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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Isocyanato-4-methoxybenzotrifluoride

Cas:16588-75-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

2-Methoxy-5-(trifluoromethyl)phenyl isocyanate

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzene,2-isocyanato-1-methoxy-4-(trifluoromethyl)- 16588-75-3

Cas:16588-75-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzene,2-isocyanato-1-methoxy-4-(trifluoromethyl)-

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Benzene,2-isocyanato-1-methoxy-4-(trifluoromethyl)-

Cas:16588-75-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE,16588-75-3

Cas:16588-75-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

Enke 2-Methoxy-5-(trifluoromethyl)phenyl isocyanate

Cas:16588-75-3

Min.Order:1 Kilogram

FOB Price: $200.0 / 300.0

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-Methoxy-5-(trifluoromethyl)phenyl isocyanate

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Isocyanato-1-methoxy-4-(trifluoromethyl)benzene Cas no.16588-75-3 98%

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-Isocyanato-1-methoxy-4-(trifluoromethyl)benzene

Cas:16588-75-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Benzene, 2-isocyanato-1-Methoxy-4-(trifluoroMethyl)-

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as:

2-isocyanato-1-methoxy-4-(trifluoromethyl)benzene

Cas:16588-75-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Kilograms/MT Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

2-methoxy-5-trifluoromethylphenyl isocyanate

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

factory?direct?sale Application:healing drugs

Benzene,2-isocyanato-1-methoxy-4-(trifluoromethyl)-

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE CAS No.16588-75-3

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

2-methoxy-5-trifluoromethylphenylisocyanate

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:off-white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as prima

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

2-Methoxy-5-TrifluoromethylphenylIsocyanate

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:100mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

The factory supplies Application:manufacturing supplies

Benzene,2-isocyanato-1-methoxy-4-(trifluoromethyl)-

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

16588-75-3

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE

Cas:16588-75-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h;88%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h;88%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h;88%
phosgene
75-44-5

phosgene

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

Conditions
ConditionsYield
With pyridine In diethyl ether; dichloromethane; toluene
With pyridine In dichloromethane; toluene at 0 - 20℃; for 3.5h;
With sodium hydrogencarbonate In dichloromethane; water at 0℃; for 0.5h;
4-(4-acetylphenoxy)-5-aminopyridine
284670-99-1

4-(4-acetylphenoxy)-5-aminopyridine

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

N,N,N',N'-tetramethyl-1,8-diaminonaphthalene
20734-58-1

N,N,N',N'-tetramethyl-1,8-diaminonaphthalene

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

Conditions
ConditionsYield
In dichloromethane
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

Conditions
ConditionsYield
With pyrographite In ethyl acetate for 2h; Reflux;
5-(4-aminophenoxy)isoindoline-1,3-dione
284462-39-1

5-(4-aminophenoxy)isoindoline-1,3-dione

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

N-(2-methoxy-5-(trifluoromethyl)phenyl)-N'-(4-(1,3-dioxoisoindolin-5-yloxy)phenyl)urea

N-(2-methoxy-5-(trifluoromethyl)phenyl)-N'-(4-(1,3-dioxoisoindolin-5-yloxy)phenyl)urea

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃; for 12 - 22h; Product distribution / selectivity;96%
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-bromo-6-fluoroaniline
65896-11-9

2-bromo-6-fluoroaniline

3-(2-bromo-6-fluorophenyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]urea
917389-23-2

3-(2-bromo-6-fluorophenyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Conditions
ConditionsYield
In acetonitrile at 35 - 88℃; for 38 - 45h; Product distribution / selectivity;87.5%
2-Fluoroaniline
348-54-9

2-Fluoroaniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea
917389-24-3

N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Conditions
ConditionsYield
In acetonitrile at 82℃; for 4h;86.4%
In acetonitrile for 4h; Reflux; Large scale;85.9%
In acetonitrile at 0℃; for 7.25h; Reflux; Large scale;85.9%
In acetonitrile for 4h; Reflux; Large scale;85.9%
In acetonitrile Reflux;
N-(4-fluoro-3-methylphenyl)-piperazine
140479-05-6

N-(4-fluoro-3-methylphenyl)-piperazine

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
791117-28-7

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

{8-fluoro-2-[4-(4-fluoro-3-methylphenyl)-1-piperazinyl]-3-[6-methoxy-3-(trifluoro-methyl)phenyl]-3,4-dihydro-4-quinazolinyl}-acetic acid methyl ester

