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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specif

Validamycin Manufacturer/High quality/Best price/In stock

Cas:37248-47-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Validamycin supplier in China

Cas:37248-47-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

High quality Validamycin Cas 37248-47-8 with good price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fi

High quality Validamycin Cas 37248-47-8 with good price

Cas:37248-47-8

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Validamycin 37248-47-8 GMP Manufacturer

Cas:37248-47-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Validamycin

Cas:37248-47-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Validamycin

Cas:37248-47-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name: Validamycin CAS no. : 37248-47-8 Molecular formula: C20H35NO13 Molecular weight:497.49 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Validamycin /CAS :37248-47-8/raw material/high-quality

Cas:37248-47-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

37248-47-8

Cas:37248-47-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 37248-47-8 with competitive price

Cas:37248-47-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High quality Validamycin with best price CAS NO.37248-47-8 CAS NO.37248-47-8

Cas:37248-47-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Validamycin

Cas:37248-47-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

Validamycin CAS:37248-47-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Validamycin CAS:37248-47-8

Cas:37248-47-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

High quality Validamycin with best price CAS NO.37248-47-8 CAS NO.37248-47-8

Cas:37248-47-8

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:37248-47-8

Cas:37248-47-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Validamycin

Cas:37248-47-8

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Validamycin

Cas:37248-47-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Rely Chemicals Ltd.

Best quality/price/service Professional manufacturing FAO Standards Appearance:white powder Package:Solid:50g,100g,200g,250g,400g,500g,1kg,10kg bag ,20kg, 25kg,40kg bag,50kg,600kg, 900kg; Aluminum Foil Bag,plastic bag, fiber bag, fiber drum,wa

fungicide Validamycin 60%TC 25%SP 20%SP 10%SL 5%SL 3%SL CAS No.:37248-47-8

Cas:37248-47-8

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Validamycin

Cas:37248-47-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

D-chiro-Inositol, 1,5,6-trideoxy-3-O-beta-D-glucopyranosyl- CAS NO.37248-47-8

Cas:37248-47-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

High quality Validamycin with best price CAS NO.37248-47-8 CAS NO.37248-47-8

Cas:37248-47-8

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Validamycin

Cas:37248-47-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Validamycin

Cas:37248-47-8

Min.Order:0

Negotiable

Type:Other

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferValidamycin

Cas:37248-47-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

jingangmycin

Cas:37248-47-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Validamycin;Validamycin A;Validacin;Solacol.99%

Cas:37248-47-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

High quality Validamycin with best price CAS NO.37248-47-8 CAS NO.37248-47-8

Cas:37248-47-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Validamycin

Cas:37248-47-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Validamycin

Cas:37248-47-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

7,2'',3'',4'',6''-penta-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidamycin A
86733-63-3

7,2'',3'',4'',6''-penta-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidamycin A

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
With ammonia; sodium In tetrahydrofuran at -78℃; for 6h;
With ammonium chloride; sodium 1) liq NH3, THF, -70 deg C, 4 h 20 min, 2) room temp., 4.5 h; Multistep reaction;
validamycin A undeca-O-acetate
86733-64-4, 121468-80-2

validamycin A undeca-O-acetate

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
With sodium methylate In methanol for 5h; Ambient temperature;
validamycin A undecabenzyl ether
73482-11-8

validamycin A undecabenzyl ether

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
With ammonium chloride; sodium 1) liq NH3, THF, -70 deg C, 4 h 20 min, 2) room temp., 4.5 h; Multistep reaction;
D-Glucose
2280-44-6

D-Glucose

culture medium

culture medium

A

validamine
32780-32-8

validamine

B

valienamine
38231-86-6

valienamine

D

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
With Streptomyces hygroscopicus var. limoneus In water at 28℃; for 168h; Further byproducts.;
D-Glucose
2280-44-6

D-Glucose

culture medium

culture medium

A

validamine
32780-32-8

validamine

B

valienamine
38231-86-6

valienamine

C

validamycin A
37248-47-8

validamycin A

D

validamycin B

validamycin B

Conditions
ConditionsYield
With Streptomyces hygroscopicus var. limoneus In water at 28℃; for 168h; Further byproducts.;
2,3,4',5',6',7'-hexa-O-benzylvalidoxylamine A
86733-61-1

