ProName: Telmisartan CAS 144701-48-4 CasNo: 144701-48-4 Molecular Formula: C33H30N4O2 Appearance: white powder Application: Pharmaceutical material and intermeida... DeliveryTime: 3 days PackAge: 25kg/drum Port: CMP ProductionCapacity: 1000
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:144701-48-4
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:144701-48-4
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inquiryItems Standard Result Appearance White or slightly yellowish crystalline powder White crystalline powder
Cas:144701-48-4
Min.Order:1 Gram
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Type:Trading Company
inquiryHubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser
telmisartan --product description: Name: Telmisartan CAS No.: 144701-48-4 Formula: C33H30N4O2 Molecular Weight: 514.62 Synonyms: (1,1-Biphenyl)-2-carboxylic acid, 4-((1,4-dimethyl-2-propyl(2,6-bi-1H-benzimidazol)-1-yl)meth
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:144701-48-4
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inquiryUnique advantages of Telmisartan Cas 144701-48-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to slightly yellowish crystalline powder Storage:Cool dry place Pack
Cas:144701-48-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:144701-48-4
Min.Order:1 Kilogram
FOB Price: $69.0 / 109.0
Type:Manufacturers
inquiryOur Advantages: GMP factory Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales s
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:144701-48-4
Min.Order:1 Gram
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Type:Manufacturers
inquiryChinese Name: Telmisartan Chinese alias: Tamisartan English Name: telmisartan English alias: Telmisartan; TELMISARTAN; CAS No. 144701-48-4 Molecular formula: C33H30N4O2 Molecular weight: 514.61700 Accurate mass: 514.23700 PSA: 72.94000 Log
Cas:144701-48-4
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Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.
Cas:144701-48-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryDensity: 1.16 Melting point: 261-263 ° C Boiling point: 771.9 ± 70.0 ° C (Predicted) Flash point: 425.798 ° C Water solubility: insoluble Steam pressure: 0mmHg at 25 ° C Solubility: DMSO:>5mg/mL at 60 ° C Refractive inde
Cas:144701-48-4
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:144701-48-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:144701-48-4
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Type:Lab/Research institutions
inquiryProduct Name Telmisartan CAS 144701-48-4 Molecular formula C33H30N4O2 EINECS 210-511-2 Melting point -58 °C
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:144701-48-4
Min.Order:10 Gram
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Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:144701-48-4
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
Cas:144701-48-4
Min.Order:1 Kilogram
FOB Price: $9.0
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:144701-48-4
Min.Order:10 Gram
FOB Price: $8.8
Type:Trading Company
inquiryProduct Name: Telmisartan CAS: 144701-48-4 MF: C33H30N4O2 MW: 514.62 EINECS: 620-494-7 Mol File: 144701-48-4.mol Telmisartan Structure Telmisartan Chemical Properties Melting point 261-263°C Boiling point 771.9±
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
Cas:144701-48-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:144701-48-4
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:144701-48-4
Min.Order:1 Kilogram
FOB Price: $78.9 / 84.3
Type:Trading Company
inquiryTelmisartan CAS:144701-48-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:144701-48-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful
Cas:144701-48-4
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,
Cas:144701-48-4
Min.Order:20 Metric Ton
Negotiable
Type:Trading Company
inquiry4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl
telmisatran
Conditions | Yield |
---|---|
Stage #1: 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl With sodium hydroxide; water In ethylene glycol for 8h; Heating / reflux; Stage #2: With acetic acid In water; ethylene glycol at 20℃; pH=4; Product distribution / selectivity; | 98% |
Stage #1: 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl With potassium hydroxide; water In ethylene glycol at 140 - 150℃; for 21h; Stage #2: With hydrogenchloride In water; ethylene glycol at 20℃; pH=7; Product distribution / selectivity; | 98% |
Stage #1: 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl With water; potassium hydroxide In ethylene glycol at 150 - 155℃; Stage #2: With water; acetic acid for 2h; pH=4 - 4.5; Product distribution / selectivity; | 98.7% |
