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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium

Cas:138786-67-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 138786-67-1 Pantoprazole Sodium

Cas:138786-67-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Pantoprazole Sodium Gb supplier in China

Cas:138786-67-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha

Pantoprazole sodium cas 138786-67-1

Cas:138786-67-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Pantoprazole Sodium Cas138786-67-1 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off white crystalline powder Storage:-20°C Freezer Package:

High quality Pantoprazole Sodium Cas138786-67-1 with good service

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $300.0 / 350.0

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

Service we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to your requirem

PANTOPRAZOLE SODIUM/138786-67-1

Cas:138786-67-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Pantoprazole Sodium Gb

Cas:138786-67-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Pantoprazole Sodium 138786-67-1 GMP Manufacturer

Cas:138786-67-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Pantoprazole Sodium

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Pantoprazole sodium

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Hubei DiBo chemical co., LTD

Name:Pantoprazole Sodium CAS NO:138786-67-1 Grade:Medical scientific research and export Molecular formula:C16H14F2N3NaO4S Molecular weight:405.3516 Product Quality 12 years of chemical raw materials Mature operation of the industry System

Pantoprazole Sodium/ CAS:138786-67-1/ raw material/ high-quality

Cas:138786-67-1

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM - 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium

Cas:138786-67-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium CAS 138786-67-1

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 138786-67-1 with best quality

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium CAS138786-67-1

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Pantoprazole sodium/ LIDE PHARMA- Factory supply / Best price

Cas:138786-67-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name Pantoprazole sodium CAS 138786-67-1 Molecular Formula C16H14F2N3NaO4S Molecular Weight

Pantoprazole sodium

Cas:138786-67-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High QualityPantoprazole sodium CAS 138786-67-1 For research Use only

Cas:138786-67-1

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium

Cas:138786-67-1

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

99%min PANTECTA Manufacturer Peptic Ulcer Treatment

Cas:138786-67-1

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Factory Supply Raw Material API CAS 164579-32-2 Pantoprazole Sodium

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Digestive system drugs Pantoprazole Sodium CAS:138786-67-1

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $201.0 / 220.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Pantoprazole Sodium CAS:138786-67-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

Pantoprazole Sodium CAS:138786-67-1

Cas:138786-67-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Chinese suppliers CAS 138786-67-1 Pantoprazole Sodium

Cas:138786-67-1

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)

Cas:138786-67-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:138786-67-1

Cas:138786-67-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

Pantoprazole Sodium CAS 138786-67-1

Cas:138786-67-1

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Pantoprazole Sodium Synonyms: 5-(difluoroMethoxy)-2-(((3,4-diMethoxypyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole, sodiuM salt;1H-benziMidazole, 5-(difluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-, sodiuM salt

Pantoprazole Sodium 99% Manufactuered in China best quality

Cas:138786-67-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
With sodium hydroxide In water; acetonitrile at 20℃;95%
With sodium hydroxide In ethanol for 5h; Reflux;95%
With sodium hydroxide In water; ethyl acetate at 20℃; for 5.5h;92%
pantoprazole sulfide
102625-64-9

pantoprazole sulfide

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
Stage #1: pantoprazole sulfide With sodium hydroxide; tert-butylhypochlorite In dichloromethane; water at 0 - 5℃; for 1h;
Stage #2: With sodium hydroxide In water; acetone at 0 - 25℃; for 7h;
95%
Stage #1: pantoprazole sulfide With potassium tungstate dihydrate; dihydrogen peroxide at -5 - 0℃; for 4.5h; pH=3.5;
Stage #2: With sodium hydroxide In water at 20℃; Temperature; Reagent/catalyst;
78.7%
With sodium hypochlorite; sodium hydroxide In methanol; water at -20 - -5℃;
Stage #1: pantoprazole sulfide With sodium hypochlorite; sodium hydroxide In water; acetonitrile at -5 - 30℃;
Stage #2: With acetic acid In dichloromethane at 25 - 30℃; pH=8 - 8.5;
Stage #3: With sodium hydroxide In dichloromethane; water at 25 - 30℃; Concentration;
Stage #1: pantoprazole sulfide With sodium hypochlorite; water; sodium hydroxide In ethyl acetate at 0 - 10℃; for 7h;
Stage #2: With sodium thiosulfate In ethyl acetate for 0.333333h;
5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
Stage #1: 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole; 2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 25 - 30℃; for 12h;
Stage #2: With sodium hydroxide; sodium hypochlorite In dichloromethane; water at 0 - 8℃; for 6h; Product distribution / selectivity;
83%
2-hydroxymethyl-3,4-dimethoxypyridine hydrochloride

