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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,4,5-Trifluoro-3-Hydroxybenzoic Acid supplier in China

Cas:116751-24-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

3-Hydroxy-2,4,5-trifluorobenzoicacid

Cas:116751-24-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,4,5-Trifluoro-3-hydroxybenzoic acid

Cas:116751-24-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Leader Biochemical Group

About Product Details

China Biggest factory Supply High Quality 3-Hydroxy-2,4,5-trifluorobenzoic acid CAS 116751-24-7

Cas:116751-24-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 116751-24-7 with best quality

Cas:116751-24-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:white to light yellow-beige powder Storage:Room temperature Package:25kg/Barrel Application:pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in China

3-Hydroxy-2,4,5-trifluorobenzoic acid;2,4,5-TRIFLUORO-3-HYDROXYBENZOIC ACID;

Cas:116751-24-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Hydroxy-2,4,5-trifluorobenzoicacid 116751-24-7

Cas:116751-24-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Fine Intermediate, 3-Hydroxy-2,4,5-trifluorobenzoic acid CAS:116751-24-7

Cas:116751-24-7

Min.Order:1 Kilogram

FOB Price: $51.4 / 58.3

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

3-Hydroxy-2,4,5-trifluorobenzoic acid CAS:116751-24-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

3-Hydroxy-2,4,5-trifluorobenzoic acid CAS:116751-24-7

Cas:116751-24-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Hydroxy-2,4,5-trifluorobenzoicacid

Cas:116751-24-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2, 4,5-Trifluoro-3-Hydroxybenzoic Acid

Cas:116751-24-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-HYDROXY-2,4,5-TRIFLUOROBENZOIC ACID

Cas:116751-24-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,4,5-Trifluoro-3-Hydroxybenzoic Acid

Cas:116751-24-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:0

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transp

3-Hydroxy-2,4,5-trifluorobenzoicacid

Cas:116751-24-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 3-Hydroxyl-2,4,5-Trifluobenzyl Acid CAS No.:116751-24-7 Molecule Formula:C7H3F3O3 Molecule Weight:192.09 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

High Quality 3-Hydroxyl-2,4,5-Trifluobenzyl Acid in stock

Cas:116751-24-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

TIANFUCHEM--116751-24-7--3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:1 Metric Ton

FOB Price: $700.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3-Hydroxy-2,4,5-trifluorobenzoic acid

Cas:116751-24-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Hydroxy-2,4,5-Trifluorobenzoic Acid cas no. 116751-24-7 98%

Cas:116751-24-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3,4,5,6-tetrafluorophthalic acid
652-03-9

3,4,5,6-tetrafluorophthalic acid

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
Stage #1: 3,4,5,6-tetrafluorophthalic acid With sodium hydroxide In water at 90℃; for 9h;
Stage #2: With hydrogenchloride; tri-n-propylamine In water at 140℃; under 7500.75 Torr; for 7h; pH=1; Temperature;
90.35%
3,4,6-trifluoro-5-hydroxyphthalic acid
28749-88-4

3,4,6-trifluoro-5-hydroxyphthalic acid

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
In water90%
In water90%
4-methoxy-3,5,6-trifluorophthalic acid
28889-41-0

4-methoxy-3,5,6-trifluorophthalic acid

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
In water74%
In water74%
2-bromo-3,4,6-trifluoro-5-hydroxy-benzoic acid

2-bromo-3,4,6-trifluoro-5-hydroxy-benzoic acid

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; zinc In water at 25℃; for 2h;1.92 g
triisopropyl(2,3,6-trifluorophenoxy)silane

triisopropyl(2,3,6-trifluorophenoxy)silane

carbon dioxide
124-38-9

carbon dioxide

A

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

B

2,3,5-trifluoro-4-hydroxybenzoic acid
156839-10-0

2,3,5-trifluoro-4-hydroxybenzoic acid

Conditions
ConditionsYield
Stage #1: triisopropyl(2,3,6-trifluorophenoxy)silane With 2,2,6,6-tetramethylpiperidinyl-lithium In diethyl ether
Stage #2: carbon dioxide In diethyl ether
Stage #3: With hydrogenchloride Title compound not separated from byproducts;
carbon dioxide
124-38-9

