:1 Kilogram
FOB Price: $50.0 / 100.0
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:32780-32-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryOur Advantages: 1. A strong scientific research team (40people in the research team, including 7 Doctors, 13Masters...). 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch o
Cas:32780-32-8
Min.Order:1 box
FOB Price: $26.0 / 30.0
Type:Trading Company
inquiryProduct name: PT141(Brmelanotide) CAS No.:32780-32-8 Molecule Formula:C7H15NO4 Molecule Weight:177.20 Purity: 99.0% Package: 5kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:32780-32-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquirybenzyl ((1S,2S,3S,4R,5R)-2,3,4-tris(benzyloxy)-5-((benzyloxy)methyl)cyclohexyl)carbamate
validamine
Conditions | Yield |
---|---|
With hydrogenchloride; palladium 10% on activated carbon; hydrogen In methanol; water; ethyl acetate under 760.051 Torr; for 20h; | 95% |
β-D-Glucopyranosylvalidamin-octaacetat
validamine
Conditions | Yield |
---|---|
(i) NH3, MeOH, (ii) NaIO4, (iii) (hydrolysis); Multistep reaction; |
(1S)-(+)-(1,2,4/3,5)-1-acetamido-2,3,4-triacetoxy-5-acetoxymethylcyclohexane
validamine
Conditions | Yield |
---|---|
With sodium methylate; hydrazine hydrate 1.) RT, 2 h, 2.) 100 deg C, 72 h; Yield given. Multistep reaction; | |
With sodium methylate; hydrazine hydrate 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h; Yield given. Multistep reaction; | |
With hydrogenchloride at 80℃; for 2h; | |
Multi-step reaction with 2 steps 1: 10percent NaOMe / methanol / 3 h / 25 °C 2: 80percent aq. NH2NH2 / 72 h / 100 °C / sealed tube View Scheme |
N-((1S,2S,3S,4R,5R)-2,3,4-Trihydroxy-5-hydroxymethyl-cyclohexyl)-acetamide
validamine
Conditions | Yield |
---|---|
With hydrazine hydrate at 100℃; for 72h; sealed tube; Yield given; |
validamine
Conditions | Yield |
---|---|
With ammonia; sodium In tetrahydrofuran at -40℃; for 1.5h; |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium benzoate; barium dihydroxide 1) DMF, 140 deg C, 120 h, 2) MeOH, reflux, 30 min, 3) H2O, 80 deg C, 4 h; Yield given. Multistep reaction; |
2,3-di-O-acetyl-N-benzyloxycarbonyl-4,6-di-O-(p-tolylsulfonyl)-5a-carba-D-glucopyranosylamine
A
validamine
Conditions | Yield |
---|---|
With sodium benzoate; barium dihydroxide 1) DMF, 140 deg C, 120 h, 2) H2O, 80 deg C, 4 h; Yield given. Multistep reaction; |
validamycin A
A
(+)-validoxylamine A
B
validamine
C
valienamine
Conditions | Yield |
---|---|
With ammonium sulfate; Flavobacterium saccharophilum IFO 13984; magnesium sulfate In phosphate buffer for 96h; pH=7.1; Hydrolysis; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
With hydrogen; nickel In water at 20℃; under 2068.59 Torr; for 20h; | A 152 mg B n/a |
D-Glucose
A
validamine
B
valienamine
C
validoxylamine A
D
validamycin A
Conditions | Yield |
---|---|
With Streptomyces hygroscopicus var. limoneus In water at 28℃; for 168h; Further byproducts.; |
Conditions | Yield |
---|---|
With Streptomyces hygroscopicus var. limoneus In water at 28℃; for 168h; Further byproducts.; |
(1R)-(1,3,4/2,6)-1,7-O-benzylidene-4-<(benzyloxycarbonyl)amino>-6-C-(hydroxymethyl)-1,2,3-cyclohexanetriol
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 89.6 percent / pyridine / 8 h / Ambient temperature 2: 0.5 N HCl / methanol / 0.5 h / Heating 3: 4.5 g / pyridine; CH2Cl2 / 14 h / Ambient temperature 4: 1) sodium benzoate, 2) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) H2O, 80 deg C, 4 h View Scheme | |
Multi-step reaction with 3 steps 1: CH2Cl2; pyridine / 14 h / Ambient temperature 2: 4.8 g / pyridine; CH2Cl2 / 15 h / Ambient temperature 3: 1) sodium benzoate, 2) N HCl, 3) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) MeOH, reflux, 30 min, 3) H2O, 80 deg C, 4 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 4.5 g / pyridine; CH2Cl2 / 14 h / Ambient temperature 2: 1) sodium benzoate, 2) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) H2O, 80 deg C, 4 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 0.5 N HCl / methanol / 0.5 h / Heating 2: 4.5 g / pyridine; CH2Cl2 / 14 h / Ambient temperature 3: 1) sodium benzoate, 2) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) H2O, 80 deg C, 4 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 4.8 g / pyridine; CH2Cl2 / 15 h / Ambient temperature 2: 1) sodium benzoate, 2) N HCl, 3) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) MeOH, reflux, 30 min, 3) H2O, 80 deg C, 4 h View Scheme |
(1R,2R,3S,4R,5R)-3,4-di-O-benzyl-5-benzyloxymethyl-1,2-O,O-sulfonyl-cyclohexane-1,2,3,4-tetraol
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) LiN3, 2.) aq. H2SO4 / 1.) DMF, 105 deg C, 2.5 h, 2.) THF, 50 deg C, 30 min 2: 96 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 3: 89 percent / tetrahydrofuran / 3 h / 80 °C 4: 98 percent / NaOMe / methanol / 6 h / Ambient temperature 5: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 6: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme |
(1R,2R,3R,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-3-O-(trifluoromethylsulfonyl)-1,2,3-cyclohexanetriol
