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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Cas:112811-68-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXYPHENYL)PROPIONIC ACID ETHYL ESTER

Cas:112811-68-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER CAS 112811-68-4

Cas:112811-68-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER CAS:112811-68-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical interm

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER CAS:112811-68-4

Cas:112811-68-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenepropanoic acid,2,4,5-trifluoro-3-methoxy-b-oxo-, ethyl ester

Cas:112811-68-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenepropanoic acid,2,4,5-trifluoro-3-methoxy-b-oxo-, ethyl ester

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL 3-METHOXY-2,4,5-TRIFLUOROBENZOYLACETATE;ETHYL-2,4,5-TRIFLUORO-3-METHOXYBENZOYLACETATE

Cas:112811-68-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzenepropanoic acid,2,4,5-trifluoro-3-methoxy-b-oxo-, ethyl ester

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Oxo-3-(2,4,5-trifluoro-3-Methoxy-phenyl)-propionic acid ethyl ester

Cas:112811-68-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)acetate

Cas:112811-68-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: 3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER Synonyms: Moxifloxacin Impurity 96;3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER;ETHYL 3-(2,4,5-TRIFLUORO-3-METHOXYPHENYL)-3-OXOPROPANOATE;

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER 112811-68-4

Cas:112811-68-4

Min.Order:1 Kilogram

FOB Price: $240.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Cas:112811-68-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-Oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propionic acid ethyl ester

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

112811-68-4

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Ethyl 3-Methoxy-2,4,5-Trifluorobenzoylacetate cas no. 112811-68-4 98%

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

3-Oxo-3(2,4,5-trifluoro-3-Methoxy phenyl) propionic acid ethyl ester

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzenepropanoic acid,2,4,5-trifluoro-3-Methoxy-b-oxo-, ethyl ester

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTERAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by expre

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

112811-68-4 Application:intermediate

Benzenepropanoic acid, 2,4,5-trifluoro-3-methoxy-b-oxo-, ethyl ester

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-Oxo-3-(2,4,5-trifluoro-3-methoxy-phenyl)-propionic acid ethyl ester

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Oxo-3-(2,4,5-trifluoro-3-methoxy-phenyl)-propionic acid ethyl ester

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

3-Oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propionic acid ethyl ester 112811-68-4

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

Ethyl 3-oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propanoate

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Other

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

3-oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propanoic acid ethyl ester

Cas:112811-68-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Yinghao Pharm Co.,Ltd.

Yinghao Pharm products include: leader molecule, heterocyclic compounds,chiral compounds, photoelectric materials, biochemical reagents etc. For example:benzene, pyrimidine, boricacid,pyridine, pyrazole, imidazole, pyrrole, fluorine and other derivat

Ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

3-OXO-3-(2,4,5-TRIFLUORO-3-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Cas:112811-68-4

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

diethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate
112811-67-3

diethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
With water; toluene-4-sulfonic acid for 16h; Heating / reflux;89%
With hydrogenchloride; water
With toluene-4-sulfonic acid In water for 3h; Reflux;17.3 g
With toluene-4-sulfonic acid In water for 9h;
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

2,4,5-trifluoro-3-methoxybenzoyl chloride
112811-66-2

2,4,5-trifluoro-3-methoxybenzoyl chloride

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
With [2,2]bipyridinyl; n-butyllithium 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h; Yield given. Multistep reaction;
Stage #1: 2,4,5-trifluoro-3-methoxybenzoyl chloride With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: hydrogen ethyl malonate In tetrahydrofuran; hexane; dichloromethane at -78 - 10℃;
Stage #1: hydrogen ethyl malonate With n-butyllithium In tetrahydrofuran at -50 - 0℃;
Stage #2: 2,4,5-trifluoro-3-methoxybenzoyl chloride In tetrahydrofuran at -50 - 20℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water
diethylmalonate potassium salt

diethylmalonate potassium salt

2,4,5-trifluoro-3-methoxybenzoyl chloride
112811-66-2

2,4,5-trifluoro-3-methoxybenzoyl chloride

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Stage #1: diethylmalonate potassium salt With triethylamine; magnesium chloride In acetonitrile at 20 - 25℃;
Stage #2: 2,4,5-trifluoro-3-methoxybenzoyl chloride With triethylamine In acetonitrile at 20℃; for 18h;
3-methoxy-2,4,5-trifluorobenzoic acid
112811-65-1