2-hydroxymethyl-3,4-dimethoxypyridine hydrochloride

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
Stage #1: 2-hydroxymethyl-3,4-dimethoxypyridine hydrochloride With thionyl chloride In dichloromethane at 0 - 15℃; for 1h;
Stage #2: 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 10 - 30℃; for 12h; pH=10 - 11;
Stage #3: With sodium hydroxide; sodium hypochlorite In dichloromethane; water at 0 - 8℃; for 6h; Product distribution / selectivity;
79.6%
(5-difluoromethoxy)-2-[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio-1H-benzimidazole
368890-20-4

(5-difluoromethoxy)-2-[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio-1H-benzimidazole

sodium methylate
124-41-4

sodium methylate

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
In methanol at 50℃; Heating / reflux;70.8%
5-(difluoromethoxy)-2-[[(4-chloro-3-methoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
409098-86-8

5-(difluoromethoxy)-2-[[(4-chloro-3-methoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
With sodium methylate In methanol at 50℃; Heating / reflux;70.8%
pantoprazole sulfide
102625-64-9

pantoprazole sulfide

A

5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole

5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole

B

pantoprazole sodium
138786-67-1

pantoprazole sodium

C

Pantoprazole sulfone

Pantoprazole sulfone

Conditions
ConditionsYield
With sodium hydroxide; sodium hypochlorite In water; ethyl acetate at -5℃; for 1 - 1.5h; Product distribution / selectivity;A n/a
B 65%
C n/a
5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / ethanol / 8 h / 80 °C
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 0 °C
3: sodium hydroxide / ethanol / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water; methanol / 3.5 h / 40 - 55 °C
2: LACTIC ACID; peracetic acid / methanol; dichloromethane / 1 h / -25 - -20 °C
3: sodium hydroxide / water; acetone / 40 - 45 °C
View Scheme
sodium hydroxide
1310-73-2

sodium hydroxide

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
In water; acetonitrile at 25 - 35℃; for 1h;
In ethanol; dichloromethane; water at 20℃; pH=12.5; Product distribution / selectivity;
2-chloromethyl-3,4-dimethoxypyridine hydrochloride

2-chloromethyl-3,4-dimethoxypyridine hydrochloride

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

pantoprazole sodium
138786-67-1

pantoprazole sodium

Conditions
ConditionsYield
Stage #1: 2-chloromethyl-3,4-dimethoxypyridine hydrochloride; 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole With sodium hydroxide In ethanol; water at 35℃; for 2h;
Stage #2: With sodium borate In ethanol at 45℃; for 2h;
Stage #3: With dihydrogen peroxide In water at 20℃; for 2.5h; Concentration; Temperature;
19.61 g
pantoprazole sodium
138786-67-1

pantoprazole sodium

zinc (S)-bis{[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)-methylsulphinyl]-1H-benzimidazolide}

zinc (S)-bis{[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)-methylsulphinyl]-1H-benzimidazolide}

Conditions
ConditionsYield
With zinc(II) chloride In water at 20℃; for 1.5h;95%
pantoprazole sodium
138786-67-1

pantoprazole sodium

magnesium {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1H-benzimidazolide} hydroxy

magnesium {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1H-benzimidazolide} hydroxy

Conditions
ConditionsYield
Stage #1: pantoprazole sodium With sodium hydroxide In water at 25℃; for 1h;
Stage #2: With magnesium chloride In water at 25℃; for 1h;
94.6%
pantoprazole sodium
138786-67-1

pantoprazole sodium

zinc(II) chloride
7646-85-7

zinc(II) chloride

zinc {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1H-benzimidazolide} hydroxy

zinc {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1H-benzimidazolide} hydroxy

Conditions
ConditionsYield
Stage #1: pantoprazole sodium With sodium hydroxide In water at 25℃; for 1h;
Stage #2: zinc(II) chloride In water at 25℃; for 20h;
94.2%
(S)-1,1,2-triphenyl-1,2-ethanediol
108998-83-0