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 89 percent / tetrahydrofuran / 3 h / 80 °C 2: 98 percent / NaOMe / methanol / 6 h / Ambient temperature 3: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 4: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme |
(1R,2R,3R,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 96 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 2: 89 percent / tetrahydrofuran / 3 h / 80 °C 3: 98 percent / NaOMe / methanol / 6 h / Ambient temperature 4: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 5: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme |
(1R,2R,3S,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 2: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme |
(1R,2R,3S,4S,6R)-3-O-Acetyl-4-azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 98 percent / NaOMe / methanol / 6 h / Ambient temperature 2: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature 3: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C View Scheme |
1,2-O-isopropylidene-α-D-glucofuranurono-5-ulose-6,3-lactone
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: 86 percent / KF / 6 h / 20 °C 2: 79 percent / D-camphorsulfonic acid / CH2Cl2 / 0.75 h / 25 °C 3: 83 percent / NaBH4 / propan-2-ol / 2 h / 25 °C 4: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C 5: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C 6: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 7: 64 percent / p-TsOH / 2 h / 25 °C 8: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 9: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 10: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 11: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme | |
Multi-step reaction with 11 steps 1: 86 percent / KF / 6 h / 20 °C 2: 79 percent / D-camphorsulfonic acid / CH2Cl2 / 0.75 h / 25 °C 3: NaBH4 / ethanol / Ambient temperature 4: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C 5: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C 6: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 7: 64 percent / p-TsOH / 2 h / 25 °C 8: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 9: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 10: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 11: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C 2: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C 3: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 4: 64 percent / p-TsOH / 2 h / 25 °C 5: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 6: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 7: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 8: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme |
(3aR,3bS,6S,6aS,7aR)-6-Hydroxy-2,2-dimethyl-6-nitromethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 79 percent / D-camphorsulfonic acid / CH2Cl2 / 0.75 h / 25 °C 2: 83 percent / NaBH4 / propan-2-ol / 2 h / 25 °C 3: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C 4: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C 5: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 6: 64 percent / p-TsOH / 2 h / 25 °C 7: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 8: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 9: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 10: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme | |
Multi-step reaction with 10 steps 1: 79 percent / D-camphorsulfonic acid / CH2Cl2 / 0.75 h / 25 °C 2: NaBH4 / ethanol / Ambient temperature 3: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C 4: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C 5: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 6: 64 percent / p-TsOH / 2 h / 25 °C 7: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 8: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 9: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 10: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 2: 64 percent / p-TsOH / 2 h / 25 °C 3: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 4: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 5: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 6: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme |
C24H25NO9
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C 2: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 3: 64 percent / p-TsOH / 2 h / 25 °C 4: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 5: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 6: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 7: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 2: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme | |
Multi-step reaction with 2 steps 1: 1.) 1percent methanolic NaOMe, 2.) pyridine / 1.) RT, 3 h, 2.) RT, 3 h 2: 1.) 1percent methanolic NaOMe, 2.) 80percent aq. NH2NH2 / 1.) RT, 2 h, 2.) 100 deg C, 72 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 2: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 3: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme | |
Multi-step reaction with 3 steps 1: 50 percent / n-Bu3SnH, 2,2'-azobisisobutyronitrile / toluene / 1 h / Heating 2: 1.) 1percent methanolic NaOMe, 2.) pyridine / 1.) RT, 3 h, 2.) RT, 3 h 3: 1.) 1percent methanolic NaOMe, 2.) 80percent aq. NH2NH2 / 1.) RT, 2 h, 2.) 100 deg C, 72 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 64 percent / p-TsOH / 2 h / 25 °C 2: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 3: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 4: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 5: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme |
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 2: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 3: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 4: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme | |
Multi-step reaction with 4 steps 1: 1.) liq. NH3, 2.) p-TsOH 2: 50 percent / n-Bu3SnH, 2,2'-azobisisobutyronitrile / toluene / 1 h / Heating 3: 1.) 1percent methanolic NaOMe, 2.) pyridine / 1.) RT, 3 h, 2.) RT, 3 h 4: 1.) 1percent methanolic NaOMe, 2.) 80percent aq. NH2NH2 / 1.) RT, 2 h, 2.) 100 deg C, 72 h View Scheme |
(3aR,3bS,6S,6aS,7aR)-6-(2-Ethoxy-ethoxy)-2,2-dimethyl-6-nitromethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one
validamine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 83 percent / NaBH4 / propan-2-ol / 2 h / 25 °C 2: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C 3: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C 4: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 5: 64 percent / p-TsOH / 2 h / 25 °C 6: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 7: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 8: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 9: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme | |
Multi-step reaction with 9 steps 1: NaBH4 / ethanol / Ambient temperature 2: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C 3: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C 4: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C 5: 64 percent / p-TsOH / 2 h / 25 °C 6: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h 7: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C 8: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h 9: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h View Scheme |
validamine
2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl isothiocyanate
N-<(1S)-(1,2,4/3,5)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl>-N'-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosyl)thiourea
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide for 0.666667h; Ambient temperature; | 92.8% |
Conditions | Yield |
---|---|
Stage #1: validamine; benzyl chloroformate In 1,4-dioxane; water at 0 - 20℃; for 2h; Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water pH=7 - 7.5; | 92% |
In 1,4-dioxane; water at 0 - 20℃; for 1h; | 88% |
In 1,4-dioxane; water 1.) 0-5 deg C, 1 h, 2.) room temp., 1 h; | 31.8 g |
validamine
Conditions | Yield |
---|---|
In 1,4-dioxane; water at 0 - 20℃; for 18h; | 88.4% |
dihydroxyacetone
validamine
N-<2-hydroxy-1-(hydroxymethyl)ethyl>validamine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium cyanoborohydride In N,N-dimethyl-formamide at 50 - 60℃; for 15h; | 55% |
validamine
acetic anhydride
(1S)-(+)-(1,2,4/3,5)-1-acetamido-2,3,4-triacetoxy-5-acetoxymethylcyclohexane
Conditions | Yield |
---|---|
With pyridine; dmap Inert atmosphere; | 52% |
With pyridine; dmap for 24h; Ambient temperature; Yield given; |
Cellobiose
validamine
A
1-O-β-D-glucopyranosyl-1L-(1,3,4/2,6)-4-amino-6-hydroxymethyl-1,2,3-cyclohexanetriol
B
validamine 2-β-glucoside
C
7-O-β-D-glucosyl validamine
Conditions | Yield |
---|---|
In water at 27℃; for 72h; β-glucosidase (from Rhodotorula lactosa); | A 48 mg B 51 mg C 125 mg |
Maltose
validamine
A
validamine 7-α-isomaltoside
B
validamine 4-α-glucoside
C
validamine 7-α-glucoside
Conditions | Yield |
---|---|
In water at 27℃; for 72h; α-glucosidase (from Rhodotorula lactosa); | A 22 mg B 44 mg C 106 mg |
Conditions | Yield |
---|---|
With pyridine 1.) isopropanol, 120 deg C, 6 d, 2.) room temp., overnight; Yield given. Multistep reaction. Yields of byproduct given; |
validamine
(1S,5S,7R,8S,1''R)-3-(5a'-carba-α-D-glucopyranosylamino)-7-(1'',2''-dihydroxyethyl)-2,6-dioxa-4-azabicyclo<3.3.0>oct-3-en-8-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92.8 percent / dimethylformamide; H2O / 0.67 h / Ambient temperature 2: 94.8 percent / HgO / diethyl ether / 46 h / Ambient temperature 3: 85.7 percent / Na / liquid ammonia; tetrahydrofuran / 0.25 h / -78 °C View Scheme |
validamine
(1S,3R,4R,5S,6S)-3-hydroxymethyl-8-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosylamino)-7-oxa-9-azabicyclo<4.3.0>non-8-ene-4,5-diol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 92.8 percent / dimethylformamide; H2O / 0.67 h / Ambient temperature 2: 94.8 percent / HgO / diethyl ether / 46 h / Ambient temperature View Scheme |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View