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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Validamine Manufacturer/High quality/Best price/In stock

Cas:32780-32-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qiuxian Yanjia Trading Co., Ltd

1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent out in 24 ho

Peptide Bremelanotide PT-141 CAS 32780-32-8

Cas:32780-32-8

Min.Order:1 box

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Top quality peptide PT-141 Acetate/Bremelanotide Acetate powder

Cas:32780-32-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Validamine

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Superiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best

Validamine API with best price and top quality

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 100.0

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

PT141 Acetate/ Bremelanotide Acetate manufacturer with low price

Cas:32780-32-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Reason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa

Peptide Bremelanotide PT-141 (10mg/vial) CAS NO.32780-32-8

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1g/foil bag Application:medicine raw material Transportation:by couri

Manufacturer high quality PT-141 Acetate Cas 32780-32-8 with good price

Cas:32780-32-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Validamine

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Validamine

Cas:32780-32-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 32780-32-8--High purity Validamine in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business re

TIANFUCHEM-- 32780-32-8--High purity Validamine in stock

Cas:32780-32-8

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Validamine

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 32780-32-8 with best quality

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

PT141 99%

Cas:32780-32-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Validamine 32780-32-8

Cas:32780-32-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates We strive to provide world-class service for every cl

Peptides API PT-141 Validamine

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

PT-141 Acetate CAS:32780-32-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

PT-141 Acetate CAS:32780-32-8

Cas:32780-32-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Validamine

Cas:32780-32-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Validamine

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Validamine

Cas:32780-32-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, Nuevo Laredo, Mexico, Vancouver, Canada, Amsterdam, The Netherlands and Melbourne, Australia. Overseas warehouses can provide some of the best selling products. We look forward to cooperating with strong loc

China Supplier PT 141 Peptide Acetate cas 32780-32-8 Free Customs Clearance

Cas:32780-32-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Validamine 32780-32-8

Cas:32780-32-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

PT-141

Cas:32780-32-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Validamine CAS 32780-32-8 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Pr

Validamine CAS 32780-32-8

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Validamine CAS 32780-32-8 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality

Validamine CAS 32780-32-8

Cas:32780-32-8

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Validamine

Cas:32780-32-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

MGF IGF-1 Ec

Cas:32780-32-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Maisheng Hebei Technology Co., Ltd.

Our Advantages: 1. A strong scientific research team (40people in the research team, including 7 Doctors, 13Masters...). 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch o

99% Purity PT141 peptide PT-141 Acetate/Bremelanotide Acetate powder CAS NO.32780-32-8

Cas:32780-32-8

Min.Order:1 box

FOB Price: $26.0 / 30.0

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: PT141(Brmelanotide) CAS No.:32780-32-8 Molecule Formula:C7H15NO4 Molecule Weight:177.20 Purity: 99.0% Package: 5kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality PT141(Brmelanotide) in stock

Cas:32780-32-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

benzyl ((1S,2S,3S,4R,5R)-2,3,4-tris(benzyloxy)-5-((benzyloxy)methyl)cyclohexyl)carbamate
1316231-06-7

benzyl ((1S,2S,3S,4R,5R)-2,3,4-tris(benzyloxy)-5-((benzyloxy)methyl)cyclohexyl)carbamate

validamine
32780-32-8

validamine

Conditions
ConditionsYield
With hydrogenchloride; palladium 10% on activated carbon; hydrogen In methanol; water; ethyl acetate under 760.051 Torr; for 20h;95%
β-D-Glucopyranosylvalidamin-octaacetat
73411-05-9, 73651-21-5

β-D-Glucopyranosylvalidamin-octaacetat

validamine
32780-32-8

validamine

Conditions
ConditionsYield
(i) NH3, MeOH, (ii) NaIO4, (iii) (hydrolysis); Multistep reaction;
(1S)-(+)-(1,2,4/3,5)-1-acetamido-2,3,4-triacetoxy-5-acetoxymethylcyclohexane
68108-50-9