(S)-1,1,2-triphenyl-1,2-ethanediol

pantoprazole sodium
138786-67-1

pantoprazole sodium

C20H18O2*C16H15F2N3O4S

C20H18O2*C16H15F2N3O4S

Conditions
ConditionsYield
With acetic acid In ethanol for 0.5h; pH=7 - 8; Reflux; Industrial scale;94%
pantoprazole sodium
138786-67-1

pantoprazole sodium

pantoprazole sodium sesquihydrate

pantoprazole sodium sesquihydrate

Conditions
ConditionsYield
With water In tert-butyl methyl ether at 20 - 30℃; for 12h; Product distribution / selectivity;92.4%
With water In di-isopropyl ether at 20 - 30℃; for 1 - 12h; Product distribution / selectivity;91.93%
With water In diethyl ether at 20 - 30℃; for 12h; Product distribution / selectivity;91.93%
With water at 0 - 35℃; Product distribution / selectivity;91.4%
With water In dichloromethane at 25 - 35℃; for 1.5h; Product distribution / selectivity;
pantoprazole sodium
138786-67-1

pantoprazole sodium

clcium {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1H-benzimidazolide} hydroxy

clcium {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1H-benzimidazolide} hydroxy

Conditions
ConditionsYield
Stage #1: pantoprazole sodium With sodium hydroxide In water at 25℃; for 1h;
Stage #2: With calcium chloride In water at 25℃; for 20h;
91.8%
pantoprazole sodium
138786-67-1

pantoprazole sodium

calcium bis{[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)-methylsulphinyl]-1H-benzimidazolide}

calcium bis{[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)-methylsulphinyl]-1H-benzimidazolide}

Conditions
ConditionsYield
With calcium chloride In water at 20℃; for 1.91667h;73%
pantoprazole sodium
138786-67-1

pantoprazole sodium

magnesium {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1H-benzimidazolide} hydroxy

magnesium {[5-(difluoromethoxy)]-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1H-benzimidazolide} hydroxy

Conditions
ConditionsYield
Stage #1: pantoprazole sodium With sodium hydroxide In water at 25℃; for 0.25h;
Stage #2: With magnesium chloride In water at 25℃; for 2.5h;
52.7%
pantoprazole sodium
138786-67-1

pantoprazole sodium

magnesium bis[5-[difluoromethoxy]-2-[[3,4-dimethoxy-2-pyridinyl]-methylsulfinyl]-1H-benzimidazolide]

magnesium bis[5-[difluoromethoxy]-2-[[3,4-dimethoxy-2-pyridinyl]-methylsulfinyl]-1H-benzimidazolide]

Conditions
ConditionsYield
With magnesium chloride In water at 20 - 30℃; for 21 - 22h;
pantoprazole sodium
138786-67-1

pantoprazole sodium

pantoprazole sodium

pantoprazole sodium

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 24h; Heating / reflux;
In tert-butyl methyl ether; acetonitrile at 20℃; for 48h;
at 100℃;
3-chlorosulfonylbenzoic acid 2-(toluene-4-sulfonyl)ethyl ester
651728-72-2

3-chlorosulfonylbenzoic acid 2-(toluene-4-sulfonyl)ethyl ester

pantoprazole sodium
138786-67-1

pantoprazole sodium

A

3-[5-difluoromethoxy-2-{(3,4-dimethoxy-pyridin-2-yl)-methanesulfinyl}-benzimidazole-1-sulfonyl]benzoic acid 2-(toluene-4-sulfonyl)ethyl ester

3-[5-difluoromethoxy-2-{(3,4-dimethoxy-pyridin-2-yl)-methanesulfinyl}-benzimidazole-1-sulfonyl]benzoic acid 2-(toluene-4-sulfonyl)ethyl ester

B

3-[6-difluoromethoxy-2-{(3,4-dimethoxy-pyridin-2-yl)-methanesulfinyl}-benzimidazole-1-sulfonyl]benzoic acid 2-(toluene-4-sulfonyl)ethyl ester
651728-78-8

