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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. It is made obtainable from us at the most reasonable rate. Our Service: 1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical are

hangzhou verychem science and technology co.ltd

Product name: Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylate Cas No: 112811-71-9 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2

Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Cas:112811-71-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assa 98%min ------------------------------------------------------------------------------------------------

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Pale yellow powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum Application:Pharmace

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Gatifloxacin Intermediate 112811-71-9 GMP manufacturer

Cas:112811-71-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

Cas:112811-71-9

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

Cas:112811-71-9

Min.Order:1 Kilogram

FOB Price: $6.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA. Product quality, process, price and service 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS 112811-71-9 IN Stock Ethyl 1

Hubei DiBo chemical co., LTD

Name:Gatifloxacin Macrolide CAS NO: 112811-71-9 Grade:Medical scientific research and export Molecular formula:C16H15F2NO4 Molecular weight:323.2914 Product Quality 12 years of chemical raw materials Mature operation of the industry System

Gatifloxacin Macrolide/ CAS:112811-71-9/ Entacapone raw material/ high-quality

Cas:112811-71-9

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Leader Biochemical Group

About Product Technical Details

Ality Chemical Corporation

We are the manufacturer of this product. If you are looking for the material's manufacturer or supplier in China, AlityGroup is your best choice. Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise

Henan Tianfu Chemical Co., Ltd.

ethyl1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate Chemical Name : ethyl1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate

ethyl1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate -

Cas:112811-71-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Gatifloxacin Intermediate CAS: 112811-71-9

Cas:112811-71-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 112811-71-9 with best quality

Cas:112811-71-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

Cas:112811-71-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid ethyl Synonyms: Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-Quinolinecarboxylate CAS:112811-71-9 MF: C16H15F2NO4 Appearance: white

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid ethyl

Cas:112811-71-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to Pale Yellow Powder Storage:R T Package:25kg/Barrel Application:Synthesis of moxifloxacin hydrochloride, moxifloxacin hydrochloride intermediate, moxifloxacin intermediate, gatifloxacin intermediate Transportation:Express/Sea/Air

Cheap Price Ready Stock 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

Cas:112811-71-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester 112811-71-9

Cas:112811-71-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Qingdao Beluga Import and Export Co., LTD

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS 112811-71-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production an

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

Cas:112811-71-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

Cas:112811-71-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS 112811-71-9

Cas:112811-71-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:112811-71-9

Cas:112811-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Triumph International Development Limilted

Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai

112811-71-9

Cas:112811-71-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:White crystalline powder/See COA for details St

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Synonyms: 1-Cyclopropyl-6,7-Difluoro-1,4-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxo-3-Quinolinecarboxylic Acid Ethyl ester;Moxifloxacin InterMe

Synthetic route

ethyl α(Z)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate

ethyl α(Z)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate

Cyclopropylamine
765-30-0

Cyclopropylamine

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Stage #1: ethyl α(Z)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate; Cyclopropylamine In diethyl ether; ethanol at 20℃; for 3h;
Stage #2: With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h;
82%
ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino)acrylate

ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino)acrylate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 18h;81%
In tetrahydrofuran; mineral oil75%
With sodium hydride In tetrahydrofuran at 20 - 40℃; for 2h;
N,N-dimethylaminoacrylic acid ethyl ester
16173-58-3

N,N-dimethylaminoacrylic acid ethyl ester

Cyclopropylamine
765-30-0

Cyclopropylamine

2,4,5-trifluoro-3-methoxybenzoyl chloride
112811-66-2

2,4,5-trifluoro-3-methoxybenzoyl chloride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Stage #1: N,N-dimethylaminoacrylic acid ethyl ester; 2,4,5-trifluoro-3-methoxybenzoyl chloride With triethylamine In ethyl acetate at 60 - 80℃; for 3h;
Stage #2: Cyclopropylamine With acetic acid In ethyl acetate for 0.5h; Temperature;
63.16%
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
112811-70-8

ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h;
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h;627 mg
With potassium carbonate In dimethyl sulfoxide
ethyl α(E)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate
925457-02-9

ethyl α(E)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol; diethyl ether / 3 h / 20 °C
2: 627 mg / K2CO3 / dimethylformamide / 5 h / 100 °C
View Scheme
3-methoxy-2,4,5-trifluorobenzoic acid
112811-65-1

