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Hubei Lidu New Material Technology Co., Ltd

Hubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,

Candesartan cilexetil

Cas:145040-37-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Candesartan Cilexetil CAS 145040-37-5 with Fast Shipment

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Candesartan cilexetil Manufacturer/High quality/Best price/In stock

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

We are very compeitive on candesartan cilexetil .Our mfr is GMP certified for this item with CEP document. Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor AT1 antago

factory supply GMP,DMF,CEP Candesartan

Cas:145040-37-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Calldesartan Cilexetil supplier in China

Cas:145040-37-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 145040-37-5 Candesartan cilexetil

Cas:145040-37-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Candesartan Cilexetil CAS NO.145040-37-5

Cas:145040-37-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Candesartan cilexetil Cas 145040-37-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off white crystalline and odourless power Storage:Cool dr

High quality Candesartan cilexetil Cas 145040-37-5 with factory price and good service

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $800.0 / 900.0

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

Our Advantages: GMP factory Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales s

Candesartan cilexetil

Cas:145040-37-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Candesartan Cilexetil[CAS No:145040-37-5] Trityl Candesartan[CAS:139481-72-4] Trityl Candesartan Cilexetil[CAS:170791-09-0] Name Candesartan cilexetil Synonyms 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2

Candesartan with GMP

Cas:145040-37-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Calldesartan Cilexetil

Cas:145040-37-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Candesartan cilexetil 145040-37-5 GMP manufacturer

Cas:145040-37-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Candesartan cilexetil

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

145040-37-5 - Physico-chemical Properties Molecular Formula C33H34N6O6 Molar Mass 610.66 Density 1.37±0.1 g/cm3(Predicted) Melting Point 168-170 C Boling Point 843.3±75.0 &deg

Factory high quality Candesartan cilexetil

Cas:145040-37-5

Min.Order:1 Gram

FOB Price: $8.0 / 9.0

Type:Lab/Research institutions

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Assay: NLT 99% Appearance:whilt powder Storage:cool and dryer Package:durm Application:API Transportation:by sea or by air Port:shanghai

candesartan cilexetil CAS NO.145040-37-5

Cas:145040-37-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Candesartan Cilexetil

Cas:145040-37-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Candesartan Cilexetil

Cas:145040-37-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. Kono Chem is located in Xi'an, Shaanxi Provin

Candesartan Cilexetil CAS 145040-37-5

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $450.0 / 500.0

Type:Other

inquiry

Hubei DiBo chemical co., LTD

Candesartan cilexetil Chinese name: candesartan ester Chinese alias: 2 ethoxy - 1 - [(2 '- (1 h - four azole nitrogen - 5 - base) [1, 1' - al - 4 - base] methyl phenyl]] - 1 h - benzene and imidazole - 7 - formic acid - 1 - [[(cyclohexano

Candesartan cilexetil Manufacturer/Cas:145040-37-5 /99.9% High purity

Cas:145040-37-5

Min.Order:25 Metric Ton

FOB Price: $2.0 / 3.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Candesartan cilexetil

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Candesartan cilexetil Basic information The precursor drug of Antihypertensive drug Candesartan---Candesartan cilexetil Candesartan cilexetil tabletsAppendix I Appendix II Side effects and adverse reactions Precautions App

TIANFU-CHEM CAS:145040-37-5 Candesartan cilexetil

Cas:145040-37-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Candesartan cilexetil In stock

Cas:145040-37-5

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 145040-37-5 with best quality

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Candesartan cilexetil CAS145040-37-5

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Candesartan cilexetil CAS NO.:145040-37-5 Molecular formula: C33H34N6O6 Molecular weight: 610.66 Appearance:White crystalline powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:Antihypertensive pharma

Candesartan cilexetil CAS:145040-37-5

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99.5% Candesartan Cilexetil (145040-37-5) Antihypertensive Powder

Cas:145040-37-5

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Candesartan cilexetil 145040-37-5

Cas:145040-37-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

GMP Factory Supply Candesartan cilexetil

Cas:145040-37-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Candesartan cilexetil Chemical Properties Melting point 168-170 C Boiling point 843.3±75.0 °C(Predicted) density 1.37±0.1 g/cm3(Predicted) storage temp. 2-8°C solubility DMSO: ≥15mg/mL form powder pka

Candesartan cilexetil,

Cas:145040-37-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder Storage:Refer to COA / MSDS Packag

