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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Labetalol hydrochloride Cas 32780-64-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum

Manufacturer high quality Labetalol hydrochloride Cas 32780-64-6 with good price

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract Labetalol Hydrochloride HACCP manufacturer

Cas:32780-64-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C19H25ClN2O3 Labetalol hydrochloride 32780-64-6

Cas:32780-64-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 32780-64-6 with fast shipping

Cas:32780-64-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

DMF GMP are all available! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the resea

Labetalol Hcl DMF GMP

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride(1:1) 32780-64-6

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Labetalol hcl

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzamide,2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride(1:1)

Cas:32780-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:25kg/drum Application:APIs Transportation:Express/Sea/Air Port:Any port in china

Manufacturer Labetalol Hydrochloride CAS:32780-64-6 Labetalol HCl

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

labetalol hydrochloride

Cas:32780-64-6

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply labetalol hydrochloride

Cas:32780-64-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products Labetalol hydrochloride

Cas:32780-64-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

supplier in China Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:vasoconstrictor Transportation:BY AIR Port:Shanghai

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualified

Factory Supply Labetalol hydrochloride Supplier Manufacturer With Competitive Price

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

Enke Labetalol hydrochloride

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Labetalol Hydrochloride CAS No.:32780-64-6 Molecule Formula:C19H25ClN2O3 Molecule Weight:364.87 Purity: 99% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality Labetalol Hydrochloride in stock

Cas:32780-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Labetalolhydrochloride

Cas:32780-64-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Labetalol hydrochloride

Cas:32780-64-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Synthetic route

2-hydroxy-5-<acetyl>benzamide hydrochloride
32780-63-5

2-hydroxy-5-<acetyl>benzamide hydrochloride

labetalol hydrochloride
32780-64-6

labetalol hydrochloride

Conditions
ConditionsYield
With hydrogen; platinum on activated charcoal; palladium oxide on charcoal In ethanol under 760 Torr; Ambient temperature;67%
PtO on carbon

PtO on carbon

4-Phenyl-2-butanone
2550-26-7

4-Phenyl-2-butanone

5-(N,N-dibenzylamino)acetylsalicylamide
30566-92-8

5-(N,N-dibenzylamino)acetylsalicylamide

labetalol hydrochloride
32780-64-6

labetalol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; trimethyleneglycol In methanol; ethanol; acetic acid; ethyl acetate
C19H22N2O3
85665-85-6

C19H22N2O3

labetalol hydrochloride
32780-64-6

labetalol hydrochloride

Conditions
ConditionsYield
Stage #1: C19H22N2O3 With water; sodium hydroxide In methanol at 1 - 20℃; for 0.5h;
Stage #2: With sodium tetrahydroborate; water In methanol at 15 - 25℃;
Stage #3: With hydrogenchloride In methanol; water at 20℃; for 2h; pH=2;
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

5-formyl-2-hydroxy-benzamide
76143-20-9

5-formyl-2-hydroxy-benzamide

Conditions
ConditionsYield
Stage #1: labetalol hydrochloride With sodium hydrogencarbonate In water
Stage #2: With sodium periodate In water at 20℃; for 0.583333h;
Stage #3: With hydrogenchloride In water for 0.0333333h;
70%
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

(R,S)-2-hydroxy-5-<2-<(1-methyl-3-phenylpropyl)amino>ethyl>benzamide hydrochloride
32551-03-4, 83167-26-4, 83167-30-0

(R,S)-2-hydroxy-5-<2-<(1-methyl-3-phenylpropyl)amino>ethyl>benzamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium dihydroxide In ethanol under 2280 Torr; for 672h; Ambient temperature;47%
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

A

(RS)-1-methyl-3-phenylpropylamine
22374-89-6

(RS)-1-methyl-3-phenylpropylamine

B

5-formyl-2-hydroxy-benzamide
76143-20-9

5-formyl-2-hydroxy-benzamide

Conditions
ConditionsYield
With sodium periodate; sodium carbonate at 25℃; for 0.166667h;
1-methyl-2-fluoropyridinium p-toluenesulfonate
58086-67-2

1-methyl-2-fluoropyridinium p-toluenesulfonate

labetalol hydrochloride
32780-64-6

labetalol hydrochloride

C25H30N3O3(1+)*C7H7O3S(1-)

