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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2-N-Propyl-4-Methyl-6- (1-methylbenzimidazole-2-yl) Benzimidazole 152628-02-9

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1265.html Product Name 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-ly)benzimidazole

Cas:152628-02-9

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Manufacturer/High quality/Best price/In stock

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole high quality

Cas:152628-02-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. Kono Chem is located in Xi'an, Shaanxi Province,

Factory supply high quality 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $95.0 / 100.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS NO.152628-02-9

Cas:152628-02-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Off-white powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum Application:pharmaceu

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Cas 152628-02-9

Cas:152628-02-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1,7'-dimethyl-2'-propyl-1H,1'H-2,5'-bibenzimidazole

Cas:152628-02-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Chemwill Asia Co., Ltd.

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS 152628-02-9 Telmisartan Intermediate CAS no 152628-02-9 4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propylbenzimidazole 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimida

Hubei DiBo chemical co., LTD

Name:2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS NO: 152628-02-9 Grade:Medical scientific research and export Molecular formula:C19H20N4 Molecular weight:304.3889 Product Quality 12 years of chemical raw materials Ma

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 152628-02-9 with competitive price

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product name 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS No. 152628-02-9 Molecular weight 304.39

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white crystalline powder Storage:ln stock Package:25kg/Carton Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 152628-02-9 2-N-Propyl-4-Methyl-6-(1-Methy with best price

Cas:152628-02-9

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole 152628-02-9

Cas:152628-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

For Telmisartan: 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Biggest Factory Manufacturer Supply Bis-Benzoimidazole CAS 152628-02-9

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $120.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS 152628-02-9 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and rese

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS 152628-02-9

Cas:152628-02-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS:152628-02-9

Cas:152628-02-9

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

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Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo

2-N-Propyl-4-Methyl-6- (1′ -Methylbenzimidazol-2-Yl) Benzimidazole CAS 152628-02-9

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

1H-Benzimidazole-2-N-Propyl-4-Methyl-6-(1'-Methylbenzimidazole-2'-Yl)

Cas:152628-02-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan BJM Pharm Inc.

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole CAS No 152628-02-9 Molecular weight 304.39 EINECS 604-866-6 Alisa TelMisartan IMpurity A ; 2-n-Propyl-4-methyl-6-(1'-meth

2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole(152628-02-9) factory supply in stock

Cas:152628-02-9

Min.Order:1 Kilogram

FOB Price: $20.0 / 50.0

Type:Other

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

2-N-PROPYL-4-METHYL-6-(1-METHYL BENZIMIDAZOL-2-YL)-BENZIMIDAZOLE

Cas:152628-02-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N-methylbenzene-1,2-diamine dihydrochloride
25148-68-9

N-methylbenzene-1,2-diamine dihydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With methanesulfonic acid In i-Amyl alcohol at 130 - 135℃; for 18h; Temperature; Solvent; Reagent/catalyst;93%
Stage #1: N-methylbenzene-1,2-diamine dihydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA at 70 - 135℃; for 13.5h;
Stage #2: With ammonia In water at 30 - 90℃; for 1h; pH=8.0 - 8.5;
77.4%
With PPA at 150℃; for 20h;5.86 g
With polyphosphoric acid at 150℃; for 14h;
C19H21IN4

C19H21IN4

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃;93%
C19H21BrN4

C19H21BrN4

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃;92%
N-methyl-1,2-phenylenediamine
4760-34-3

N-methyl-1,2-phenylenediamine

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With methanesulfonic acid; phosphorus pentoxide at 75 - 145℃;
Stage #2: With sodium hydroxide In water pH=< 3; Product distribution / selectivity;
90%
With polyphosphoric acid at 150 - 155℃; for 4h; Inert atmosphere;80%
With PPA at 150 - 155℃; Inert atmosphere;
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid at 70 - 130℃; for 8.5h;
Stage #2: With hydrogenchloride In methanol; water at 25℃; for 0.166667h;
Stage #3: With ammonium hydroxide In methanol; water at 25℃; for 1h; Reagent/catalyst;
C26H28N4O3S