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
telmisatran
Conditions | Yield |
---|---|
Stage #1: 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester With methanol; sodium hydroxide; water for 2h; Heating / reflux; Stage #2: With acetic acid In water | 98.6% |
Stage #1: 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester With methanol; potassium hydroxide for 24h; Reflux; Stage #2: With formic acid Product distribution / selectivity; | 96% |
Stage #1: 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester With sodium hydroxide In methanol; water for 3h; Reflux; Stage #2: With acetic acid In methanol; water pH=5; | 95% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
4'-bromomethylbiphenyl-2-carboxylic acid
telmisatran
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 1h; Stage #2: 4'-bromomethylbiphenyl-2-carboxylic acid In N,N-dimethyl-formamide at 10℃; Solvent; Reagent/catalyst; Temperature; | 95% |
tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride
telmisatran
Conditions | Yield |
---|---|
Stage #1: tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride With acetic acid In water Heating / reflux; Stage #2: With sodium hydroxide In water at 80 - 90℃; | 93.3% |
With sodium hydroxide; water In water; acetic acid at 80 - 90℃; Heating / reflux; | 93.3% |
tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate
telmisatran
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran at 100℃; Reagent/catalyst; Solvent; | 93% |
With trifluoroacetic acid In N,N-dimethyl-formamide for 4h; | 70% |
With trifluoroacetic acid In N-methyl-acetamide | 63.9% |
With trifluoroacetic acid In dichloromethane for 24h; Ambient temperature; Yield given; |
4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt
telmisatran
Conditions | Yield |
---|---|
Stage #1: 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt With pyrographite In methanol at 25℃; for 0.5h; Stage #2: With acetic acid In methanol at 5℃; for 1h; | 93% |
at 60℃; for 12h; Temperature; Time; | 91% |
telmisatran
Conditions | Yield |
---|---|
Stage #1: 4'-[(2-butyrylamino-3-methyl-5-(1N-methyl-1H-benzimidazol-2-yl)-phenylamino)-methyl]-biphenyl-2-carboxylic acid isopropyl ester With acetic acid for 3h; Reflux; Stage #2: With sodium hydroxide In ethanol for 12h; Reflux; Stage #3: With hydrogenchloride In ethanol; water for 1h; pH=5 - 6; Cooling; | 92% |
4'-[(2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-benzimidazol-1-yl)methyl]-biphenyl-2-carboxaldehyde
telmisatran
Conditions | Yield |
---|---|
With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide In water; acetonitrile at 10 - 20℃; for 1.5h; | 90.6% |
With oxone In N,N-dimethyl acetamide at 20 - 120℃; for 27.5h; | |
With sodium perborate In acetic acid at 100℃; |
Conditions | Yield |
---|---|
With palladium diacetate; sodium carbonate In 1,4-dioxane at 80℃; for 6h; Reagent/catalyst; Solvent; Suzuki Coupling; Inert atmosphere; | 90.05% |
4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide
telmisatran
Conditions | Yield |
---|---|
Stage #1: 4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide With sulfuric acid In water at 125℃; for 28h; Stage #2: With sodium hydroxide In dichloromethane; water pH=5.4; | 89% |
Stage #1: 4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide With potassium hydroxide In propylene glycol at 85 - 150℃; Stage #2: With water; acetic acid at 25 - 85℃; for 1.25h; | 84% |
2-bromo-1-methyl-1H-benzo[d]imidazole
telmisatran
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide In ethanol; water at 150℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Temperature; Suzuki Coupling; Microwave irradiation; Sealed tube; | 89% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide In ethanol; water at 150℃; under 13680.9 Torr; for 0.5h; Reagent/catalyst; Temperature; Suzuki Coupling; Microwave irradiation; Sealed tube; | 89% |
telmisatran
Conditions | Yield |
---|---|
Stage #1: telmisartan tert-butyl ester oxalate With water; sodium hydroxide In butan-1-ol at 115 - 120℃; Stage #2: With hydrogenchloride In water; butan-1-ol at 10 - 30℃; for 5h; pH=4.5 - 5; | 88.4% |
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
telmisatran
Conditions | Yield |
---|---|
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h; Stage #2: With water; acetic acid In water; dimethyl sulfoxide at 20℃; pH=3.8 - 4; Product distribution / selectivity; | 88% |
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h; Stage #2: With water; acetic acid In water; dimethyl sulfoxide pH=4.2; Product distribution / selectivity; | 80% |
telmisatran
