As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:220000-87-3
Min.Order:1 Kilogram
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inquirySorafenib Intermediates Cas no. 220000-87-3 N-Methyl-4-chloropyridine-2-carboxamide Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manu
Cas:220000-87-3
Min.Order:100 Gram
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inquiryItems Standard Result Appearance Yellowish to off-white crystalline powder Comply Purity 98%min
Cas:220000-87-3
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:220000-87-3
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inquiryProduct Description Product Name N-Methyl-4-chloropyridine-2-carboxamide CAS No. 220000-87-3 Appearance Off-white to yellowish powder Assay ≥99% Capacity 100mt/year
Cas:220000-87-3
Min.Order:1 Gram
FOB Price: $6.0
Type:Lab/Research institutions
inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:10g/100g/1kg/foil bag Application:pharmaceutical intermediate Transpor
Cas:220000-87-3
Min.Order:10 Gram
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Type:Trading Company
inquiryN-Methyl-4-chloropyridine-2-carboxamide CAS No.:220000-87-3 Name: N-Methyl-4-chloropyridine-2-carboxamide Synonyms: 4-Chloro-N-methyl-2-pyridinecarboxamide Molecular Structure Molecular Formula: C7H7ClN2O
Cas:220000-87-3
Min.Order:1 Kilogram
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inquiryPurity 99% with good quality Fast delivery Prompt shipment Appearance:pale-yellow solid Storage:Store in cool dry place Application:Pharmaceutical intermediates Port:Shanghai, Nanjing
Cas:220000-87-3
Min.Order:1 Metric Ton
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Cas:220000-87-3
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:220000-87-3
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inquiryName:N-Methyl-4-chloropyridine-2-carboxamide CAS NO: 220000-87-3 Grade:Medical chemicals and exports Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerabi
Cas:220000-87-3
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
Cas:220000-87-3
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:220000-87-3
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:220000-87-3
Min.Order:1 Kilogram
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Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:220000-87-3
Min.Order:10 Kilogram
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Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:220000-87-3
Min.Order:1 Kilogram
FOB Price: $289.0 / 499.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:220000-87-3
Min.Order:10 Gram
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Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:220000-87-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support ★.Shortest delivery time . Appearance:Refer to COA Storage:Store in dry, cool and ventilated place Package:A
Cas:220000-87-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryN-Methyl-4-chloropyridine-2-carboxamide CAS: 220000-87-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high
Cas:220000-87-3
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:220000-87-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:220000-87-3
Min.Order:0
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Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:220000-87-3
Min.Order:10 Gram
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Type:Trading Company
inquiryWe are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates Storage:-20°C Freezer Application:Pharmaceutical intermediate Port:Chinese main port
Cas:220000-87-3
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
N-Methyl-4-chloropyridine-2-carboxamide CAS: 220000-87-3 Specification product name n-methyl-4-chloropyridine-2-carboxamide cas no. 220000-87-3 appearance off-white to yellowish powder assay
Cas:220000-87-3
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:220000-87-3
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Type:Manufacturers
inquiryAppearance:white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/Shanghai
Cas:220000-87-3