(1S)-(+)-(1,2,4/3,5)-1-acetamido-2,3,4-triacetoxy-5-acetoxymethylcyclohexane

validamine
32780-32-8

validamine

Conditions
ConditionsYield
With sodium methylate; hydrazine hydrate 1.) RT, 2 h, 2.) 100 deg C, 72 h; Yield given. Multistep reaction;
With sodium methylate; hydrazine hydrate 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h; Yield given. Multistep reaction;
With hydrogenchloride at 80℃; for 2h;
Multi-step reaction with 2 steps
1: 10percent NaOMe / methanol / 3 h / 25 °C
2: 80percent aq. NH2NH2 / 72 h / 100 °C / sealed tube
View Scheme
N-((1S,2S,3S,4R,5R)-2,3,4-Trihydroxy-5-hydroxymethyl-cyclohexyl)-acetamide
124492-65-5

N-((1S,2S,3S,4R,5R)-2,3,4-Trihydroxy-5-hydroxymethyl-cyclohexyl)-acetamide

validamine
32780-32-8

validamine

Conditions
ConditionsYield
With hydrazine hydrate at 100℃; for 72h; sealed tube; Yield given;
(1S,2R,3R,4R,6S)-6-Amino-2,3-bis-benzyloxy-4-benzyloxymethyl-cyclohexanol

(1S,2R,3R,4R,6S)-6-Amino-2,3-bis-benzyloxy-4-benzyloxymethyl-cyclohexanol

validamine
32780-32-8

validamine

Conditions
ConditionsYield
With ammonia; sodium In tetrahydrofuran at -40℃; for 1.5h;
3-O-acetyl 4,6-O-benzylidene-N-benzyloxycarbonyl-2-O-(p-tolylsulfonyl)-5a-carba-D-glucopyranosylamine

3-O-acetyl 4,6-O-benzylidene-N-benzyloxycarbonyl-2-O-(p-tolylsulfonyl)-5a-carba-D-glucopyranosylamine

A

validamine
32780-32-8

validamine

B

2-epi-Validamine
191740-46-2

2-epi-Validamine

Conditions
ConditionsYield
With hydrogenchloride; sodium benzoate; barium dihydroxide 1) DMF, 140 deg C, 120 h, 2) MeOH, reflux, 30 min, 3) H2O, 80 deg C, 4 h; Yield given. Multistep reaction;
2,3-di-O-acetyl-N-benzyloxycarbonyl-4,6-di-O-(p-tolylsulfonyl)-5a-carba-D-glucopyranosylamine
191723-81-6

2,3-di-O-acetyl-N-benzyloxycarbonyl-4,6-di-O-(p-tolylsulfonyl)-5a-carba-D-glucopyranosylamine

A

validamine
32780-32-8

validamine

B

4-epi-validamine

4-epi-validamine

Conditions
ConditionsYield
With sodium benzoate; barium dihydroxide 1) DMF, 140 deg C, 120 h, 2) H2O, 80 deg C, 4 h; Yield given. Multistep reaction;
validamycin A
37248-47-8

validamycin A

A

(+)-validoxylamine A
38665-10-0

(+)-validoxylamine A

B

validamine
32780-32-8

validamine

C

valienamine
38231-86-6

valienamine

Conditions
ConditionsYield
With ammonium sulfate; Flavobacterium saccharophilum IFO 13984; magnesium sulfate In phosphate buffer for 96h; pH=7.1; Hydrolysis; Title compound not separated from byproducts;
valienamine
38231-86-6

valienamine

A

validamine
32780-32-8

validamine

B

5-epi-validamine
38231-87-7

5-epi-validamine

Conditions
ConditionsYield
With hydrogen; nickel In water at 20℃; under 2068.59 Torr; for 20h;A 152 mg
B n/a
D-Glucose
2280-44-6

D-Glucose

culture medium

culture medium

A

validamine
32780-32-8

validamine

B

valienamine
38231-86-6

valienamine

D

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
With Streptomyces hygroscopicus var. limoneus In water at 28℃; for 168h; Further byproducts.;
D-Glucose
2280-44-6

