We are concentrating on APIs and pharmaceutical intermediates. It is made obtainable from us at the most reasonable rate. Our Service: 1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical are
Cas:112811-71-9
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inquiryProduct name: Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylate Cas No: 112811-71-9 Assay: 99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2
Cas:112811-71-9
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inquiryItems Standard Result Assa 98%min ------------------------------------------------------------------------------------------------
Cas:112811-71-9
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Pale yellow powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum Application:Pharmace
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
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inquiryChemwill Asia co.,Ltd is one of the leading manufacturer in CHINA. Product quality, process, price and service 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS 112811-71-9 IN Stock Ethyl 1
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Type:Manufacturers
inquiryName:Gatifloxacin Macrolide CAS NO: 112811-71-9 Grade:Medical scientific research and export Molecular formula:C16H15F2NO4 Molecular weight:323.2914 Product Quality 12 years of chemical raw materials Mature operation of the industry System
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inquiryAbout Product Technical Details
Cas:112811-71-9
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inquiryWe are the manufacturer of this product. If you are looking for the material's manufacturer or supplier in China, AlityGroup is your best choice. Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise
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inquiryethyl1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate Chemical Name : ethyl1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
Cas:112811-71-9
Min.Order:1 Kilogram
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:112811-71-9
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryName: 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid ethyl Synonyms: Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-Quinolinecarboxylate CAS:112811-71-9 MF: C16H15F2NO4 Appearance: white
Cas:112811-71-9
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Type:Other
inquiryAppearance:White to Pale Yellow Powder Storage:R T Package:25kg/Barrel Application:Synthesis of moxifloxacin hydrochloride, moxifloxacin hydrochloride intermediate, moxifloxacin intermediate, gatifloxacin intermediate Transportation:Express/Sea/Air
Cas:112811-71-9
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:112811-71-9
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:112811-71-9
Min.Order:1 Gram
FOB Price: $309.0 / 318.0
Type:Trading Company
inquiry1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS 112811-71-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production an
Cas:112811-71-9
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:112811-71-9
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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Type:Manufacturers
inquiryAppearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai
Cas:112811-71-9
Min.Order:100 Metric Ton
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Type:Lab/Research institutions
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:White crystalline powder/See COA for details St
Cas:112811-71-9
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Type:Trading Company
inquiryProduct Name: 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Synonyms: 1-Cyclopropyl-6,7-Difluoro-1,4-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxo-3-Quinolinecarboxylic Acid Ethyl ester;Moxifloxacin InterMe
Cas:112811-71-9
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryCyclopropylamine
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: ethyl α(Z)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate; Cyclopropylamine In diethyl ether; ethanol at 20℃; for 3h; Stage #2: With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h; | 82% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran for 18h; | 81% |
In tetrahydrofuran; mineral oil | 75% |
With sodium hydride In tetrahydrofuran at 20 - 40℃; for 2h; |
N,N-dimethylaminoacrylic acid ethyl ester
Cyclopropylamine
2,4,5-trifluoro-3-methoxybenzoyl chloride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: N,N-dimethylaminoacrylic acid ethyl ester; 2,4,5-trifluoro-3-methoxybenzoyl chloride With triethylamine In ethyl acetate at 60 - 80℃; for 3h; Stage #2: Cyclopropylamine With acetic acid In ethyl acetate for 0.5h; Temperature; | 63.16% |
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h; | |
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 5h; | 627 mg |
With potassium carbonate In dimethyl sulfoxide |
ethyl α(E)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol; diethyl ether / 3 h / 20 °C 2: 627 mg / K2CO3 / dimethylformamide / 5 h / 100 °C View Scheme |