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiry4-Chloro-N-methylpyridine-2-carboxamide is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:Off-white to light yellow solid Storage:Room temperature, Keep in Dark Place. Package:Kilogr
Cas:220000-87-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:220000-87-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry4-Chloro-pyridine-2-carboxylic acid methyl ester
methylamine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With magnesium chloride In tetrahydrofuran at 20℃; for 2.25h; | 98.5% |
In methanol at 0 - 5℃; for 2h; | 98% |
magnesium chloride In tetrahydrofuran at 20℃; for 2.25h; | 98.5% |
methylamine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 10℃; for 6h; Temperature; Solvent; | 98% |
In tetrahydrofuran; methanol at 0 - 5℃; for 5h; Product distribution / selectivity; | 97% |
In tetrahydrofuran; methanol at 0 - 5℃; Inert atmosphere; | 97% |
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With methylamine In tetrahydrofuran; methanol; ethyl acetate | 97% |
With methylamine In tetrahydrofuran; methanol; ethyl acetate | 97% |
With methylamine In tetrahydrofuran; methanol; ethyl acetate | 97% |
With methylamine In tetrahydrofuran; methanol; ethyl acetate | 97% |
With methylamine In tetrahydrofuran; methanol at 0 - 3℃; for 4h; |
B
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With methylamine In tetrahydrofuran; methanol; ethyl acetate | A 97% B n/a |
methylamine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 20℃; for 5h; Inert atmosphere; | 94% |
With sodium hydroxide In tetrahydrofuran at -5℃; for 3h; Temperature; Solvent; | 93% |
In tetrahydrofuran; methanol at 0 - 3℃; for 4h; Product distribution / selectivity; | 88% |
4-chloro-2-pyridinecarbaldehyde
methylamine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
In methanol at 0 - 25℃; for 6h; | 82.1% |
methylamine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
Stage #1: methyl 4-chloropyridine-2-carboxylate hydrochloride With magnesium chloride In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: methylamine at 20℃; for 16.3333h; | 81% |
Stage #1: methyl 4-chloropyridine-2-carboxylate hydrochloride With magnesium chloride In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: methylamine In tetrahydrofuran at 20℃; for 16.33h; | 81% |
4-chloro-pyridine-2-carbonyl chloride
methylamine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; for 3.5h; | 81% |
In dichloromethane at 0 - 20℃; for 3h; | 81% |
With triethylamine In tetrahydrofuran; water for 3h; Cooling with ice; | 78% |
Conditions | Yield |
---|---|
Stage #1: 4-chloropicolinic acid With thionyl chloride at 80℃; for 3h; Stage #2: methylamine With triethylamine In dichloromethane at 20 - 27℃; for 2h; | 46% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 48h; | 22% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 3h; | |
With hydrogenchloride In ethanol; water at 120℃; for 4h; Solvent; Temperature; | 15.2 g |
Conditions | Yield |
---|---|
Stage #1: 2-Picolinic acid With thionyl chloride In N,N-dimethyl-formamide at 45 - 72℃; for 72h; Stage #2: methylamine In tetrahydrofuran; water at 0 - 20℃; for 4h; Temperature; | 39% |
Stage #1: 2-Picolinic acid With thionyl chloride In N,N-dimethyl-formamide Stage #2: methylamine | |
Stage #1: 2-Picolinic acid With thionyl chloride; N,N-dimethyl-formamide at 45 - 75℃; for 72h; Stage #2: methylamine In tetrahydrofuran; water at 0 - 25℃; for 4h; |
Conditions | Yield |
---|---|
Stage #1: 4-Chloropyridine; N-Methylformamide With sulfuric acid; dihydrogen peroxide; iron(II) sulfate In water at 20 - 60℃; for 21h; light protection; Stage #2: With sodium hydroxide In water | 5.3% |
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate In water at 20 - 60℃; for 21h; Product distribution / selectivity; Menisci reaction; | 5.3% |
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate at 20 - 60℃; for 21h; | 5.3% |
4-Chloropyridine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
Stage #1: 4-Chloropyridine With sulfuric acid; dihydrogen peroxide; iron(II) sulfate In N-Methylformamide; water at 20 - 60℃; for 21h; Menisci reaction; Absence of light; Stage #2: With sodium hydroxide In N-Methylformamide; water | 5.3% |