carbon dioxide

1,2,4-trifluoro-3-(methoxymethoxy)benzene

1,2,4-trifluoro-3-(methoxymethoxy)benzene

A

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

B

2,3,5-trifluoro-4-hydroxybenzoic acid
156839-10-0

2,3,5-trifluoro-4-hydroxybenzoic acid

Conditions
ConditionsYield
Stage #1: 1,2,4-trifluoro-3-(methoxymethoxy)benzene With n-butyllithium In tetrahydrofuran
Stage #2: carbon dioxide In tetrahydrofuran; hexane
Stage #3: With hydrogenchloride In water Title compound not separated from byproducts;
Stage #1: 1,2,4-trifluoro-3-(methoxymethoxy)benzene With lithium diisopropyl amide In tetrahydrofuran
Stage #2: carbon dioxide In tetrahydrofuran
Stage #3: With hydrogenchloride In water Title compound not separated from byproducts;
1-bromo-2,3,5-trifluoro-4-(methoxymethoxy)benzene
851341-31-6

1-bromo-2,3,5-trifluoro-4-(methoxymethoxy)benzene

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 2,2,6,6-tetramethylpiperidine; potassium tert-butoxide; N,N,N',N'',N''-pentamethylenediamine / butyllithium / tetrahydrofuran; hexane / 0.75 h / -125 °C
1.2: tetrahydrofuran; hexane
2.1: HCl / H2O
3.1: 1.92 g / NaOH; zinc powder / H2O / 2 h / 25 °C
View Scheme
2-bromo-3,4,6-trifluoro-5-methoxymethoxy-benzoic acid

2-bromo-3,4,6-trifluoro-5-methoxymethoxy-benzoic acid

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / H2O
2: 1.92 g / NaOH; zinc powder / H2O / 2 h / 25 °C
View Scheme
2,3,6-trifluorophenol
113798-74-6

2,3,6-trifluorophenol

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 82 percent / imidazole / dimethylformamide / 20 h / 25 °C
2.1: lithium 2,2,6,6-tetramethylpiperidide / diethyl ether
2.2: diethyl ether
2.3: hydrochloric acid
View Scheme
Multi-step reaction with 5 steps
1.1: 87 percent / N-bromosuccinimide / CHCl3 / 2 h / 0 °C
2.1: 88 percent / N-ethyldiisopropylamine / CH2Cl2 / 2 h / 25 °C
3.1: 2,2,6,6-tetramethylpiperidine; potassium tert-butoxide; N,N,N',N'',N''-pentamethylenediamine / butyllithium / tetrahydrofuran; hexane / 0.75 h / -125 °C
3.2: tetrahydrofuran; hexane
4.1: HCl / H2O
5.1: 1.92 g / NaOH; zinc powder / H2O / 2 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 87 percent / N-ethyldiisopropylamine / CH2Cl2 / 25 °C
2.1: lithium diisopropylamide / tetrahydrofuran
2.2: tetrahydrofuran
2.3: HCl / H2O
View Scheme
4-bromo-2,3,6-trifluorophenol
192446-70-1

4-bromo-2,3,6-trifluorophenol

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 88 percent / N-ethyldiisopropylamine / CH2Cl2 / 2 h / 25 °C
2.1: 2,2,6,6-tetramethylpiperidine; potassium tert-butoxide; N,N,N',N'',N''-pentamethylenediamine / butyllithium / tetrahydrofuran; hexane / 0.75 h / -125 °C
2.2: tetrahydrofuran; hexane
3.1: HCl / H2O
4.1: 1.92 g / NaOH; zinc powder / H2O / 2 h / 25 °C
View Scheme
N-methyl-tetrafluorophthalimide
33795-85-6

N-methyl-tetrafluorophthalimide

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
Stage #1: N-methyl-tetrafluorophthalimide With sodium hydroxide for 10h; Reflux;
Stage #2: With sulfuric acid at 70 - 105℃; for 8h; Temperature; Reagent/catalyst;
Multi-step reaction with 2 steps
1: sodium hydroxide; zinc(II) chloride / water / 8 h / 100 °C / Large scale
2: hydrogenchloride / Reflux
View Scheme
Multi-step reaction with 2 steps
1: water; zinc(II) chloride; sodium hydroxide / 8 h / 100 °C / Large scale
2: hydrogenchloride / water / Reflux
View Scheme
C8F3O5(3-)*3Na(1+)