D-Glucose

culture medium

culture medium

A

validamine
32780-32-8

validamine

B

valienamine
38231-86-6

valienamine

C

validamycin A
37248-47-8

validamycin A

D

validamycin B

validamycin B

Conditions
ConditionsYield
With Streptomyces hygroscopicus var. limoneus In water at 28℃; for 168h; Further byproducts.;
(1R)-(1,3,4/2,6)-1,7-O-benzylidene-4-<(benzyloxycarbonyl)amino>-6-C-(hydroxymethyl)-1,2,3-cyclohexanetriol
89859-47-2

(1R)-(1,3,4/2,6)-1,7-O-benzylidene-4-<(benzyloxycarbonyl)amino>-6-C-(hydroxymethyl)-1,2,3-cyclohexanetriol

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 89.6 percent / pyridine / 8 h / Ambient temperature
2: 0.5 N HCl / methanol / 0.5 h / Heating
3: 4.5 g / pyridine; CH2Cl2 / 14 h / Ambient temperature
4: 1) sodium benzoate, 2) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) H2O, 80 deg C, 4 h
View Scheme
Multi-step reaction with 3 steps
1: CH2Cl2; pyridine / 14 h / Ambient temperature
2: 4.8 g / pyridine; CH2Cl2 / 15 h / Ambient temperature
3: 1) sodium benzoate, 2) N HCl, 3) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) MeOH, reflux, 30 min, 3) H2O, 80 deg C, 4 h
View Scheme
Acetic acid (1S,2S,3S,5R,6R)-2-acetoxy-3-benzyloxycarbonylamino-6-hydroxy-5-hydroxymethyl-cyclohexyl ester

Acetic acid (1S,2S,3S,5R,6R)-2-acetoxy-3-benzyloxycarbonylamino-6-hydroxy-5-hydroxymethyl-cyclohexyl ester

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 4.5 g / pyridine; CH2Cl2 / 14 h / Ambient temperature
2: 1) sodium benzoate, 2) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) H2O, 80 deg C, 4 h
View Scheme
2,3-di-O-acetyl-4,6-O-benzylidene-N-benzyloxycarbonyl-5a-carba-D-glucopyranosylamine

2,3-di-O-acetyl-4,6-O-benzylidene-N-benzyloxycarbonyl-5a-carba-D-glucopyranosylamine

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 0.5 N HCl / methanol / 0.5 h / Heating
2: 4.5 g / pyridine; CH2Cl2 / 14 h / Ambient temperature
3: 1) sodium benzoate, 2) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) H2O, 80 deg C, 4 h
View Scheme
Toluene-4-sulfonic acid (4aR,6S,7S,8S,8aR)-6-benzyloxycarbonylamino-8-hydroxy-2-phenyl-hexahydro-benzo[1,3]dioxin-7-yl ester

Toluene-4-sulfonic acid (4aR,6S,7S,8S,8aR)-6-benzyloxycarbonylamino-8-hydroxy-2-phenyl-hexahydro-benzo[1,3]dioxin-7-yl ester

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 4.8 g / pyridine; CH2Cl2 / 15 h / Ambient temperature
2: 1) sodium benzoate, 2) N HCl, 3) Ba(OH)2 / 1) DMF, 140 deg C, 120 h, 2) MeOH, reflux, 30 min, 3) H2O, 80 deg C, 4 h
View Scheme
(1R,2R,3S,4R,5R)-3,4-di-O-benzyl-5-benzyloxymethyl-1,2-O,O-sulfonyl-cyclohexane-1,2,3,4-tetraol
151693-59-3

(1R,2R,3S,4R,5R)-3,4-di-O-benzyl-5-benzyloxymethyl-1,2-O,O-sulfonyl-cyclohexane-1,2,3,4-tetraol

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) LiN3, 2.) aq. H2SO4 / 1.) DMF, 105 deg C, 2.5 h, 2.) THF, 50 deg C, 30 min
2: 96 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C
3: 89 percent / tetrahydrofuran / 3 h / 80 °C
4: 98 percent / NaOMe / methanol / 6 h / Ambient temperature
5: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature
6: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C
View Scheme
(1R,2R,3R,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-3-O-(trifluoromethylsulfonyl)-1,2,3-cyclohexanetriol
166376-50-7

(1R,2R,3R,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-3-O-(trifluoromethylsulfonyl)-1,2,3-cyclohexanetriol

