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Zhejiang Huili Pharmaceutical Co., Ltd

ProName: Telmisartan CAS 144701-48-4 CasNo: 144701-48-4 Molecular Formula: C33H30N4O2 Appearance: white powder Application: Pharmaceutical material and intermeida... DeliveryTime: 3 days PackAge: 25kg/drum Port: CMP ProductionCapacity: 1000

Telmisartan

Cas:144701-48-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Telmisartan Manufacturer/High quality/Best price/In stock

Cas:144701-48-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% factory price Telmisartan powder

Cas:144701-48-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 999.0

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or slightly yellowish crystalline powder White crystalline powder

High purity 144701-48-4 telmisartan

Cas:144701-48-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser

Telmisartan CAS 144701-48-4

Cas:144701-48-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

telmisartan --product description: Name: Telmisartan CAS No.: 144701-48-4 Formula: C33H30N4O2 Molecular Weight: 514.62 Synonyms: (1,1-Biphenyl)-2-carboxylic acid, 4-((1,4-dimethyl-2-propyl(2,6-bi-1H-benzimidazol)-1-yl)meth

CAS:144701-48-4 Telmisartan

Cas:144701-48-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Telmisartan 144701-48-4

Cas:144701-48-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Telmisartan Cas 144701-48-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to slightly yellowish crystalline powder Storage:Cool dry place Pack

Factory supply high quality Telmisartan Cas 144701-48-4 with best price

Cas:144701-48-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

High quality 99% Telmisartan supplier Powder cas:144701-48-4

Cas:144701-48-4

Min.Order:1 Kilogram

FOB Price: $69.0 / 109.0

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

Our Advantages: GMP factory Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales s

TELMISARTAN

Cas:144701-48-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Telmisartan

Cas:144701-48-4

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Telmisartan 144701-48-4 ISO Producer

Cas:144701-48-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Chinese Name: Telmisartan Chinese alias: Tamisartan English Name: telmisartan English alias: Telmisartan; TELMISARTAN; CAS No. 144701-48-4 Molecular formula: C33H30N4O2 Molecular weight: 514.61700 Accurate mass: 514.23700 PSA: 72.94000 Log

Telmisartan Manufacturer/Cas:144701-48-4 /99.9% High purity

Cas:144701-48-4

Min.Order:100 Metric Ton

FOB Price: $2.0 / 5.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

TIANFU CHEM 144701-48-4 Telmisartan

Cas:144701-48-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Density: 1.16 Melting point: 261-263 ° C Boiling point: 771.9 ± 70.0 ° C (Predicted) Flash point: 425.798 ° C Water solubility: insoluble Steam pressure: 0mmHg at 25 ° C Solubility: DMSO:>5mg/mL at 60 ° C Refractive inde

Telmisartan 144701-48-4

Cas:144701-48-4

Min.Order:5 Kilogram

FOB Price: $20.0 / 80.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 144701-48-4 with fast shipping

Cas:144701-48-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Telmisartan/ LIDE PHARMA- Factory supply / Best price

Cas:144701-48-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name Telmisartan CAS 144701-48-4 Molecular formula C33H30N4O2 EINECS 210-511-2 Melting point -58 °C

Telmisartan CAS:144701-48-4

Cas:144701-48-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

China Supply Telmisartan CAS 144701-48-4 Telmisartan Powder with Best Price

Cas:144701-48-4

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr

Hotsale Antihypertensive Drugs Telmisartan 99%

Cas:144701-48-4

Min.Order:1 Kilogram

FOB Price: $9.0

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Product Name: Telmisartan CAS: 144701-48-4 MF: C33H30N4O2 MW: 514.62 EINECS: 620-494-7 Mol File: 144701-48-4.mol Telmisartan Structure Telmisartan Chemical Properties Melting point 261-263°C Boiling point 771.9±

Telmisartan

Cas:144701-48-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

144701-48-4 CAS 99% Ready stock Manufacturer Telmisartan

Cas:144701-48-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Telmisartan CAS 144701-48-4 For research Use only