C8F3O5(3-)*3Na(1+)

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions
ConditionsYield
With hydrogenchloride Reflux;
With hydrogenchloride In water Reflux;
ethyl iodide
75-03-6

ethyl iodide

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

ethyl 3-ethoxy-2,4,5-trifluorobenzoate
172602-80-1

ethyl 3-ethoxy-2,4,5-trifluorobenzoate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide for 18h;92%
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

methyl iodide
74-88-4

methyl iodide

methyl 3-methoxy-2,4,5-trifluorobenzoate
136897-64-8

methyl 3-methoxy-2,4,5-trifluorobenzoate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide for 18h;91%
With sodium hydride In N,N-dimethyl-formamide
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

methyl 3-methoxy-2,4,5-trifluorobenzoate
136897-64-8

methyl 3-methoxy-2,4,5-trifluorobenzoate

2,4,5-trifluoro-3-hydroxybenzoic acid methyl ester
137234-92-5

2,4,5-trifluoro-3-hydroxybenzoic acid methyl ester

Conditions
ConditionsYield
With potassium iodide In N,N-dimethyl acetamide; water91%
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

3-methoxy-2,4,5-trifluorobenzoic acid
112811-65-1

3-methoxy-2,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
With potassium dihydrogenphosphate; N-ethyl-N,N-diisopropylamine In water at 170℃; for 8h; Reagent/catalyst; Solvent; Temperature; Autoclave;85.2%
Stage #1: 2,4,5-trifluoro-3-hydroxybenzoic acid; carbonic acid dimethyl ester With sodium hydroxide at 55 - 60℃; for 2h; pH=8 - 10; Large scale;
Stage #2: With hydrogenchloride In water at 35℃; Large scale;
85%
methanol
67-56-1

methanol

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

2,4,5-trifluoro-3-hydroxybenzoic acid methyl ester
137234-92-5

2,4,5-trifluoro-3-hydroxybenzoic acid methyl ester

Conditions
ConditionsYield
sulfuric acid at 70℃; for 18h; Sealed tube; Heating / reflux;79%
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

methyl 3-methoxy-2,4,5-trifluorobenzoate
136897-64-8

methyl 3-methoxy-2,4,5-trifluorobenzoate

2,4,5-trifluoro-3-hydroxybenzoic acid methyl ester
137234-92-5

2,4,5-trifluoro-3-hydroxybenzoic acid methyl ester

Conditions
ConditionsYield
With dmap; potassium iodide In water; carbonic acid dimethyl ester78%
2-(tert-butyldimethylsilyloxy)ethyl bromide
86864-60-0

2-(tert-butyldimethylsilyloxy)ethyl bromide

2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl-3-[(2-{[(1,1-dimethylethyl)(dimethyl)siyl]oxy}ethyl)oxy]-2,4,5-trifluorobenzoate
838856-71-6

2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl-3-[(2-{[(1,1-dimethylethyl)(dimethyl)siyl]oxy}ethyl)oxy]-2,4,5-trifluorobenzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 15h;23%
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

2,4,5-Trifluoro-3-hydroxy-benzoyl chloride
1042641-60-0

2,4,5-Trifluoro-3-hydroxy-benzoyl chloride

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃;
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

3-ethoxy-2,4,5-trifluorobenzoyl chloride
172602-81-2

3-ethoxy-2,4,5-trifluorobenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

3-ethoxy-2,4,5-trifluorobenzoic acid
169507-61-3

3-ethoxy-2,4,5-trifluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

ethyl (3-ethoxy-2,4,5-trifluorobenzoyl)acetate
172602-82-3

ethyl (3-ethoxy-2,4,5-trifluorobenzoyl)acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

(Z)-3-Ethoxy-2-(3-ethoxy-2,4,5-trifluoro-benzoyl)-acrylic acid ethyl ester

(Z)-3-Ethoxy-2-(3-ethoxy-2,4,5-trifluoro-benzoyl)-acrylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

(Z)-3-Cyclopropylamino-2-(3-ethoxy-2,4,5-trifluoro-benzoyl)-acrylic acid ethyl ester
1027303-55-4

(Z)-3-Cyclopropylamino-2-(3-ethoxy-2,4,5-trifluoro-benzoyl)-acrylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
6: ethanol / 18 h
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