C26H28N4O3S

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With sodium hydroxide In water; acetonitrile at 20℃;90%
2-n-propyl-4-methyl-6-formylchlorobenzimidazole

2-n-propyl-4-methyl-6-formylchlorobenzimidazole

N-methyl-o-phenylenediamine hydrochloride

N-methyl-o-phenylenediamine hydrochloride

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-formylchlorobenzimidazole; N-methyl-o-phenylenediamine hydrochloride With triethylamine In dichloromethane at 40℃; for 3h; Large scale;
Stage #2: With acetic acid In dichloromethane at 60℃; for 5h; Temperature; Reagent/catalyst; Solvent; Large scale;
89.96%
C19H22N4O

C19H22N4O

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With p-toluenesulfonyl chloride In water; acetonitrile at 0 - 20℃;88%
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 0 - 20 °C
2: sodium hydroxide / acetonitrile; water / 20 °C
View Scheme
2-methyl-4-(1-methyl-1H-benzimidazol-2-yl)-6-nitrobenzenamine
1345840-05-2

2-methyl-4-(1-methyl-1H-benzimidazol-2-yl)-6-nitrobenzenamine

butyraldehyde
123-72-8

butyraldehyde

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With sodium dithionite In methanol; water for 12h; Reflux;85%
C19H21N3O*ClH

C19H21N3O*ClH

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Stage #1: C19H21N3O*ClH With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide In acetonitrile at 80 - 85℃; for 2h;
Stage #2: With hydroxylamine In acetonitrile at 20℃; for 1h;
Stage #3: With triethylamine; p-toluenesulfonyl chloride at 0 - 20℃;
85%
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / acetonitrile / 2 h / 80 - 85 °C
2: p-toluenesulfonyl chloride / acetonitrile; water / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / acetonitrile / 2 h / 80 - 85 °C
2: triethylamine / acetonitrile / 0 - 20 °C
3: sodium hydroxide / acetonitrile; water / 20 °C
View Scheme
N1-methylbenzene-1,2-diamine hydrochloride
81684-80-2

N1-methylbenzene-1,2-diamine hydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

A

desmethyl dibenzimidazole
884330-09-0

desmethyl dibenzimidazole

B

7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide
884330-18-1

7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide

C

3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide
884330-17-0

3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide

D

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With polyphosphoric acid at 150 - 155℃;A n/a
B n/a
C n/a
D 84%
N-[2-methyl-4-(1-methylbenzimidazole)-2-yl-6-nitrophenyl]-butanamide
1083158-66-0

N-[2-methyl-4-(1-methylbenzimidazole)-2-yl-6-nitrophenyl]-butanamide

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In isopropyl alcohol at 100℃; under 6000.6 Torr; for 12h; Temperature; Solvent; Reagent/catalyst; Autoclave;82.3%
N1-methylbenzene-1,2-diamine hydrochloride
81684-80-2

N1-methylbenzene-1,2-diamine hydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With phosphorus pentoxide; phosphoric acid at 70 - 130℃;
Stage #2: With ammonia In water; ethyl acetate for 3h; pH=9 - 10; Product distribution / selectivity; Cooling with ice;
82%
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA; Polyphosphoric acid (PPA) In water at 90 - 155℃; for 5.75 - 7h;
Stage #2: With sodium hydroxide In water pH=5.5 - 6; Product distribution / selectivity;
N-methyl-1,2-phenylenediamine
4760-34-3

N-methyl-1,2-phenylenediamine

4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester
152628-00-7

4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With polyphosphoric acid at 150℃; for 12h;62%
C19H21BrN4

C19H21BrN4

A

C15H14BrN3

C15H14BrN3

B

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With caesium carbonate; copper(II) oxide In dimethyl sulfoxide at 130℃; for 8h;A 19.9%
B 61.3%
3-methyl-5-(1-methyl-1H-benzoimidazol-2-yl)-benzene-1,2-diamine