Conditions | Yield |
---|---|
With sodium hydroxide; sulfuric acid; dihydrogen peroxide In N-Methylformamide; hexane; water; ethyl acetate | 5.3% |
With sodium hydroxide; sulfuric acid; dihydrogen peroxide In N-Methylformamide; hexane; water; ethyl acetate | 5.3% |
Conditions | Yield |
---|---|
With sodium hydroxide; sulfuric acid In N-Methylformamide; hexane; water; ethyl acetate | 5.3% |
4-Chloropyridine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With sodium hydroxide; sulfuric acid; dihydrogen peroxide In N-Methylformamide; hexane; water; ethyl acetate | 5.3% |
4-chloro-pyridine-2-carbonyl chloride
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2 h / 30 °C 2: tetrahydrofuran; methanol / 3 h / 2 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 2: tetrahydrofuran View Scheme | |
Multi-step reaction with 2 steps 1: 0.75 h / 20 - 55 °C 2: methanol / 2 h / 0 - 5 °C View Scheme |
4-chloropicolinic acid
methylamine hydrochloride
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 40h; | |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 2h; | |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 40h; | |
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 5 - 15℃; Reagent/catalyst; Temperature; | 12.1 g |
phosgene
4-(3-aminophenoxy)pyridine-2-carboxamide
2-Methoxy-5-trifluoromethyl-aniline
4-chloro-N-methylpicolinamide
4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide
2-methoxy-5-trifluoromethylphenyl isocyanate
amino-4 hydroxy-2 toluene
2-Methoxy-5-trifluoromethyl-aniline
A
3-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-4-methylaniline
B
4-chloro-N-methylpicolinamide
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With CDI | |
With CDI |
4-chloro-2-methoxy-5-(trifluoromethyl)phenylaniline
4-chloro-2-methoxy-5-(trifluoromethyl)phenyl isocyanate
4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide
2-chloro 4-aminophenol
A
4-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-3-chloroaniline
B
4-chloro-N-methylpicolinamide
4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide
2-chloro 4-aminophenol
4-bromo-3-(trifluoromethyl)phenyl isocyanate
4-bromo-3-(trifluoromethyl)aniline
A
4-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-3-chloroaniline
B
4-chloro-N-methylpicolinamide
4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide
amino-4 hydroxy-2 toluene
4-chloro-3-(trifluoromethyl)phenyl isocyanate
A
3-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-4-methylaniline
B
4-chloro-N-methylpicolinamide
4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide
amino-4 hydroxy-2 toluene
4-chloro-3-(trifluoromethyl)phenyl isocyanate
B
4-chloro-N-methylpicolinamide
4-(3-aminophenoxy)-N-methylpicolinamide
amino-4 hydroxy-2 toluene
4-bromo-3-(trifluoromethyl)phenyl isocyanate
4-bromo-3-(trifluoromethyl)aniline
A
3-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-4-methylaniline
B
4-chloro-N-methylpicolinamide
4-(4-aminophenoxy)-N,N-dimethylpicolinamide
4-bromo-3-(trifluoromethyl)phenyl isocyanate
4-bromo-3-(trifluoromethyl)aniline
4-chloro-N-methylpicolinamide
2-chloro 4-aminophenol
4-chloro-3-(trifluoromethyl)phenyl isocyanate
B
4-chloro-N-methylpicolinamide
3-Iodophenol
4-chloro-N-methylpicolinamide
4-(3-iodophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 100℃; | 100% |
4-chloro-N-methylpicolinamide
4-chloro-N-methyl-pyridine-2-carboxamide hydrochloride
Conditions | Yield |
---|---|
With acetyl chloride In ethanol at 20 - 30℃; for 1.5h; | 100% |
With hydrogenchloride In water; acetone at 5 - 40℃; for 1h; | 86% |
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With ethanol; acetyl chloride In toluene at 20 - 30℃; | 100% |
With acetyl chloride In ethanol; toluene at 20℃; for 1.5h; | 156.3 g |
bis(pinacol)diborane
4-chloro-N-methylpicolinamide
N-methyl-4-( 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium acetate; palladium diacetate In 1,4-dioxane at 100℃; for 18h; Inert atmosphere; | 99% |
With potassium acetate; palladium diacetate; tricyclohexylphosphine In 1,4-dioxane at 100℃; for 4h; Inert atmosphere; |