2,3,4',5',6',7'-hexa-O-benzylvalidoxylamine A

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 55.7 percent / imidazole / CHCl3 / 40 h / Heating
2: 74.2 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 4.5 h / Ambient temperature
3: 1) sodium, 2) ammonium chloride / 1) liq NH3, THF, -70 deg C, 4 h 20 min, 2) room temp., 4.5 h
View Scheme
Multi-step reaction with 3 steps
1: 61 percent / imidazole / CHCl3 / 48 h / Heating
2: 84 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 10 h / Ambient temperature
3: liquid ammonia, sodium / tetrahydrofuran / 6 h / -78 °C
View Scheme
7-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidoxylamine A
86733-62-2

7-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidoxylamine A

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74.2 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 4.5 h / Ambient temperature
2: 1) sodium, 2) ammonium chloride / 1) liq NH3, THF, -70 deg C, 4 h 20 min, 2) room temp., 4.5 h
View Scheme
Multi-step reaction with 2 steps
1: 84 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 10 h / Ambient temperature
2: liquid ammonia, sodium / tetrahydrofuran / 6 h / -78 °C
View Scheme
2,3,4',5',6',7'-hexa-O-benzyl-4,7-O-benzylidenevalidoxylamine A
86756-42-5, 102131-10-2

2,3,4',5',6',7'-hexa-O-benzyl-4,7-O-benzylidenevalidoxylamine A

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 59 percent / aq acetic acid (80percent) / 20 h / 60 °C
2: 55.7 percent / imidazole / CHCl3 / 40 h / Heating
3: 74.2 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 4.5 h / Ambient temperature
4: 1) sodium, 2) ammonium chloride / 1) liq NH3, THF, -70 deg C, 4 h 20 min, 2) room temp., 4.5 h
View Scheme
Multi-step reaction with 4 steps
1: 86 percent / aq. 80percent acetic acid / 9 h / 50 °C
2: 61 percent / imidazole / CHCl3 / 48 h / Heating
3: 84 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 10 h / Ambient temperature
4: liquid ammonia, sodium / tetrahydrofuran / 6 h / -78 °C
View Scheme
4,7-O-benzylidenevalidoxylamine A hexa-O-acetate
86733-60-0, 102131-09-9

4,7-O-benzylidenevalidoxylamine A hexa-O-acetate

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1)methanolic sodium methoxyde (1M), 2) sodium hydride / 1) methanol, room temp., 50 min, 2) DMF, room temp., 23 h
2: 59 percent / aq acetic acid (80percent) / 20 h / 60 °C
3: 55.7 percent / imidazole / CHCl3 / 40 h / Heating
4: 74.2 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 4.5 h / Ambient temperature
5: 1) sodium, 2) ammonium chloride / 1) liq NH3, THF, -70 deg C, 4 h 20 min, 2) room temp., 4.5 h
View Scheme
1D-(1,3,6/2)-6-amino-4-benzyloxymethyl-1,2,3-tri-O-benzyltrihydroxycyclohex-4-ene
114779-32-7

1D-(1,3,6/2)-6-amino-4-benzyloxymethyl-1,2,3-tri-O-benzyltrihydroxycyclohex-4-ene

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 75 percent / propan-2-ol / 110 h / 120 °C
2: 89 percent / sodium hydride, di-imidazolyl sulphone / dimethylformamide / 1.5 h / 50 °C
3: 91 percent / propan-2-ol / 4 h / 80 °C
4: 75 percent / H2 / Ranei nickel T-4 / dioxane; ethanol / 6 h / 60 °C
5: 86 percent / aq. 80percent acetic acid / 9 h / 50 °C
6: 61 percent / imidazole / CHCl3 / 48 h / Heating
7: 84 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 10 h / Ambient temperature
8: liquid ammonia, sodium / tetrahydrofuran / 6 h / -78 °C
View Scheme
(1aR,2S,3S,3aR,5R,7aS,7bR)-2,3-Bis-benzyloxy-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene
114779-35-0, 148347-66-4