{8-fluoro-2-[4-(4-fluoro-3-methylphenyl)-1-piperazinyl]-3-[6-methoxy-3-(trifluoro-methyl)phenyl]-3,4-dihydro-4-quinazolinyl}-acetic acid methyl ester

Conditions
ConditionsYield
79%
(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
791117-28-7

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

methyl (2E)-3-(3-fluoro-2-((((2-methoxy-5-(trifluoromethyl)phenyl)imino)methylene)amino)phenyl)acrylate

methyl (2E)-3-(3-fluoro-2-((((2-methoxy-5-(trifluoromethyl)phenyl)imino)methylene)amino)phenyl)acrylate

Conditions
ConditionsYield
In dichloromethane at 20℃;62%
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

3-chloro-aniline
108-42-9

3-chloro-aniline

1-(3-chlorophenyl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)urea

1-(3-chlorophenyl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)urea

Conditions
ConditionsYield
In dichloromethane at 0℃; for 0.75h;55%
9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole
796069-32-4

9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
791117-28-7

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

[8-fluoro-3-(2-methoxy-5-trifluoromethyl-phenyl)-2-(9-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)-3,4-dihydro-quinazolin-4-yl]acetic acid methyl ester
796069-35-7

[8-fluoro-3-(2-methoxy-5-trifluoromethyl-phenyl)-2-(9-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)-3,4-dihydro-quinazolin-4-yl]acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester; 2-methoxy-5-trifluoromethylphenyl isocyanate In dichloromethane at 20℃;
Stage #2: 9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole With silica gel In 1,4-dioxane; dichloromethane at 20℃; Heating / reflux;
42%
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

(2E)-3-{2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
138386-58-0

(2E)-3-{2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

(2E)-3-{2-[(iminomethylen)amino]phenyl}-acrylic acid methyl ester-1-methoxy-4-(trifluoromethyl)-benzene

(2E)-3-{2-[(iminomethylen)amino]phenyl}-acrylic acid methyl ester-1-methoxy-4-(trifluoromethyl)-benzene

Conditions
ConditionsYield
In dichloromethane at 20℃;38%
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

4-fluoroaniline
371-40-4

4-fluoroaniline

N-(2-methoxy-5-(trifluoromethyl)phenyl)-N'-(4-fluorophenyl)urea

N-(2-methoxy-5-(trifluoromethyl)phenyl)-N'-(4-fluorophenyl)urea

Conditions
ConditionsYield
In ethyl acetate
In ethyl acetate at 20℃; for 72h;
In ethyl acetate at 20℃; for 72h;
In ethyl acetate at 20℃; for 72h; Product distribution / selectivity;
C19H23N5O

C19H23N5O

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-{4-[2-(2-dimethylamino-ethylamino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-3-(2-methoxy-5-trifluoromethyl-phenyl)-urea

1-{4-[2-(2-dimethylamino-ethylamino)-6-methyl-pyrimidin-4-yloxy]-naphthalen-1-yl}-3-(2-methoxy-5-trifluoromethyl-phenyl)-urea

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;
C20H22N4O2

C20H22N4O2

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-methoxy-5-trifluoromethyl-phenyl)-3-[4-(6-methyl-2-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea

1-(2-methoxy-5-trifluoromethyl-phenyl)-3-[4-(6-methyl-2-morpholin-4-ylmethyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃;
3-(2-pyridin-4-yl-imidazol-1-ylmethyl)-phenylamine

3-(2-pyridin-4-yl-imidazol-1-ylmethyl)-phenylamine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-methoxy-5-trifluoromethyl-phenyl)-3-[3-(2-pyridin-4-yl-imidazol-1-ylmethyl)-phenyl]-urea

1-(2-methoxy-5-trifluoromethyl-phenyl)-3-[3-(2-pyridin-4-yl-imidazol-1-ylmethyl)-phenyl]-urea

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide
4-(4-acetylphenoxy)-5-aminopyridine
284670-99-1

4-(4-acetylphenoxy)-5-aminopyridine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

4-Hydroxyacetophenone
99-93-4

4-Hydroxyacetophenone

1-(4-(4-nitrophenoxy)phenyl)ethanone
75919-92-5

1-(4-(4-nitrophenoxy)phenyl)ethanone

4-chloro-pyridine-2-carbonyl chloride
53750-66-6

4-chloro-pyridine-2-carbonyl chloride

3-(4-(2-(N-methylcarbamoyl)phenylthio)aniline

3-(4-(2-(N-methylcarbamoyl)phenylthio)aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

isopropylamine
75-31-0

isopropylamine

A

4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline
284462-89-1

4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline

B

4-amino-phenol
123-30-8

4-amino-phenol

4-(4-(2-(N-methylcarbamoyl)phenylthio)aniline

4-(4-(2-(N-methylcarbamoyl)phenylthio)aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