3-methoxy-2,4,5-trifluorobenzoic acid

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
2.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
2.2: hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C
View Scheme
Multi-step reaction with 2 steps
1.1: (COCl)2; DMF / CH2Cl2
2.1: MgCl2; Et3N / acetonitrile / 20 - 25 °C
2.2: Et3N / acetonitrile / 18 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
2: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
View Scheme
methyl 3-methoxy-2,4,5-trifluorobenzoate
136897-64-8

methyl 3-methoxy-2,4,5-trifluorobenzoate

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aq. NaOH / methanol
2.1: (COCl)2; DMF / CH2Cl2
3.1: MgCl2; Et3N / acetonitrile / 20 - 25 °C
3.2: Et3N / acetonitrile / 18 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 61 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature
2: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature
3: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h
View Scheme
2,4,5-trifluoro-3-methoxybenzoyl chloride
112811-66-2

2,4,5-trifluoro-3-methoxybenzoyl chloride

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; magnesium chloride / ethyl acetate
2: hydrogenchloride; water
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium; tetrachloromethane / ethanol / 2.5 h / Reflux
1.2: 2 h
2.1: toluene-4-sulfonic acid / water / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: magnesium ethylate / toluene
2: toluene-4-sulfonic acid / water / 9 h
View Scheme
ethyl potassium malonate
6148-64-7

ethyl potassium malonate

2,4,5-trifluoro-3-methoxybenzoyl chloride
112811-66-2

2,4,5-trifluoro-3-methoxybenzoyl chloride

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Stage #1: ethyl potassium malonate With magnesium chloride In ethyl acetate at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With triethylamine In ethyl acetate at 20℃; for 0.5h; Inert atmosphere;
Stage #3: 2,4,5-trifluoro-3-methoxybenzoyl chloride In ethyl acetate for 2h; Inert atmosphere; Reflux;
21.3 g
With triethylamine
2,4,5-trifluoro-3-methoxy-benzamide
112811-64-0

2,4,5-trifluoro-3-methoxy-benzamide

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid / 3.5 h / 100 °C
2: thionyl chloride / 3 h
3: magnesium ethylate / toluene
4: toluene-4-sulfonic acid / water / 9 h
View Scheme
3-methoxy-2,4,5-trifluorobenzonitrile
112811-63-9

3-methoxy-2,4,5-trifluorobenzonitrile

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sulfuric acid; water / 1 h / 110 °C
2: sulfuric acid / 3.5 h / 100 °C
3: thionyl chloride / 3 h
4: magnesium ethylate / toluene
5: toluene-4-sulfonic acid / water / 9 h
View Scheme
1-bromo-2,4,5-trifluoro-3-methoxybenzene
13332-24-6

1-bromo-2,4,5-trifluoro-3-methoxybenzene

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C
2: sulfuric acid; water / 1 h / 110 °C
3: sulfuric acid / 3.5 h / 100 °C
4: thionyl chloride / 3 h
5: magnesium ethylate / toluene
6: toluene-4-sulfonic acid / water / 9 h
View Scheme
orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

ethyl (2Z)-3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
866954-86-1

ethyl (2Z)-3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

Conditions
ConditionsYield
With acetic anhydride at 120 - 150℃; for 1.5 - 3h; Product distribution / selectivity;100%
With acetic anhydride for 4h; Heating;
trifluoroethylamine
753-90-2

trifluoroethylamine

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester
874482-36-7

3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

Conditions
ConditionsYield
Stage #1: orthoformic acid triethyl ester; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With acetic anhydride for 2h; Heating / reflux;
Stage #2: trifluoroethylamine In ethanol at 0 - 20℃;
100%
Stage #1: orthoformic acid triethyl ester; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With acetic anhydride for 2h; Heating / reflux;
Stage #2: trifluoroethylamine In ethanol at 0 - 20℃;
cyclopropyl isothiocyanate
56601-42-4

cyclopropyl isothiocyanate

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

methyl iodide
74-88-4

methyl iodide

ethyl 3-cyclopropylamino-3-methylsulfanyl-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

ethyl 3-cyclopropylamino-3-methylsulfanyl-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