(1aR,2S,3S,3aR,5R,7aS,7bR)-2,3-Bis-benzyloxy-5-phenyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 75 percent / propan-2-ol / 110 h / 120 °C
2: 89 percent / sodium hydride, di-imidazolyl sulphone / dimethylformamide / 1.5 h / 50 °C
3: 91 percent / propan-2-ol / 4 h / 80 °C
4: 75 percent / H2 / Ranei nickel T-4 / dioxane; ethanol / 6 h / 60 °C
5: 86 percent / aq. 80percent acetic acid / 9 h / 50 °C
6: 61 percent / imidazole / CHCl3 / 48 h / Heating
7: 84 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 10 h / Ambient temperature
8: liquid ammonia, sodium / tetrahydrofuran / 6 h / -78 °C
View Scheme
(1S,2R,5R,7R,8S,10S)-8,9-dibenzyloxy-11-<(1S)-(1,4,6/5)-4,5,6-tribenzyloxy-3-benzyloxymethylcyclohex-2enyl>-5-phenyl-4,6-dioxa-11-azatricyclo<8.1.0.0.2,7>undecane
117295-71-3

(1S,2R,5R,7R,8S,10S)-8,9-dibenzyloxy-11-<(1S)-(1,4,6/5)-4,5,6-tribenzyloxy-3-benzyloxymethylcyclohex-2enyl>-5-phenyl-4,6-dioxa-11-azatricyclo<8.1.0.0.2,7>undecane

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 91 percent / propan-2-ol / 4 h / 80 °C
2: 75 percent / H2 / Ranei nickel T-4 / dioxane; ethanol / 6 h / 60 °C
3: 86 percent / aq. 80percent acetic acid / 9 h / 50 °C
4: 61 percent / imidazole / CHCl3 / 48 h / Heating
5: 84 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 10 h / Ambient temperature
6: liquid ammonia, sodium / tetrahydrofuran / 6 h / -78 °C
View Scheme
2,3,4',5',6',7'-hexa-O-benzyl-4,5-O-benzyllidenevalidoxylamine B
117320-21-5

2,3,4',5',6',7'-hexa-O-benzyl-4,5-O-benzyllidenevalidoxylamine B

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 89 percent / sodium hydride, di-imidazolyl sulphone / dimethylformamide / 1.5 h / 50 °C
2: 91 percent / propan-2-ol / 4 h / 80 °C
3: 75 percent / H2 / Ranei nickel T-4 / dioxane; ethanol / 6 h / 60 °C
4: 86 percent / aq. 80percent acetic acid / 9 h / 50 °C
5: 61 percent / imidazole / CHCl3 / 48 h / Heating
6: 84 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 10 h / Ambient temperature
7: liquid ammonia, sodium / tetrahydrofuran / 6 h / -78 °C
View Scheme
2,3,4',5',6',7'-hexa-O-benzyl-4,7-O-benzylidene-6-p-toluenesulphenylvalidoxylamine A
117295-72-4

2,3,4',5',6',7'-hexa-O-benzyl-4,7-O-benzylidene-6-p-toluenesulphenylvalidoxylamine A

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 75 percent / H2 / Ranei nickel T-4 / dioxane; ethanol / 6 h / 60 °C
2: 86 percent / aq. 80percent acetic acid / 9 h / 50 °C
3: 61 percent / imidazole / CHCl3 / 48 h / Heating
4: 84 percent / silver trifluoromethanesulphonate, 1,1,3,3-tetramethylurea / CH2Cl2 / 10 h / Ambient temperature
5: liquid ammonia, sodium / tetrahydrofuran / 6 h / -78 °C
View Scheme
uridine 5′-diphosphate glucose disodium salt

uridine 5′-diphosphate glucose disodium salt

(+)-validoxylamine A
38665-10-0

(+)-validoxylamine A

validamycin A
37248-47-8

validamycin A

Conditions
ConditionsYield
With recombinant His6-tagged validamycin glycosyltransferase at 30℃; pH=7.5; aq. buffer; Enzymatic reaction;
acetic anhydride
108-24-7

acetic anhydride

validamycin A
37248-47-8

validamycin A

validamycin A undeca-O-acetate
86733-64-4, 121468-80-2

validamycin A undeca-O-acetate

Conditions
ConditionsYield
In pyridine Ambient temperature;60%
Yield given;
validamycin A
37248-47-8

