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Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualified

Factory Supply Candesartan Supplier Manufacturer With Competitive Price

Cas:139481-59-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Candesartan Manufacturer/High quality/Best price/In stock

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

Superiority kono is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in

Candesartan cas 139481-59-7 good quality and price

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Candesartan Cas 139481-59-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:1kg/foil bag Applicatio

Reliable manufacturer supply Candesartan Cas 139481-59-7 with top quality and reasonable price

Cas:139481-59-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Antihypertensioives 99% Candesartan Supplier powder cas:139481-59-7

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $199.0 / 299.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Candesartan 139481-59-7 GMP Manufacturer

Cas:139481-59-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Candesartan

Cas:139481-59-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on

Candesartan 139481-59-7

Cas:139481-59-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 139481-59-7 with competitive price

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

HOT!!factory supply top quality Candesartan with reasonable price CAS:139481-59-7

Cas:139481-59-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

CAS NO.:139481-59-7 Molecular formula: C24H20N6O3 Molecular weight: 440.45 Appearance: White or off-white crystalline powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:Anti- hypertension drug Transportatio

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99% Candesartan 139481-59-7 Anti Hypertensive Drugs White Crystalline Powder

Cas:139481-59-7

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Candesartan 139481-59-7

Cas:139481-59-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Candesartan CAS: 139481-59-7 MF: C24H20N6O3 MW: 440.45 Mol File: 139481-59-7.mol Candesartan Structure Candesartan Chemical Properties Melting point 183-185°C Boiling point 754.8±70.0 °C(Predicted

Candesartan

Cas:139481-59-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $550.0 / 600.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Candesartan CAS:139481-59-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Candesartan CAS:139481-59-7

Cas:139481-59-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Candesartan cas:139481-59-7

Cas:139481-59-7

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Candesartan

Cas:139481-59-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Candesartan 139481-59-7

Cas:139481-59-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Candesartan

Cas:139481-59-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Candesartan CAS 139481-59-7 with Fast Shipment

Cas:139481-59-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Shanghai Systeam Biochem CO.,ltd

METHYL-6-DEOXY-A-D-GLUCOPYRANOSIDE (We are one of a few suppliers that can offer custom synthesis service of this product) We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract resear

Candesartan

Cas:139481-59-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate
139481-69-9

methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Stage #1: methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate With sodium hydroxide; water In methanol at 78 - 80℃; for 1h;
Stage #2: With acetic acid In ethyl acetate at 10 - 15℃; pH=4 - 5;
95%
With methanol; sodium hydroxide; water at 10 - 70℃;90%
With sodium hydroxide In methanol at 80 - 90℃; for 1h;85%
ethyl 2-ethoxy-1-{[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl}-benzimidazole-7-carboxylate
856414-35-2

ethyl 2-ethoxy-1-{[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl}-benzimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
With lithium hydroxide In ethanol at 80℃; for 3h;85%
ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate
139481-58-6

ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Stage #1: ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate With sodium hydroxide; ethanol; water for 24h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; water pH=4 - 4.5;
80%
Stage #1: ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate With sodium hydroxide; water In o-xylene at 25 - 65℃; for 3h;
Stage #2: With acetic acid In methanol pH=4.5 - 5.5;
With water; sodium hydroxide at 40 - 80℃; Reagent/catalyst;
candesartan cilexetil

candesartan cilexetil

A

methanol-methyl carbonate

methanol-methyl carbonate

B

candesartan
139481-59-7

candesartan

C

cyclohexanol
108-93-0

cyclohexanol

Conditions
ConditionsYield
With sodium hydroxide In methanol; dichloromethane at 30℃; for 8h;A n/a
B 78.01%
C n/a
methanol ethyl acetate
914771-42-9

methanol ethyl acetate

ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate
139481-58-6

ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
With sodium hydroxide In ethanol67%
methyl 2-carboxy-3-nitrobenzoate
21606-04-2