3-methoxy-2,4,5-trifluorobenzoic acid
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: oxalyl chloride; DMF / CH2Cl2 / 24 h / 20 °C 2: 1.88 g / Et3N / toluene / 5 h / 90 °C 3: ethanol; diethyl ether / 3 h / 20 °C 4: 627 mg / K2CO3 / dimethylformamide / 5 h / 100 °C View Scheme | |
Multi-step reaction with 5 steps 1: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature 2: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h 3: acetic anhydride / 22 h / Heating 4: ethanol / 18 h / Ambient temperature 5: 81 percent / NaH / tetrahydrofuran / 18 h View Scheme | |
Multi-step reaction with 4 steps 1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 24 h 2: triethylamine / toluene / 5 h / 90 °C 3: diethyl ether; ethanol / 3 h / 25 °C 4: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C View Scheme |
2,4,5-trifluoro-3-methoxybenzoyl chloride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.88 g / Et3N / toluene / 5 h / 90 °C 2: ethanol; diethyl ether / 3 h / 20 °C 3: 627 mg / K2CO3 / dimethylformamide / 5 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: NEt3 / toluene / 5 h / 90 °C 2: ethanol; diethyl ether / 3 h / 20 °C 3: potassium carbonate / dimethylformamide / 5 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h 2: acetic anhydride / 22 h / Heating 3: ethanol / 18 h / Ambient temperature 4: 81 percent / NaH / tetrahydrofuran / 18 h View Scheme |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NEt3 / toluene / 5 h / 90 °C 2: ethanol; diethyl ether / 3 h / 20 °C 3: potassium carbonate / dimethylformamide / 5 h / 100 °C View Scheme |
(Z)-3-Diethylamino-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol; diethyl ether / 3 h / 20 °C 2: potassium carbonate / dimethylformamide / 5 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: diethyl ether; ethanol / 3 h / 25 °C 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C View Scheme |
methyl 3-methoxy-2,4,5-trifluorobenzoate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 61 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature 2: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature 3: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h 4: acetic anhydride / 22 h / Heating 5: ethanol / 18 h / Ambient temperature 6: 81 percent / NaH / tetrahydrofuran / 18 h View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic anhydride / 22 h / Heating 2: ethanol / 18 h / Ambient temperature 3: 81 percent / NaH / tetrahydrofuran / 18 h View Scheme | |
Multi-step reaction with 3 steps 1: acetic anhydride / 11 h 2: ethanol / 2 h / 20 °C 3: sodiumfluoride / N,N-dimethyl-formamide / 5 h View Scheme |
ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol / 18 h / Ambient temperature 2: 81 percent / NaH / tetrahydrofuran / 18 h View Scheme | |
Multi-step reaction with 2 steps 1: ethanol / 2 h / 20 °C 2: sodiumfluoride / N,N-dimethyl-formamide / 5 h View Scheme |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; mineral oil |
ethyl 3-(diethylamino)acrylate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / toluene / 5 h / 90 °C 2.1: ethanol; diethyl ether / 3 h / 20 °C 2.2: 5 h / 100 °C View Scheme |
2,4,5-trifluoro-3-methoxy-benzamide
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: sulfuric acid / 3.5 h / 100 °C 2: thionyl chloride / 3 h 3: magnesium ethylate / toluene 4: toluene-4-sulfonic acid / water / 9 h 5: acetic anhydride / 11 h 6: ethanol / 2 h / 20 °C 7: sodiumfluoride / N,N-dimethyl-formamide / 5 h View Scheme |
3-methoxy-2,4,5-trifluorobenzonitrile
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: sulfuric acid; water / 1 h / 110 °C 2: sulfuric acid / 3.5 h / 100 °C 3: thionyl chloride / 3 h 4: magnesium ethylate / toluene 5: toluene-4-sulfonic acid / water / 9 h 6: acetic anhydride / 11 h 7: ethanol / 2 h / 20 °C 8: sodiumfluoride / N,N-dimethyl-formamide / 5 h View Scheme |
diethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / water / 9 h 2: acetic anhydride / 11 h 3: ethanol / 2 h / 20 °C 4: sodiumfluoride / N,N-dimethyl-formamide / 5 h View Scheme |
1-bromo-2,4,5-trifluoro-3-methoxybenzene
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C 2: sulfuric acid; water / 1 h / 110 °C 3: sulfuric acid / 3.5 h / 100 °C 4: thionyl chloride / 3 h 5: magnesium ethylate / toluene 6: toluene-4-sulfonic acid / water / 9 h 7: acetic anhydride / 11 h 8: ethanol / 2 h / 20 °C 9: sodiumfluoride / N,N-dimethyl-formamide / 5 h View Scheme |
N-methyl-tetrafluorophthalimide
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hydroxide / 10 h / Reflux 1.2: 8 h / 70 - 105 °C 2.1: 2 h / 35 - 80 °C / pH 8.55 - > 12 / Alkaline conditions 3.1: thionyl chloride / 5 h / 80 °C 4.1: triethylamine / toluene / 3 h / 55 °C 5.1: toluene / 2 h / 30 - 45 °C 6.1: potassium fluoride; tetrabutylammomium bromide / N,N-dimethyl-formamide / 6 h / 120 °C / 1125.11 Torr View Scheme |
2,4,5-trifluoro-3-hydroxybenzoic acid
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2 h / 35 - 80 °C / pH 8.55 - > 12 / Alkaline conditions 2: thionyl chloride / 5 h / 80 °C 3: triethylamine / toluene / 3 h / 55 °C 4: toluene / 2 h / 30 - 45 °C 5: potassium fluoride; tetrabutylammomium bromide / N,N-dimethyl-formamide / 6 h / 120 °C / 1125.11 Torr View Scheme |