validamycin A

1L-(1,2,4/3)-1-Methyl-2,3,4-cyclohexantriol
92621-62-0

1L-(1,2,4/3)-1-Methyl-2,3,4-cyclohexantriol

Conditions
ConditionsYield
(reduction);
validamycin A
37248-47-8

validamycin A

5a-carba-1,5-anhydro-L-iditol
139561-46-9

5a-carba-1,5-anhydro-L-iditol

Conditions
ConditionsYield
(reduction);
benzyl bromide
100-39-0

benzyl bromide

validamycin A
37248-47-8

validamycin A

validamycin A undecabenzyl ether
73482-11-8

validamycin A undecabenzyl ether

Conditions
ConditionsYield
With sodium hydride 1) DMF, r.t., 1 h, 2) r.t., 23 h; Yield given. Multistep reaction;
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

acetic anhydride
108-24-7

acetic anhydride

validamycin A
37248-47-8

validamycin A

A

N-(tert-butyloxycarbonyl)-4,5,6-tri-O-acetyl-valienamine-3-aldehyde
223608-50-2

N-(tert-butyloxycarbonyl)-4,5,6-tri-O-acetyl-valienamine-3-aldehyde

B

Acetic acid (1S,2S,3R,4S,6S)-2,3-diacetoxy-6-tert-butoxycarbonylamino-4-formyl-cyclohexyl ester

Acetic acid (1S,2S,3R,4S,6S)-2,3-diacetoxy-6-tert-butoxycarbonylamino-4-formyl-cyclohexyl ester

Conditions
ConditionsYield
Multistep reaction;A 8 mg
B n/a
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

acetic anhydride
108-24-7

acetic anhydride

validamycin A
37248-47-8

validamycin A

A

N-(tert-butyloxycarbonyl)-4,5,6-tri-O-acetyl-valienamine

N-(tert-butyloxycarbonyl)-4,5,6-tri-O-acetyl-valienamine

B

N-(tert-butyloxycarbonyl)-4,5,6-tri-O-acetyl-validamine

N-(tert-butyloxycarbonyl)-4,5,6-tri-O-acetyl-validamine

Conditions
ConditionsYield
Multistep reaction. Title compound not separated from byproducts;
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

acetic anhydride
108-24-7

acetic anhydride

validamycin A
37248-47-8

validamycin A

mono-4-methoxytrityl chloride
14470-28-1

mono-4-methoxytrityl chloride

A

N-(tert-butoxycarbonyl)-4,5,6-tri-O-acetyl-7-(4-monomethoxytrityl)-valienamine

N-(tert-butoxycarbonyl)-4,5,6-tri-O-acetyl-7-(4-monomethoxytrityl)-valienamine

B

N-(tert-butoxycarbonyl)-4,5,6-tri-O-acetyl-7-(4-monomethoxytrityl)-validamine

N-(tert-butoxycarbonyl)-4,5,6-tri-O-acetyl-7-(4-monomethoxytrityl)-validamine

Conditions
ConditionsYield
Multistep reaction. Title compound not separated from byproducts;
validamycin A
37248-47-8

validamycin A

A

(+)-validoxylamine A
38665-10-0

(+)-validoxylamine A

B

validamine
32780-32-8

validamine

C

valienamine
38231-86-6

valienamine

Conditions
ConditionsYield
With ammonium sulfate; Flavobacterium saccharophilum IFO 13984; magnesium sulfate In phosphate buffer for 96h; pH=7.1; Hydrolysis; Title compound not separated from byproducts;
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

validamycin A
37248-47-8

validamycin A

N-(tert-butyloxycarbonyl)-valienamide
85240-37-5

N-(tert-butyloxycarbonyl)-valienamide

A

N-(tert-butyloxycarbonyl)-7-(4-monomethoxytrityl)-valienamine

N-(tert-butyloxycarbonyl)-7-(4-monomethoxytrityl)-valienamine

B

N-(tert-butyloxycarbonyl)-7-(4-monomethoxytrityl)-validamine

N-(tert-butyloxycarbonyl)-7-(4-monomethoxytrityl)-validamine

Conditions
ConditionsYield
Stage #1: validamycin A With ammonium sulfate; Flavobacterium saccharophilum IFO 13984; magnesium sulfate In phosphate buffer for 96h; pH=7.1; Hydrolysis;
Stage #2: 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile In 1,4-dioxane; water at 20℃; Acylation;
Stage #3: N-(tert-butyloxycarbonyl)-valienamide With dmap; triethylamine In dichloromethane at 20℃; for 168000h; Etherification; Title compound not separated from byproducts;
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

