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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1265.html Product Name 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
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inquiryXi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. Kono Chem is located in Xi'an, Shaanxi Province,
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Type:Manufacturers
inquiry2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS 152628-02-9 Telmisartan Intermediate CAS no 152628-02-9 4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propylbenzimidazole 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimida
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inquiryName:2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS NO: 152628-02-9 Grade:Medical scientific research and export Molecular formula:C19H20N4 Molecular weight:304.3889 Product Quality 12 years of chemical raw materials Ma
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Type:Other
inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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inquiryProduct name 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS No. 152628-02-9 Molecular weight 304.39
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Type:Other
inquiryAppearance:White to off-white crystalline powder Storage:ln stock Package:25kg/Carton Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china
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Type:Lab/Research institutions
inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
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Type:Lab/Research institutions
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Type:Lab/Research institutions
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inquiry2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS No 152628-02-9 Molecular weight 304.39 EINECS 604-866-6 Alisa TelMisartan IMpurity A ; 2-n-Propyl-4-methyl-6-(1'-meth
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Type:Other
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Negotiable
Type:Lab/Research institutions
inquiryN-methylbenzene-1,2-diamine dihydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With methanesulfonic acid In i-Amyl alcohol at 130 - 135℃; for 18h; Temperature; Solvent; Reagent/catalyst; | 93% |
Stage #1: N-methylbenzene-1,2-diamine dihydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA at 70 - 135℃; for 13.5h; Stage #2: With ammonia In water at 30 - 90℃; for 1h; pH=8.0 - 8.5; | 77.4% |
With PPA at 150℃; for 20h; | 5.86 g |
With polyphosphoric acid at 150℃; for 14h; |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃; | 93% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃; | 92% |
N-methyl-1,2-phenylenediamine
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With methanesulfonic acid; phosphorus pentoxide at 75 - 145℃; Stage #2: With sodium hydroxide In water pH=< 3; Product distribution / selectivity; | 90% |
With polyphosphoric acid at 150 - 155℃; for 4h; Inert atmosphere; | 80% |
With PPA at 150 - 155℃; Inert atmosphere; | |
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid at 70 - 130℃; for 8.5h; Stage #2: With hydrogenchloride In methanol; water at 25℃; for 0.166667h; Stage #3: With ammonium hydroxide In methanol; water at 25℃; for 1h; Reagent/catalyst; |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetonitrile at 20℃; | 90% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-formylchlorobenzimidazole; N-methyl-o-phenylenediamine hydrochloride With triethylamine In dichloromethane at 40℃; for 3h; Large scale; Stage #2: With acetic acid In dichloromethane at 60℃; for 5h; Temperature; Reagent/catalyst; Solvent; Large scale; | 89.96% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With p-toluenesulfonyl chloride In water; acetonitrile at 0 - 20℃; | 88% |
Multi-step reaction with 2 steps 1: triethylamine / acetonitrile / 0 - 20 °C 2: sodium hydroxide / acetonitrile; water / 20 °C View Scheme |
2-methyl-4-(1-methyl-1H-benzimidazol-2-yl)-6-nitrobenzenamine
butyraldehyde
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With sodium dithionite In methanol; water for 12h; Reflux; | 85% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: C19H21N3O*ClH With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide In acetonitrile at 80 - 85℃; for 2h; Stage #2: With hydroxylamine In acetonitrile at 20℃; for 1h; Stage #3: With triethylamine; p-toluenesulfonyl chloride at 0 - 20℃; | 85% |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / acetonitrile / 2 h / 80 - 85 °C 2: p-toluenesulfonyl chloride / acetonitrile; water / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / acetonitrile / 2 h / 80 - 85 °C 2: triethylamine / acetonitrile / 0 - 20 °C 3: sodium hydroxide / acetonitrile; water / 20 °C View Scheme |
N1-methylbenzene-1,2-diamine hydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
A
desmethyl dibenzimidazole
B
7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide
C
3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide
D
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With polyphosphoric acid at 150 - 155℃; | A n/a B n/a C n/a D 84% |
N-[2-methyl-4-(1-methylbenzimidazole)-2-yl-6-nitrophenyl]-butanamide
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In isopropyl alcohol at 100℃; under 6000.6 Torr; for 12h; Temperature; Solvent; Reagent/catalyst; Autoclave; | 82.3% |
