Candesartan cilexetil Candesartan cilexetil 145040-37-5
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1.Product description
Product Name: Candesartan cilexetil
CAS: 145040-37-5
MF: C33H34N6O6
MW: 610.66
2.Physical properties
White to off white powder
Freely souble in chloroform, sparingly soluble in methanol, very slightly soluble in touene and insoluble in water
3.Specification
Item |
Requirements |
Test Results |
Appearance |
White to off white powder |
White powder |
Solubility |
Freely souble in chloroform, sparingly soluble in methanol, very slightly soluble in touene and insoluble in water |
qualified |
Identification |
|
|
IR |
Similar to standard |
qualified |
UV |
Similar to standard max. at 255±2nm |
qualified |
Related impurities(HPLC) |
Total impurities≤1.0% |
0.28% |
Ethyl candesartan ≤0.5% |
0.004% |
|
Desethyl candesartan ≤0.5% |
0.003% |
|
Individual impurity ≤0.5% |
0.12% |
|
Loss on drying |
≤0.5% |
0.31% |
Melting point |
158~166℃ |
158.7~159.7℃ |
PH |
5.5-7.0 |
6.4 |
Heavy Metals |
≤10ppm |
qualified |
Residue on ignition |
≤0.1% |
0.04% |
Assay(HPLC) |
98.0%~102.0% |
99.8% |
Conclusion |
It complies with all the requirements of the Enterprise standard
|
4.Application
Candesartan is used alone or together with other medicines to treat high blood pressure (hypertension) in adults and children 1 to 16 years of age. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.
Grapefruit and grapefruit juice can react adversely with over 85 prescription medications.
Candesartan is also used to treat heart failure in adults and cut down on the number of hospital visits for heart problems.
Candesartan is an angiotensin II receptor blocker (ARB). It works by blocking the action of a substance in the body that causes the blood vessels to tighten. As a result, candesartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
5.Packing
25KG/Drum or as per your requirement
6.Storage:
To be stored in a dry and ventilative warehouse. Handled with care; Kept away from moisture, heat and poisonous substances.
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