validamycin A
37248-47-8

validamycin A

A

N-(tert-butyloxycarbonyl)-valienamide
85240-37-5

N-(tert-butyloxycarbonyl)-valienamide

B

N-(tert-butyloxycarbonyl)-validamine

N-(tert-butyloxycarbonyl)-validamine

Conditions
ConditionsYield
Stage #1: validamycin A With ammonium sulfate; Flavobacterium saccharophilum IFO 13984; magnesium sulfate In phosphate buffer for 96h; pH=7.1; Hydrolysis;
Stage #2: 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile In 1,4-dioxane; water at 20℃; Acylation; Title compound not separated from byproducts;
validamycin A
37248-47-8

validamycin A

(+)-validoxylamine A
38665-10-0

(+)-validoxylamine A

Conditions
ConditionsYield
With acid
With sulfuric acid; acetic acid Inert atmosphere;
validamycin A
37248-47-8

validamycin A

C21H29NO8
1316288-57-9

C21H29NO8

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; acetic acid / Inert atmosphere
2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
View Scheme
validamycin A
37248-47-8

validamycin A

A

1D-(1,3,6/2)-6-amino-4-benzyloxymethyl-1,2,3-tri-O-benzyltrihydroxycyclohex-4-ene
114779-32-7

1D-(1,3,6/2)-6-amino-4-benzyloxymethyl-1,2,3-tri-O-benzyltrihydroxycyclohex-4-ene

B

2,3,4,7-tetra-O-benzylvalidamine
139499-19-7

2,3,4,7-tetra-O-benzylvalidamine

C

(2R,3S,4R,5R)-2,3,4-tris(benzyloxy)-5-[(benzyloxy)methyl]cyclohexanone
124330-57-0

(2R,3S,4R,5R)-2,3,4-tris(benzyloxy)-5-[(benzyloxy)methyl]cyclohexanone

D

(4R,5S,6R)-4,5,6-tris(benzyloxy)-3-((benzyloxy)methyl)-2-cyclohexen-1-one
110391-10-1

(4R,5S,6R)-4,5,6-tris(benzyloxy)-3-((benzyloxy)methyl)-2-cyclohexen-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid; acetic acid / Inert atmosphere
2: sodium hydride / N,N-dimethyl-formamide / Inert atmosphere
3: N-Bromosuccinimide / water; acetonitrile / 15 h / 20 °C / Inert atmosphere
View Scheme
validamycin A
37248-47-8

validamycin A

((1R,2R,3S,4S,5S)-2,3,4-tris(benzyloxy)-5-(((1S,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-((benzyloxy)methyl)cyclohex-2-en-1-yl)amino)cyclohexyl)methanol
137063-37-7

((1R,2R,3S,4S,5S)-2,3,4-tris(benzyloxy)-5-(((1S,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-((benzyloxy)methyl)cyclohex-2-en-1-yl)amino)cyclohexyl)methanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid; acetic acid / Inert atmosphere
2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
3.2: 3 h / 20 °C / Inert atmosphere
4.1: diisobutylaluminium hydride / hexane; dichloromethane / 6.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
validamycin A
37248-47-8

validamycin A

(4aR,6S,7S,8S,8aR)-7,8-bis(benzyloxy)-2-phenyl-N-((1S,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-((benzyloxy)methyl)cyclohex-2-en-1-yl)hexahydro-4H-benzo[d][1,3]dioxin-6-amine
86756-42-5, 102131-10-2

(4aR,6S,7S,8S,8aR)-7,8-bis(benzyloxy)-2-phenyl-N-((1S,4R,5S,6S)-4,5,6-tris(benzyloxy)-3-((benzyloxy)methyl)cyclohex-2-en-1-yl)hexahydro-4H-benzo[d][1,3]dioxin-6-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid; acetic acid / Inert atmosphere
2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
3.2: 3 h / 20 °C / Inert atmosphere
View Scheme

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