145040-37-5 cas Candesartan cilexetil CP 99.6% ready stock

Cas:145040-37-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

cilexetil trityl candesartan
170791-09-0

cilexetil trityl candesartan

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With hydrogenchloride In methanol; dichloromethane at -14 - -12℃; Temperature; Flow reactor; Large scale;98%
With iron(III) chloride In methanol; dichloromethane at 23℃; for 48h; Time; Reagent/catalyst;96%
With methanol; zinc(II) chloride In butanone at 20 - 40℃; for 2.5h; Product distribution / selectivity;95.23%
orthocarbonic acid tetraethyl ester
78-09-1

orthocarbonic acid tetraethyl ester

2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-aminobenzoic acid-1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester
1236156-65-2

2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-aminobenzoic acid-1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With acetic acid In ethyl acetate at 30℃; Temperature;93.9%
With acetic acid In toluene at 60℃; for 2h;81%
orthocarbonic acid tetraethyl ester
78-09-1

orthocarbonic acid tetraethyl ester

C30H32N6O5*C2H2O4

C30H32N6O5*C2H2O4

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Stage #1: C30H32N6O5*C2H2O4 With potassium carbonate In ethyl acetate at 10 - 15℃; pH=6 - 7;
Stage #2: orthocarbonic acid tetraethyl ester In acetic acid at 0 - 25℃; for 15h;
92.3%
1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 1-({4-[2-(1-benzyl-1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-2-ethoxy-1H-1,3-benzodiazole-7-carboxylate
1307853-85-5

1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 1-({4-[2-(1-benzyl-1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-2-ethoxy-1H-1,3-benzodiazole-7-carboxylate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With 5% palladium on barium sulphate; ammonium formate In water; isopropyl alcohol at 25℃; for 14h; Temperature; Time;92.1%
With 5% palladium on barium sulphate; ammonium formate In water; isopropyl alcohol at 25℃; for 14h;80%
With ammonium formate; palladium over charcoal In water; isopropyl alcohol at 55 - 60℃; for 12 - 15h;
With rosenmund catalyst; ammonium formate In water; isopropyl alcohol
1N-HCl

1N-HCl

cilexetil trityl candesartan
170791-09-0

cilexetil trityl candesartan

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With sodium bicarbonate In methanol; dichloromethane; water; ethyl acetate75%
2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
139481-72-4

2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With water In methanol; toluene for 2 - 4h; Product distribution / selectivity; Heating / reflux;67%
C41H42N6O7
1307853-79-7

C41H42N6O7

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With ammonium formate; 5%-palladium/activated carbon In water; isopropyl alcohol at 40 - 50℃; for 17h;55%
2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
139481-72-4

2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid

1N-HCl

1N-HCl

cyclohexyl (1-iodoethyl)carbonate
95789-69-8, 102672-57-1

cyclohexyl (1-iodoethyl)carbonate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With potassium carbonate In methanol; ethanol; water; N,N-dimethyl-formamide
methanolic hydrogen chloride

methanolic hydrogen chloride

cilexetil trityl candesartan
170791-09-0

cilexetil trityl candesartan

octanol
111-87-5

octanol

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With hydrogenchloride In methanol; ethanol; hexane; dichloromethane; water; acetone
cilexetil trityl candesartan
170791-09-0

cilexetil trityl candesartan

A

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate
869631-11-8

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate

B

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With methanol for 24h; Product distribution / selectivity; Heating / reflux;
With methanol; formic acid In dichloromethane at 25℃; for 5 - 23h; Product distribution / selectivity;
Stage #1: cilexetil trityl candesartan With methanol; water; zinc(II) chloride for 2.5h; Heating / reflux;
Stage #2: With water; sodium hydrogencarbonate In methanol at 20℃; pH=6.11; Product distribution / selectivity;
2-ethoxy-1-[(2'-cyanobiphenyl-4-yl)methyl]-1H-benzimidazole-7-carboxylicacid-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
632322-62-4

2-ethoxy-1-[(2'-cyanobiphenyl-4-yl)methyl]-1H-benzimidazole-7-carboxylicacid-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With azido tributyltin (IV) In toluene for 52.5h; Heating / reflux;
1-chloroethyl cyclohexyl carbonate
99464-83-2

1-chloroethyl cyclohexyl carbonate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

candesartan
139481-59-7

candesartan

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Stage #1: tert-butyldimethylsilyl chloride; candesartan With triethylamine In chloroform at 20℃; for 3h;
Stage #2: 1-chloroethyl cyclohexyl carbonate With triethylamine In chloroform for 24h;
candesartan
139481-59-7

candesartan

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 3.75 h / 25 - 35 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 60 - 65 °C
3.1: formic acid; methanol / dichloromethane / 7 h / 30 - 35 °C
3.2: 0.33 h / 15 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
3: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 3.5 h / 15 - 23 °C / Flow reactor; Large scale
2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Flow reactor; Alkaline conditions; Large scale
3: hydrogenchloride / dichloromethane; methanol / -14 - -12 °C / Flow reactor; Large scale
View Scheme
methyl 2-carboxy-3-nitrobenzoate
21606-04-2

