1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualified
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryUnique advantages of Candesartan Cas 139481-59-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:1kg/foil bag Applicatio
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryCAS NO.:139481-59-7 Molecular formula: C24H20N6O3 Molecular weight: 440.45 Appearance: White or off-white crystalline powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:Anti- hypertension drug Transportatio
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Product Name: Candesartan CAS: 139481-59-7 MF: C24H20N6O3 MW: 440.45 Mol File: 139481-59-7.mol Candesartan Structure Candesartan Chemical Properties Melting point 183-185°C Boiling point 754.8±70.0 °C(Predicted
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inquiryMETHYL-6-DEOXY-A-D-GLUCOPYRANOSIDE (We are one of a few suppliers that can offer custom synthesis service of this product) We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract resear
methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate
candesartan
Conditions | Yield |
---|---|
Stage #1: methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate With sodium hydroxide; water In methanol at 78 - 80℃; for 1h; Stage #2: With acetic acid In ethyl acetate at 10 - 15℃; pH=4 - 5; | 95% |
With methanol; sodium hydroxide; water at 10 - 70℃; | 90% |
With sodium hydroxide In methanol at 80 - 90℃; for 1h; | 85% |
ethyl 2-ethoxy-1-{[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl}-benzimidazole-7-carboxylate
candesartan
Conditions | Yield |
---|---|
With lithium hydroxide In ethanol at 80℃; for 3h; | 85% |
ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate
candesartan
Conditions | Yield |
---|---|
Stage #1: ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate With sodium hydroxide; ethanol; water for 24h; Heating / reflux; Stage #2: With hydrogenchloride In ethanol; water pH=4 - 4.5; | 80% |
Stage #1: ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate With sodium hydroxide; water In o-xylene at 25 - 65℃; for 3h; Stage #2: With acetic acid In methanol pH=4.5 - 5.5; | |
With water; sodium hydroxide at 40 - 80℃; Reagent/catalyst; |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; dichloromethane at 30℃; for 8h; | A n/a B 78.01% C n/a |
methanol ethyl acetate
ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate
candesartan
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol | 67% |
methyl 2-carboxy-3-nitrobenzoate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: SOCl2, DMF / toluene / 0.5 h / Heating 2: NaN3 / acetone; H2O / 1 h 3: 1.5 h / Heating 4: 85 percent / K2CO3 / acetonitrile / 4 h / Heating 5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 6: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 7: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 8: 100 percent / trimethyltin azide / toluene / 29 h / Heating 9: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2.5 h / 75 °C 2.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C 2.2: 1 h / 80 - 85 °C 3.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C 3.2: 3 h / Reflux 4.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux 4.2: 4.5 h / -10 - 0 °C 4.3: 0.5 h / Reflux 5.1: acetic acid / toluene / 6 h / Reflux 6.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux 6.2: 0 - 20 °C 7.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 7.2: 3 h / 0 °C / pH 4 View Scheme |
acid chloride of 1-methylhydrogen-3-nitrophthalate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: NaN3 / acetone; H2O / 1 h 2: 1.5 h / Heating 3: 85 percent / K2CO3 / acetonitrile / 4 h / Heating 4: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 5: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 6: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 7: 100 percent / trimethyltin azide / toluene / 29 h / Heating 8: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C 1.2: 1 h / 80 - 85 °C 2.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C 2.2: 3 h / Reflux 3.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux 3.2: 4.5 h / -10 - 0 °C 3.3: 0.5 h / Reflux 4.1: acetic acid / toluene / 6 h / Reflux 5.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux 5.2: 0 - 20 °C 6.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 6.2: 3 h / 0 °C / pH 4 View Scheme |
3-nitrophthalic acid