3-methyl-5-(1-methyl-1H-benzoimidazol-2-yl)-benzene-1,2-diamine

butyric acid
107-92-6

butyric acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With polyphosporic acid at 120℃; for 4h;47%
C19H21ClN4

C19H21ClN4

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 130℃;13%
methyl 4-amino-3-methylbenzoate
18595-14-7

methyl 4-amino-3-methylbenzoate

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: chlorobenzene / 100 °C
2: fuming HNO3, 60percent H2SO4 / 0 °C
3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
4: glacial CH3COOH / 1.5 h / Heating
5: 5.46 g / aq. NaOH / methanol / 2 h / Heating
6: 5.86 g / polyphosphoric acid / 20 h / 150 °C
View Scheme
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane / 0 °C
2: sulfuric acid; nitric acid
3: hydrogen / methanol / 100 °C / 3750.38 Torr
4: acetic acid / 1 h / Reflux
5: sodium hydroxide / water; methanol / 2 h / Reflux
6: polyphosphoric acid / 14 h / 150 °C
View Scheme
methyl 4-(n-butyrylamino)-3-methylbenzoate
301533-59-5

methyl 4-(n-butyrylamino)-3-methylbenzoate

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: fuming HNO3, 60percent H2SO4 / 0 °C
2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
3: glacial CH3COOH / 1.5 h / Heating
4: 5.46 g / aq. NaOH / methanol / 2 h / Heating
5: 5.86 g / polyphosphoric acid / 20 h / 150 °C
View Scheme
Multi-step reaction with 5 steps
1: sulfuric acid; nitric acid
2: hydrogen / methanol / 100 °C / 3750.38 Torr
3: acetic acid / 1 h / Reflux
4: sodium hydroxide / water; methanol / 2 h / Reflux
5: polyphosphoric acid / 14 h / 150 °C
View Scheme
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester
152628-00-7

4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5.46 g / aq. NaOH / methanol / 2 h / Heating
2: 5.86 g / polyphosphoric acid / 20 h / 150 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / methanol / 80 °C
2.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C
2.2: 3 h / pH 9 - 10 / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / water; methanol / 2 h / Reflux
2: polyphosphoric acid / 14 h / 150 °C
View Scheme
methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate
675882-71-0

methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: glacial CH3COOH / 1.5 h / Heating
2: 5.46 g / aq. NaOH / methanol / 2 h / Heating
3: 5.86 g / polyphosphoric acid / 20 h / 150 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid / 1 h / Reflux
2: sodium hydroxide / water; methanol / 2 h / Reflux
3: polyphosphoric acid / 14 h / 150 °C
View Scheme
4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester
152628-01-8

4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
2: glacial CH3COOH / 1.5 h / Heating
3: 5.46 g / aq. NaOH / methanol / 2 h / Heating
4: 5.86 g / polyphosphoric acid / 20 h / 150 °C
View Scheme
Multi-step reaction with 2 steps
1.1: water; sodium dithionite / 70 - 100 °C
2.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C
2.2: 3 h / pH 9 - 10 / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: sodium dithionite / water / 70 - 100 °C
2.1: sodium hydroxide; water / methanol / 80 °C
3.1: phosphorus pentoxide; phosphoric acid / 70 - 130 °C
3.2: 3 h / pH 9 - 10 / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1: hydrogen / methanol / 100 °C / 3750.38 Torr
2: acetic acid / 1 h / Reflux
3: sodium hydroxide / water; methanol / 2 h / Reflux
4: polyphosphoric acid / 14 h / 150 °C
View Scheme
3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide
884330-17-0

3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Stage #1: 3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide With PPA at 150 - 155℃;
Stage #2: With sodium hydroxide In water at 70 - 80℃; for 0.5 - 0.75h; pH=5 - 6; Product distribution / selectivity;
7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide
884330-18-1

7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Stage #1: 7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide With PPA at 150 - 155℃;
Stage #2: With sodium hydroxide In water at 70 - 80℃; for 0.5 - 0.75h; pH=5 - 6; Product distribution / selectivity;
C15H13N3O3
1345840-14-3