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 89 percent / tetrahydrofuran / 3 h / 80 °C
2: 98 percent / NaOMe / methanol / 6 h / Ambient temperature
3: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature
4: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C
View Scheme
(1R,2R,3R,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol
166376-48-3

(1R,2R,3R,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C
2: 89 percent / tetrahydrofuran / 3 h / 80 °C
3: 98 percent / NaOMe / methanol / 6 h / Ambient temperature
4: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature
5: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C
View Scheme
(1R,2R,3S,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol
166376-52-9

(1R,2R,3S,4S,6R)-4-Azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature
2: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C
View Scheme
(1R,2R,3S,4S,6R)-3-O-Acetyl-4-azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol
166376-51-8

(1R,2R,3S,4S,6R)-3-O-Acetyl-4-azido-1,2-di-O-benzyl-6-<(benzyloxy)methyl>-1,2,3-cyclohexanetriol

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / NaOMe / methanol / 6 h / Ambient temperature
2: H2 / Raney nickel / ethyl acetate / 18 h / Ambient temperature
3: Na, NH3 / tetrahydrofuran / 1.5 h / -40 °C
View Scheme
1,2-O-isopropylidene-α-D-glucofuranurono-5-ulose-6,3-lactone
5040-08-4

1,2-O-isopropylidene-α-D-glucofuranurono-5-ulose-6,3-lactone

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 86 percent / KF / 6 h / 20 °C
2: 79 percent / D-camphorsulfonic acid / CH2Cl2 / 0.75 h / 25 °C
3: 83 percent / NaBH4 / propan-2-ol / 2 h / 25 °C
4: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C
5: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C
6: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
7: 64 percent / p-TsOH / 2 h / 25 °C
8: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
9: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
10: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
11: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
Multi-step reaction with 11 steps
1: 86 percent / KF / 6 h / 20 °C
2: 79 percent / D-camphorsulfonic acid / CH2Cl2 / 0.75 h / 25 °C
3: NaBH4 / ethanol / Ambient temperature
4: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C
5: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C
6: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
7: 64 percent / p-TsOH / 2 h / 25 °C
8: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
9: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
10: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
11: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
(3aR,5R,6S,6aR)-5-((R)-1-Hydroxymethyl-2-nitro-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol

(3aR,5R,6S,6aR)-5-((R)-1-Hydroxymethyl-2-nitro-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C
2: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C
3: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
4: 64 percent / p-TsOH / 2 h / 25 °C
5: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
6: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
7: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
8: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
(3aR,3bS,6S,6aS,7aR)-6-Hydroxy-2,2-dimethyl-6-nitromethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one
152434-60-1

(3aR,3bS,6S,6aS,7aR)-6-Hydroxy-2,2-dimethyl-6-nitromethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 79 percent / D-camphorsulfonic acid / CH2Cl2 / 0.75 h / 25 °C
2: 83 percent / NaBH4 / propan-2-ol / 2 h / 25 °C
3: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C
4: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C
5: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
6: 64 percent / p-TsOH / 2 h / 25 °C
7: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
8: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
9: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
10: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
Multi-step reaction with 10 steps
1: 79 percent / D-camphorsulfonic acid / CH2Cl2 / 0.75 h / 25 °C
2: NaBH4 / ethanol / Ambient temperature
3: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C
4: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C
5: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
6: 64 percent / p-TsOH / 2 h / 25 °C
7: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
8: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
9: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
10: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
C21H21NO9

C21H21NO9

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
2: 64 percent / p-TsOH / 2 h / 25 °C
3: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
4: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
5: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
6: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
C24H25NO9
152434-63-4

C24H25NO9

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C
2: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
3: 64 percent / p-TsOH / 2 h / 25 °C
4: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
5: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
6: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
7: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
C27H29NO9

C27H29NO9

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
2: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
Multi-step reaction with 2 steps
1: 1.) 1percent methanolic NaOMe, 2.) pyridine / 1.) RT, 3 h, 2.) RT, 3 h
2: 1.) 1percent methanolic NaOMe, 2.) 80percent aq. NH2NH2 / 1.) RT, 2 h, 2.) 100 deg C, 72 h
View Scheme
C27H28N2O11