methyl 2-carboxy-3-nitrobenzoate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: SOCl2, DMF / toluene / 0.5 h / Heating
2: NaN3 / acetone; H2O / 1 h
3: 1.5 h / Heating
4: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
6: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
7: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
8: 100 percent / trimethyltin azide / toluene / 29 h / Heating
9: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 7 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2.5 h / 75 °C
2.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
2.2: 1 h / 80 - 85 °C
3.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
3.2: 3 h / Reflux
4.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
4.2: 4.5 h / -10 - 0 °C
4.3: 0.5 h / Reflux
5.1: acetic acid / toluene / 6 h / Reflux
6.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
6.2: 0 - 20 °C
7.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
7.2: 3 h / 0 °C / pH 4
View Scheme
acid chloride of 1-methylhydrogen-3-nitrophthalate
73833-13-3

acid chloride of 1-methylhydrogen-3-nitrophthalate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: NaN3 / acetone; H2O / 1 h
2: 1.5 h / Heating
3: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
4: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
5: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
6: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
7: 100 percent / trimethyltin azide / toluene / 29 h / Heating
8: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
1.2: 1 h / 80 - 85 °C
2.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
2.2: 3 h / Reflux
3.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
3.2: 4.5 h / -10 - 0 °C
3.3: 0.5 h / Reflux
4.1: acetic acid / toluene / 6 h / Reflux
5.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
5.2: 0 - 20 °C
6.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
6.2: 3 h / 0 °C / pH 4
View Scheme
3-nitrophthalic acid
603-11-2

3-nitrophthalic acid

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: concd. H2SO4 / methanol
2: SOCl2, DMF / toluene / 0.5 h / Heating
3: NaN3 / acetone; H2O / 1 h
4: 1.5 h / Heating
5: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
6: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
7: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
8: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
9: 100 percent / trimethyltin azide / toluene / 29 h / Heating
10: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sulfuric acid / 24.75 h / 20 - 65 °C
2.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2.5 h / 75 °C
3.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
3.2: 1 h / 80 - 85 °C
4.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
4.2: 3 h / Reflux
5.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
5.2: 4.5 h / -10 - 0 °C
5.3: 0.5 h / Reflux
6.1: acetic acid / toluene / 6 h / Reflux
7.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
7.2: 0 - 20 °C
8.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
8.2: 3 h / 0 °C / pH 4
View Scheme
methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate
57113-90-3

methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
2: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
3: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
4: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
5: 100 percent / trimethyltin azide / toluene / 29 h / Heating
6: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
1.2: 3 h / Reflux
2.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
2.2: 4.5 h / -10 - 0 °C
2.3: 0.5 h / Reflux
3.1: acetic acid / toluene / 6 h / Reflux
4.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
4.2: 0 - 20 °C
5.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
5.2: 3 h / 0 °C / pH 4
View Scheme
2-Azidocarbonyl-3-nitro-benzoic acid methyl ester
856414-36-3

2-Azidocarbonyl-3-nitro-benzoic acid methyl ester

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.5 h / Heating
2: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
3: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
4: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
5: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
6: 100 percent / trimethyltin azide / toluene / 29 h / Heating
7: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate
136304-78-4

methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
2: 100 percent / trimethyltin azide / toluene / 29 h / Heating
3: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid / toluene / 6 h / Reflux
2.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
2.2: 0 - 20 °C
3.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
3.2: 3 h / 0 °C / pH 4
View Scheme
methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate
139481-28-0

methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
2: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
3: 100 percent / trimethyltin azide / toluene / 29 h / Heating
4: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 4 steps
1.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
1.2: 4.5 h / -10 - 0 °C
1.3: 0.5 h / Reflux
2.1: acetic acid / toluene / 6 h / Reflux
3.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
3.2: 0 - 20 °C
4.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
4.2: 3 h / 0 °C / pH 4
View Scheme
methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate
139481-44-0

methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / trimethyltin azide / toluene / 29 h / Heating
2: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1: azido tributyltin (IV) / N,N-dimethyl-formamide / 20 h / 140 - 150 °C
2: sodium hydroxide; water / 20 h / 70 - 80 °C
View Scheme
methyl 2-amino>-3-nitrobenzoate
139481-38-2

methyl 2-amino>-3-nitrobenzoate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
2: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
3: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
4: 100 percent / trimethyltin azide / toluene / 29 h / Heating
5: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
methyl 1-[(2-cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate

methyl 1-[(2-cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
1.2: 0 - 20 °C
2.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
2.2: 3 h / 0 °C / pH 4
View Scheme
candesartan cilexetil
145040-37-5

candesartan cilexetil

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
With Bis(p-nitrophenyl) phosphate In dimethyl sulfoxide; acetonitrile at 37℃; for 0.0333333h; pH=7.5; Reagent/catalyst; Enzymatic reaction;
methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
With methanol; sodium hydroxide at 50℃; for 3h;44.5 g
2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester
150058-27-8

