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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiry3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER CAS:112811-68-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical interm
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct Name: 3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER Synonyms: Moxifloxacin Impurity 96;3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER;ETHYL 3-(2,4,5-TRIFLUORO-3-METHOXYPHENYL)-3-OXOPROPANOATE;
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiry3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTERAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by expre
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryR & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
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inquiryYinghao Pharm products include: leader molecule, heterocyclic compounds,chiral compounds, photoelectric materials, biochemical reagents etc. For example:benzene, pyrimidine, boricacid,pyridine, pyrazole, imidazole, pyrrole, fluorine and other derivat
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inquirydiethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
With water; toluene-4-sulfonic acid for 16h; Heating / reflux; | 89% |
With hydrogenchloride; water | |
With toluene-4-sulfonic acid In water for 3h; Reflux; | 17.3 g |
With toluene-4-sulfonic acid In water for 9h; |
hydrogen ethyl malonate
2,4,5-trifluoro-3-methoxybenzoyl chloride
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
With [2,2]bipyridinyl; n-butyllithium 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h; Yield given. Multistep reaction; | |
Stage #1: 2,4,5-trifluoro-3-methoxybenzoyl chloride With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: hydrogen ethyl malonate In tetrahydrofuran; hexane; dichloromethane at -78 - 10℃; | |
Stage #1: hydrogen ethyl malonate With n-butyllithium In tetrahydrofuran at -50 - 0℃; Stage #2: 2,4,5-trifluoro-3-methoxybenzoyl chloride In tetrahydrofuran at -50 - 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; water |
2,4,5-trifluoro-3-methoxybenzoyl chloride
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Stage #1: diethylmalonate potassium salt With triethylamine; magnesium chloride In acetonitrile at 20 - 25℃; Stage #2: 2,4,5-trifluoro-3-methoxybenzoyl chloride With triethylamine In acetonitrile at 20℃; for 18h; |
3-methoxy-2,4,5-trifluorobenzoic acid
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C 2.1: n-BuLi / hexane; tetrahydrofuran / -78 °C 2.2: hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: (COCl)2; DMF / CH2Cl2 2.1: MgCl2; Et3N / acetonitrile / 20 - 25 °C 2.2: Et3N / acetonitrile / 18 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature 2: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h View Scheme |
methyl 3-methoxy-2,4,5-trifluorobenzoate
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aq. NaOH / methanol 2.1: (COCl)2; DMF / CH2Cl2 3.1: MgCl2; Et3N / acetonitrile / 20 - 25 °C 3.2: Et3N / acetonitrile / 18 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 61 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature 2: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature 3: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h View Scheme |
2,4,5-trifluoro-3-methoxybenzoyl chloride
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine; magnesium chloride / ethyl acetate 2: hydrogenchloride; water View Scheme | |
Multi-step reaction with 2 steps 1.1: magnesium; tetrachloromethane / ethanol / 2.5 h / Reflux 1.2: 2 h 2.1: toluene-4-sulfonic acid / water / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: magnesium ethylate / toluene 2: toluene-4-sulfonic acid / water / 9 h View Scheme |
ethyl potassium malonate
2,4,5-trifluoro-3-methoxybenzoyl chloride
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Stage #1: ethyl potassium malonate With magnesium chloride In ethyl acetate at 20℃; for 0.5h; Inert atmosphere; Stage #2: With triethylamine In ethyl acetate at 20℃; for 0.5h; Inert atmosphere; Stage #3: 2,4,5-trifluoro-3-methoxybenzoyl chloride In ethyl acetate for 2h; Inert atmosphere; Reflux; | 21.3 g |
With triethylamine |
2,4,5-trifluoro-3-methoxy-benzamide
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / 3.5 h / 100 °C 2: thionyl chloride / 3 h 3: magnesium ethylate / toluene 4: toluene-4-sulfonic acid / water / 9 h View Scheme |
3-methoxy-2,4,5-trifluorobenzonitrile
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sulfuric acid; water / 1 h / 110 °C 2: sulfuric acid / 3.5 h / 100 °C 3: thionyl chloride / 3 h 4: magnesium ethylate / toluene 5: toluene-4-sulfonic acid / water / 9 h View Scheme |
1-bromo-2,4,5-trifluoro-3-methoxybenzene
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C 2: sulfuric acid; water / 1 h / 110 °C 3: sulfuric acid / 3.5 h / 100 °C 4: thionyl chloride / 3 h 5: magnesium ethylate / toluene 6: toluene-4-sulfonic acid / water / 9 h View Scheme |
orthoformic acid triethyl ester
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
ethyl (2Z)-3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
Conditions | Yield |
---|---|
With acetic anhydride at 120 - 150℃; for 1.5 - 3h; Product distribution / selectivity; | 100% |
With acetic anhydride for 4h; Heating; |
trifluoroethylamine
orthoformic acid triethyl ester
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: orthoformic acid triethyl ester; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With acetic anhydride for 2h; Heating / reflux; Stage #2: trifluoroethylamine In ethanol at 0 - 20℃; | 100% |
Stage #1: orthoformic acid triethyl ester; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With acetic anhydride for 2h; Heating / reflux; Stage #2: trifluoroethylamine In ethanol at 0 - 20℃; |
cyclopropyl isothiocyanate
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
methyl iodide
Conditions | Yield |
---|---|
Stage #1: cyclopropyl isothiocyanate; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 24h; | 92% |
