Tigecycline is not thought to be extensively metabolised, although some trace metabolites have been identified including a glucuronide, an N-acetyl metabolite, and a tigecycline epimer. Tigecycline is primarily eliminated (about 60 %) via biliary exc
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Cas:220620-09-7
Min.Order:1 Kilogram
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inquirySpecifications CAS No.: 220620-09-7 Other Names: Tigecycline MF: C29H39N5O8, C29H39N5O8 Place of Origin: China (Mainland) Type: Phar
Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha
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inquirySleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric
Tigecycline CAS NO.:220620-09-7 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distributio
Cas:220620-09-7
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Cas:220620-09-7
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1. Direct manufacturer 2. Stock available 3. Stable and fine quality 4. Premium service Appearance:white powder Storage:Amber Vial, -20°C Freezer Package:bag/bottle/drum Application:anti biotics Transportation:common t
TIANFUCHEM--220620-09-7--Tigecycline factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relation
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inquiryWe are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Cas:220620-09-7
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Name Tigecycline CAS 220620-09-7 MF C29H39N5O8 MW 585.65
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inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:220620-09-7
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Cas:220620-09-7
Min.Order:10 Gram
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Cas:220620-09-7
Min.Order:1 Gram
FOB Price: $30.0 / 32.0
Type:Trading Company
inquiryTigecycline CAS:220620-09-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:220620-09-7
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Appearance:orange powder Storage:As normal Package:25kgs net carton drums Application:220620-09-7 Port:SHANGHAI
Tigecycline CAS: 220620-09-7 Specification Item Standard Structural data confirmation 1. H-NMR: The data of structure are identical with reference standard 2. HPLC-MS: Ensure the
Product Detail Minimum Order Qty. 10 Gram
Cas:220620-09-7
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryConditions | Yield |
---|---|
With sodium iodide In N,N-dimethyl acetamide at 50℃; for 2h; | 92% |
Stage #1: 9-chloroacetamidominocycline; tert-butylamine With sodium iodide at 20℃; Stage #2: In water pH=5 - ~ 7.2; Product distribution / selectivity; | 50% |
With sodium iodide at 25 - 40℃; for 6h; Product distribution / selectivity; |
tigecycline
Conditions | Yield |
---|---|
In water at 0 - 5℃; for 2h; | 90% |
tigecycline
Conditions | Yield |
---|---|
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; <4S-(4α,12aα)>-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride In water at 0 - 6℃; for 1h; Industry scale; Stage #2: With hydrogenchloride; ammonia In methanol; dichloromethane; water at 0 - 25℃; pH=0.42 - 7.4; Product distribution / selectivity; | 77% |
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; <4S-(4α,12aα)>-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride In water at 0 - 6℃; for 1h; Industry scale; Stage #2: With hydrogenchloride; ammonia In methanol; dichloromethane; water at 0 - 25℃; pH=0.42 - 7.4; Product distribution / selectivity; | 77% |
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; <4S-(4α,12aα)>-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride In water at 0 - 6℃; for 1h; Industry scale; Stage #2: With hydrogenchloride; ammonia In methanol; dichloromethane; water at 0 - 25℃; pH=0.42 - 7.4; Product distribution / selectivity; | 77% |
[4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
tigecycline
Conditions | Yield |
---|---|
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; [4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide In water at 0 - 5℃; for 0.666667 - 1h; Stage #2: With ammonia In water at 0 - 5℃; pH=7.2; Product distribution / selectivity; | 76.8% |
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; [4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide In water at 0 - 5℃; for 0.666667 - 1h; Stage #2: With ammonia In methanol; dichloromethane; water at 0 - 5℃; for 0.25h; pH=7.2; Product distribution / selectivity; | 76.8% |
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; [4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide In water at 0 - 5℃; for 0.666667 - 1h; Stage #2: With ammonia In methanol; dichloromethane; water at 0 - 5℃; for 0.25h; pH=7.2; Product distribution / selectivity; | 76.8% |
Conditions | Yield |
---|---|
Stage #1: 9-chloroacetamidominocycline hydrochloride; tert-butylamine With sodium iodide at 20℃; Stage #2: In water pH=5 - ~ 7.2; Product distribution / selectivity; | 35% |
3,3-dimethylbutanoic acid chloride
[4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
tigecycline
Conditions | Yield |
---|---|
With sodium iodide at 33 - 38℃; for 4h; Product distribution / selectivity; |
[4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
B
tigecycline
Conditions | Yield |
---|---|
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; [4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide In water at 0 - 5℃; for 0.666667 - 1h; Stage #2: With ammonia In water at 0 - 5℃; pH=7.2; Product distribution / selectivity; | |
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; [4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide In dichloromethane at 10 - 15℃; for 2h; Stage #2: With ammonia In methanol; dichloromethane; water at 5 - 8℃; pH=7.2; Product distribution / selectivity; | |