2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / N,N-dimethyl acetamide / 60 °C / Inert atmosphere
2: sodium hydroxide; methanol / 3 h / 50 °C
View Scheme
ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
139481-41-7

ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: azido tributyltin (IV) / 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 - 150 °C
2: sodium hydroxide; water / 40 - 80 °C
View Scheme
ethyl 1-(4-bromobenzyl)-2-ethoxy-benzimidazole-7-carboxylate
854538-88-8

ethyl 1-(4-bromobenzyl)-2-ethoxy-benzimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
2.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
2.2: pH 4 - 4.5
View Scheme
ethyl 3-amino-2-(4-bromobenzylamine)-benzoate
916891-90-2

ethyl 3-amino-2-(4-bromobenzylamine)-benzoate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid / 1 h / 80 °C
2.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
3.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
3.2: pH 4 - 4.5
View Scheme
ethyl 2-(4-bromobenzylamine)-3-nitrobenzoate
854538-89-9

ethyl 2-(4-bromobenzylamine)-3-nitrobenzoate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux
1.2: 0 °C
2.1: sodium hydroxide; water
3.1: acetic acid / 1 h / 80 °C
4.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
5.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
5.2: pH 4 - 4.5
View Scheme
ethyl 3-amino-2-(4-bromobenzylamine)-benzoate hydrochloride

ethyl 3-amino-2-(4-bromobenzylamine)-benzoate hydrochloride

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide; water
2.1: acetic acid / 1 h / 80 °C
3.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
4.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
4.2: pH 4 - 4.5
View Scheme
ethyl 2-ethoxy-1-[[2'-[(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-[1,1']biphenyl-4-yl]methyl]-1H-benzoimidazole-7-carboxylate
916891-91-3

ethyl 2-ethoxy-1-[[2'-[(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-[1,1']biphenyl-4-yl]methyl]-1H-benzoimidazole-7-carboxylate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium formate / palladium 10% on activated carbon / ethanol / 72 h / Heating / reflux
2.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
2.2: pH 4 - 4.5
View Scheme
ethyl 2-chloro-3-nitrobenzoate
3979-45-1

ethyl 2-chloro-3-nitrobenzoate

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / toluene / 12 h / Heating / reflux
2.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux
2.2: 0 °C
3.1: sodium hydroxide; water
4.1: acetic acid / 1 h / 80 °C
5.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
6.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
6.2: pH 4 - 4.5
View Scheme
2-chloro-3-nitrobezoic acid
3970-35-2

2-chloro-3-nitrobezoic acid

candesartan
139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sulfuric acid / 24 h / 15 - 30 °C / Heating / reflux
2.1: triethylamine / toluene / 12 h / Heating / reflux
3.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux
3.2: 0 °C
4.1: sodium hydroxide; water
5.1: acetic acid / 1 h / 80 °C
6.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
7.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
7.2: pH 4 - 4.5
View Scheme
candesartan
139481-59-7

candesartan

(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazol-7-yl)methanol
924654-25-1