Cas:144701-48-4

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

anti-cancer agent, Telmisartan CAS:144701-48-4

Cas:144701-48-4

Min.Order:1 Kilogram

FOB Price: $78.9 / 84.3

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Telmisartan CAS:144701-48-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Telmisartan CAS:144701-48-4

Cas:144701-48-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Factory stock, favorable price CAS 144701-48-4 Telmisartan

Cas:144701-48-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Telmisartan

Cas:144701-48-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Telmisartan CAS NO.: 144701-48-4CAS NO.: 144701-48-4

Cas:144701-48-4

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

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Synthetic route

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl
144702-27-2

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl With sodium hydroxide; water In ethylene glycol for 8h; Heating / reflux;
Stage #2: With acetic acid In water; ethylene glycol at 20℃; pH=4; Product distribution / selectivity;
98%
Stage #1: 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl With potassium hydroxide; water In ethylene glycol at 140 - 150℃; for 21h;
Stage #2: With hydrogenchloride In water; ethylene glycol at 20℃; pH=7; Product distribution / selectivity;
98%
Stage #1: 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl With water; potassium hydroxide In ethylene glycol at 150 - 155℃;
Stage #2: With water; acetic acid for 2h; pH=4 - 4.5; Product distribution / selectivity;
98.7%
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
528560-93-2

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester With methanol; sodium hydroxide; water for 2h; Heating / reflux;
Stage #2: With acetic acid In water
98.6%
Stage #1: 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester With methanol; potassium hydroxide for 24h; Reflux;
Stage #2: With formic acid Product distribution / selectivity;
96%
Stage #1: 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester With sodium hydroxide In methanol; water for 3h; Reflux;
Stage #2: With acetic acid In methanol; water pH=5;
95%
2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

4'-bromomethylbiphenyl-2-carboxylic acid
150766-86-2

4'-bromomethylbiphenyl-2-carboxylic acid

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 1h;
Stage #2: 4'-bromomethylbiphenyl-2-carboxylic acid In N,N-dimethyl-formamide at 10℃; Solvent; Reagent/catalyst; Temperature;
95%
tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride
515815-48-2

tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride With acetic acid In water Heating / reflux;
Stage #2: With sodium hydroxide In water at 80 - 90℃;
93.3%
With sodium hydroxide; water In water; acetic acid at 80 - 90℃; Heating / reflux;93.3%
tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate
144702-26-1

tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran at 100℃; Reagent/catalyst; Solvent;93%
With trifluoroacetic acid In N,N-dimethyl-formamide for 4h;70%
With trifluoroacetic acid In N-methyl-acetamide63.9%
With trifluoroacetic acid In dichloromethane for 24h; Ambient temperature; Yield given;
4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt
960356-44-9

4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt With pyrographite In methanol at 25℃; for 0.5h;
Stage #2: With acetic acid In methanol at 5℃; for 1h;
93%
at 60℃; for 12h; Temperature; Time;91%
4'-[(2-butyrylamino-3-methyl-5-(1N-methyl-1H-benzimidazol-2-yl)-phenylamino)-methyl]-biphenyl-2-carboxylic acid isopropyl ester

4'-[(2-butyrylamino-3-methyl-5-(1N-methyl-1H-benzimidazol-2-yl)-phenylamino)-methyl]-biphenyl-2-carboxylic acid isopropyl ester

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 4'-[(2-butyrylamino-3-methyl-5-(1N-methyl-1H-benzimidazol-2-yl)-phenylamino)-methyl]-biphenyl-2-carboxylic acid isopropyl ester With acetic acid for 3h; Reflux;
Stage #2: With sodium hydroxide In ethanol for 12h; Reflux;
Stage #3: With hydrogenchloride In ethanol; water for 1h; pH=5 - 6; Cooling;
92%
4'-[(2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-benzimidazol-1-yl)methyl]-biphenyl-2-carboxaldehyde
172525-90-5

4'-[(2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-benzimidazol-1-yl)methyl]-biphenyl-2-carboxaldehyde

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide In water; acetonitrile at 10 - 20℃; for 1.5h;90.6%
With oxone In N,N-dimethyl acetamide at 20 - 120℃; for 27.5h;
With sodium perborate In acetic acid at 100℃;
C25H25BN2O4