5-amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-4-oxo-3-quinolinecarboxylic acid
172602-86-7

5-amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-4-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
6: ethanol / 18 h
7: NaH / tetrahydrofuran / 5 h / Ambient temperature
8: 61 percent / KNO3, conc. H2SO4 / 18 h / Ambient temperature
9: 89 percent / H2 / Raney nickel / tetrahydrofuran / 4 h / 24 - 30 °C / 1241.2 - 1551.4 Torr
10: 90 percent / 1.0 N aq. NaOH / ethanol / 18 h / Ambient temperature
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-4-oxo-3-quinolinecarboxylate
172602-83-4

ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
6: ethanol / 18 h
7: NaH / tetrahydrofuran / 5 h / Ambient temperature
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

ethyl 5-amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-4-oxo-3-quinolinecarboxylate
172602-85-6

ethyl 5-amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
6: ethanol / 18 h
7: NaH / tetrahydrofuran / 5 h / Ambient temperature
8: 61 percent / KNO3, conc. H2SO4 / 18 h / Ambient temperature
9: 89 percent / H2 / Raney nickel / tetrahydrofuran / 4 h / 24 - 30 °C / 1241.2 - 1551.4 Torr
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-5-nitro-4-oxo-3-quinolinecarboxylate
172602-84-5

ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-5-nitro-4-oxo-3-quinolinecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
6: ethanol / 18 h
7: NaH / tetrahydrofuran / 5 h / Ambient temperature
8: 61 percent / KNO3, conc. H2SO4 / 18 h / Ambient temperature
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

5-Amino-7-(3-amino-piperidin-1-yl)-1-cyclopropyl-8-ethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

5-Amino-7-(3-amino-piperidin-1-yl)-1-cyclopropyl-8-ethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
6: ethanol / 18 h
7: NaH / tetrahydrofuran / 5 h / Ambient temperature
8: 61 percent / KNO3, conc. H2SO4 / 18 h / Ambient temperature
9: 89 percent / H2 / Raney nickel / tetrahydrofuran / 4 h / 24 - 30 °C / 1241.2 - 1551.4 Torr
10: 90 percent / 1.0 N aq. NaOH / ethanol / 18 h / Ambient temperature
11: 1.) Et3N, 2.) TFA / 1.) DMSO, CH3CN, RT, 18 h, 2.) CH2Cl2, from 0 deg C to RT, 1 h
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

5-Amino-7-(3-amino-pyrrolidin-1-yl)-1-cyclopropyl-8-ethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

5-Amino-7-(3-amino-pyrrolidin-1-yl)-1-cyclopropyl-8-ethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
6: ethanol / 18 h
7: NaH / tetrahydrofuran / 5 h / Ambient temperature
8: 61 percent / KNO3, conc. H2SO4 / 18 h / Ambient temperature
9: 89 percent / H2 / Raney nickel / tetrahydrofuran / 4 h / 24 - 30 °C / 1241.2 - 1551.4 Torr
10: 90 percent / 1.0 N aq. NaOH / ethanol / 18 h / Ambient temperature
11: 1.) Et3N, 2.) TFA / 1.) DMSO, CH3CN, RT, 18 h, 2.) CH2Cl2, from 0 deg C to RT, 1 h
View Scheme
2,4,5-trifluoro-3-hydroxybenzoic acid
116751-24-7

2,4,5-trifluoro-3-hydroxybenzoic acid

5-Amino-7-(3-aminomethyl-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-8-ethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

5-Amino-7-(3-aminomethyl-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-8-ethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 92 percent / NaH / dimethylformamide / 18 h
2: 79 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
3: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
4: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
5: acetic anhydride / 18 h / Heating
6: ethanol / 18 h
7: NaH / tetrahydrofuran / 5 h / Ambient temperature
8: 61 percent / KNO3, conc. H2SO4 / 18 h / Ambient temperature
9: 89 percent / H2 / Raney nickel / tetrahydrofuran / 4 h / 24 - 30 °C / 1241.2 - 1551.4 Torr
10: 90 percent / 1.0 N aq. NaOH / ethanol / 18 h / Ambient temperature
11: 1.) Et3N, 2.) TFA / 1.) DMSO, CH3CN, RT, 18 h, 2.) CH2Cl2, from 0 deg C to RT, 1 h
View Scheme

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