C25H30N3O3(1+)*C7H7O3S(1-)

Conditions
ConditionsYield
With triethylamine In dimethyl sulfoxide; acetonitrile at 20℃; for 0.0833333h;
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

A

(Z)-2-hydroxy-5-({2-[(2-{4-[1-(4-hydroxy-phenyl)-2-phenyI-but-1-enyl]-phenoxy}-ethyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide

(Z)-2-hydroxy-5-({2-[(2-{4-[1-(4-hydroxy-phenyl)-2-phenyI-but-1-enyl]-phenoxy}-ethyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide

B

(E)-2-hydroxy-5-({2-[(2-{4-[1-(4-hydroxy-phenyl)-2-phenyI-but-1-enyl]-phenoxy}-ethyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide

(E)-2-hydroxy-5-({2-[(2-{4-[1-(4-hydroxy-phenyl)-2-phenyI-but-1-enyl]-phenoxy}-ethyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: ethanol; water
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

A

(Z)-N-[2-hydroxy-5-({2-[(2-{4-[1-(4-hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-ethyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide]-doxorubicin

(Z)-N-[2-hydroxy-5-({2-[(2-{4-[1-(4-hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-ethyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide]-doxorubicin

B

(E)-N-[2-hydroxy-5-({2-[(2-{4-[1-(4-hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-ethyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide]-doxorubicin

(E)-N-[2-hydroxy-5-({2-[(2-{4-[1-(4-hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-ethyl)-methyl-amino]-ethoxyimino}-methyl)-benzamide]-doxorubicin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: water; N,N-dimethyl-formamide / 0.75 h / 55 °C
3.1: trifluoroacetic acid / ethanol; water / 2 h / 20 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

5-(2-bromoethoxymethyl)-2-hydroxybenzamide
636595-41-0

5-(2-bromoethoxymethyl)-2-hydroxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: 55 °C
2.2: 4 h / 20 - 55 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

2-hydroxy-5-(4-hydroxy-but-2-ynyloxymethyl)-benzamide
636595-52-3

2-hydroxy-5-(4-hydroxy-but-2-ynyloxymethyl)-benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

2-hydroxy-5-[2-(2-hydroxyethoxy)ethoxymethyl]benzamide
636595-48-7

2-hydroxy-5-[2-(2-hydroxyethoxy)ethoxymethyl]benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 70 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

6-(4-bromobut-2-ynyloxymethyl)-2,2-dimethyl-2,3-dihydrobenzo[e][1,3]oxazin-4-one
636595-66-9

6-(4-bromobut-2-ynyloxymethyl)-2,2-dimethyl-2,3-dihydrobenzo[e][1,3]oxazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 85 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 1 h / 20 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

6-(4-hydroxybut-2-ynyloxymethyl)-2,2-dimethyl-2,3-dihydro-benzol[e][1,3]-oxazin-4-one
636595-58-9

6-(4-hydroxybut-2-ynyloxymethyl)-2,2-dimethyl-2,3-dihydro-benzol[e][1,3]-oxazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 85 °C / Heating / reflux
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

6-[2-(2-hydroxyethoxy)ethoxymethyl]-2,2-dimethyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one
636595-54-5

6-[2-(2-hydroxyethoxy)ethoxymethyl]-2,2-dimethyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 70 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 80 °C / Heating / reflux
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

2-hydroxy-5-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxymethyl}-benzamide
636595-50-1

2-hydroxy-5-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxymethyl}-benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 70 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

methanesulfonic acid 2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)ethoxy]ethyl ester
636595-61-4

methanesulfonic acid 2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)ethoxy]ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 70 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 80 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 2 h / 20 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

6-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxymethyl}-2,2-dimethyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one
636595-56-7

6-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxymethyl}-2,2-dimethyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 70 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 80 °C / Heating / reflux
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

5-{4-[3-(4-cyano-3-trifluoromethyl-phenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]-but-2-ynyloxymethyl}-2-hydroxy-benzamide
636595-81-8

5-{4-[3-(4-cyano-3-trifluoromethyl-phenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]-but-2-ynyloxymethyl}-2-hydroxy-benzamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 85 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 6 h / 20 °C
6.1: water; toluene-4-sulfonic acid / methanol / 24 h / 90 °C / Heating / reflux
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

