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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Manufacturer/High quality/Best price/In stock

Cas:152628-03-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-N-Propyl-4-Methyl-6-Carboxylate-1H-Benzimidazole supplier in China

Cas:152628-03-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid CAS NO.152628-03-0

Cas:152628-03-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-N-Propyl-4-Methyl-6-Carboxylate-1H-Benzimidazole

Cas:152628-03-0

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 152628-03-0 1H-Benzimidazole-5-carboxylicacid, 7-methyl-2-propyl-

Cas:152628-03-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid -- CHemwill

Cas:152628-03-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Good quantity 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Basic information Product Name: 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Synonyms: 4-METHYL-2-N-PROPY

4-Methyl-2-propyl-6-benzimidazolecarboxylic Acid

Cas:152628-03-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 152628-03-0 with best quality

Cas:152628-03-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid CAS NO 152628-03-0

Cas:152628-03-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Off-white to white powder Storage:Room temperature Package:25kg/drum Application:Pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in china

High Quality Telmisartan intermediate

Cas:152628-03-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Benzimidazole-5-carboxylicacid, 7-methyl-2-propyl- 152628-03-0

Cas:152628-03-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic Acid CAS 152628-03-0 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capa

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic Acid CAS 152628-03-0

Cas:152628-03-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Benzimidazole-5-carboxylicacid, 7-methyl-2-propyl-

Cas:152628-03-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo

4-Methyl-2-N-Propyl-1h-Benzimidazole-6-Carboxylic Acid CAS 152628-03-0

Cas:152628-03-0

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Benzimidazole-5-carboxylicacid, 7-methyl-2-propyl-

Cas:152628-03-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-N-Propyl-4-Methyl-6-Carboxylate-1H-Benzimidazole

Cas:152628-03-0

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

4-METHYL-2-N-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID

Cas:152628-03-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid CAS NO.152628-03-0

Cas:152628-03-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy Top Purity 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Basic information Product Name: 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Synonyms: 4-METHYL-2-N-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID;4-METHYL-2-PROPYL-1H-BENZIMIDAZOLE-6-CARBO

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Cas:152628-03-0

Min.Order:0

Negotiable

Type:Other

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Siwei Development Group Ltd.

Product name: 2-n-Propyl-4-Methyl-6-Carboxylate-1H-Benzimidazole CAS No.: 152628-03-0 Molecule Formula:C12H14N2O2 Molecule Weight:218.25 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Ente

Lower Price 2-n-Propyl-4-Methyl-6-Carboxylate-1H-Benzimidazole

Cas:152628-03-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Synthetic route

C12H16N2O2

C12H16N2O2

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With sodium hypochlorite; sodium hydroxide In water at 16℃; for 0.5h; Temperature;97%
4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester
152628-01-8

4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With sodium dithionite; water at 70 - 100℃;96.4%
Multi-step reaction with 3 steps
1: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
2: 90 percent / acetic acid / 2 h / Heating
3: 82.3 percent / NaOH; water / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
2: glacial CH3COOH / 1.5 h / Heating
3: 5.46 g / aq. NaOH / methanol / 2 h / Heating
View Scheme
3,4-diamino-5-methylbenzoic acid
37901-95-4

3,4-diamino-5-methylbenzoic acid

triethyl orthobutyrate
24964-76-9

triethyl orthobutyrate

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid In N,N-dimethyl-formamide at 70℃; for 9h; Reagent/catalyst; Temperature;94.4%
carbon monoxide
201230-82-2

carbon monoxide

6-bromo-4-methyl-2-propylbenzimidazole
215239-53-5

6-bromo-4-methyl-2-propylbenzimidazole

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With water; potassium carbonate; triphenylphosphine; palladium dichloride In 1,4-dioxane at 60 - 100℃; under 6750.68 - 10501.1 Torr; for 49.5h; Product distribution / selectivity; Autoclave;89%
2-n-propyl-4,6-dimethylbenzimidazole

2-n-propyl-4,6-dimethylbenzimidazole

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With N-hydroxyphthalimide; oxygen; cobalt(II) 2-ethylhexanoate; acetic acid at 110℃; under 7500.75 Torr; for 2h;88.8%
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester
152628-00-7