C25H25BN2O4

2-bromo-1-methyl-1H-benzo[d]imidazole
49572-60-3

2-bromo-1-methyl-1H-benzo[d]imidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With palladium diacetate; sodium carbonate In 1,4-dioxane at 80℃; for 6h; Reagent/catalyst; Solvent; Suzuki Coupling; Inert atmosphere;90.05%
4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide
915124-86-6

4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide With sulfuric acid In water at 125℃; for 28h;
Stage #2: With sodium hydroxide In dichloromethane; water pH=5.4;
89%
Stage #1: 4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide With potassium hydroxide In propylene glycol at 85 - 150℃;
Stage #2: With water; acetic acid at 25 - 85℃; for 1.25h;
84%
potassium (1-(2′-carboxy-[1,1′-biphenyl]-4-yl)-4-methyl-2-propylbenzimidazole-6-yl)trifluoroborate

potassium (1-(2′-carboxy-[1,1′-biphenyl]-4-yl)-4-methyl-2-propylbenzimidazole-6-yl)trifluoroborate

2-bromo-1-methyl-1H-benzo[d]imidazole
49572-60-3

2-bromo-1-methyl-1H-benzo[d]imidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide In ethanol; water at 150℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Temperature; Suzuki Coupling; Microwave irradiation; Sealed tube;89%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide In ethanol; water at 150℃; under 13680.9 Torr; for 0.5h; Reagent/catalyst; Temperature; Suzuki Coupling; Microwave irradiation; Sealed tube;89%
telmisartan tert-butyl ester oxalate

telmisartan tert-butyl ester oxalate

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: telmisartan tert-butyl ester oxalate With water; sodium hydroxide In butan-1-ol at 115 - 120℃;
Stage #2: With hydrogenchloride In water; butan-1-ol at 10 - 30℃; for 5h; pH=4.5 - 5;
88.4%
Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
114772-38-2

Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h;
Stage #2: With water; acetic acid In water; dimethyl sulfoxide at 20℃; pH=3.8 - 4; Product distribution / selectivity;
88%
Stage #1: Methyl 4'-(bromomethyl)biphenyl-2-carboxylate; 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydroxide In dimethyl sulfoxide at 25 - 50℃; for 4h;
Stage #2: With water; acetic acid In water; dimethyl sulfoxide pH=4.2; Product distribution / selectivity;
80%
4-{[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazol-1-yl]methyl}chlorobenzene

4-{[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazol-1-yl]methyl}chlorobenzene

sodium 2-carboxylic acid phenylborate

sodium 2-carboxylic acid phenylborate

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In 2-methyltetrahydrofuran; water at 65℃; for 20h; Inert atmosphere;88%
3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
1191259-51-4

3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With hydrogenchloride; water at 100 - 105℃; for 30h;85%
With hydrogenchloride; water at 100 - 105℃; for 30h; Inert atmosphere;85%
Stage #1: 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole With hydrogenchloride; water for 30h; Reflux;
Stage #2: With sodium hydroxide In water at 0 - 20℃; pH=9 - 10;
Stage #3: With acetic acid In water; acetonitrile for 2h; pH=5 - 5.5;
85%
4-(chloromethyl)biphenyl-2'-carboxylic acid
667457-41-2

4-(chloromethyl)biphenyl-2'-carboxylic acid

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Cooling with ice;
Stage #2: 4-(chloromethyl)biphenyl-2'-carboxylic acid In N,N-dimethyl-formamide at 20 - 50℃; for 5h; Reagent/catalyst; Temperature;
84%
4'-[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid dihydrochloride

4'-[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid dihydrochloride

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With ammonia In methanol; water at 0 - 55℃; for 7.75h; pH=6.5;82.2%
3'-{[2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl}-1,7'-dimethyl-2'-propyl-1H.3'H-2,5'-bibenzimidazole

3'-{[2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl}-1,7'-dimethyl-2'-propyl-1H.3'H-2,5'-bibenzimidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With hydrogenchloride In water at 100 - 110℃; for 30h;80%
4'-(1,4'-dimethyl-2'-propyl-1H-[2,5']dibenzimidazolyl-3'-ylmethyl)biphenyl-2-carboxylic acid methyl ester hydrochloride
884330-05-6