C27H28N2O11

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
2: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
3: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
Multi-step reaction with 3 steps
1: 50 percent / n-Bu3SnH, 2,2'-azobisisobutyronitrile / toluene / 1 h / Heating
2: 1.) 1percent methanolic NaOMe, 2.) pyridine / 1.) RT, 3 h, 2.) RT, 3 h
3: 1.) 1percent methanolic NaOMe, 2.) 80percent aq. NH2NH2 / 1.) RT, 2 h, 2.) 100 deg C, 72 h
View Scheme
C21H21NO9

C21H21NO9

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 64 percent / p-TsOH / 2 h / 25 °C
2: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
3: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
4: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
5: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
C27H27NO12

C27H27NO12

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
2: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
3: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
4: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
Multi-step reaction with 4 steps
1: 1.) liq. NH3, 2.) p-TsOH
2: 50 percent / n-Bu3SnH, 2,2'-azobisisobutyronitrile / toluene / 1 h / Heating
3: 1.) 1percent methanolic NaOMe, 2.) pyridine / 1.) RT, 3 h, 2.) RT, 3 h
4: 1.) 1percent methanolic NaOMe, 2.) 80percent aq. NH2NH2 / 1.) RT, 2 h, 2.) 100 deg C, 72 h
View Scheme
(3aR,3bS,6S,6aS,7aR)-6-(2-Ethoxy-ethoxy)-2,2-dimethyl-6-nitromethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one
152434-61-2

(3aR,3bS,6S,6aS,7aR)-6-(2-Ethoxy-ethoxy)-2,2-dimethyl-6-nitromethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one

validamine
32780-32-8

validamine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 83 percent / NaBH4 / propan-2-ol / 2 h / 25 °C
2: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C
3: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C
4: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
5: 64 percent / p-TsOH / 2 h / 25 °C
6: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
7: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
8: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
9: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
Multi-step reaction with 9 steps
1: NaBH4 / ethanol / Ambient temperature
2: 178 mg / pyridine / CH2Cl2 / 0.5 h / 25 °C
3: 84 mg / aq.trifluoroacetic acid / 1 h / 40 °C
4: 140 mg / CsF / dimethylformamide / 0.5 h / 25 °C
5: 64 percent / p-TsOH / 2 h / 25 °C
6: 1.) liq.NH3, 2.) p-TsOH*H2O / 1.) THF, -78 deg C, 9 min; 2.) 25 deg C, 2 h
7: 50 percent / n-Bu3SnH, AIBN / toluene / 1 h / 110 °C
8: 1.) sodium methoxide, 2.) pyridine / 1.) MeOH, 25 deg C, 3 h; 25 deg C, 12 h
9: 1.) sodium methoxide, 2.) aq. hydrazine / 1.) MeOH, 25 deg C, 2 h; 2.) 100 deg C, 72 h
View Scheme
validamine
32780-32-8

validamine

2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl isothiocyanate
93173-26-3

2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl isothiocyanate

N-<(1S)-(1,2,4/3,5)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl>-N'-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosyl)thiourea
162414-07-5

N-<(1S)-(1,2,4/3,5)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl>-N'-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosyl)thiourea

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide for 0.666667h; Ambient temperature;92.8%
validamine
32780-32-8

validamine

benzyl chloroformate
501-53-1

benzyl chloroformate

N-(benzyloxycarbonyl)validamine
85281-05-6

N-(benzyloxycarbonyl)validamine

Conditions
ConditionsYield
Stage #1: validamine; benzyl chloroformate In 1,4-dioxane; water at 0 - 20℃; for 2h;
Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water pH=7 - 7.5;
92%
In 1,4-dioxane; water at 0 - 20℃; for 1h;88%
In 1,4-dioxane; water 1.) 0-5 deg C, 1 h, 2.) room temp., 1 h;31.8 g
validamine
32780-32-8

validamine

S-tert-butoxycarbonyl-2-thioxo-4,6-dimethylpyrimidine

S-tert-butoxycarbonyl-2-thioxo-4,6-dimethylpyrimidine

N-(tert-butyloxycarbonyl)-validamine

N-(tert-butyloxycarbonyl)-validamine

Conditions
ConditionsYield
In 1,4-dioxane; water at 0 - 20℃; for 18h;88.4%
dihydroxyacetone
96-26-4