4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide; water In methanol for 2h; Heating;82.3%
With water; sodium hydroxide In methanol at 80℃; Product distribution / selectivity;80%
With sodium hydroxide In methanol for 2h; Heating;5.46 g
methyl 4-amino-3-methylbenzoate
18595-14-7

methyl 4-amino-3-methylbenzoate

butyryl chloride
141-75-3

butyryl chloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: methyl 4-amino-3-methylbenzoate; butyryl chloride With triethylamine In dichloromethane at 0℃;
Stage #2: With sulfuric acid; nitric acid In dichloromethane at -20℃; Further stages;
52%
pentanal
110-62-3

pentanal

4-amino-3-methyl-5-nitrobenzoic acid
37901-94-3

4-amino-3-methyl-5-nitrobenzoic acid

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With sodium dithionite In ethanol; water at 70℃; for 2h;37%
7-methyl-2-propyl-3H-benzimidazole-5-carbonitrile
153036-72-7

7-methyl-2-propyl-3H-benzimidazole-5-carbonitrile

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride; water In 1,4-dioxane at 100℃; for 16h;30%
3-methyl-4-nitrobenzoic acid
3113-71-1

3-methyl-4-nitrobenzoic acid

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 74.3 percent / sulfuric acid / 2 h / Heating
2: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
3: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
4: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C
5: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
6: 90 percent / acetic acid / 2 h / Heating
7: 82.3 percent / NaOH; water / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 30 - 45 °C / 750.08 - 7500.75 Torr / Autoclave
2: bromine / methanol / 0 - 10 °C
3: triethylamine; potassium carbonate; N,N,N,N,-tetramethylethylenediamine; sodium azide; copper(l) chloride / N,N-dimethyl-formamide; water / pH Ca. 8 / Inert atmosphere; Reflux
4: N,N-dimethyl-formamide / 0 - 5 °C
View Scheme
methyl 4-amino-3-methylbenzoate
18595-14-7

methyl 4-amino-3-methylbenzoate

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
2: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C
3: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
4: 90 percent / acetic acid / 2 h / Heating
5: 82.3 percent / NaOH; water / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: chlorobenzene / 100 °C
2: fuming HNO3, 60percent H2SO4 / 0 °C
3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
4: glacial CH3COOH / 1.5 h / Heating
5: 5.46 g / aq. NaOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 0 °C
2: sulfuric acid; nitric acid
3: hydrogen / methanol / 100 °C / 3750.38 Torr
4: acetic acid / 1 h / Reflux
5: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane
2: nitric acid / -15 °C
3: hydrazine hydrate
4: acetic acid / Reflux
5: sodium hydroxide; water / methanol / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane
1.2: -15 °C
2.1: sodium hydroxide / water; methanol / Reflux
View Scheme
methyl 3-methyl-4-nitrobenzoate
24078-21-5

methyl 3-methyl-4-nitrobenzoate

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
3: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C
4: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
5: 90 percent / acetic acid / 2 h / Heating
6: 82.3 percent / NaOH; water / methanol / 2 h / Heating
View Scheme
methyl 4-(n-butyrylamino)-3-methylbenzoate
301533-59-5

methyl 4-(n-butyrylamino)-3-methylbenzoate

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C
2: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
3: 90 percent / acetic acid / 2 h / Heating
4: 82.3 percent / NaOH; water / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: fuming HNO3, 60percent H2SO4 / 0 °C
2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
3: glacial CH3COOH / 1.5 h / Heating
4: 5.46 g / aq. NaOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid
2: hydrogen / methanol / 100 °C / 3750.38 Torr
3: acetic acid / 1 h / Reflux
4: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: nitric acid / -15 °C
2: hydrazine hydrate
3: acetic acid / Reflux
4: sodium hydroxide; water / methanol / 2 h / Reflux
View Scheme
methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate
675882-71-0

methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / acetic acid / 2 h / Heating
2: 82.3 percent / NaOH; water / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: glacial CH3COOH / 1.5 h / Heating
2: 5.46 g / aq. NaOH / methanol / 2 h / Heating
View Scheme
Stage #1: methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate With sodium hydroxide; water at 95 - 100℃; for 4 - 5h;
Stage #2: With hydrogenchloride In water at 25 - 30℃; for 0.583333 - 0.75h; pH=4.5 - 5; Product distribution / selectivity;
3-amino-4-butyramido-5-methylbenzoic acid
884330-16-9

3-amino-4-butyramido-5-methylbenzoic acid

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
With acetic acid at 60 - 65℃; Product distribution / selectivity;
ethyl 7-methyl-2-propyl-3H-benzo[d]imidazol-5-carboxylate
1235469-21-2

ethyl 7-methyl-2-propyl-3H-benzo[d]imidazol-5-carboxylate

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl 7-methyl-2-propyl-3H-benzo[d]imidazol-5-carboxylate With sodium hydroxide In ethanol; water at 90℃;
Stage #2: With hydrogenchloride In water pH=6; Product distribution / selectivity;
4-amino 3-methylbenzoic acid
2486-70-6