3-methoxy-2,4,5-trifluorobenzoic acid

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: oxalyl chloride; DMF / CH2Cl2 / 24 h / 20 °C
2: 1.88 g / Et3N / toluene / 5 h / 90 °C
3: ethanol; diethyl ether / 3 h / 20 °C
4: 627 mg / K2CO3 / dimethylformamide / 5 h / 100 °C
View Scheme
Multi-step reaction with 5 steps
1: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
2: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
3: acetic anhydride / 22 h / Heating
4: ethanol / 18 h / Ambient temperature
5: 81 percent / NaH / tetrahydrofuran / 18 h
View Scheme
Multi-step reaction with 4 steps
1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 24 h
2: triethylamine / toluene / 5 h / 90 °C
3: diethyl ether; ethanol / 3 h / 25 °C
4: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C
View Scheme
2,4,5-trifluoro-3-methoxybenzoyl chloride
112811-66-2

2,4,5-trifluoro-3-methoxybenzoyl chloride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.88 g / Et3N / toluene / 5 h / 90 °C
2: ethanol; diethyl ether / 3 h / 20 °C
3: 627 mg / K2CO3 / dimethylformamide / 5 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: NEt3 / toluene / 5 h / 90 °C
2: ethanol; diethyl ether / 3 h / 20 °C
3: potassium carbonate / dimethylformamide / 5 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
2: acetic anhydride / 22 h / Heating
3: ethanol / 18 h / Ambient temperature
4: 81 percent / NaH / tetrahydrofuran / 18 h
View Scheme
ethyl 3-(N,N-diethylamino)acrylate

ethyl 3-(N,N-diethylamino)acrylate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NEt3 / toluene / 5 h / 90 °C
2: ethanol; diethyl ether / 3 h / 20 °C
3: potassium carbonate / dimethylformamide / 5 h / 100 °C
View Scheme
(Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester
722542-90-7

(Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol; diethyl ether / 3 h / 20 °C
2: potassium carbonate / dimethylformamide / 5 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: diethyl ether; ethanol / 3 h / 25 °C
2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C
View Scheme
methyl 3-methoxy-2,4,5-trifluorobenzoate
136897-64-8

methyl 3-methoxy-2,4,5-trifluorobenzoate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 61 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
2: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
3: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
4: acetic anhydride / 22 h / Heating
5: ethanol / 18 h / Ambient temperature
6: 81 percent / NaH / tetrahydrofuran / 18 h
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic anhydride / 22 h / Heating
2: ethanol / 18 h / Ambient temperature
3: 81 percent / NaH / tetrahydrofuran / 18 h
View Scheme
Multi-step reaction with 3 steps
1: acetic anhydride / 11 h
2: ethanol / 2 h / 20 °C
3: sodiumfluoride / N,N-dimethyl-formamide / 5 h
View Scheme
ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
122375-85-3

ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / 18 h / Ambient temperature
2: 81 percent / NaH / tetrahydrofuran / 18 h
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 2 h / 20 °C
2: sodiumfluoride / N,N-dimethyl-formamide / 5 h
View Scheme
ethyl 3-cyclopropylamino-2-(3-methoxy-2,4,5-trifluorobenzoyl)acrylate

ethyl 3-cyclopropylamino-2-(3-methoxy-2,4,5-trifluorobenzoyl)acrylate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; mineral oil
ethyl 3-(diethylamino)acrylate
13894-28-5

ethyl 3-(diethylamino)acrylate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / toluene / 5 h / 90 °C
2.1: ethanol; diethyl ether / 3 h / 20 °C
2.2: 5 h / 100 °C
View Scheme
2,4,5-trifluoro-3-methoxy-benzamide
112811-64-0

2,4,5-trifluoro-3-methoxy-benzamide

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: sulfuric acid / 3.5 h / 100 °C
2: thionyl chloride / 3 h
3: magnesium ethylate / toluene
4: toluene-4-sulfonic acid / water / 9 h
5: acetic anhydride / 11 h
6: ethanol / 2 h / 20 °C
7: sodiumfluoride / N,N-dimethyl-formamide / 5 h
View Scheme
3-methoxy-2,4,5-trifluorobenzonitrile
112811-63-9

3-methoxy-2,4,5-trifluorobenzonitrile

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: sulfuric acid; water / 1 h / 110 °C
2: sulfuric acid / 3.5 h / 100 °C
3: thionyl chloride / 3 h
4: magnesium ethylate / toluene
5: toluene-4-sulfonic acid / water / 9 h
6: acetic anhydride / 11 h
7: ethanol / 2 h / 20 °C
8: sodiumfluoride / N,N-dimethyl-formamide / 5 h
View Scheme
diethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate
112811-67-3

diethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / water / 9 h
2: acetic anhydride / 11 h
3: ethanol / 2 h / 20 °C
4: sodiumfluoride / N,N-dimethyl-formamide / 5 h
View Scheme
1-bromo-2,4,5-trifluoro-3-methoxybenzene
13332-24-6