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; [4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide In N,N-dimethyl-formamide at 10 - 15℃; for 2h; Stage #2: With ammonia In methanol; water; N,N-dimethyl-formamide at 5 - 8℃; pH=7.2; Product distribution / selectivity; |
B
tigecycline
Conditions | Yield |
---|---|
Stage #1: 2-tert-butylaminoacetylchloride hydrochloride; <4S-(4α,12aα)>-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride In water at 0 - 6℃; for 1 - 3h; Stage #2: With ammonia In water at 0 - 10℃; pH=7.2; Product distribution / selectivity; |
tigecycline
Conditions | Yield |
---|---|
Stage #1: <4S-(4α,12aα)>-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide disulfate With sodium carbonate In water at 0℃; pH=2 - 3; Inert atmosphere; Stage #2: 2-tert-butylaminoacetylchloride hydrochloride With sodium carbonate In water at 0 - 30℃; pH=6.7; Inert atmosphere; |
[4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
tigecycline
Conditions | Yield |
---|---|
Stage #1: N-t-butylglycine anhydride; [4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide With triethylamine; N-ethyl-N,N-diisopropylamine at 20℃; Stage #2: With sulfuric acid; potassium nitrate for 1h; Cooling with ice; Stage #3: With formaldehyd; palladium 10% on activated carbon; hydrogen In 2-methoxy-ethanol; water at 20℃; under 1520.1 Torr; |
tert-butylaminoacetic acid
[4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
tigecycline
Conditions | Yield |
---|---|
Stage #1: tert-butylaminoacetic acid; [4S-(4aα,12aα)]-9-amino-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide With triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; diisopropyl-carbodiimide at 20℃; for 3.333h; Stage #2: With sulfuric acid; potassium nitrate for 1h; Cooling with ice; Stage #3: With formaldehyd; palladium 10% on activated carbon; hydrogen In 2-methoxy-ethanol; water at 20℃; under 1520.1 Torr; for 10h; Reagent/catalyst; | 4.139 g |
tigecycline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: water / 0 - 15 °C 2: sulfuric acid; potassium nitrate; nitric acid / -5 - 5 °C 3: rhodium contaminated with carbon; hydrogen / methanol / 12 h / 20 °C / 3000.3 Torr 4: palladium on activated charcoal; hydrogen / 2-methoxy-ethanol / 20 °C / 3000.3 Torr View Scheme |
tigecycline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid; potassium nitrate; nitric acid / -5 - 5 °C 2: rhodium contaminated with carbon; hydrogen / methanol / 12 h / 20 °C / 3000.3 Torr 3: palladium on activated charcoal; hydrogen / 2-methoxy-ethanol / 20 °C / 3000.3 Torr View Scheme |
Conditions | Yield |
---|---|
Stage #1: C27H35N5O8 With palladium on activated charcoal; hydrogen In 2-methoxy-ethanol at 20℃; under 3000.3 Torr; Stage #2: formaldehyd With hydrogen In methanol |
Demeclocycline
tigecycline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: sulfuric acid; potassium nitrate; nitric acid / 3 h / -5 - 5 °C 2: palladium on activated charcoal; hydrogen / methanol / 12 h / 20 °C / 30003 Torr 3: water / 0 - 15 °C 4: sulfuric acid; potassium nitrate; nitric acid / -5 - 5 °C 5: rhodium contaminated with carbon; hydrogen / methanol / 12 h / 20 °C / 3000.3 Torr 6: palladium on activated charcoal; hydrogen / 2-methoxy-ethanol / 20 °C / 3000.3 Torr View Scheme |
tigecycline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: palladium on activated charcoal; hydrogen / methanol / 12 h / 20 °C / 30003 Torr 2: water / 0 - 15 °C 3: sulfuric acid; potassium nitrate; nitric acid / -5 - 5 °C 4: rhodium contaminated with carbon; hydrogen / methanol / 12 h / 20 °C / 3000.3 Torr 5: palladium on activated charcoal; hydrogen / 2-methoxy-ethanol / 20 °C / 3000.3 Torr View Scheme |
tigecycline
Conditions | Yield |
---|---|
In water at 0 - 5℃; for 1h; Inert atmosphere; |
tigecycline
tigecycline hydrochloride
Conditions | Yield |
---|---|
Stage #1: tigecycline In acetone at 20℃; for 1.83333h; Stage #2: With hydrogenchloride In water; acetone at 20℃; for 5h; Product distribution / selectivity; | 97% |
Stage #1: tigecycline In acetonitrile at 20℃; for 1h; Stage #2: With hydrogenchloride In water; acetonitrile at 20℃; for 4 - 20h; Product distribution / selectivity; | 88% |
With hydrogenchloride In water at 20℃; for 92h; Product distribution / selectivity; | 33% |
tigecycline
Conditions | Yield |
---|---|
Stage #1: tigecycline With mercury(II) diacetate In N,N-dimethyl-formamide at 20℃; for 1.5h; Molecular sieve; Stage #2: With dipotassium hydrogenphosphate; water; edetate disodium In N,N-dimethyl-formamide at 0 - 5℃; for 0.833333h; pH=5.5; | 94% |
Conditions | Yield |
---|---|
Stage #1: tigecycline With ethylenediaminetetraacetic acid; silver carbonate In dimethyl sulfoxide at 20℃; for 16h; Molecular sieve; Stage #2: With dipotassium hydrogenphosphate; water; edetate disodium In dimethyl sulfoxide; acetonitrile at 0 - 5℃; for 0.833333h; pH=5.5; Stage #3: trifluoroacetic acid HPLC; | 83% |
tigecycline
Conditions | Yield |
---|---|
With hydrogenchloride In dichloromethane; acetonitrile at 20 - 70℃; |
tigecycline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: mercury(II) diacetate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Molecular sieve 1.2: 0.83 h / 0 - 5 °C / pH 5.5 2.1: edetate disodium / 30 h / 35 °C / pH 6.4 / aq. phosphate buffer View Scheme |
tigecycline
Conditions | Yield |
---|---|
With mercury(II) diacetate In N,N-dimethyl-formamide at 20℃; for 1.5h; Molecular sieve; | 580 mg |
Conditions | Yield |
---|---|
In aq. buffer at 25℃; pH=7.5; |
Conditions | Yield |
---|---|
In aq. buffer at 75℃; for 0.25h; pH=9; pH-value; Solvent; Temperature; |
tigecycline
Conditions | Yield |
---|---|
With oxygen; tetracycline destructase Tet(X4)-producing Escherichia coli JM109 strain pBAD24; NADPH at 37℃; for 3h; Enzymatic reaction; |
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