N1-methylbenzene-1,2-diamine hydrochloride
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With phosphorus pentoxide; phosphoric acid at 70 - 130℃; Stage #2: With ammonia In water; ethyl acetate for 3h; pH=9 - 10; Product distribution / selectivity; Cooling with ice; | 82% |
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA; Polyphosphoric acid (PPA) In water at 90 - 155℃; for 5.75 - 7h; Stage #2: With sodium hydroxide In water pH=5.5 - 6; Product distribution / selectivity; |
N-methyl-1,2-phenylenediamine
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With polyphosphoric acid at 150℃; for 12h; | 62% |
B
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With caesium carbonate; copper(II) oxide In dimethyl sulfoxide at 130℃; for 8h; | A 19.9% B 61.3% |
butyric acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With polyphosporic acid at 120℃; for 4h; | 47% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃; | 13% |
methyl 4-amino-3-methylbenzoate
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: chlorobenzene / 100 °C 2: fuming HNO3, 60percent H2SO4 / 0 °C 3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 4: glacial CH3COOH / 1.5 h / Heating 5: 5.46 g / aq. NaOH / methanol / 2 h / Heating 6: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme | |
Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 0 °C 2: sulfuric acid; nitric acid 3: hydrogen / methanol / 100 °C / 3750.38 Torr 4: acetic acid / 1 h / Reflux 5: sodium hydroxide / water; methanol / 2 h / Reflux 6: polyphosphoric acid / 14 h / 150 °C View Scheme |
methyl 4-(n-butyrylamino)-3-methylbenzoate
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: fuming HNO3, 60percent H2SO4 / 0 °C 2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 3: glacial CH3COOH / 1.5 h / Heating 4: 5.46 g / aq. NaOH / methanol / 2 h / Heating 5: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme | |
Multi-step reaction with 5 steps 1: sulfuric acid; nitric acid 2: hydrogen / methanol / 100 °C / 3750.38 Torr 3: acetic acid / 1 h / Reflux 4: sodium hydroxide / water; methanol / 2 h / Reflux 5: polyphosphoric acid / 14 h / 150 °C View Scheme |
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 5.46 g / aq. NaOH / methanol / 2 h / Heating 2: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / methanol / 80 °C 2.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C 2.2: 3 h / pH 9 - 10 / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / water; methanol / 2 h / Reflux 2: polyphosphoric acid / 14 h / 150 °C View Scheme |
methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating 3: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid / 1 h / Reflux 2: sodium hydroxide / water; methanol / 2 h / Reflux 3: polyphosphoric acid / 14 h / 150 °C View Scheme |
4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 2: glacial CH3COOH / 1.5 h / Heating 3: 5.46 g / aq. NaOH / methanol / 2 h / Heating 4: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: water; sodium dithionite / 70 - 100 °C 2.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C 2.2: 3 h / pH 9 - 10 / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium dithionite / water / 70 - 100 °C 2.1: sodium hydroxide; water / methanol / 80 °C 3.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C 3.2: 3 h / pH 9 - 10 / Cooling with ice View Scheme | |
Multi-step reaction with 4 steps 1: hydrogen / methanol / 100 °C / 3750.38 Torr 2: acetic acid / 1 h / Reflux 3: sodium hydroxide / water; methanol / 2 h / Reflux 4: polyphosphoric acid / 14 h / 150 °C View Scheme |
3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: 3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide With PPA at 150 - 155℃; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 0.5 - 0.75h; pH=5 - 6; Product distribution / selectivity; |
7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: 7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide With PPA at 150 - 155℃; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 0.5 - 0.75h; pH=5 - 6; Product distribution / selectivity; |
C15H13N3O3
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 1.2: 3.5 h / 5 - 20 °C 2.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 3.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme |
2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzimidazole
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 2: sodium dithionite / methanol; water / 12 h / Reflux View Scheme |
4-hydroxy-3-methyl-benzaldehyde
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: nitric acid / 1.67 h / -15 °C 2.1: sodium hydroxide / water / 0.5 h 2.2: 6.25 h / 0 - 70 °C 3.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 4.2: 3.5 h / 5 - 20 °C 5.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 6.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme |
4-hydroxy-3-methyl-5-nitrobenzaldehyde
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydroxide / water / 0.5 h 1.2: 6.25 h / 0 - 70 °C 2.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 3.2: 3.5 h / 5 - 20 °C 4.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 5.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme |
4-methoxy-3-methyl-5-nitrobenzaldehyde
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 2.2: 3.5 h / 5 - 20 °C 3.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 4.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme |
ortho-cresol