4'-(1,4'-dimethyl-2'-propyl-1H-[2,5']dibenzimidazolyl-3'-ylmethyl)biphenyl-2-carboxylic acid methyl ester hydrochloride

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 4'-(1,4'-dimethyl-2'-propyl-1H-[2,5']dibenzimidazolyl-3'-ylmethyl)biphenyl-2-carboxylic acid methyl ester hydrochloride With potassium hydroxide In acetonitrile at 80 - 85℃; for 2h;
Stage #2: With acetic acid In water; acetonitrile at 60 - 65℃; for 2h; pH=5 - 5.5;
77%
4'-chloromethylbiphenyl-2-carboxylic acid methyl ester

4'-chloromethylbiphenyl-2-carboxylic acid methyl ester

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole
152628-02-9

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Stage #1: 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole With potassium hydroxide In acetonitrile for 0.166667h;
Stage #2: 4'-chloromethylbiphenyl-2-carboxylic acid methyl ester In acetonitrile
Stage #3: With hydrogenchloride In water
75.1%
3-(4-((1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)methyl)phenyl)propiolic acid
1197049-22-1

3-(4-((1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)methyl)phenyl)propiolic acid

acetylene
74-86-2

acetylene

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,2-bis-(diphenylphosphino)ethane In tetrahydrofuran at 30℃; for 8h; Inert atmosphere;68%
carbon monoxide
201230-82-2

carbon monoxide

3'-((2'-bromobiphenyl-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
1206701-77-0

3'-((2'-bromobiphenyl-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
With tributyl-amine; cesium acetate; palladium diacetate; triphenylphosphine In water; N,N-dimethyl-formamide at 120℃; for 24h;60%
methyl 4-amino-3-methylbenzoate
18595-14-7

methyl 4-amino-3-methylbenzoate

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: chlorobenzene / 100 °C
2: fuming HNO3, 60percent H2SO4 / 0 °C
3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
4: glacial CH3COOH / 1.5 h / Heating
5: 5.46 g / aq. NaOH / methanol / 2 h / Heating
6: 5.86 g / polyphosphoric acid / 20 h / 150 °C
7: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h
8: CF3COOH / CH2Cl2 / 24 h / Ambient temperature
View Scheme
N-methylbenzene-1,2-diamine dihydrochloride
25148-68-9

N-methylbenzene-1,2-diamine dihydrochloride

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5.86 g / polyphosphoric acid / 20 h / 150 °C
2: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h
3: CF3COOH / CH2Cl2 / 24 h / Ambient temperature
View Scheme
4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
152628-03-0

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5.86 g / polyphosphoric acid / 20 h / 150 °C
2: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h
3: CF3COOH / CH2Cl2 / 24 h / Ambient temperature
View Scheme
methyl 4-(n-butyrylamino)-3-methylbenzoate
301533-59-5

methyl 4-(n-butyrylamino)-3-methylbenzoate

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: fuming HNO3, 60percent H2SO4 / 0 °C
2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
3: glacial CH3COOH / 1.5 h / Heating
4: 5.46 g / aq. NaOH / methanol / 2 h / Heating
5: 5.86 g / polyphosphoric acid / 20 h / 150 °C
6: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h
7: CF3COOH / CH2Cl2 / 24 h / Ambient temperature
View Scheme
4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester
152628-00-7

4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 5.46 g / aq. NaOH / methanol / 2 h / Heating
2: 5.86 g / polyphosphoric acid / 20 h / 150 °C
3: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h
4: CF3COOH / CH2Cl2 / 24 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / methanol / 80 °C
2.1: sodium hydroxide / N,N-dimethyl-formamide; water / 0.5 h / 0 - 5 °C
2.2: 0.5 h
3.1: sodium hydroxide / methanol / 80 °C
3.2: 5 - 10 °C / pH 6 - 6.5
View Scheme
Multi-step reaction with 5 steps
1.1: potassium hydroxide / N,N-dimethyl-formamide / 20 - 32 °C
2.1: water; sodium hydroxide / methanol / 70 °C
2.2: 2 h / pH 3 - 4
3.1: thionyl chloride / 4 h / 78 - 80 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 0.5 h / 5 - 10 °C / Inert atmosphere
4.2: 85 °C
4.3: pH 9 - 10
5.1: water; potassium hydroxide / ethylene glycol / 150 - 155 °C
5.2: 2 h / pH 4 - 4.5
View Scheme
methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate
675882-71-0