C15H13N3O3

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h
1.2: 3.5 h / 5 - 20 °C
2.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave
3.1: sodium dithionite / methanol; water / 12 h / Reflux
View Scheme
2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzimidazole
1345840-21-2

2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzimidazole

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave
2: sodium dithionite / methanol; water / 12 h / Reflux
View Scheme
4-hydroxy-3-methyl-benzaldehyde
15174-69-3

4-hydroxy-3-methyl-benzaldehyde

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: nitric acid / 1.67 h / -15 °C
2.1: sodium hydroxide / water / 0.5 h
2.2: 6.25 h / 0 - 70 °C
3.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h
4.2: 3.5 h / 5 - 20 °C
5.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave
6.1: sodium dithionite / methanol; water / 12 h / Reflux
View Scheme
4-hydroxy-3-methyl-5-nitrobenzaldehyde
54674-91-8

4-hydroxy-3-methyl-5-nitrobenzaldehyde

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 0.5 h
1.2: 6.25 h / 0 - 70 °C
2.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h
3.2: 3.5 h / 5 - 20 °C
4.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave
5.1: sodium dithionite / methanol; water / 12 h / Reflux
View Scheme
4-methoxy-3-methyl-5-nitrobenzaldehyde
861792-67-8

4-methoxy-3-methyl-5-nitrobenzaldehyde

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h
2.2: 3.5 h / 5 - 20 °C
3.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave
4.1: sodium dithionite / methanol; water / 12 h / Reflux
View Scheme
ortho-cresol
95-48-7

ortho-cresol

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium hydroxide / water / 6.5 h / 60 °C
2.1: nitric acid / 1.67 h / -15 °C
3.1: sodium hydroxide / water / 0.5 h
3.2: 6.25 h / 0 - 70 °C
4.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h
5.2: 3.5 h / 5 - 20 °C
6.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave
7.1: sodium dithionite / methanol; water / 12 h / Reflux
View Scheme
methyl 3,4-diamino-5-methylbenzoate
668276-43-5

methyl 3,4-diamino-5-methylbenzoate

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: polyphosphoric acid / 0.17 h / 150 °C / 1551.49 Torr / Irradiation
2: polyphosphoric acid / 12 h / 150 °C
View Scheme
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
114772-38-2

Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
528560-93-2

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In dimethyl sulfoxide; isopropyl alcohol Inert atmosphere;
Stage #2: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate In dimethyl sulfoxide; isopropyl alcohol at 30 - 35℃; for 6h; Inert atmosphere;
95.1%
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 0 - 10℃; for 3.416h; Solvent; Reagent/catalyst; Temperature;95%
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In dimethyl sulfoxide; isopropyl alcohol at 45℃; for 1h;
Stage #2: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate In dimethyl sulfoxide; isopropyl alcohol at 30℃; for 6h;
94.8%
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

4'-bromomethylbiphenyl-2-carboxylic acid
150766-86-2

4'-bromomethylbiphenyl-2-carboxylic acid

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 1h;
Stage #2: 4'-bromomethylbiphenyl-2-carboxylic acid In N,N-dimethyl-formamide at 10℃; Solvent; Reagent/catalyst; Temperature;
95%
4'-chloromethylbiphenyl-2-carboxylic acid methyl ester

4'-chloromethylbiphenyl-2-carboxylic acid methyl ester

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
528560-93-2

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetonitrile for 0.166667h;
Stage #2: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester In acetonitrile
92%
(4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone
1241048-04-3

(4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

[4-[[2-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl](phenyl)methanone

[4-[[2-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl](phenyl)methanone

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 0.5h;
Stage #2: (4-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone In tetrahydrofuran; mineral oil at 50℃; for 3h;
91.9%
2-mesitylenesulphonyl chloride
773-64-8

2-mesitylenesulphonyl chloride

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

3-(mesitylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

3-(mesitylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃;90%
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
114772-38-2

Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h;
Stage #2: With water; acetic acid In water; dimethyl sulfoxide at 20℃; pH=3.8 - 4; Product distribution / selectivity;
88%
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h;
Stage #2: With water; acetic acid In water; dimethyl sulfoxide pH=4.2; Product distribution / selectivity;
80%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl
144702-27-2

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 1h;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In ISOPROPYLAMIDE at 5 - 10℃; for 2h;
87.5%
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 1h;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In ISOPROPYLAMIDE at 5 - 10℃; for 2h;
87.5%
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetone at 20 - 25℃;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In acetone at 20 - 25℃; Product distribution / selectivity;
87.73%
2,5-dichlorobenzenesulphonyl chloride
5402-73-3

2,5-dichlorobenzenesulphonyl chloride

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

3-(2,5-dichlorophenylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

3-(2,5-dichlorophenylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃;87%
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester
114772-40-6

4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate
144702-26-1

tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 10℃; for 4h;86%
With sodium In methanol at 70℃; Reagent/catalyst; Temperature; Solvent;71%
With potassium tert-butylate In N,N-dimethyl acetamide at 75 - 80℃; for 3h; Inert atmosphere;70%
With potassium tert-butylate 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h; Multistep reaction;
With potassium tert-butylate In dimethyl sulfoxide at 25 - 30℃; for 3.5h; Product distribution / selectivity;
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

(5-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone
145303-52-2

(5-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone

[5-[[2-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl](phenyl)methanone

[5-[[2-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl](phenyl)methanone

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 0.5h;
Stage #2: (5-(bromomethyl)-1H-indol-1-yl)(phenyl)methanone In tetrahydrofuran; mineral oil at 50℃; for 3h;
85.6%
2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
158144-51-5

2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
1191259-51-4

3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #2: 2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; Reflux; Inert atmosphere;
85%
4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline
158144-52-6

4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
1191259-51-4

3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #2: 4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline In tetrahydrofuran; N,N-dimethyl acetamide at 20℃; Inert atmosphere; Reflux;
85%
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

4-bromobenzenesulfonyl chloride
98-58-8

4-bromobenzenesulfonyl chloride

3-(4-bromophenylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

3-(4-bromophenylsulfonyl)-1,7-dimethyl-2-propyl-1H,3H-2,5-bibenzo[d]imidazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃;84%
4-(chloromethyl)biphenyl-2'-carboxylic acid
667457-41-2

4-(chloromethyl)biphenyl-2'-carboxylic acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Cooling with ice;
Stage #2: 4-(chloromethyl)biphenyl-2'-carboxylic acid In N,N-dimethyl-formamide at 20 - 50℃; for 5h; Reagent/catalyst; Temperature;
84%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

1,7-dimethyl-2-propyl-3-tosyl-1H,3H-2,5-bibenzo[d]imidazole

1,7-dimethyl-2-propyl-3-tosyl-1H,3H-2,5-bibenzo[d]imidazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydroxide In benzene at 0 - 20℃;83%
1-bromomethyl-4-bromobenzene
589-15-1

1-bromomethyl-4-bromobenzene

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

3'-(4-bromobenzyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole

3'-(4-bromobenzyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide at 25 - 35℃; Inert atmosphere;80%
With potassium carbonate In ISOPROPYLAMIDE at 20℃; for 8h;
2-Bromo-4'-(bromomethyl)biphenyl
1187523-96-1

2-Bromo-4'-(bromomethyl)biphenyl

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

3'-((2'-bromobiphenyl-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
1206701-77-0

3'-((2'-bromobiphenyl-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium tert-butylate In ISOPROPYLAMIDE at 20 - 30℃;
Stage #2: 2-Bromo-4'-(bromomethyl)biphenyl In ISOPROPYLAMIDE at 5 - 10℃;
75.4%
4'-chloromethylbiphenyl-2-carboxylic acid methyl ester

4'-chloromethylbiphenyl-2-carboxylic acid methyl ester

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetonitrile for 0.166667h;
Stage #2: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester In acetonitrile
Stage #3: With hydrogenchloride In water
75.1%
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