1-bromo-2,4,5-trifluoro-3-methoxybenzene

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C
2: sulfuric acid; water / 1 h / 110 °C
3: sulfuric acid / 3.5 h / 100 °C
4: thionyl chloride / 3 h
5: magnesium ethylate / toluene
6: toluene-4-sulfonic acid / water / 9 h
7: acetic anhydride / 11 h
8: ethanol / 2 h / 20 °C
9: sodiumfluoride / N,N-dimethyl-formamide / 5 h
View Scheme
N-methyl-tetrafluorophthalimide
33795-85-6

N-methyl-tetrafluorophthalimide

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydroxide / 10 h / Reflux
1.2: 8 h / 70 - 105 °C
2.1: 2 h / 35 - 80 °C / pH 8.55 - > 12 / Alkaline conditions
3.1: thionyl chloride / 5 h / 80 °C
4.1: triethylamine / toluene / 3 h / 55 °C
5.1: toluene / 2 h / 30 - 45 °C
6.1: potassium fluoride; tetrabutylammomium bromide / N,N-dimethyl-formamide / 6 h / 120 °C / 1125.11 Torr
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2 h / 35 - 80 °C / pH 8.55 - > 12 / Alkaline conditions
2: thionyl chloride / 5 h / 80 °C
3: triethylamine / toluene / 3 h / 55 °C
4: toluene / 2 h / 30 - 45 °C
5: potassium fluoride; tetrabutylammomium bromide / N,N-dimethyl-formamide / 6 h / 120 °C / 1125.11 Torr
View Scheme
cyclopropyl bromide
4333-56-6

cyclopropyl bromide

6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester
121996-72-3

6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester

methyl iodide
74-88-4

methyl iodide

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Stage #1: 6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester; methyl iodide With sodium carbonate In toluene at 25℃;
Stage #2: cyclopropyl bromide In toluene Reflux;
150.81 g
ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate
138998-47-7

ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethyl acetate / 5 h / 25 °C
2.1: potassium carbonate / toluene / Reflux
3.1: sulfuric acid / water / 5 h / 25 °C
4.1: potassium carbonate / benzene / 25 °C
4.2: Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: ethyl acetate / 5 h / 25 °C
2.1: potassium carbonate / toluene / Reflux
3.1: sulfuric acid / water / 5 h / 25 °C
4.1: sodium carbonate / toluene / 25 °C
4.2: Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: ethyl acetate / 5 h / 25 °C
2.1: potassium carbonate / toluene / Reflux
3.1: sulfuric acid / water / 5 h / 25 °C
4.1: potassium carbonate / 25 °C
4.2: Reflux
View Scheme
cyclopropyl benzenesulfonate

cyclopropyl benzenesulfonate

6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester
121996-72-3

6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester

Methyl benzenesulfonate
80-18-2

Methyl benzenesulfonate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Stage #1: 6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester; Methyl benzenesulfonate With potassium carbonate at 25℃;
Stage #2: cyclopropyl benzenesulfonate Reflux;
125.17g
2-(2,3,4,5-tetrafluorophenyl)formyl-3-(1-hydroxy-1-phenylmethyl)amino acrylic acid ethyl ester

2-(2,3,4,5-tetrafluorophenyl)formyl-3-(1-hydroxy-1-phenylmethyl)amino acrylic acid ethyl ester

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / toluene / Reflux
2.1: sulfuric acid / water / 5 h / 25 °C
3.1: potassium carbonate / benzene / 25 °C
3.2: Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / toluene / Reflux
2.1: sulfuric acid / water / 5 h / 25 °C
3.1: sodium carbonate / toluene / 25 °C
3.2: Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / toluene / Reflux
2.1: sulfuric acid / water / 5 h / 25 °C
3.1: potassium carbonate / 25 °C
3.2: Reflux
View Scheme
dimethylphosphoric acid
813-78-5

dimethylphosphoric acid

cyclopropyl chloride
7393-45-5

cyclopropyl chloride

6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester
121996-72-3

6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Stage #1: dimethylphosphoric acid; 6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester With potassium carbonate In benzene at 25℃;
Stage #2: cyclopropyl chloride In benzene Reflux;
144.78g
C19H13F2NO4