cyclopropyl bromide
6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester
methyl iodide
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: 6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester; methyl iodide With sodium carbonate In toluene at 25℃; Stage #2: cyclopropyl bromide In toluene Reflux; | 150.81 g |
ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: ethyl acetate / 5 h / 25 °C 2.1: potassium carbonate / toluene / Reflux 3.1: sulfuric acid / water / 5 h / 25 °C 4.1: potassium carbonate / benzene / 25 °C 4.2: Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: ethyl acetate / 5 h / 25 °C 2.1: potassium carbonate / toluene / Reflux 3.1: sulfuric acid / water / 5 h / 25 °C 4.1: sodium carbonate / toluene / 25 °C 4.2: Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: ethyl acetate / 5 h / 25 °C 2.1: potassium carbonate / toluene / Reflux 3.1: sulfuric acid / water / 5 h / 25 °C 4.1: potassium carbonate / 25 °C 4.2: Reflux View Scheme |
6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester
Methyl benzenesulfonate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: 6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester; Methyl benzenesulfonate With potassium carbonate at 25℃; Stage #2: cyclopropyl benzenesulfonate Reflux; | 125.17g |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / toluene / Reflux 2.1: sulfuric acid / water / 5 h / 25 °C 3.1: potassium carbonate / benzene / 25 °C 3.2: Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / toluene / Reflux 2.1: sulfuric acid / water / 5 h / 25 °C 3.1: sodium carbonate / toluene / 25 °C 3.2: Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / toluene / Reflux 2.1: sulfuric acid / water / 5 h / 25 °C 3.1: potassium carbonate / 25 °C 3.2: Reflux View Scheme |
dimethylphosphoric acid
cyclopropyl chloride
6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: dimethylphosphoric acid; 6,7-difluoro-8-hydroxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester With potassium carbonate In benzene at 25℃; Stage #2: cyclopropyl chloride In benzene Reflux; | 144.78g |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sulfuric acid / water / 5 h / 25 °C 2.1: potassium carbonate / benzene / 25 °C 2.2: Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: sulfuric acid / water / 5 h / 25 °C 2.1: sodium carbonate / toluene / 25 °C 2.2: Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: sulfuric acid / water / 5 h / 25 °C 2.1: potassium carbonate / 25 °C 2.2: Reflux View Scheme |
boric acid
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
Conditions | Yield |
---|---|
Stage #1: boric acid With acetic anhydride at 90℃; for 1h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 110℃; for 2h; Temperature; | 99% |
boric acid
acetic anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: boric acid; acetic anhydride With zinc(II) chloride at 60 - 115℃; for 1h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 55 - 110℃; for 3h; | 98.9% |
boric acid
acetic anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
Conditions | Yield |
---|---|
Stage #1: boric acid; acetic anhydride at 100 - 110℃; for 1.5h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 90 - 100℃; | 98% |
Stage #1: boric acid; acetic anhydride With acetic acid at 100 - 110℃; for 1h; Large scale; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 70 - 110℃; for 2h; Large scale; | 93% |
Stage #1: boric acid; acetic anhydride at 75 - 140℃; for 1h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 100 - 105℃; for 1h; |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 65℃; for 15h; Solvent; Temperature; | 96.83% |
With sulfuric acid; acetic acid In water for 2h; Reflux; | 95.92% |
With hydrogenchloride for 3h; Heating; | 90% |
propionic acid anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O3,O4-bis(propyloxy-O)borate
Conditions | Yield |
---|---|
Stage #1: propionic acid anhydride With boric acid at 80 - 90℃; for 2h; Heating / reflux; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 70 - 100℃; for 4h; | 96% |
Stage #1: propionic acid anhydride With boron trioxide In propionic acid at 150℃; for 5h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate In propionic acid at 50 - 115℃; for 4h; | 91.2% |
boric acid
propionic acid anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O3,O4-bis(propyloxy-O)borate
Conditions | Yield |
---|---|
Stage #1: boric acid; propionic acid anhydride at 80 - 90℃; for 2h; Reflux; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 70 - 100℃; | 96% |
boric acid
acetic anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: boric acid; acetic anhydride With zinc(II) chloride for 1.5h; Heating; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With acetic acid for 5h; | 95.9% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
With tetrafluoroboric acid In water at 30 - 100℃; for 5h; | 95.8% |
With boron trifluoride diethyl etherate In tetrahydrofuran for 48h; Heating; | 78% |
With boron trifluoride diethyl etherate In tetrahydrofuran for 48h; Reflux; Inert atmosphere; | 56% |