(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazol-7-yl)methanol

Conditions
ConditionsYield
Stage #1: candesartan With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 50℃; for 6.5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
96.5%
With lithium aluminium tetrahydride In tetrahydrofuran at -78℃;90%
Stage #1: candesartan With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;
Stage #2: With water In tetrahydrofuran at 0℃; for 0.5h;
77%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;77%
trityl chloride
76-83-5

trityl chloride

candesartan
139481-59-7

candesartan

2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
139481-72-4

2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 15 - 23℃; for 3.5h; Temperature; Flow reactor; Large scale;94%
With triethylamine In acetone at 55 - 60℃; for 4 - 8h; Product distribution / selectivity;90%
With triethylamine In acetone at 55 - 60℃; Product distribution / selectivity;90%
candesartan
139481-59-7

candesartan

C24H20N6O3*H3N

C24H20N6O3*H3N

Conditions
ConditionsYield
With ammonium hydroxide In water for 2h;89%
ethylenediamine
107-15-3

ethylenediamine

candesartan
139481-59-7

candesartan

C24H20N6O3*C2H8N2

C24H20N6O3*C2H8N2

Conditions
ConditionsYield
In water for 2h;85%
Trimethylenediamine
109-76-2

Trimethylenediamine

candesartan
139481-59-7

candesartan

C24H20N6O3*C3H10N2

C24H20N6O3*C3H10N2

Conditions
ConditionsYield
In water for 2h;80%
trityl chloride
76-83-5

trityl chloride

candesartan
139481-59-7

candesartan

2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylic acid
894806-43-0

2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane for 1h; Ambient temperature;76%
zinc(II) acetate dihydrate
5970-45-6

zinc(II) acetate dihydrate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

candesartan
139481-59-7

candesartan

C24H18N6O3(2-)*2C3H7NO*Zn(2+)

C24H18N6O3(2-)*2C3H7NO*Zn(2+)

Conditions
ConditionsYield
In methanol68%
ethyl acetate-benzene

ethyl acetate-benzene

trityl chloride
76-83-5

trityl chloride

candesartan
139481-59-7

candesartan

2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
139481-72-4

2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane66%
pyridine
110-86-1

pyridine

water
7732-18-5

water

candesartan
139481-59-7

candesartan

cadmium(II) iodide

cadmium(II) iodide

C24H18N6O3(2-)*Cd(2+)*C5H5N*H2O

C24H18N6O3(2-)*Cd(2+)*C5H5N*H2O

Conditions
ConditionsYield
In methanol at 150℃; for 72h; Autoclave;56%
4,4'-bipyridine
553-26-4

4,4'-bipyridine

zinc(II) sulfate heptahydrate

zinc(II) sulfate heptahydrate

candesartan
139481-59-7

candesartan

2C24H18N6O3(2-)*2Zn(2+)*C10H8N2

2C24H18N6O3(2-)*2Zn(2+)*C10H8N2

Conditions
ConditionsYield
In methanol; water at 135℃; for 72h; Autoclave;45%
1-chloromethyl-3-methylbutylamine hydrochloride
1160386-36-6

1-chloromethyl-3-methylbutylamine hydrochloride

candesartan
139481-59-7

candesartan

2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide
1160386-25-3

2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DCM at 20℃;15%
candesartan
139481-59-7

candesartan

uridine-5'-diphospho-α-D-glucuronic acid trisodium salt
63700-19-6

uridine-5'-diphospho-α-D-glucuronic acid trisodium salt

candesartan-O-glucuronide

candesartan-O-glucuronide

Conditions
ConditionsYield
With saccharic acid-1,4-lactone; recombinant human UDP-glucuronyltransferase 1A8 at 37℃; for 48h;7.4%
candesartan
139481-59-7

candesartan

uridine-5'-diphospho-α-D-glucuronic acid trisodium salt
63700-19-6

uridine-5'-diphospho-α-D-glucuronic acid trisodium salt

candesartan-N2-glucuronide

candesartan-N2-glucuronide

Conditions
ConditionsYield
With saccharic acid-1,4-lactone; recombinant human UDP-glucuronyltransferase 1A3 at 37℃; for 48h;4%
candesartan
139481-59-7

candesartan

2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid acetoxymethyl ester

2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid acetoxymethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature
2: potassium iodide, potassium carbonate / dimethylformamide / 2 h / 60 °C
3: 1N aq. HCl / methanol / 1.5 h / Ambient temperature
View Scheme
candesartan
139481-59-7

candesartan

2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-acetoxy-ethyl ester

2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-acetoxy-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature
2: potassium iodide, potassium carbonate / dimethylformamide / 2 h / 60 °C
3: 1N aq. HCl / methanol / 1.5 h / Ambient temperature
View Scheme
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