CasNo.284461-73-0,CAS: 284461-73-0 Sorafenib factory sales,(284461-73-0) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99.5%
Payment Terms : L/C,T/T,Other

Keywords

Sorafenib Sorafenib high purity 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

Quick Details

Appearance:powder
Application:Pharmaceutical
PackAge:according to customers' requirements
ProductionCapacity:100|Kilogram|Week
Storage:store in cool and dry
Transportation:by sea or by air

Superiority:

Description:

English name:Sorafenib

Synonyms:BAY43-9006;N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea

Specification: 98%

CAS NO.:284461-73-0

Appearance: White crystalline powder

Molecular weight: 464.82

Molecular formula:C21H16ClF3N4O3

Items	Specifications	Results
Appearance	Off white powder to white powder	Off-white powder
Identification	H-NMR, MS	Complies
Water content	< 0.5%	0.06%
Loss on Drying	<1.0%	0.02%
Related Impurity by HPLC	Total impurity ≤1.0% Single impurity≤0.3%	0.05% 0.04%
Purity (HPLC)	≥99%	99.95%

Function and Application:

Sorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation. Studies indicate that Sorafenib induces c-Raf phosphorylation

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at both Ser-43 and Ser-259. When combined with vitamin K1 phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, Sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that Sorafenib inhibits other kinases such as Flk-1 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit.

Details:

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Pioneer. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, PIONEER can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.