With boron trifluoride diethyl etherate; potassium carbonate In tetrahydrofuran |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate
Conditions | Yield |
---|---|
Stage #1: acetic anhydride With boric acid at 70 - 90℃; for 1h; Heating / reflux; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 100 - 105℃; for 1h; | 95.2% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
With poly(methylhydrosiloxane) at 100℃; for 7h; Product distribution / selectivity; | 95% |
With Hexamethyldisiloxane at 100℃; for 7h; Product distribution / selectivity; | 92% |
acetic anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
Conditions | Yield |
---|---|
Stage #1: acetic anhydride With boron oxide In acetic acid at 110℃; for 2.5h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate In acetic acid at 50 - 90℃; for 4h; Temperature; | 94.8% |
Stage #1: acetic anhydride With boric acid at 75 - 140℃; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 70 - 105℃; |
butanoic acid anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: butanoic acid anhydride With boron trioxide at 180℃; for 5h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 50 - 115℃; for 4h; | 94.8% |
benzoic acid anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
Stage #1: benzoic acid anhydride With boron trioxide at 200℃; for 5h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 50 - 200℃; for 4h; | 93.2% |
boric acid
propionic acid anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
With glycine at 80 - 98℃; for 2.5h; Temperature; Inert atmosphere; | 92.9% |
acetic anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
boron trioxide
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate
Conditions | Yield |
---|---|
Stage #1: acetic anhydride; boron trioxide With acetic acid at 90 - 100℃; for 2h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate at 50 - 60℃; for 5h; Temperature; | 91.1% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
trifluoroacetic anhydride
Conditions | Yield |
---|---|
Stage #1: trifluoroacetic anhydride With boron trioxide In trifluoroacetic acid at 80℃; for 4h; Stage #2: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate In trifluoroacetic acid at 30 - 80℃; for 2h; | 90.2% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane
moxifloxacin hydrochloride
Conditions | Yield |
---|---|
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boric acid; acetic anhydride at 90 - 100℃; for 3h; Stage #2: With triethylamine In acetonitrile at 20℃; for 0.5h; Stage #3: (1S,6S)-2,8-diazabicyclo[4.3.0]nonane Temperature; Solvent; Reagent/catalyst; Further stages; | 89.78% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With water; hydrogen bromide; acetic acid at 100℃; | 89.6% |
triethyl borate
acetic anhydride
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate
Conditions | Yield |
---|---|
With acetic acid; zinc(II) chloride at 40 - 70℃; for 3h; Temperature; | 88.2% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-nitro-8-methoxy-4-oxoquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With potassium nitrite; sulfuric acid at 20℃; for 6h; | 88% |
Multi-step reaction with 2 steps 1: sulfuric acid; water / acetic acid / 1 h 2: potassium nitrate / sulfuric acid / 0.75 h / 5 °C View Scheme |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
A
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
With hydrogen bromide In water at 100℃; for 18h; | A 86% B 10% |
(RS)-2-methylpiperazine
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
gatifloxacin
Conditions | Yield |
---|---|
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boric acid; acetic anhydride; zinc(II) chloride at 80℃; for 2h; Stage #2: (RS)-2-methylpiperazine With triethylamine In acetonitrile at 20℃; | 80.67% |
boron trifluoride diethyl etherate
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran for 96h; Reflux; | 78% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 62.5℃; for 24h; Solvent; Reagent/catalyst; Temperature; | 78% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-5-nitro-4-oxo-3-quinolinecarboxylate
Conditions | Yield |
---|---|
With sulfuric acid; potassium nitrate for 18h; Ambient temperature; | 70% |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate
1-cyclopropyl-7-[(1α,5α,6α)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boron trifluoride diethyl etherate In tetrahydrofuran Heating; Stage #2: tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate In acetonitrile for 168h; Heating; |
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
(1α,5α,6α)-6-(tert-butoxycarbonyl)aminomethylene-3-azabicyclo[3.1.0]hexane
1-cyclopropyl-7-[(1α,5α,6α)-6-[[[(1,1-dimethylethoxy)carbonyl]amino]-methyl]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
Conditions | Yield |
---|---|
Stage #1: ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate With boron trifluoride diethyl etherate In tetrahydrofuran Heating; Stage #2: (1α,5α,6α)-6-(tert-butoxycarbonyl)aminomethylene-3-azabicyclo[3.1.0]hexane In acetonitrile for 168h; Heating; |
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