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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Mono-Ethyl Malonate supplier in China

Cas:1071-46-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Malonic acid monoethyl ester

Cas:1071-46-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

Ethyl hydrogen malonate manufacturer

Cas:1071-46-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Ality Chemical Corporation

3-Hydroxy-2-naphthoic acid Basic information Product Name: 3-Hydroxy-2-naphthoic acid Synonyms: 3-hydroxy-2-naphthoicaci;3-Hydroxy-beta-naphthoic acid;developer8;developerbon;Kyselina 3-hydroxy-2-naftoova;kyselina3-hydroxy-2-naftoova;Miketazol Deve

Factory Supply 2,3 Acid

Cas:1071-46-1

Min.Order:1 Gram

Negotiable

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 1071-46-1 with best price

Cas:1071-46-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Pale yellow liquid Storage:room temperature Package:200kg/drum Application:Ethyl Hydrogen Malonate has been shown to impair brain mitochondrial succinate and malate transport. It is also found in the extract of Hericum erinaceus mushroom

Ethyl hydrogen malonate with high quality

Cas:1071-46-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethyl hydrogen malonate 1071-46-1

Cas:1071-46-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl Hydrogen Malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Manufacturers

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Monoethyl malonic acid

Cas:1071-46-1

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Product Name:Ethyl hydrogen malonateSynonyms:ETHYL HYDROGEN MALONATE;MONOETHYL MALONATE;3-ethoxy-3-oxapropanoic acid;Monoethyl malonic acid;3-ethoxy-3-oxo-propanoic acid;Ethyl hydrogen malonate, 90+%;Ethoxycarbonylacetic acid;Malonic acid 1

TIANFUCHEM--1071-46-1---Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Ethyl Hydrogen Malonate CAS No.: 1071-46-1 Molecule Formula:C5H8O4 Molecule Weight:132.11 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING IT

Lower Price Ethyl Hydrogen Malonate

Cas:1071-46-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Ethylhydrogenmalonate

Cas:1071-46-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Ethyl hydrogen malonate Synonyms: ETHYL HYDROGEN MALONATE;MONOETHYL MALONATE;3-ethoxy-3-oxapropanoic acid;Monoethyl malonic acid;3-ethoxy-3-oxo-propanoic acid;Ethyl hydrogen malonate, 90+%;Ethoxycarbonylacetic acid;Malonic acid 1

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Ethyl Hydrogen Malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Ethoxy-3-oxopropanoic acid cas no. 1071-46-1 98%

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Other

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

High Purity Mono-Ethyl Malonate 1071-46-1

Cas:1071-46-1

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Malonic acid monoethyl ester

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 3-Ethoxy-3-oxopropanoic acid 500g

Cas:1071-46-1

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Ethyl hydrogen malonate, 96%

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Mono-Ethyl Malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Ethyl hydrogen malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Ethyl hydrogen Malonate

Cas:1071-46-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl potassium malonate
6148-64-7

ethyl potassium malonate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With hydrogenchloride In water at 5℃; for 1h;100%
With hydrogenchloride In water at 0℃; for 0.666667h;99%
With hydrogenchloride In water Inert atmosphere; Cooling with ice;91%
diethyl malonate
105-53-3

diethyl malonate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 25℃; for 1h;94%
With potassium hydroxide In tetrahydrofuran at 0℃; for 1h;90%
Stage #1: diethyl malonate With potassium hydroxide; water In tetrahydrofuran at 0℃; for 1h;
Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0℃; Product distribution / selectivity;
90%
ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With potassium phosphate buffer; nitrilase from Alcaligenes faecalis ATCC8750 at 30℃; for 7h; pH=7.3;94%
With benzene-1,2-dicarboxylic acid at 250℃; under 7600 Torr; for 0.25h; microwave irradiation;53%
With benzene-1,2-dicarboxylic acid at 240℃; under 3040 Torr; for 1h;10%
With copper(II) sulfate at 240℃; for 1h;9%
ethanol
64-17-5

ethanol

malonic acid
141-82-2

malonic acid

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With boric acid Heating;80%
With sulfuric acid
With sulfuric acid In acetone for 168h;
With boric acid for 18h; Reflux;
at 80℃;
diethyl malonate
105-53-3

diethyl malonate

A

malonic acid
141-82-2

malonic acid

B

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
Stage #1: diethyl malonate With water; potassium hydroxide In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: In tetrahydrofuran; water Acidic conditions;
A 8.3%
B 76.9%
Stage #1: diethyl malonate With water; potassium hydroxide at 0℃; for 6h;
Stage #2: Acidic aq. solution;
A 36.6%
B 35.6%
malonic acid
141-82-2