4-amino 3-methylbenzoic acid

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium nitrite; tartaric acid / water; ethanol / 2 h / 35 °C
2: sodium dithionite; water / methanol / 2 h / 75 - 80 °C
3: methanesulfonic acid / N,N-dimethyl-formamide / 9 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1: bromine / methanol / 0 - 10 °C
2: triethylamine; potassium carbonate; N,N,N,N,-tetramethylethylenediamine; sodium azide; copper(l) chloride / N,N-dimethyl-formamide; water / pH Ca. 8 / Inert atmosphere; Reflux
3: N,N-dimethyl-formamide / 0 - 5 °C
View Scheme
5-nitro-m-xylene
99-12-7

5-nitro-m-xylene

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: nitric acid; sulfuric acid / 3 h / -10 - -5 °C
2: 5%-palladium/activated carbon; hydrogen / methanol / 6 h / 60 °C / 3750.38 Torr / Autoclave
3: polyphosphoric acid / 16 h / 120 - 125 °C
4: cobalt(II) 2-ethylhexanoate; N-hydroxyphthalimide; acetic acid; oxygen / 2 h / 110 °C / 7500.75 Torr
View Scheme
3,5-dimethyl-1,2-dinitrobenzene
65151-56-6

3,5-dimethyl-1,2-dinitrobenzene

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5%-palladium/activated carbon; hydrogen / methanol / 6 h / 60 °C / 3750.38 Torr / Autoclave
2: polyphosphoric acid / 16 h / 120 - 125 °C
3: cobalt(II) 2-ethylhexanoate; N-hydroxyphthalimide; acetic acid; oxygen / 2 h / 110 °C / 7500.75 Torr
View Scheme
C8H8N4O2

C8H8N4O2

butyraldehyde
123-72-8

butyraldehyde

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 0 - 5℃;40 g
N-methylbenzene-1,2-diamine dihydrochloride
25148-68-9

N-methylbenzene-1,2-diamine dihydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With methanesulfonic acid In i-Amyl alcohol at 130 - 135℃; for 18h; Temperature; Solvent; Reagent/catalyst;93%
Stage #1: N-methylbenzene-1,2-diamine dihydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA at 70 - 135℃; for 13.5h;
Stage #2: With ammonia In water at 30 - 90℃; for 1h; pH=8.0 - 8.5;
77.4%
With PPA at 150℃; for 20h;5.86 g
With polyphosphoric acid at 150℃; for 14h;
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
114772-38-2

Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
528560-93-2

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With sodium hydroxide In water; N,N-dimethyl-formamide at 0 - 5℃; for 0.5h;
Stage #2: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate In water; N,N-dimethyl-formamide for 0.5h;
92.1%
N-methyl-1,2-phenylenediamine
4760-34-3

N-methyl-1,2-phenylenediamine

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With methanesulfonic acid; phosphorus pentoxide at 75 - 145℃;
Stage #2: With sodium hydroxide In water pH=< 3; Product distribution / selectivity;
90%
With polyphosphoric acid at 150 - 155℃; for 4h; Inert atmosphere;80%
With PPA at 150 - 155℃; Inert atmosphere;
Stage #1: N-methyl-1,2-phenylenediamine; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid at 70 - 130℃; for 8.5h;
Stage #2: With hydrogenchloride In methanol; water at 25℃; for 0.166667h;
Stage #3: With ammonium hydroxide In methanol; water at 25℃; for 1h; Reagent/catalyst;
2-amino-phenol
95-55-6

2-amino-phenol

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

6-(benzo[d]oxazol-2-yl)-4-methyl-2-propyl-1H-benzo[d]imidazole

6-(benzo[d]oxazol-2-yl)-4-methyl-2-propyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
Stage #1: 2-amino-phenol With polyphosphoric acid at 80 - 85℃; for 0.25h; Green chemistry;
Stage #2: 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With polyphosphoric acid at 80 - 150℃; Green chemistry;
85%
With polyphosphoric acid at 80 - 150℃; for 12h;58.7%
With polyphosphoric acid at 80 - 150℃; for 12h;58.7%
With polyphosphate at 80 - 150℃; for 12h;54%
N1-methylbenzene-1,2-diamine hydrochloride
81684-80-2

N1-methylbenzene-1,2-diamine hydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

A

desmethyl dibenzimidazole
884330-09-0

desmethyl dibenzimidazole

B

7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide
884330-18-1

7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide

C

3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide
884330-17-0

3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide

D

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
With polyphosphoric acid at 150 - 155℃;A n/a
B n/a
C n/a
D 84%
N1-methylbenzene-1,2-diamine hydrochloride
81684-80-2