Conditions
ConditionsYield
Stage #1: cyclopropyl isothiocyanate; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 24h;
92%
anti-2-[2-fluoro-(4-methoxyphenyl)sulfinyl]ethylamine

anti-2-[2-fluoro-(4-methoxyphenyl)sulfinyl]ethylamine

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

(Z)-3-[(R)-2-Fluoro-2-((R)-4-methoxy-benzenesulfinyl)-ethylamino]-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

(Z)-3-[(R)-2-Fluoro-2-((R)-4-methoxy-benzenesulfinyl)-ethylamino]-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide dimethyl acetal; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate In benzene for 1h; Heating;
Stage #2: anti-2-[2-fluoro-(4-methoxyphenyl)sulfinyl]ethylamine In toluene at 20℃; for 2h;
89%
(4aS,7aS)-tert-butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

(4aS,7aS)-tert-butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

(4aS,7aS)-tert-butyl 6-(4-(3-ethoxypropanol)-3,6-difluoro-2-methoxyphenyl)octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

(4aS,7aS)-tert-butyl 6-(4-(3-ethoxypropanol)-3,6-difluoro-2-methoxyphenyl)octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In toluene; acetonitrile at 25 - 50℃; for 76h;84%
7-(S)-acetylamimo-5-azaspiro[2.4]heptane
627532-46-1

7-(S)-acetylamimo-5-azaspiro[2.4]heptane

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

ethyl 4-[7-(S)-acetylamimo-5-azaspiro[2.4]hept-5-yl]-2,5-difluoro-3-methoxybenzoylacetate
627532-48-3

ethyl 4-[7-(S)-acetylamimo-5-azaspiro[2.4]hept-5-yl]-2,5-difluoro-3-methoxybenzoylacetate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 70℃; for 7h;76%
Isobutyl iodide
513-38-2

Isobutyl iodide

cyclopropyl isothiocyanate
56601-42-4

cyclopropyl isothiocyanate

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

C19H24F3NO4S

C19H24F3NO4S

Conditions
ConditionsYield
Stage #1: cyclopropyl isothiocyanate; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With tetrabutylammomium bromide; potassium hydroxide In N,N-dimethyl-formamide
Stage #2: Isobutyl iodide
76%
(7S)-5-azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester
127199-45-5

(7S)-5-azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

ethyl 4-[7-(S)-tert-butoxycarbonylamino-5-azaspiro[2.4]hept-5-yl]-2,5-difluoro-3-methoxybenzoylacetate
627532-31-4

ethyl 4-[7-(S)-tert-butoxycarbonylamino-5-azaspiro[2.4]hept-5-yl]-2,5-difluoro-3-methoxybenzoylacetate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 25 - 50℃; for 76h;74%
cyclopropyl isothiocyanate
56601-42-4

cyclopropyl isothiocyanate

ethyl iodide
75-03-6

ethyl iodide

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

C18H22F3NO4S

C18H22F3NO4S

Conditions
ConditionsYield
Stage #1: cyclopropyl isothiocyanate; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With tetrabutylammomium bromide; potassium hydroxide In N,N-dimethyl-formamide
Stage #2: ethyl iodide
74%
2-fluoroethylamine hydrochloride
460-08-2

2-fluoroethylamine hydrochloride

triethyl <14C>orthoformate
108055-42-1

triethyl <14C>orthoformate

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

6,7-difluoro-1-(2-fluoroethyl)-8-methoxy-1,4-dihydro-4-oxo[2-14 C1]quinoline-3-carboxylic acid ethyl ester

6,7-difluoro-1-(2-fluoroethyl)-8-methoxy-1,4-dihydro-4-oxo[2-14 C1]quinoline-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: triethyl <14C>orthoformate; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With acetic anhydride; potassium carbonate for 1h; Reflux; Inert atmosphere;
Stage #2: 2-fluoroethylamine hydrochloride With potassium carbonate In dimethyl sulfoxide at 47 - 78℃; for 4h; Inert atmosphere; Further stages;
53%
orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
122375-85-3

ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

Conditions
ConditionsYield
With acetic anhydride for 22h; Heating;
With acetic anhydride
With acetic anhydride
With acetic anhydride for 8h; Reflux;
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-2-methylsulfanyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
922492-57-7

ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-2-methylsulfanyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / dimethylformamide / 0 - 20 °C
1.2: 92 percent / dimethylformamide / 24 h / 20 °C
2.1: sodium hydride / dimethylformamide / 75 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium hydroxide; tetrabutylammomium bromide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
1.3: 3 h / Inert atmosphere
2.1: potassium tert-butylate / toluene / 16 h / Inert atmosphere; Reflux
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

ethyl 1-cyclopropyl-6,7-difluoro-2-methanesulfinyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
922492-58-8

ethyl 1-cyclopropyl-6,7-difluoro-2-methanesulfinyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / dimethylformamide / 0 - 20 °C
1.2: 92 percent / dimethylformamide / 24 h / 20 °C
2.1: sodium hydride / dimethylformamide / 75 °C
3.1: m-chloroperbenzoic acid / CH2Cl2 / 20 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

6,7-difluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
767307-41-5

6,7-difluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Ac2O / 4 h / Heating
2: dimethylsulfoxide / 18 h / 20 °C
3: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

1-(4-acetoxy-phenyl)-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

1-(4-acetoxy-phenyl)-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Ac2O / 4 h / Heating
2: dimethylsulfoxide / 18 h / 20 °C
3: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

(Z)-3-(4-Hydroxy-phenylamino)-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

(Z)-3-(4-Hydroxy-phenylamino)-2-(2,4,5-trifluoro-3-methoxy-benzoyl)-acrylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Ac2O / 4 h / Heating
2: dimethylsulfoxide / 18 h / 20 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

C19H12BF4NO5

C19H12BF4NO5

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Ac2O / 4 h / Heating
2: dimethylsulfoxide / 18 h / 20 °C
3: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
5: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid

6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Ac2O / 4 h / Heating
2.1: dimethylsulfoxide / 18 h / 20 °C
3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating
6.1: NaHCO3 / acetonitrile / 12 h / 65 °C
6.2: 49 percent / Et3N / ethanol / 3 h / 65 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Ac2O / 4 h / Heating
2.1: dimethylsulfoxide / 18 h / 20 °C
3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating
6.1: NaHCO3 / acetonitrile / 12 h / 65 °C
6.2: 35 percent / Et3N / ethanol / 3 h / 65 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-7-(1-methyl-hexahydro-pyrrolo[3,4-b]pyrrol-5-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-7-(1-methyl-hexahydro-pyrrolo[3,4-b]pyrrol-5-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Ac2O / 4 h / Heating
2.1: dimethylsulfoxide / 18 h / 20 °C
3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating
6.1: NaHCO3 / acetonitrile / 12 h / 65 °C
6.2: Et3N / ethanol / 3 h / 65 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

7-((3R,5S)-3,5-Dimethyl-piperazin-1-yl)-6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-((3R,5S)-3,5-Dimethyl-piperazin-1-yl)-6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Ac2O / 4 h / Heating
2.1: dimethylsulfoxide / 18 h / 20 °C
3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating
6.1: NaHCO3 / acetonitrile / 12 h / 65 °C
6.2: 41 percent / Et3N / ethanol / 3 h / 65 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

7-((1R,5S,6S)-6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-((1R,5S,6S)-6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: Ac2O / 4 h / Heating
2.1: dimethylsulfoxide / 18 h / 20 °C
3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating
6.1: NaHCO3 / acetonitrile / 12 h / 65 °C
6.2: Et3N / ethanol / 3 h / 65 °C
7.1: aq. HCl / tetrahydrofuran; dioxane / 12 h / 20 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

7-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Ac2O / 4 h / Heating
2.1: dimethylsulfoxide / 18 h / 20 °C
3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating
6.1: NaHCO3 / acetonitrile / 12 h / 65 °C
6.2: Et3N / ethanol / 3 h / 65 °C
View Scheme
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

7-[3-(tert-butoxycarbonylamino-methyl)-pyrrolidin-1-yl]-6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-[3-(tert-butoxycarbonylamino-methyl)-pyrrolidin-1-yl]-6-fluoro-1-(4-hydroxy-phenyl)-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Ac2O / 4 h / Heating
2.1: dimethylsulfoxide / 18 h / 20 °C
3.1: K2CO3 / dimethylsulfoxide / 1.17 h / 95 °C
4.1: 75 percent / Et3N / acetone; ethyl acetate / 12 h / 20 °C
5.1: 78 percent / BF3*OEt2 / tetrahydrofuran / 12 h / Heating
6.1: NaHCO3 / acetonitrile / 12 h / 65 °C
6.2: Et3N / ethanol / 3 h / 65 °C
View Scheme

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