methyl 2-carboxy-3-nitrobenzoate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2.5 h / 75 °C
2.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
2.2: 1 h / 80 - 85 °C
3.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
3.2: 3 h / Reflux
4.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
4.2: 4.5 h / -10 - 0 °C
4.3: 0.5 h / Reflux
5.1: acetic acid / toluene / 6 h / Reflux
6.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
6.2: 0 - 20 °C
7.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
7.2: 3 h / 0 °C / pH 4
8.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
9.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
10.1: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
Multi-step reaction with 8 steps
1.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 20 - 31 °C / Inert atmosphere
1.2: 9 h / 85 - 87 °C
1.3: 3 h / 50 - 55 °C
2.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
3.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
4.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
5.1: acetic acid / 1 h / 90 °C
6.1: sodium hydroxide / methanol / 2 h / 90 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
8.1: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate
57113-90-3

methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
1.2: 3 h / Reflux
2.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
2.2: 4.5 h / -10 - 0 °C
2.3: 0.5 h / Reflux
3.1: acetic acid / toluene / 6 h / Reflux
4.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
4.2: 0 - 20 °C
5.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
5.2: 3 h / 0 °C / pH 4
6.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
7.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
8.1: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
Multi-step reaction with 7 steps
1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
2: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
3: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
4: acetic acid / 1 h / 90 °C
5: sodium hydroxide / methanol / 2 h / 90 °C
6: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
7: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate
139481-69-9

methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
1.2: 3 h / 0 °C / pH 4
2.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
4.1: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate
136304-78-4

methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetic acid / toluene / 6 h / Reflux
2.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
2.2: 0 - 20 °C
3.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
3.2: 3 h / 0 °C / pH 4
4.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
6.1: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
3-nitrophthalic acid
603-11-2

3-nitrophthalic acid

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: sulfuric acid / 24.75 h / 20 - 65 °C
2.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2.5 h / 75 °C
3.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
3.2: 1 h / 80 - 85 °C
4.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
4.2: 3 h / Reflux
5.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
5.2: 4.5 h / -10 - 0 °C
5.3: 0.5 h / Reflux
6.1: acetic acid / toluene / 6 h / Reflux
7.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
7.2: 0 - 20 °C
8.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
8.2: 3 h / 0 °C / pH 4
9.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
10.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
11.1: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate
139481-28-0

methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
1.2: 4.5 h / -10 - 0 °C
1.3: 0.5 h / Reflux
2.1: acetic acid / toluene / 6 h / Reflux
3.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
3.2: 0 - 20 °C
4.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
4.2: 3 h / 0 °C / pH 4
5.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
6.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
7.1: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
acid chloride of 1-methylhydrogen-3-nitrophthalate
73833-13-3

acid chloride of 1-methylhydrogen-3-nitrophthalate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
1.2: 1 h / 80 - 85 °C
2.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
2.2: 3 h / Reflux
3.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
3.2: 4.5 h / -10 - 0 °C
3.3: 0.5 h / Reflux
4.1: acetic acid / toluene / 6 h / Reflux
5.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
5.2: 0 - 20 °C
6.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
6.2: 3 h / 0 °C / pH 4
7.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
8.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
9.1: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
methyl 1-[(2-cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate

methyl 1-[(2-cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
1.2: 0 - 20 °C
2.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
2.2: 3 h / 0 °C / pH 4
3.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C
4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C
5.1: hydrogen / palladium 10% on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr
View Scheme
1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(N-triphenylmethyltetrazole-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(N-triphenylmethyltetrazole-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In methanol; toluene at 20℃; under 2280.15 Torr; Product distribution / selectivity;
benzoyl chloride
98-88-4

benzoyl chloride

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: triethylamine / tetrahydrofuran / 7 - 16 °C
2.1: phosphorus pentachloride / dichloromethane / -11 - 19 °C
2.2: 7 h / -6 - 20 °C
3.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere
4.1: sodium methylate / methanol / 1.5 h / 20 °C
5.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C
6.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
7.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
8.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
9.1: acetic acid / 1 h / 90 °C
10.1: sodium hydroxide / methanol / 2 h / 90 °C
11.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
12.1: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
4-bromobenzyl acetate
21388-92-1

4-bromobenzyl acetate

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere
2: sodium methylate / methanol / 1.5 h / 20 °C
3: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C
4: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
5: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
6: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
7: acetic acid / 1 h / 90 °C
8: sodium hydroxide / methanol / 2 h / 90 °C
9: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
10: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
4-bromobenzenemethanol
873-75-6