C19H13F2NO4

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / water / 5 h / 25 °C
2.1: potassium carbonate / benzene / 25 °C
2.2: Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: sulfuric acid / water / 5 h / 25 °C
2.1: sodium carbonate / toluene / 25 °C
2.2: Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: sulfuric acid / water / 5 h / 25 °C
2.1: potassium carbonate / 25 °C
2.2: Reflux
View Scheme
boric acid
11113-50-1

boric acid

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
139693-52-0

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate

Conditions
ConditionsYield
Stage #1: boric acid With acetic anhydride at 90℃; for 1h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 110℃; for 2h; Temperature;
99%
boric acid
11113-50-1

boric acid

acetic anhydride
108-24-7

acetic anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

C20H22BF2NO8

C20H22BF2NO8

Conditions
ConditionsYield
Stage #1: boric acid; acetic anhydride With zinc(II) chloride at 60 - 115℃; for 1h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 55 - 110℃; for 3h;
98.9%
boric acid
11113-50-1

boric acid

acetic anhydride
108-24-7

acetic anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
139693-52-0

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate

Conditions
ConditionsYield
Stage #1: boric acid; acetic anhydride at 100 - 110℃; for 1.5h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 90 - 100℃;
98%
Stage #1: boric acid; acetic anhydride With acetic acid at 100 - 110℃; for 1h; Large scale;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 70 - 110℃; for 2h; Large scale;
93%
Stage #1: boric acid; acetic anhydride at 75 - 140℃; for 1h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 100 - 105℃; for 1h;
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
112811-72-0

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 65℃; for 15h; Solvent; Temperature;96.83%
With sulfuric acid; acetic acid In water for 2h; Reflux;95.92%
With hydrogenchloride for 3h; Heating;90%
propionic acid anhydride
123-62-6

propionic acid anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O3,O4-bis(propyloxy-O)borate
496919-99-4

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O3,O4-bis(propyloxy-O)borate

Conditions
ConditionsYield
Stage #1: propionic acid anhydride With boric acid at 80 - 90℃; for 2h; Heating / reflux;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 70 - 100℃; for 4h;
96%
Stage #1: propionic acid anhydride With boron trioxide In propionic acid at 150℃; for 5h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate In propionic acid at 50 - 115℃; for 4h;
91.2%
boric acid
11113-50-1

boric acid

propionic acid anhydride
123-62-6

propionic acid anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O3,O4-bis(propyloxy-O)borate
496919-99-4

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O3,O4-bis(propyloxy-O)borate

Conditions
ConditionsYield
Stage #1: boric acid; propionic acid anhydride at 80 - 90℃; for 2h; Reflux;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 70 - 100℃;
96%
boric acid
11113-50-1

boric acid

acetic anhydride
108-24-7

acetic anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

C18H17BF2NO8

C18H17BF2NO8

Conditions
ConditionsYield
Stage #1: boric acid; acetic anhydride With zinc(II) chloride for 1.5h; Heating;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With acetic acid for 5h;
95.9%
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

(1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron

(1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron

Conditions
ConditionsYield
With tetrafluoroboric acid In water at 30 - 100℃; for 5h;95.8%
With boron trifluoride diethyl etherate In tetrahydrofuran for 48h; Heating;78%
With boron trifluoride diethyl etherate In tetrahydrofuran for 48h; Reflux; Inert atmosphere;56%
With boron trifluoride diethyl etherate; potassium carbonate In tetrahydrofuran
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate
139678-43-6

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate

Conditions
ConditionsYield
Stage #1: acetic anhydride With boric acid at 70 - 90℃; for 1h; Heating / reflux;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 100 - 105℃; for 1h;
95.2%
tetrafluoroboric acid

tetrafluoroboric acid

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

(1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron

(1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron

Conditions
ConditionsYield
With poly(methylhydrosiloxane) at 100℃; for 7h; Product distribution / selectivity;95%
With Hexamethyldisiloxane at 100℃; for 7h; Product distribution / selectivity;92%
acetic anhydride
108-24-7

acetic anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
139693-52-0

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate

Conditions
ConditionsYield
Stage #1: acetic anhydride With boron oxide In acetic acid at 110℃; for 2.5h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate In acetic acid at 50 - 90℃; for 4h; Temperature;
94.8%
Stage #1: acetic anhydride With boric acid at 75 - 140℃;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 70 - 105℃;
butanoic acid anhydride
106-31-0

butanoic acid anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

C22H24BF2NO8

C22H24BF2NO8

Conditions
ConditionsYield
Stage #1: butanoic acid anhydride With boron trioxide at 180℃; for 5h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 50 - 115℃; for 4h;
94.8%
benzoic acid anhydride
93-97-0

benzoic acid anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

C28H20BF2NO8

C28H20BF2NO8

Conditions
ConditionsYield
Stage #1: benzoic acid anhydride With boron trioxide at 200℃; for 5h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 50 - 200℃; for 4h;
93.2%
boric acid
11113-50-1