malonic acid

ethyl acetate
141-78-6

ethyl acetate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With iron(III) perchlorate for 2h; Ambient temperature;76%
ethyl malonamate
7597-56-0

ethyl malonamate

A

acetamide
60-35-5

acetamide

B

malonic acid
141-82-2

malonic acid

C

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

D

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
With phthalic anhydride at 240 - 250℃; under 3040 Torr; for 1h; Hydrolysis;A n/a
B n/a
C 53%
D n/a
carbon monoxide
201230-82-2

carbon monoxide

ethyl iodoacetae
623-48-3

ethyl iodoacetae

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With dmap; bis-triphenylphosphine-palladium(II) chloride; pyrrole; triethylamine In water; toluene UV-irradiation; Autoclave;52%
malonic acid ethyl ester 2-thioxo-2H-pyridin-1-yl ester

malonic acid ethyl ester 2-thioxo-2H-pyridin-1-yl ester

A

(Ethoxycarbonyl)methyl 2-pyridyl sulfide
28856-92-0

(Ethoxycarbonyl)methyl 2-pyridyl sulfide

B

2,2'-dipyridyldisulphide
2127-03-9

2,2'-dipyridyldisulphide

C

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
In benzene photolysis; Irradiation;A 48%
B 3%
C 17%
carbon dioxide
124-38-9

carbon dioxide

ethyl bromoacetate
105-36-2

ethyl bromoacetate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With tetraethylammonium chloride; silver; magnesium In acetonitrile at 0℃; under 760.051 Torr; Electrolysis;38%
ethyl acetate
141-78-6

ethyl acetate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With diethyl ether; ammonia; sodium amide nachfolgendes Behandeln mit festem CO2;
With triphenylmethyl sodium at 0℃; nachfolgendes Behandeln mit festem CO2;
ethanol
64-17-5

ethanol

S,S'-diethyl dithiomalonate
16501-24-9

S,S'-diethyl dithiomalonate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With potassium hydroxide Heating;
ethyl (ethylthio)carbonylacetate
16694-80-7

ethyl (ethylthio)carbonylacetate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With potassium hydroxide In ethanol Heating;
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

acetic acid
64-19-7

acetic acid

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
(i) LDA, (ii) /BRN= 385653/; Multistep reaction;
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

ethanol
64-17-5

ethanol

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
for 24h; Heating;
In toluene for 2h; Heating; Yield given;
In toluene for 5h; Heating;
diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

A

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

B

2-Eth-(Z)-ylidene-malonic acid monoethyl ester

2-Eth-(Z)-ylidene-malonic acid monoethyl ester

C

2-Eth-(E)-ylidene-malonic acid monoethyl ester

2-Eth-(E)-ylidene-malonic acid monoethyl ester

Conditions
ConditionsYield
With water pH 8;
tert-Butyl ethyl malonate
32864-38-3

tert-Butyl ethyl malonate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With bromocatecholborane In dichloromethane for 18h; Ambient temperature; Yield given;
carbon dioxide
124-38-9

carbon dioxide

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
In tetrahydrofuran at 5℃; electrochemical oxidation;
carbon dioxide
124-38-9

carbon dioxide

ethyl acetate
141-78-6

ethyl acetate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
Reaktion des Natriumenolats;
potassium salt of monoethyl ester

potassium salt of monoethyl ester

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With hydrogenchloride
3,4-dibromo-2-oxo-but-3-ene-1,1,4-tricarboxylic acid-1,1-diethyl ester

3,4-dibromo-2-oxo-but-3-ene-1,1,4-tricarboxylic acid-1,1-diethyl ester

alkali, aqueous

alkali, aqueous

A

dibromomaleic acid
608-37-7

dibromomaleic acid

B

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
Erwaermen;
oxo-ethane-1,1,2-tricarboxylic acid triethyl ester
861351-52-2

oxo-ethane-1,1,2-tricarboxylic acid triethyl ester

water
7732-18-5

water

hydrochloric acid , concentrated

hydrochloric acid , concentrated

A

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

B

oxalic acid
144-62-7

oxalic acid

oxo-ethane-1,1,2-tricarboxylic acid triethyl ester
861351-52-2

oxo-ethane-1,1,2-tricarboxylic acid triethyl ester

water
7732-18-5

water

sulfuric acid , aqueous

sulfuric acid , aqueous

A

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

B

oxalic acid
144-62-7

oxalic acid

Conditions
ConditionsYield
Erhitzen;
diethyl malonate
105-53-3

diethyl malonate

Me3SiCH2C(Me)=CH(CH2)2CH(Me)-X

Me3SiCH2C(Me)=CH(CH2)2CH(Me)-X

A

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

B

Na2S2O8

Na2S2O8

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / KOH / ethanol / 1 h / Heating
2: 100 percent / HCl / H2O / 1 h / 5 °C
View Scheme
diethyl malonate
105-53-3

diethyl malonate

PhCOCH2-X

PhCOCH2-X

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 50 percent / KOH / ethanol
2: 55 percent / conc. HCl / H2O
View Scheme
ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl-<3-bromo propionate>

ethyl-<3-bromo propionate>

A

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

B

sodium hydroxide

sodium hydroxide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) HCl, benzene, (ii) H2O
2: KOH / ethanol / Heating
View Scheme
sodium monoethyl malonate
43167-10-8

sodium monoethyl malonate

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
With hydrogenchloride; water pH=3;52.2 g
2,4-oxetanedione
15159-48-5