4-bromobenzenemethanol

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: dmap; triethylamine / tetrahydrofuran / 15 - 30 °C
2: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere
3: sodium methylate / methanol / 1.5 h / 20 °C
4: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C
5: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
6: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
7: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
8: acetic acid / 1 h / 90 °C
9: sodium hydroxide / methanol / 2 h / 90 °C
10: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
11: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
5-Phenyl-1H-tetrazole
18039-42-4

5-Phenyl-1H-tetrazole

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice
1.2: 1 h
2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere
3.1: sodium methylate / methanol / 1.5 h / 20 °C
4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C
5.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
6.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
7.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
8.1: acetic acid / 1 h / 90 °C
9.1: sodium hydroxide / methanol / 2 h / 90 °C
10.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
11.1: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
Multi-step reaction with 11 steps
1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice
2: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere
3: sodium methylate / methanol / 1.5 h / 20 °C
4: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C
5: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
6: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
7: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
8: acetic acid / 1 h / 90 °C
9: sodium hydroxide / methanol / 2 h / 90 °C
10: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
11: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
1-(p-methoxybenzyl)-5-phenyl-1H-tetrazole
512182-38-6

1-(p-methoxybenzyl)-5-phenyl-1H-tetrazole

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere
2: sodium methylate / methanol / 1.5 h / 20 °C
3: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C
4: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
5: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
6: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
7: acetic acid / 1 h / 90 °C
8: sodium hydroxide / methanol / 2 h / 90 °C
9: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
10: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
N-(4-methoxybenzyl)benzamide
41882-10-4

N-(4-methoxybenzyl)benzamide

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: phosphorus pentachloride / dichloromethane / -11 - 19 °C
1.2: 7 h / -6 - 20 °C
2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere
3.1: sodium methylate / methanol / 1.5 h / 20 °C
4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C
5.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
6.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
7.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
8.1: acetic acid / 1 h / 90 °C
9.1: sodium hydroxide / methanol / 2 h / 90 °C
10.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
11.1: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
5-[4'-(bromomethyl)biphenyl-2-yl]-1-(p-methoxybenzyl)-1H-tetrazole
1307853-40-2

5-[4'-(bromomethyl)biphenyl-2-yl]-1-(p-methoxybenzyl)-1H-tetrazole

candesartan cilexetil
145040-37-5

candesartan cilexetil

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere
2: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C
3: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
4: acetic acid / 1 h / 90 °C
5: sodium hydroxide / methanol / 2 h / 90 °C
6: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C
7: ammonium formate / 5%-palladium/activated carbon / isopropyl alcohol; water / 17 h / 40 - 50 °C
View Scheme
candesartan cilexetil
145040-37-5

candesartan cilexetil

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate
869631-11-8

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate

Conditions
ConditionsYield
With hydrogenchloride; water In acetone for 6h; Reflux;87.9%
nebivolol
118457-16-2

nebivolol

candesartan cilexetil
145040-37-5

candesartan cilexetil

candensartan cilexetil-nebivolol salt

candensartan cilexetil-nebivolol salt

Conditions
ConditionsYield
In ethanol at 20 - 45℃; for 5h; Concentration; Solvent; Temperature; Time;81%
candesartan cilexetil
145040-37-5

candesartan cilexetil

methyl iodide
74-88-4

methyl iodide

1-(((cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2’-(1-methyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

1-(((cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2’-(1-methyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

Conditions
ConditionsYield
In dichloromethane Reflux;79%
candesartan cilexetil
145040-37-5

candesartan cilexetil

A

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate
869631-11-8

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate

B

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
914613-35-7

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate

C

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
914613-36-8

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate

Conditions
ConditionsYield
at 55℃; for 336h; Product distribution / selectivity;
at 55℃; for 336h; Product distribution / selectivity;
candesartan cilexetil
145040-37-5

candesartan cilexetil

A

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate
869631-11-8

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate

B

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
914613-36-8

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate

Conditions
ConditionsYield
In ethanol at 50℃; for 31h; Product distribution / selectivity;
trityl chloride
76-83-5

trityl chloride

candesartan cilexetil
145040-37-5

candesartan cilexetil

cilexetil trityl candesartan
170791-09-0

cilexetil trityl candesartan

Conditions
ConditionsYield
With triethylamine for 1h; Heating / reflux;
ethyl iodide
75-03-6

ethyl iodide

candesartan cilexetil
145040-37-5

candesartan cilexetil

A

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
914613-35-7

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate

B

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
914613-36-8

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate

Conditions
ConditionsYield
Stage #1: candesartan cilexetil With potassium carbonate In acetone at 20℃; for 1h; Inert atmosphere;
Stage #2: ethyl iodide In acetone at 20℃; for 24h;
A 2.5 g
B 2.9 g

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