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; triphenylphosphine In 2-methyltetrahydrofuran; water at 65℃; for 20h; Inert atmosphere; | 88% |
3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
telmisatran
Conditions | Yield |
---|---|
With hydrogenchloride; water at 100 - 105℃; for 30h; | 85% |
With hydrogenchloride; water at 100 - 105℃; for 30h; Inert atmosphere; | 85% |
Stage #1: 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole With hydrogenchloride; water for 30h; Reflux; Stage #2: With sodium hydroxide In water at 0 - 20℃; pH=9 - 10; Stage #3: With acetic acid In water; acetonitrile for 2h; pH=5 - 5.5; | 85% |
4-(chloromethyl)biphenyl-2'-carboxylic acid
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
telmisatran
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Cooling with ice; Stage #2: 4-(chloromethyl)biphenyl-2'-carboxylic acid In N,N-dimethyl-formamide at 20 - 50℃; for 5h; Reagent/catalyst; Temperature; | 84% |
telmisatran
Conditions | Yield |
---|---|
With ammonia In methanol; water at 0 - 55℃; for 7.75h; pH=6.5; | 82.2% |
telmisatran
Conditions | Yield |
---|---|
With hydrogenchloride In water at 100 - 110℃; for 30h; | 80% |
4'-(1,4'-dimethyl-2'-propyl-1H-[2,5']dibenzimidazolyl-3'-ylmethyl)biphenyl-2-carboxylic acid methyl ester hydrochloride
telmisatran
Conditions | Yield |
---|---|
Stage #1: 4'-(1,4'-dimethyl-2'-propyl-1H-[2,5']dibenzimidazolyl-3'-ylmethyl)biphenyl-2-carboxylic acid methyl ester hydrochloride With potassium hydroxide In acetonitrile at 80 - 85℃; for 2h; Stage #2: With acetic acid In water; acetonitrile at 60 - 65℃; for 2h; pH=5 - 5.5; | 77% |
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
telmisatran
Conditions | Yield |
---|---|
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetonitrile for 0.166667h; Stage #2: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester In acetonitrile Stage #3: With hydrogenchloride In water | 75.1% |
3-(4-((1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)methyl)phenyl)propiolic acid
acetylene
telmisatran
Conditions | Yield |
---|---|
bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,2-bis-(diphenylphosphino)ethane In tetrahydrofuran at 30℃; for 8h; Inert atmosphere; | 68% |
carbon monoxide
3'-((2'-bromobiphenyl-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
telmisatran
Conditions | Yield |
---|---|
With tributyl-amine; cesium acetate; palladium diacetate; triphenylphosphine In water; N,N-dimethyl-formamide at 120℃; for 24h; | 60% |
methyl 4-amino-3-methylbenzoate
telmisatran
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: chlorobenzene / 100 °C 2: fuming HNO3, 60percent H2SO4 / 0 °C 3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 4: glacial CH3COOH / 1.5 h / Heating 5: 5.46 g / aq. NaOH / methanol / 2 h / Heating 6: 5.86 g / polyphosphoric acid / 20 h / 150 °C 7: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 8: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme |
N-methylbenzene-1,2-diamine dihydrochloride
telmisatran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 5.86 g / polyphosphoric acid / 20 h / 150 °C 2: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 3: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme |
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
telmisatran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 5.86 g / polyphosphoric acid / 20 h / 150 °C 2: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 3: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme |
methyl 4-(n-butyrylamino)-3-methylbenzoate
telmisatran
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: fuming HNO3, 60percent H2SO4 / 0 °C 2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 3: glacial CH3COOH / 1.5 h / Heating 4: 5.46 g / aq. NaOH / methanol / 2 h / Heating 5: 5.86 g / polyphosphoric acid / 20 h / 150 °C 6: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 7: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme |
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester
telmisatran
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 5.46 g / aq. NaOH / methanol / 2 h / Heating 2: 5.86 g / polyphosphoric acid / 20 h / 150 °C 3: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 4: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide; water / methanol / 80 °C 2.1: sodium hydroxide / N,N-dimethyl-formamide; water / 0.5 h / 0 - 5 °C 2.2: 0.5 h 3.1: sodium hydroxide / methanol / 80 °C 3.2: 5 - 10 °C / pH 6 - 6.5 View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium hydroxide / N,N-dimethyl-formamide / 20 - 32 °C 2.1: water; sodium hydroxide / methanol / 70 °C 2.2: 2 h / pH 3 - 4 3.1: thionyl chloride / 4 h / 78 - 80 °C / Inert atmosphere 4.1: triethylamine / dichloromethane / 0.5 h / 5 - 10 °C / Inert atmosphere 4.2: 85 °C 4.3: pH 9 - 10 5.1: water; potassium hydroxide / ethylene glycol / 150 - 155 °C 5.2: 2 h / pH 4 - 4.5 View Scheme |
methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate
telmisatran
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating 3: 5.86 g / polyphosphoric acid / 20 h / 150 °C 4: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 5: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme | |
Multi-step reaction with 6 steps 1.1: toluene-4-sulfonic acid / toluene / Reflux 2.1: potassium hydroxide / N,N-dimethyl-formamide / 20 - 32 °C 3.1: water; sodium hydroxide / methanol / 70 °C 3.2: 2 h / pH 3 - 4 4.1: thionyl chloride / 4 h / 78 - 80 °C / Inert atmosphere 5.1: triethylamine / dichloromethane / 0.5 h / 5 - 10 °C / Inert atmosphere 5.2: 85 °C 5.3: pH 9 - 10 6.1: water; potassium hydroxide / ethylene glycol / 150 - 155 °C 6.2: 2 h / pH 4 - 4.5 View Scheme |
4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester
telmisatran
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 2: glacial CH3COOH / 1.5 h / Heating 3: 5.46 g / aq. NaOH / methanol / 2 h / Heating 4: 5.86 g / polyphosphoric acid / 20 h / 150 °C 5: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 6: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1.1: water; sodium dithionite / 70 - 100 °C 2.1: sodium hydroxide / N,N-dimethyl-formamide; water / 0.5 h / 0 - 5 °C 2.2: 0.5 h 3.1: sodium hydroxide / methanol / 80 °C 3.2: 5 - 10 °C / pH 6 - 6.5 View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium dithionite / water / 70 - 100 °C 2.1: sodium hydroxide; water / methanol / 80 °C 3.1: sodium hydroxide / N,N-dimethyl-formamide; water / 0.5 h / 0 - 5 °C 3.2: 0.5 h 4.1: sodium hydroxide / methanol / 80 °C 4.2: 5 - 10 °C / pH 6 - 6.5 View Scheme | |
Multi-step reaction with 7 steps 1.1: hydrogen / nickel / methanol / 30 - 36 °C / 2574.5 - 3310.08 Torr / Autoclave 2.1: toluene-4-sulfonic acid / toluene / Reflux 3.1: potassium hydroxide / N,N-dimethyl-formamide / 20 - 32 °C 4.1: water; sodium hydroxide / methanol / 70 °C 4.2: 2 h / pH 3 - 4 5.1: thionyl chloride / 4 h / 78 - 80 °C / Inert atmosphere 6.1: triethylamine / dichloromethane / 0.5 h / 5 - 10 °C / Inert atmosphere 6.2: 85 °C 6.3: pH 9 - 10 7.1: water; potassium hydroxide / ethylene glycol / 150 - 155 °C 7.2: 2 h / pH 4 - 4.5 View Scheme |
Conditions | Yield |
---|---|
In tetrahydrofuran for 2h; Solvent; Reflux; | 98.6% |
telmisatran
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; | 98% |
telmisatran
4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt
Conditions | Yield |
---|---|
With ammonia In ethanol at 10 - 15℃; Solvent; Temperature; Large scale; | 96.3% |
With ammonium hydroxide In ethanol; water at 25℃; for 0.166667h; Time; | |
With ammonia In methanol |
telmisatran
telmisartan sodium
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water; toluene at 78℃; for 0.5h; | 96% |
Stage #1: telmisatran With sodium hydroxide In methanol; water at 20℃; for 2h; Stage #2: In ethanol; tert-butyl methyl ether at 20℃; for 4.5h; Product distribution / selectivity; Heating / reflux; | 95% |
With sodium hydroxide In ethanol at 20℃; for 1h; | 81% |
temozolomide
telmisatran
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 95% |
telmisatran
Conditions | Yield |
---|---|
With zinc(II) chloride In acetone at 53℃; for 2h; Product distribution / selectivity; | 93% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 50℃; for 12h; Solvent; Temperature; | 93% |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 65℃; for 18h; Reagent/catalyst; Temperature; Solvent; | 92% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 8h; Solvent; Temperature; Reagent/catalyst; | 92% |
Conditions | Yield |
---|---|
With sodium carbonate In dimethyl sulfoxide at 65℃; for 9h; | 91% |
Conditions | Yield |
---|---|
for 8h; Reflux; | 90% |
Conditions | Yield |
---|---|
With sodium carbonate In dimethyl sulfoxide at 65℃; for 8h; | 90% |
Conditions | Yield |
---|---|
for 8h; Reflux; | 89% |
telmisatran
Conditions | Yield |
---|---|
With dmap; trifluoromethyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1h; Inert atmosphere; Schlenk technique; | 89% |
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In tetrahydrofuran at 20℃; | |
With (bis-(2-methoxyethyl)amino)sulfur trufluoride In dichloromethane at 0℃; for 1h; |
telmisatran
Conditions | Yield |
---|---|
With calcium hydroxide In methanol at 60 - 65℃; for 12h; | 87% |
With calcium hydroxide In methanol Heating / reflux; |
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