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: concd. H2SO4 / methanol 2: SOCl2, DMF / toluene / 0.5 h / Heating 3: NaN3 / acetone; H2O / 1 h 4: 1.5 h / Heating 5: 85 percent / K2CO3 / acetonitrile / 4 h / Heating 6: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 7: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 8: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 9: 100 percent / trimethyltin azide / toluene / 29 h / Heating 10: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: sulfuric acid / 24.75 h / 20 - 65 °C 2.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2.5 h / 75 °C 3.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C 3.2: 1 h / 80 - 85 °C 4.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C 4.2: 3 h / Reflux 5.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux 5.2: 4.5 h / -10 - 0 °C 5.3: 0.5 h / Reflux 6.1: acetic acid / toluene / 6 h / Reflux 7.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux 7.2: 0 - 20 °C 8.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 8.2: 3 h / 0 °C / pH 4 View Scheme |
methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 85 percent / K2CO3 / acetonitrile / 4 h / Heating 2: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 3: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 4: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 5: 100 percent / trimethyltin azide / toluene / 29 h / Heating 6: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C 1.2: 3 h / Reflux 2.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux 2.2: 4.5 h / -10 - 0 °C 2.3: 0.5 h / Reflux 3.1: acetic acid / toluene / 6 h / Reflux 4.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux 4.2: 0 - 20 °C 5.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 5.2: 3 h / 0 °C / pH 4 View Scheme |
2-Azidocarbonyl-3-nitro-benzoic acid methyl ester
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 1.5 h / Heating 2: 85 percent / K2CO3 / acetonitrile / 4 h / Heating 3: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 4: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 5: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 6: 100 percent / trimethyltin azide / toluene / 29 h / Heating 7: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme |
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 2: 100 percent / trimethyltin azide / toluene / 29 h / Heating 3: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid / toluene / 6 h / Reflux 2.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux 2.2: 0 - 20 °C 3.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 3.2: 3 h / 0 °C / pH 4 View Scheme |
methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 2: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 3: 100 percent / trimethyltin azide / toluene / 29 h / Heating 4: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux 1.2: 4.5 h / -10 - 0 °C 1.3: 0.5 h / Reflux 2.1: acetic acid / toluene / 6 h / Reflux 3.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux 3.2: 0 - 20 °C 4.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 4.2: 3 h / 0 °C / pH 4 View Scheme |
methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / trimethyltin azide / toluene / 29 h / Heating 2: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: azido tributyltin (IV) / N,N-dimethyl-formamide / 20 h / 140 - 150 °C 2: sodium hydroxide; water / 20 h / 70 - 80 °C View Scheme |
methyl 2-amino>-3-nitrobenzoate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 2: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 3: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 4: 100 percent / trimethyltin azide / toluene / 29 h / Heating 5: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme |
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux 1.2: 0 - 20 °C 2.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 2.2: 3 h / 0 °C / pH 4 View Scheme |
candesartan cilexetil
candesartan
Conditions | Yield |
---|---|
With Bis(p-nitrophenyl) phosphate In dimethyl sulfoxide; acetonitrile at 37℃; for 0.0333333h; pH=7.5; Reagent/catalyst; Enzymatic reaction; |
candesartan
Conditions | Yield |
---|---|
With methanol; sodium hydroxide at 50℃; for 3h; | 44.5 g |
2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / N,N-dimethyl acetamide / 60 °C / Inert atmosphere 2: sodium hydroxide; methanol / 3 h / 50 °C View Scheme |
ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: azido tributyltin (IV) / 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 - 150 °C 2: sodium hydroxide; water / 40 - 80 °C View Scheme |
ethyl 1-(4-bromobenzyl)-2-ethoxy-benzimidazole-7-carboxylate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C 2.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux 2.2: pH 4 - 4.5 View Scheme |
ethyl 3-amino-2-(4-bromobenzylamine)-benzoate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetic acid / 1 h / 80 °C 2.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C 3.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux 3.2: pH 4 - 4.5 View Scheme |