boric acid

propionic acid anhydride
123-62-6

propionic acid anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

C20H20BF2NO8

C20H20BF2NO8

Conditions
ConditionsYield
With glycine at 80 - 98℃; for 2.5h; Temperature; Inert atmosphere;92.9%
acetic anhydride
108-24-7

acetic anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

boron trioxide
1103242-32-5

boron trioxide

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
139693-52-0

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate

Conditions
ConditionsYield
Stage #1: acetic anhydride; boron trioxide With acetic acid at 90 - 100℃; for 2h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 50 - 60℃; for 5h; Temperature;
91.1%
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

C18H10BF8NO8

C18H10BF8NO8

Conditions
ConditionsYield
Stage #1: trifluoroacetic anhydride With boron trioxide In trifluoroacetic acid at 80℃; for 4h;
Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate In trifluoroacetic acid at 30 - 80℃; for 2h;
90.2%
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
151213-40-0

(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

moxifloxacin hydrochloride
186826-86-8

moxifloxacin hydrochloride

Conditions
ConditionsYield
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boric acid; acetic anhydride at 90 - 100℃; for 3h;
Stage #2: With triethylamine In acetonitrile at 20℃; for 0.5h;
Stage #3: (1S,6S)-2,8-diazabicyclo[4.3.0]nonane Temperature; Solvent; Reagent/catalyst; Further stages;
89.78%
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid
154093-72-8

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid

Conditions
ConditionsYield
With water; hydrogen bromide; acetic acid at 100℃;89.6%
triethyl borate
150-46-9

triethyl borate

acetic anhydride
108-24-7

acetic anhydride

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate
139678-43-6

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate

Conditions
ConditionsYield
With acetic acid; zinc(II) chloride at 40 - 70℃; for 3h; Temperature;88.2%
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-nitro-8-methoxy-4-oxoquinoline-3-carboxylic acid
112811-77-5

1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-nitro-8-methoxy-4-oxoquinoline-3-carboxylic acid

Conditions
ConditionsYield
With potassium nitrite; sulfuric acid at 20℃; for 6h;88%
Multi-step reaction with 2 steps
1: sulfuric acid; water / acetic acid / 1 h
2: potassium nitrate / sulfuric acid / 0.75 h / 5 °C
View Scheme
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

A

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid
154093-72-8

1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid

B

C12H9F2NO2

C12H9F2NO2

Conditions
ConditionsYield
With hydrogen bromide In water at 100℃; for 18h;A 86%
B 10%
(RS)-2-methylpiperazine
109-07-9

(RS)-2-methylpiperazine

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boric acid; acetic anhydride; zinc(II) chloride at 80℃; for 2h;
Stage #2: (RS)-2-methylpiperazine With triethylamine In acetonitrile at 20℃;
80.67%
boron trifluoride diethyl etherate
109-63-7

boron trifluoride diethyl etherate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester
847233-56-1

1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran for 96h; Reflux;78%
C15H18N2O2

C15H18N2O2

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

C31H32FN3O6

C31H32FN3O6

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 62.5℃; for 24h; Solvent; Reagent/catalyst; Temperature;78%
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-5-nitro-4-oxo-3-quinolinecarboxylate
172602-78-7

ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-5-nitro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
With sulfuric acid; potassium nitrate for 18h; Ambient temperature;70%
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate
134575-17-0

tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate

1-cyclopropyl-7-[(1α,5α,6α)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
925457-06-3

1-cyclopropyl-7-[(1α,5α,6α)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boron trifluoride diethyl etherate In tetrahydrofuran Heating;
Stage #2: tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate In acetonitrile for 168h; Heating;
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

(1α,5α,6α)-6-(tert-butoxycarbonyl)aminomethylene-3-azabicyclo[3.1.0]hexane
134575-12-5

(1α,5α,6α)-6-(tert-butoxycarbonyl)aminomethylene-3-azabicyclo[3.1.0]hexane

1-cyclopropyl-7-[(1α,5α,6α)-6-[[[(1,1-dimethylethoxy)carbonyl]amino]-methyl]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
925457-07-4

1-cyclopropyl-7-[(1α,5α,6α)-6-[[[(1,1-dimethylethoxy)carbonyl]amino]-methyl]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boron trifluoride diethyl etherate In tetrahydrofuran Heating;
Stage #2: (1α,5α,6α)-6-(tert-butoxycarbonyl)aminomethylene-3-azabicyclo[3.1.0]hexane In acetonitrile for 168h; Heating;

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