dihydroxyacetone

validamine
32780-32-8

validamine

N-<2-hydroxy-1-(hydroxymethyl)ethyl>validamine
83470-79-5

N-<2-hydroxy-1-(hydroxymethyl)ethyl>validamine

Conditions
ConditionsYield
With hydrogenchloride; sodium cyanoborohydride In N,N-dimethyl-formamide at 50 - 60℃; for 15h;55%
validamine
32780-32-8

validamine

acetic anhydride
108-24-7

acetic anhydride

(1S)-(+)-(1,2,4/3,5)-1-acetamido-2,3,4-triacetoxy-5-acetoxymethylcyclohexane
68108-50-9

(1S)-(+)-(1,2,4/3,5)-1-acetamido-2,3,4-triacetoxy-5-acetoxymethylcyclohexane

Conditions
ConditionsYield
With pyridine; dmap Inert atmosphere;52%
With pyridine; dmap for 24h; Ambient temperature; Yield given;
validamine
32780-32-8

validamine

acetic anhydride
108-24-7

acetic anhydride

Methyl 3,4-anhydro-α-D-galactopyranoside
24578-12-9

Methyl 3,4-anhydro-α-D-galactopyranoside

A

Acetic acid (2R,3R,4R,5R,6S)-5-acetoxy-2-acetoxymethyl-6-methoxy-4-((1S,2S,3S,4R,5R)-2,3,4-triacetoxy-5-acetoxymethyl-cyclohexylamino)-tetrahydro-pyran-3-yl ester

Acetic acid (2R,3R,4R,5R,6S)-5-acetoxy-2-acetoxymethyl-6-methoxy-4-((1S,2S,3S,4R,5R)-2,3,4-triacetoxy-5-acetoxymethyl-cyclohexylamino)-tetrahydro-pyran-3-yl ester

B

Acetic acid (2S,3R,4S,5R,6S)-3-acetoxy-6-acetoxymethyl-2-methoxy-5-((1S,2S,3S,4R,5R)-2,3,4-triacetoxy-5-acetoxymethyl-cyclohexylamino)-tetrahydro-pyran-4-yl ester

Acetic acid (2S,3R,4S,5R,6S)-3-acetoxy-6-acetoxymethyl-2-methoxy-5-((1S,2S,3S,4R,5R)-2,3,4-triacetoxy-5-acetoxymethyl-cyclohexylamino)-tetrahydro-pyran-4-yl ester

Conditions
ConditionsYield
With pyridine 1.) isopropanol, 120 deg C, 6 d, 2.) room temp., overnight; Yield given. Multistep reaction. Yields of byproduct given;
validamine
32780-32-8

validamine

(1S,5S,7R,8S,1''R)-3-(5a'-carba-α-D-glucopyranosylamino)-7-(1'',2''-dihydroxyethyl)-2,6-dioxa-4-azabicyclo<3.3.0>oct-3-en-8-ol
162414-09-7

(1S,5S,7R,8S,1''R)-3-(5a'-carba-α-D-glucopyranosylamino)-7-(1'',2''-dihydroxyethyl)-2,6-dioxa-4-azabicyclo<3.3.0>oct-3-en-8-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92.8 percent / dimethylformamide; H2O / 0.67 h / Ambient temperature
2: 94.8 percent / HgO / diethyl ether / 46 h / Ambient temperature
3: 85.7 percent / Na / liquid ammonia; tetrahydrofuran / 0.25 h / -78 °C
View Scheme
validamine
32780-32-8

validamine

(1S,3R,4R,5S,6S)-3-hydroxymethyl-8-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosylamino)-7-oxa-9-azabicyclo<4.3.0>non-8-ene-4,5-diol
162414-08-6

(1S,3R,4R,5S,6S)-3-hydroxymethyl-8-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosylamino)-7-oxa-9-azabicyclo<4.3.0>non-8-ene-4,5-diol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92.8 percent / dimethylformamide; H2O / 0.67 h / Ambient temperature
2: 94.8 percent / HgO / diethyl ether / 46 h / Ambient temperature
View Scheme

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