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium hydroxide / water / 6.5 h / 60 °C 2.1: nitric acid / 1.67 h / -15 °C 3.1: sodium hydroxide / water / 0.5 h 3.2: 6.25 h / 0 - 70 °C 4.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 5.2: 3.5 h / 5 - 20 °C 6.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 7.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme |
methyl 3,4-diamino-5-methylbenzoate
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: polyphosphoric acid / 0.17 h / 150 °C / 1551.49 Torr / Irradiation 2: polyphosphoric acid / 12 h / 150 °C View Scheme |
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In dimethyl sulfoxide; isopropyl alcohol Inert atmosphere; Stage #2: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate In dimethyl sulfoxide; isopropyl alcohol at 30 - 35℃; for 6h; Inert atmosphere; | 95.1% |
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 0 - 10℃; for 3.416h; Solvent; Reagent/catalyst; Temperature; | 95% |
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In dimethyl sulfoxide; isopropyl alcohol at 45℃; for 1h; Stage #2: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate In dimethyl sulfoxide; isopropyl alcohol at 30℃; for 6h; | 94.8% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
4'-bromomethylbiphenyl-2-carboxylic acid
telmisatran
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 1h; Stage #2: 4'-bromomethylbiphenyl-2-carboxylic acid In N,N-dimethyl-formamide at 10℃; Solvent; Reagent/catalyst; Temperature; | 95% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetonitrile for 0.166667h; Stage #2: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester In acetonitrile | 92% |
(4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 0.5h; Stage #2: (4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone In tetrahydrofuran; mineral oil at 50℃; for 3h; | 91.9% |
2-mesitylenesulphonyl chloride
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃; | 90% |
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
telmisatran
Conditions | Yield |
---|---|
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h; Stage #2: With water; acetic acid In water; dimethyl sulfoxide at 20℃; pH=3.8 - 4; Product distribution / selectivity; | 88% |
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h; Stage #2: With water; acetic acid In water; dimethyl sulfoxide pH=4.2; Product distribution / selectivity; | 80% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 1h; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In ISOPROPYLAMIDE at 5 - 10℃; for 2h; | 87.5% |
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 1h; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In ISOPROPYLAMIDE at 5 - 10℃; for 2h; | 87.5% |
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetone at 20 - 25℃; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In acetone at 20 - 25℃; Product distribution / selectivity; | 87.73% |
2,5-dichlorobenzenesulphonyl chloride
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃; | 87% |
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate
Conditions | Yield |
---|---|
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 10℃; for 4h; | 86% |
With sodium In methanol at 70℃; Reagent/catalyst; Temperature; Solvent; | 71% |
With potassium tert-butylate In N,N-dimethyl acetamide at 75 - 80℃; for 3h; Inert atmosphere; | 70% |
With potassium tert-butylate 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h; Multistep reaction; | |
With potassium tert-butylate In dimethyl sulfoxide at 25 - 30℃; for 3.5h; Product distribution / selectivity; |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
(5-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 0.5h; Stage #2: (5-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone In tetrahydrofuran; mineral oil at 50℃; for 3h; | 85.6% |
2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: 2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; Reflux; Inert atmosphere; | 85% |
4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: 4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; Inert atmosphere; Reflux; | 85% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
4-bromobenzenesulfonyl chloride
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃; | 84% |
4-(chloromethyl)biphenyl-2'-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
telmisatran
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Cooling with ice; Stage #2: 4-(chloromethyl)biphenyl-2'-carboxylic acid In N,N-dimethyl-formamide at 20 - 50℃; for 5h; Reagent/catalyst; Temperature; | 84% |
p-toluenesulfonyl chloride
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃; | 83% |
1-bromomethyl-4-bromobenzene
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide at 25 - 35℃; Inert atmosphere; | 80% |
With potassium carbonate In ISOPROPYLAMIDE at 20℃; for 8h; |
2-Bromo-4'-(bromomethyl)biphenyl
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
3'-((2'-bromobiphenyl-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20 - 30℃; Stage #2: 2-Bromo-4'-(bromomethyl)biphenyl In ISOPROPYLAMIDE at 5 - 10℃; | 75.4% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
telmisatran
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetonitrile for 0.166667h; Stage #2: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester In acetonitrile Stage #3: With hydrogenchloride In water | 75.1% |
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