3-[6-difluoromethoxy-2-{(3,4-dimethoxy-pyridin-2-yl)-methanesulfinyl}-benzimidazole-1-sulfonyl]benzoic acid 2-(toluene-4-sulfonyl)ethyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate; triethylamine In dichloromethane at 20℃; for 1.5h;
(4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester
651728-13-1

(4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester

pantoprazole sodium
138786-67-1

pantoprazole sodium

A

4-[5-difluoromethoxy-2-{(3,4-dimethoxypyridin-2-yl)methanesulfinyl}benzimidazole-1-sulfonyl]phenoxyacetic acid 2-(toluene-4-sulfonyl)ethyl ester

4-[5-difluoromethoxy-2-{(3,4-dimethoxypyridin-2-yl)methanesulfinyl}benzimidazole-1-sulfonyl]phenoxyacetic acid 2-(toluene-4-sulfonyl)ethyl ester

B

4-[6-difluoromethoxy-2-{(3,4-dimethoxypyridin-2-yl)methanesulfinyl}benzimidazole-1-sulfonyl]phenoxyacetic acid 2-(toluene-4-sulfonyl)ethyl ester
651728-69-7

4-[6-difluoromethoxy-2-{(3,4-dimethoxypyridin-2-yl)methanesulfinyl}benzimidazole-1-sulfonyl]phenoxyacetic acid 2-(toluene-4-sulfonyl)ethyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate; triethylamine In dichloromethane
With sodium hydrogencarbonate; triethylamine In dichloromethane Inert atmosphere;
pantoprazole sodium
138786-67-1

pantoprazole sodium

A

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chloromethyl]sulfinyl]-1H-benzimidazole
812664-93-0

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chloromethyl]sulfinyl]-1H-benzimidazole

B

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)chlorohydroxymethyl]sulfinyl]-1H-benzimidazole
812664-94-1

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)chlorohydroxymethyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With sodium hydroxide; sodium hypochlorite In water; acetonitrile at 20℃; for 12h;
pantoprazole sodium
138786-67-1

pantoprazole sodium

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
102625-70-7

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Stage #1: pantoprazole sodium With ethanol
Stage #2: With water
pantoprazole sodium
138786-67-1

pantoprazole sodium

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate
797789-88-9

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate

Conditions
ConditionsYield
In acetone Purification / work up; Heating / reflux;
With water In ethyl acetate; acetone at 0 - 55℃; for 2.25h; Product distribution / selectivity;
With water In ethyl acetate at 0 - 5℃; for 2h; Product distribution / selectivity;
pantoprazole sodium
138786-67-1

pantoprazole sodium

pantoprazole sodium sesquihydrate

pantoprazole sodium sesquihydrate

Conditions
ConditionsYield
With water In ethyl acetate; acetone at 0 - 55℃; for 2.25h; Product distribution / selectivity;
With water In ethyl acetate at 0 - 5℃; for 2h; Product distribution / selectivity;
(4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester
651728-13-1

(4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester

pantoprazole sodium
138786-67-1

pantoprazole sodium

A

4-[6-difluoromethoxy-2-{(3,4-dimethoxypyridin-2-yl)methanesulfinyl}benzimidazole-1-sulfonyl]phenoxyacetic acid sodium salt

4-[6-difluoromethoxy-2-{(3,4-dimethoxypyridin-2-yl)methanesulfinyl}benzimidazole-1-sulfonyl]phenoxyacetic acid sodium salt

B

4-[5-difluoromethoxy-2-{(3,4-dimethoxypyridin-2-yl)methanesulfinyl}benzimidazole-1-sulfonyl]phenoxyacetic acid sodium salt

4-[5-difluoromethoxy-2-{(3,4-dimethoxypyridin-2-yl)methanesulfinyl}benzimidazole-1-sulfonyl]phenoxyacetic acid sodium salt

Conditions
ConditionsYield
Stage #1: (4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester; pantoprazole sodium With sodium hydrogencarbonate; triethylamine In dichloromethane Inert atmosphere;
Stage #2: With water; sodium hydrogencarbonate In acetonitrile at 65℃; for 5h; Inert atmosphere;
pantoprazole sodium
138786-67-1

pantoprazole sodium

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

C16H14F2N3O4S(1-)*C42H70O35*Na(1+)

C16H14F2N3O4S(1-)*C42H70O35*Na(1+)

Conditions
ConditionsYield
In water

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