5-(2-{2-[3-(4-cyano-3-trifluoromethyl-phenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]-ethoxy}-ethoxymethyl)-2-hydroxy-benzamide

5-(2-{2-[3-(4-cyano-3-trifluoromethyl-phenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]-ethoxy}-ethoxymethyl)-2-hydroxy-benzamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 70 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 80 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 2 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 24 h / 60 °C
6.1: water; toluene-4-sulfonic acid / methanol / 30 h / 90 °C / Heating / reflux
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile
636595-74-9

4-{3-[4-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)but-2-ynyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 85 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 6 h / 20 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile
636595-68-1

4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 70 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 80 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 2 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 24 h / 60 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

5-[2-(4-{4-[3-(4-cyano-3-trifluoromethyl-phenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]-butyl}-piperazin-1-yl)-ethoxymethyl]-2-hydroxy-benzamide

5-[2-(4-{4-[3-(4-cyano-3-trifluoromethyl-phenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]-butyl}-piperazin-1-yl)-ethoxymethyl]-2-hydroxy-benzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: 55 °C
2.2: 4 h / 20 - 55 °C
3.1: triethylamine / tetrahydrofuran / 20 h / Heating / reflux
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

N-(5-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]but-2-ynyloxymethyl}-2-hydroxybenzamidomethyl)doxorubicin
636595-43-2

N-(5-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]but-2-ynyloxymethyl}-2-hydroxybenzamidomethyl)doxorubicin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 85 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 6 h / 20 °C
6.1: water; toluene-4-sulfonic acid / methanol / 24 h / 90 °C / Heating / reflux
7.1: water; N,N-dimethyl-formamide / 0.25 h / 55 °C
7.2: 0.25 h / 55 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

N-(5-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]but-2-ynyloxymethyl}-2-hydroxybenzamidomethyl)doxorubicin acetate

N-(5-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]but-2-ynyloxymethyl}-2-hydroxybenzamidomethyl)doxorubicin acetate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 85 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 6 h / 20 °C
6.1: water; toluene-4-sulfonic acid / methanol / 24 h / 90 °C / Heating / reflux
7.1: water; N,N-dimethyl-formamide / 0.25 h / 55 °C
7.2: 0.25 h / 55 °C
8.1: chloroform
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

doxorubicin-5-formylsalicylamide
850256-37-0

doxorubicin-5-formylsalicylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: water; N,N-dimethyl-formamide / 0.42 h / 60 °C
2.2: 0.42 h / 60 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

doxaliform
850256-41-6

doxaliform

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: water; N,N-dimethyl-formamide / 0.75 h / 55 °C
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

5-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolin-1-yl]but-2-ynyloxymethyl}-2-butyryloxymethoxybenzamide

5-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolin-1-yl]but-2-ynyloxymethyl}-2-butyryloxymethoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 85 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 6 h / 20 °C
6.1: water; toluene-4-sulfonic acid / methanol / 24 h / 90 °C / Heating / reflux
7.1: potassium carbonate / acetone / 0.5 h / 20 °C
7.2: 4 h / Heating / reflux
View Scheme
labetalol hydrochloride
32780-64-6

labetalol hydrochloride

N-(5-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]but-2-ynyloxymethyl}-2-butyryloxymethoxybenzamidomethyl)-doxorubicin

N-(5-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]but-2-ynyloxymethyl}-2-butyryloxymethoxybenzamidomethyl)-doxorubicin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate / water
1.2: 0.58 h / 20 °C
1.3: 0.03 h
2.1: decaborane / 5 h / 60 °C
3.1: toluene-4-sulfonic acid / acetone / 1.5 h / 85 °C / Heating / reflux
4.1: pyridine / tetrahydrofuran / 0.5 h / 20 °C
4.2: 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
5.2: 6 h / 20 °C
6.1: water; toluene-4-sulfonic acid / methanol / 24 h / 90 °C / Heating / reflux
7.1: potassium carbonate / acetone / 0.5 h / 20 °C
7.2: 4 h / Heating / reflux
8.1: water; N,N-dimethyl-formamide / 0.25 h / 55 °C
8.2: 0.25 h / 55 °C
View Scheme

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