methyl 4-(n-butyrylamino)-3-methyl-5-aminobenzoate

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: glacial CH3COOH / 1.5 h / Heating
2: 5.46 g / aq. NaOH / methanol / 2 h / Heating
3: 5.86 g / polyphosphoric acid / 20 h / 150 °C
4: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h
5: CF3COOH / CH2Cl2 / 24 h / Ambient temperature
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / toluene / Reflux
2.1: potassium hydroxide / N,N-dimethyl-formamide / 20 - 32 °C
3.1: water; sodium hydroxide / methanol / 70 °C
3.2: 2 h / pH 3 - 4
4.1: thionyl chloride / 4 h / 78 - 80 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 0.5 h / 5 - 10 °C / Inert atmosphere
5.2: 85 °C
5.3: pH 9 - 10
6.1: water; potassium hydroxide / ethylene glycol / 150 - 155 °C
6.2: 2 h / pH 4 - 4.5
View Scheme
4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester
152628-01-8

4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester

telmisatran
144701-48-4

telmisatran

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr
2: glacial CH3COOH / 1.5 h / Heating
3: 5.46 g / aq. NaOH / methanol / 2 h / Heating
4: 5.86 g / polyphosphoric acid / 20 h / 150 °C
5: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h
6: CF3COOH / CH2Cl2 / 24 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1.1: water; sodium dithionite / 70 - 100 °C
2.1: sodium hydroxide / N,N-dimethyl-formamide; water / 0.5 h / 0 - 5 °C
2.2: 0.5 h
3.1: sodium hydroxide / methanol / 80 °C
3.2: 5 - 10 °C / pH 6 - 6.5
View Scheme
Multi-step reaction with 4 steps
1.1: sodium dithionite / water / 70 - 100 °C
2.1: sodium hydroxide; water / methanol / 80 °C
3.1: sodium hydroxide / N,N-dimethyl-formamide; water / 0.5 h / 0 - 5 °C
3.2: 0.5 h
4.1: sodium hydroxide / methanol / 80 °C
4.2: 5 - 10 °C / pH 6 - 6.5
View Scheme
Multi-step reaction with 7 steps
1.1: hydrogen / nickel / methanol / 30 - 36 °C / 2574.5 - 3310.08 Torr / Autoclave
2.1: toluene-4-sulfonic acid / toluene / Reflux
3.1: potassium hydroxide / N,N-dimethyl-formamide / 20 - 32 °C
4.1: water; sodium hydroxide / methanol / 70 °C
4.2: 2 h / pH 3 - 4
5.1: thionyl chloride / 4 h / 78 - 80 °C / Inert atmosphere
6.1: triethylamine / dichloromethane / 0.5 h / 5 - 10 °C / Inert atmosphere
6.2: 85 °C
6.3: pH 9 - 10
7.1: water; potassium hydroxide / ethylene glycol / 150 - 155 °C
7.2: 2 h / pH 4 - 4.5
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

telmisatran
144701-48-4

telmisatran

telmisartan methanesulfonate

telmisartan methanesulfonate

Conditions
ConditionsYield
In tetrahydrofuran for 2h; Solvent; Reflux;98.6%
N-tert-butoxycarbonyl-O-diethylcarbamoyl-N-bromopropylhydroxylamine

N-tert-butoxycarbonyl-O-diethylcarbamoyl-N-bromopropylhydroxylamine

telmisatran
144701-48-4

telmisatran

3-((tert-butoxycarbonyl)((diethylcarbamoyl)oxy)amino)propyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