Conditions | Yield |
---|---|
at 150℃; | 98% |
at 150℃; | 62% |
at 150℃; | 62% |
at 150℃; | 62% |
at 150℃; Neat (no solvent); | 62% |
4-amino-phenol
4-chloro-N-methylpicolinamide
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
With potassium tert-butylate In N,N-dimethyl-formamide at 25℃; for 1h; | 97% |
Stage #1: 4-amino-phenol With potassium hydroxide for 0.166667h; Stage #2: 4-chloro-N-methylpicolinamide for 1.5h; | 97.3% |
With 18-crown-6 ether In acetonitrile for 1.5h; Reagent/catalyst; Solvent; Temperature; Reflux; | 92.5% |
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide Inert atmosphere; Heating; | 97% |
4-amino-3-fluorophenol
4-chloro-N-methylpicolinamide
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
Conditions | Yield |
---|---|
With potassium carbonate In 1,2-dichloro-ethane for 4h; Reflux; | 96.3% |
Stage #1: 4-amino-3-fluorophenol With potassium tert-butylate In tetrahydrofuran at 20 - 30℃; for 2h; Stage #2: 4-chloro-N-methylpicolinamide In tetrahydrofuran Reagent/catalyst; Solvent; Temperature; Reflux; | 94% |
Stage #1: 4-amino-3-fluorophenol With potassium tert-butylate In dimethyl amine at 20℃; for 2h; Inert atmosphere; Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate In dimethyl amine at 85℃; Time; Inert atmosphere; | 92% |
4-bromo-phenol
4-chloro-N-methylpicolinamide
[4-(4-bromophenoxy)(2-pyridyl)]-N-methylcarboxamide
Conditions | Yield |
---|---|
Stage #1: 4-bromo-phenol With potassium tert-butylate In N,N-dimethyl-formamide for 2h; Stage #2: 4-chloro-N-methylpicolinamide With potassium hydroxide In N,N-dimethyl-formamide at 80℃; for 8h; Reagent/catalyst; | 96.2% |
Stage #1: 4-bromo-phenol With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 11h; Inert atmosphere; | 90% |
4-nitro-phenol
4-chloro-N-methylpicolinamide
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 4-nitro-phenol; 4-chloro-N-methylpicolinamide With potassium carbonate for 4h; Reflux; Stage #2: With iron(III) chloride; hydrazine hydrate; FeCl3/C In ethanol for 3h; Concentration; Reflux; | 94.6% |
Stage #1: 4-nitro-phenol With potassium hydroxide for 0.166667h; Heating; Green chemistry; Stage #2: 4-chloro-N-methylpicolinamide for 1.5h; Green chemistry; Stage #3: With iron(III) chloride; pyrographite; hydrazine hydrate In ethanol; 1,2-dichloro-ethane for 3h; Reflux; Green chemistry; | 94.5% |
3-fluoro-4-nitrophenol
4-chloro-N-methylpicolinamide
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
Conditions | Yield |
---|---|
Stage #1: 3-fluoro-4-nitrophenol; 4-chloro-N-methylpicolinamide With potassium carbonate In acetonitrile for 4h; Green chemistry; Stage #2: With iron(III) chloride; hydrazine hydrate; pyrographite In methanol for 3h; Reflux; Green chemistry; | 92.5% |
With potassium hydroxide for 1.5h; | 92.4% |
7-hydroxynaphthalene-2-carboxylic acid
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With caesium carbonate In dimethyl sulfoxide at 120℃; for 15h; | 91% |
4-amino-phenol
4-chloro-3-(trifluoromethyl)phenyl isocyanate
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-amino-phenol; 4-chloro-3-(trifluoromethyl)phenyl isocyanate; 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 80℃; Solvent; Reagent/catalyst; Temperature; | 90.6% |
4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
With potassium carbonate In toluene Heating; | 90% |
With tetrabutylammomium bromide; potassium iodide; potassium hydroxide In tetrahydrofuran at 80℃; for 10h; Solvent; Reagent/catalyst; | 89.4% |
Stage #1: 4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol With potassium tert-butylate In N,N-dimethyl-formamide for 2h; Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate at 80℃; for 6h; | 50% |
3-fluorophenol
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
Stage #1: 3-fluorophenol With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 100℃; for 5h; Solvent; Reagent/catalyst; Temperature; Time; | 89.3% |
Stage #1: 3-fluorophenol With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 30h; Cooling with ice; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 100℃; for 5h; | 89.56% |