N,N-dimethyl-formamide dimethyl acetal
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Stage #1: N,N-dimethyl-formamide dimethyl acetal; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate In benzene for 1h; Heating; Stage #2: anti-2-[2-fluoro-(4-methoxyphenyl)sulfinyl]ethylamine In toluene at 20℃; for 2h; | 89% |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
With triethylamine In toluene; acetonitrile at 25 - 50℃; for 76h; | 84% |
7-(S)-acetylamimo-5-azaspiro[2.4]heptane
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
ethyl 4-[7-(S)-acetylamimo-5-azaspiro[2.4]hept-5-yl]-2,5-difluoro-3-methoxybenzoylacetate
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 70℃; for 7h; | 76% |
Isobutyl iodide
cyclopropyl isothiocyanate
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Stage #1: cyclopropyl isothiocyanate; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With tetrabutylammomium bromide; potassium hydroxide In N,N-dimethyl-formamide Stage #2: Isobutyl iodide | 76% |
(7S)-5-azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
ethyl 4-[7-(S)-tert-butoxycarbonylamino-5-azaspiro[2.4]hept-5-yl]-2,5-difluoro-3-methoxybenzoylacetate
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 25 - 50℃; for 76h; | 74% |
cyclopropyl isothiocyanate
ethyl iodide
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Stage #1: cyclopropyl isothiocyanate; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With tetrabutylammomium bromide; potassium hydroxide In N,N-dimethyl-formamide Stage #2: ethyl iodide | 74% |
2-fluoroethylamine hydrochloride
triethyl <14C>orthoformate
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Stage #1: triethyl <14C>orthoformate; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With acetic anhydride; potassium carbonate for 1h; Reflux; Inert atmosphere; Stage #2: 2-fluoroethylamine hydrochloride With potassium carbonate In dimethyl sulfoxide at 47 - 78℃; for 4h; Inert atmosphere; Further stages; | 53% |
orthoformic acid triethyl ester
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
Conditions | Yield |
---|---|
With acetic anhydride for 22h; Heating; | |
With acetic anhydride | |
With acetic anhydride | |
With acetic anhydride for 8h; Reflux; |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-2-methylsulfanyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydride / dimethylformamide / 0 - 20 °C 1.2: 92 percent / dimethylformamide / 24 h / 20 °C 2.1: sodium hydride / dimethylformamide / 75 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium hydroxide; tetrabutylammomium bromide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 1.3: 3 h / Inert atmosphere 2.1: potassium tert-butylate / toluene / 16 h / Inert atmosphere; Reflux View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
ethyl 1-cyclopropyl-6,7-difluoro-2-methanesulfinyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydride / dimethylformamide / 0 - 20 °C 1.2: 92 percent / dimethylformamide / 24 h / 20 °C 2.1: sodium hydride / dimethylformamide / 75 °C 3.1: m-chloroperbenzoic acid / CH2Cl2 / 20 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
6,7-difluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Ac2O / 4 h / Heating 2: dimethylsulfoxide / 18 h / 20 °C 3: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Ac2O / 4 h / Heating 2: dimethylsulfoxide / 18 h / 20 °C 3: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Ac2O / 4 h / Heating 2: dimethylsulfoxide / 18 h / 20 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Ac2O / 4 h / Heating 2: dimethylsulfoxide / 18 h / 20 °C 3: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C 5: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Ac2O / 4 h / Heating 2.1: dimethylsulfoxide / 18 h / 20 °C 3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C 5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating 6.1: NaHCO3 / acetonitrile / 12 h / 65 °C 6.2: 49 percent / Et3N / ethanol / 3 h / 65 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Ac2O / 4 h / Heating 2.1: dimethylsulfoxide / 18 h / 20 °C 3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C 5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating 6.1: NaHCO3 / acetonitrile / 12 h / 65 °C 6.2: 35 percent / Et3N / ethanol / 3 h / 65 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Ac2O / 4 h / Heating 2.1: dimethylsulfoxide / 18 h / 20 °C 3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C 5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating 6.1: NaHCO3 / acetonitrile / 12 h / 65 °C 6.2: Et3N / ethanol / 3 h / 65 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Ac2O / 4 h / Heating 2.1: dimethylsulfoxide / 18 h / 20 °C 3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C 5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating 6.1: NaHCO3 / acetonitrile / 12 h / 65 °C 6.2: 41 percent / Et3N / ethanol / 3 h / 65 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: Ac2O / 4 h / Heating 2.1: dimethylsulfoxide / 18 h / 20 °C 3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C 5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating 6.1: NaHCO3 / acetonitrile / 12 h / 65 °C 6.2: Et3N / ethanol / 3 h / 65 °C 7.1: aq. HCl / tetrahydrofuran; dioxane / 12 h / 20 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Ac2O / 4 h / Heating 2.1: dimethylsulfoxide / 18 h / 20 °C 3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C 5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating 6.1: NaHCO3 / acetonitrile / 12 h / 65 °C 6.2: Et3N / ethanol / 3 h / 65 °C View Scheme |
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Ac2O / 4 h / Heating 2.1: dimethylsulfoxide / 18 h / 20 °C 3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C 4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C 5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating 6.1: NaHCO3 / acetonitrile / 12 h / 65 °C 6.2: Et3N / ethanol / 3 h / 65 °C View Scheme |
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