3-((tert-butoxycarbonyl)((diethylcarbamoyl)oxy)amino)propyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;98%
telmisatran
144701-48-4

telmisatran

4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt
960356-44-9

4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt

Conditions
ConditionsYield
With ammonia In ethanol at 10 - 15℃; Solvent; Temperature; Large scale;96.3%
With ammonium hydroxide In ethanol; water at 25℃; for 0.166667h; Time;
With ammonia In methanol
telmisatran
144701-48-4

telmisatran

telmisartan sodium
515815-47-1

telmisartan sodium

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water; toluene at 78℃; for 0.5h;96%
Stage #1: telmisatran With sodium hydroxide In methanol; water at 20℃; for 2h;
Stage #2: In ethanol; tert-butyl methyl ether at 20℃; for 4.5h; Product distribution / selectivity; Heating / reflux;
95%
With sodium hydroxide In ethanol at 20℃; for 1h;81%
temozolomide
85622-93-1

temozolomide

telmisatran
144701-48-4

telmisatran

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
528560-93-2

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube;95%
telmisatran
144701-48-4

telmisatran

2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-2-propylbenzoimidazol-1-yl]methyl]phenyl]benzoic acid zinc salt

2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-2-propylbenzoimidazol-1-yl]methyl]phenyl]benzoic acid zinc salt

Conditions
ConditionsYield
With zinc(II) chloride In acetone at 53℃; for 2h; Product distribution / selectivity;93%
C15H22N4O5

C15H22N4O5

telmisatran
144701-48-4

telmisatran

C48H50N8O6

C48H50N8O6

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;93%
diiodomethane
75-11-6

diiodomethane

telmisatran
144701-48-4

telmisatran

C67H60N8O4

C67H60N8O4

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 50℃; for 12h; Solvent; Temperature;93%
dichloromethane
75-09-2

dichloromethane

telmisatran
144701-48-4

telmisatran

C67H60N8O4

C67H60N8O4

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 65℃; for 18h; Reagent/catalyst; Temperature; Solvent;92%
telmisatran
144701-48-4

telmisatran

1,2-dibromomethane
74-95-3

1,2-dibromomethane

C67H60N8O4

C67H60N8O4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 8h; Solvent; Temperature; Reagent/catalyst;92%
iodobromomethane
557-68-6

iodobromomethane

telmisatran
144701-48-4

telmisatran

C67H60N8O4

C67H60N8O4

Conditions
ConditionsYield
With sodium carbonate In dimethyl sulfoxide at 65℃; for 9h;91%
diphenyltin(IV) dichloride
1135-99-5

diphenyltin(IV) dichloride

telmisatran
144701-48-4

telmisatran

C78H68N8O4Sn

C78H68N8O4Sn

Conditions
ConditionsYield
for 8h; Reflux;90%
Chloroiodomethane
593-71-5

Chloroiodomethane

telmisatran
144701-48-4

telmisatran

C67H60N8O4

C67H60N8O4

Conditions
ConditionsYield
With sodium carbonate In dimethyl sulfoxide at 65℃; for 8h;90%
dibutyltin chloride
683-18-1

dibutyltin chloride

telmisatran
144701-48-4

telmisatran

C74H76N8O4Sn

C74H76N8O4Sn

Conditions
ConditionsYield
for 8h; Reflux;89%
telmisatran
144701-48-4

telmisatran

4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)[1,1'-biphenyl]-2-carbonyl fluoride

4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)[1,1'-biphenyl]-2-carbonyl fluoride

Conditions
ConditionsYield
With dmap; trifluoromethyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1h; Inert atmosphere; Schlenk technique;89%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In tetrahydrofuran at 20℃;
With (bis-(2-methoxyethyl)amino)sulfur trufluoride In dichloromethane at 0℃; for 1h;
telmisatran
144701-48-4

telmisatran

2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-2-propylbenzoimidazol-1-yl]methyl]phenyl]benzoic acid calcium salt

2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-2-propylbenzoimidazol-1-yl]methyl]phenyl]benzoic acid calcium salt

Conditions
ConditionsYield
With calcium hydroxide In methanol at 60 - 65℃; for 12h;87%
With calcium hydroxide In methanol Heating / reflux;
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