5-(4-aminophenoxy)-2-methylisoindoline-1,3-dione

5-(4-aminophenoxy)-2-methylisoindoline-1,3-dione

4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide
284462-44-8

4-(4-amino-3-chloro-phenoxy)-pyridine-2-carboxylic acid methylamide

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

amino-4 hydroxy-2 toluene
2835-95-2

amino-4 hydroxy-2 toluene

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

A

3-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-4-methylaniline
284462-92-6

3-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-4-methylaniline

B

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

4-(4-aminophenoxy)-N,N-dimethylpicolinamide
284462-86-8

4-(4-aminophenoxy)-N,N-dimethylpicolinamide

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

4-(1-oxoisoindolin-5-yloxy)aniline
284462-54-0

4-(1-oxoisoindolin-5-yloxy)aniline

4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline
284462-89-1

4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

methyl 5-(4-aminophenoxy)pyridine-3-carboxylate
284462-58-4

methyl 5-(4-aminophenoxy)pyridine-3-carboxylate

N-methylphthalimide
550-44-7

N-methylphthalimide

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

2-Methoxy-5-trifluoromethyl-aniline
349-65-5

2-Methoxy-5-trifluoromethyl-aniline

4-chloro-N-methylpicolinamide
220000-87-3

4-chloro-N-methylpicolinamide

5-methyl-1-(pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine
915295-45-3

5-methyl-1-(pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(5-methyl-1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(5-methyl-1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

Conditions
ConditionsYield
In dichloromethane for 4h;
1-(Pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine
915295-51-1

1-(Pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;
6-(3-aminophenyl)-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine
1044656-17-8

6-(3-aminophenyl)-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine

2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

1-(2-metoxy-5-trifluoromethyl-phenyl)-3-(3-{8-[(-pyridin-4-yl-methyl)-amino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-urea
847024-36-6

1-(2-metoxy-5-trifluoromethyl-phenyl)-3-(3-{8-[(-pyridin-4-yl-methyl)-amino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-urea

Conditions
ConditionsYield
In toluene at 20℃; for 0.5h;
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

4-(2-aminoethyl)-2-nitro-phenylamine
159417-93-3

4-(2-aminoethyl)-2-nitro-phenylamine

C17H17F3N4O4
863910-65-0

C17H17F3N4O4

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h;
2-methoxy-5-trifluoromethylphenyl isocyanate
16588-75-3

2-methoxy-5-trifluoromethylphenyl isocyanate

(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid
917389-32-3

(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: acetonitrile / Reflux
2: acetic acid; palladium diacetate
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / Reflux
4: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / chlorobenzene / Reflux
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / Reflux
6: ethyl acetate / 20 °C
7: sodium hydrogencarbonate; sodium hydroxide; water / tert-butyl methyl ether / Reflux; Large scale
View Scheme
Multi-step reaction with 6 steps
1.1: acetonitrile / 4 h / Reflux; Large scale
2.1: acetic acid; sulfuric acid; sulfur trioxide; palladium diacetate; oxygen / 20 h / 20 °C / Inert atmosphere; Large scale
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 4 h / Reflux; Large scale
4.1: trichlorophosphate / chlorobenzene / 3 h / Reflux; Large scale
4.2: 9 h / Reflux; Large scale
5.1: ethyl acetate / 1 h / 20 °C / Large scale
5.2: 72 h / 20 °C / Large scale
6.1: sodium hydrogencarbonate / water; tert-butyl methyl ether / Large scale
6.2: Reflux; Large scale
View Scheme
Multi-step reaction with 7 steps
1.1: acetonitrile / 7.25 h / 0 °C / Reflux; Large scale
2.1: acetic acid / Inert atmosphere; Large scale
2.2: 20 h / 20 °C / Inert atmosphere; Large scale
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 4 h / 55 °C / Reflux; Large scale
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / chlorobenzene / 12 h / Reflux; Large scale
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 4 h / Reflux; Large scale
6.1: ethyl acetate / 76 h / 0 - 20 °C / Large scale
7.1: sodium hydrogencarbonate; water; sodium hydroxide / tert-butyl methyl ether / 22 °C / Reflux; Large scale
View Scheme

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