N1-methylbenzene-1,2-diamine hydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Conditions
ConditionsYield
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With phosphorus pentoxide; phosphoric acid at 70 - 130℃;
Stage #2: With ammonia In water; ethyl acetate for 3h; pH=9 - 10; Product distribution / selectivity; Cooling with ice;
82%
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride; 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With PPA; Polyphosphoric acid (PPA) In water at 90 - 155℃; for 5.75 - 7h;
Stage #2: With sodium hydroxide In water pH=5.5 - 6; Product distribution / selectivity;
4-chloro-N-methyl-o-phenylenediamine hydrochloride

4-chloro-N-methyl-o-phenylenediamine hydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

5-chloro-1,7’-dimethyl-2’-propyl-1H,3’H-2,5’-bibenzo[d]imidazole

5-chloro-1,7’-dimethyl-2’-propyl-1H,3’H-2,5’-bibenzo[d]imidazole

Conditions
ConditionsYield
Stage #1: 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 50℃; for 2h;
Stage #2: 4-chloro-N-methyl-o-phenylenediamine hydrochloride In N,N-dimethyl-formamide at 110℃; Temperature; Solvent;
82%
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

4-methyl-2-propyl-N-(R-α-methylphenethyl)-1H-benzimidazole-6-carboxamide

4-methyl-2-propyl-N-(R-α-methylphenethyl)-1H-benzimidazole-6-carboxamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;71.4%
ethanol
64-17-5

ethanol

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

ethyl 7-methyl-2-propyl-3H-benzo[d]imidazol-5-carboxylate
1235469-21-2

ethyl 7-methyl-2-propyl-3H-benzo[d]imidazol-5-carboxylate

Conditions
ConditionsYield
With thionyl chloride at 0 - 80℃; for 3h;71%
2-amino-4-methylphenol hydrochloride
2977-71-1

2-amino-4-methylphenol hydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)benzimidazole
675882-72-1

2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)benzimidazole

Conditions
ConditionsYield
With PPA at 160℃; for 20h;67.1%
(R)-3-amino-4-phenyl-N'-(benzyloxy)butanamide trifluoroacetate
115364-67-5

(R)-3-amino-4-phenyl-N'-(benzyloxy)butanamide trifluoroacetate

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid ((R)-1-benzyl-2-benzyloxycarbamoylethyl)amide
1160386-08-2

7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid ((R)-1-benzyl-2-benzyloxycarbamoylethyl)amide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 20℃;41%
2-amino-3-hydroxypyridine
16867-03-1

2-amino-3-hydroxypyridine

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

2-propyl-4-methyl-6-(oxazolo[4,5-b]pyridine-2-yl)benzimidazole

2-propyl-4-methyl-6-(oxazolo[4,5-b]pyridine-2-yl)benzimidazole

Conditions
ConditionsYield
With polyphosphate at 80 - 150℃; for 12h;40%
2-methyl-6-aminophenol hydrochloride

2-methyl-6-aminophenol hydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

7-methyl-2-(4-methyl-2-propyl-1H-benzo[d]imidazol-6-yl)benzo[d]oxazole
885046-11-7

7-methyl-2-(4-methyl-2-propyl-1H-benzo[d]imidazol-6-yl)benzo[d]oxazole

Conditions
ConditionsYield
With PPA at 160℃;
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carbonitrile
675882-83-4

4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: polyphosphoric acid / 160 °C
2: NaH / 1,2-dimethoxy-ethane / 20 °C
View Scheme
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

4'-[[2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)-benzimidazol-1-yl]methyl]-2-cyanobiphenyl
675882-77-6

4'-[[2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)-benzimidazol-1-yl]methyl]-2-cyanobiphenyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67.1 percent / polyphosphoric acid / 20 h / 160 °C
2: 86.5 percent / NaH / 1,2-dimethoxy-ethane / 4 h / 20 °C
View Scheme
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carboxylic acid

4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: polyphosphoric acid / 160 °C
2: NaH / 1,2-dimethoxy-ethane / 20 °C
3: NaOH; water / methanol / Heating
View Scheme
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

methyl 4'-[[2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)-benzimidazol-1-yl]methyl]biphenyl-2-carboxylate
675882-75-4

methyl 4'-[[2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)-benzimidazol-1-yl]methyl]biphenyl-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67.1 percent / polyphosphoric acid / 20 h / 160 °C
2: 84.7 percent / NaH / 1,2-dimethoxy-ethane / 4 h / 20 °C
View Scheme
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carboxylic acid methyl ester
675882-81-2

4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: polyphosphoric acid / 160 °C
2: NaH / 1,2-dimethoxy-ethane / 20 °C
View Scheme
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