Stage #1: 3-fluorophenol With potassium hydroxide In N,N-dimethyl-formamide at 0 - 50℃; for 0.5h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 100℃; | 81.3% |
Stage #1: 3-fluorophenol With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 110℃; for 16h; Inert atmosphere; Schlenk technique; | 61% |
5-Aminosalicylic Acid
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
Stage #1: 5-Aminosalicylic Acid With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 90℃; for 6h; | 89.2% |
7-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
4-chloro-N-methylpicolinamide
7-((2-[(methylamino)carbonyl]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 7-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; 4-chloro-N-methylpicolinamide With caesium carbonate In N,N-dimethyl-formamide at 100℃; Stage #2: With hydrogenchloride In water pH=3; | 89% |
N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide
4-amino-phenol
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: N-[4-chloro-3-(trifluoromethyl)phenyl]-1H-imidazole-1-carboxamide; 4-amino-phenol; 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 20℃; for 3h; Stage #2: With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 80℃; | 88.5% |
4-nitro-phenol
4-chloro-N-methylpicolinamide
4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine
Conditions | Yield |
---|---|
Stage #1: 4-nitro-phenol With sodium hydroxide In water; isopropyl alcohol at 25℃; for 1h; Stage #2: 4-chloro-N-methylpicolinamide With tetrabutylammomium bromide; potassium carbonate In water; isopropyl alcohol at 70 - 80℃; Reagent/catalyst; | 88.2% |
In ethyl acetate | 21.3 g |
6-aminopyridin-3-ol
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
Stage #1: 6-aminopyridin-3-ol With potassium tert-butylate In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl acetamide at 108℃; for 18h; | 88% |
Stage #1: 6-aminopyridin-3-ol With potassium tert-butylate In N,N-dimethyl acetamide at 20℃; for 3h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl acetamide at 20℃; for 48h; | 61% |
Stage #1: 6-aminopyridin-3-ol With potassium tert-butylate In N,N-dimethyl acetamide at 20℃; for 3h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl acetamide at 20℃; for 48h; | 61% |
Stage #1: 6-aminopyridin-3-ol With potassium tert-butylate In N,N-dimethyl acetamide at 20℃; for 3h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl acetamide at 20℃; for 48h; | 61% |
With potassium tert-butylate In N,N-dimethyl acetamide at 20℃; for 51h; | 61% |
N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride
4-amino-phenol
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: N-[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl chloride; 4-amino-phenol; 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 80℃; | 85.5% |
4-amino-phenol
(4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester
4-chloro-N-methylpicolinamide
sorafenib
Conditions | Yield |
---|---|
Stage #1: 4-amino-phenol; (4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester; 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 20℃; for 3h; Stage #2: With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 80℃; | 85.4% |
4-amino-2-methylphenol
4-chloro-N-methylpicolinamide
4-(4-amino-2-methylphenoxy)-N-methylpicolinamide
Conditions | Yield |
---|---|
Stage #1: 4-amino-2-methylphenol With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 0.5h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl acetamide at 100℃; | 84% |
Stage #1: 4-amino-2-methylphenol With potassium tert-butylate In N,N-dimethyl acetamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl acetamide at 100℃; | 84% |
methyl 5-amino-2-hydroxybenzoate
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
Stage #1: methyl 5-amino-2-hydroxybenzoate With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 4-chloro-N-methylpicolinamide In N,N-dimethyl-formamide at 80℃; for 5h; | 83.7% |
2-Aminopyrazine
4-chloro-N-methylpicolinamide
Conditions | Yield |
---|---|
With C33H43ClNiO6P2; sodium phenoxide In tetrahydrofuran at 80℃; for 16h; Sealed tube; Inert atmosphere; | 83% |
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