ethyl 2-(4-bromobenzylamine)-3-nitrobenzoate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux 1.2: 0 °C 2.1: sodium hydroxide; water 3.1: acetic acid / 1 h / 80 °C 4.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C 5.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux 5.2: pH 4 - 4.5 View Scheme |
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydroxide; water 2.1: acetic acid / 1 h / 80 °C 3.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C 4.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux 4.2: pH 4 - 4.5 View Scheme |
ethyl 2-ethoxy-1-[[2'-[(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-[1,1']biphenyl-4-yl]methyl]-1H-benzoimidazole-7-carboxylate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium formate / palladium 10% on activated carbon / ethanol / 72 h / Heating / reflux 2.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux 2.2: pH 4 - 4.5 View Scheme |
ethyl 2-chloro-3-nitrobenzoate
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: triethylamine / toluene / 12 h / Heating / reflux 2.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux 2.2: 0 °C 3.1: sodium hydroxide; water 4.1: acetic acid / 1 h / 80 °C 5.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C 6.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux 6.2: pH 4 - 4.5 View Scheme |
2-chloro-3-nitrobezoic acid
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sulfuric acid / 24 h / 15 - 30 °C / Heating / reflux 2.1: triethylamine / toluene / 12 h / Heating / reflux 3.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux 3.2: 0 °C 4.1: sodium hydroxide; water 5.1: acetic acid / 1 h / 80 °C 6.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C 7.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux 7.2: pH 4 - 4.5 View Scheme |
candesartan
(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazol-7-yl)methanol
Conditions | Yield |
---|---|
Stage #1: candesartan With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 50℃; for 6.5h; Stage #2: With hydrogenchloride In tetrahydrofuran; water | 96.5% |
With lithium aluminium tetrahydride In tetrahydrofuran at -78℃; | 90% |
Stage #1: candesartan With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; Stage #2: With water In tetrahydrofuran at 0℃; for 0.5h; | 77% |
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; | 77% |
trityl chloride
candesartan
2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 15 - 23℃; for 3.5h; Temperature; Flow reactor; Large scale; | 94% |
With triethylamine In acetone at 55 - 60℃; for 4 - 8h; Product distribution / selectivity; | 90% |
With triethylamine In acetone at 55 - 60℃; Product distribution / selectivity; | 90% |
candesartan
Conditions | Yield |
---|---|
With ammonium hydroxide In water for 2h; | 89% |
Conditions | Yield |
---|---|
In water for 2h; | 85% |
Conditions | Yield |
---|---|
In water for 2h; | 80% |
trityl chloride
candesartan
2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 1h; Ambient temperature; | 76% |
zinc(II) acetate dihydrate
N,N-dimethyl-formamide
candesartan
Conditions | Yield |
---|---|
In methanol | 68% |
trityl chloride
candesartan
2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In dichloromethane | 66% |
Conditions | Yield |
---|---|
In methanol at 150℃; for 72h; Autoclave; | 56% |
4,4'-bipyridine
candesartan
Conditions | Yield |
---|---|
In methanol; water at 135℃; for 72h; Autoclave; | 45% |
1-chloromethyl-3-methylbutylamine hydrochloride
candesartan
2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DCM at 20℃; | 15% |
candesartan
uridine-5'-diphospho-α-D-glucuronic acid trisodium salt
Conditions | Yield |
---|---|
With saccharic acid-1,4-lactone; recombinant human UDP-glucuronyltransferase 1A8 at 37℃; for 48h; | 7.4% |
candesartan
uridine-5'-diphospho-α-D-glucuronic acid trisodium salt
Conditions | Yield |
---|---|
With saccharic acid-1,4-lactone; recombinant human UDP-glucuronyltransferase 1A3 at 37℃; for 48h; | 4% |
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 76 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature 2: potassium iodide, potassium carbonate / dimethylformamide / 2 h / 60 °C 3: 1N aq. HCl / methanol / 1.5 h / Ambient temperature View Scheme |
candesartan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 76 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature 2: potassium iodide, potassium carbonate / dimethylformamide / 2 h / 60 °C 3: 1N aq. HCl / methanol / 1.5 h / Ambient temperature View Scheme |
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