2,4-oxetanedione

ethanol
64-17-5

ethanol

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

Conditions
ConditionsYield
at -65℃;
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

phenylacetyl chloride
103-80-0

phenylacetyl chloride

ethyl 3-oxo-4-phenylbutyrate
718-08-1

ethyl 3-oxo-4-phenylbutyrate

Conditions
ConditionsYield
Stage #1: hydrogen ethyl malonate With n-butyllithium In tetrahydrofuran; hexane at -78 - -10℃;
Stage #2: phenylacetyl chloride In tetrahydrofuran; hexane at -78℃; for 0.166667h; Further stages.;
100%
With [2,2]bipyridinyl; n-butyllithium In tetrahydrofuran; hexane at -65℃; for 0.0833333h;85%
75%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-Butyl ethyl malonate
32864-38-3

tert-Butyl ethyl malonate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 0.25h;100%
With dicyclohexyl-carbodiimide In acetonitrile for 2h;66%
With diphenyl phosphoryl azide; triethylamine
With 2-chloro-1-methyl-pyridinium iodide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h;
With dicyclohexyl-carbodiimide In acetonitrile at 25℃; for 1h;
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

2,4,5-trifluorobenzoyl chloride
88419-56-1

2,4,5-trifluorobenzoyl chloride

ethyl 2,4,5-trifluorobenzoylacetate
98349-24-7

ethyl 2,4,5-trifluorobenzoylacetate

Conditions
ConditionsYield
Stage #1: hydrogen ethyl malonate With n-butyllithium; triphenylmethane In tetrahydrofuran Metallation;
Stage #2: 2,4,5-trifluorobenzoyl chloride In tetrahydrofuran at 20℃; for 1h; Acetylation;
100%
Stage #1: hydrogen ethyl malonate With n-butyllithium In tetrahydrofuran at -75 - -5℃; for 0.0333333h;
Stage #2: 2,4,5-trifluorobenzoyl chloride In tetrahydrofuran at -75 - 20℃;
Stage #3: With hydrogenchloride; water In tetrahydrofuran; ethyl acetate
89%
With n-butyllithium; biquinoline 1.) THF, -30 deg C to - 5 deg C, 2.) -50 deg C, 0.5 h; Yield given. Multistep reaction;
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

magnesium bis(3-ethoxy-3-oxopropanoate)
37517-78-5

magnesium bis(3-ethoxy-3-oxopropanoate)

Conditions
ConditionsYield
With magnesium(II) chloride hexahydrate; potassium hydroxide In water Cooling with ice;100%
With magnesium In tetrahydrofuran for 4h; Heating / reflux;
With magnesium ethylate In tetrahydrofuran at 20℃; for 2.5h;
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

(2R)-tetrahydrofuran-2-carboxylic acid chloride
148151-47-7

(2R)-tetrahydrofuran-2-carboxylic acid chloride

ethyl 3-oxo-3-[(2R)-tetrahydrofuran-2-yl]propanoate
1161825-32-6

ethyl 3-oxo-3-[(2R)-tetrahydrofuran-2-yl]propanoate

Conditions
ConditionsYield
Stage #1: hydrogen ethyl malonate With n-butyllithium In tetrahydrofuran; hexanes at -78 - -5℃;
Stage #2: (2R)-tetrahydrofuran-2-carboxylic acid chloride In tetrahydrofuran; hexanes at -65℃; for 1h;
100%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

(2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate
1227685-20-2

(2S,4R)-1-benzyl 4-methyl 4-amino-2-methylpiperidine-1,4-dicarboxylate

1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)amino]-2-methylpiperidine-1,4-dicarboxylate

1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)amino]-2-methylpiperidine-1,4-dicarboxylate

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;100%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

m-formylphenyl benzoic acid
619-21-6

m-formylphenyl benzoic acid

(E)-3-(3-ethoxy-3-oxoprop-1-en-1-yl)benzoic acid
91047-79-9

(E)-3-(3-ethoxy-3-oxoprop-1-en-1-yl)benzoic acid

Conditions
ConditionsYield
With piperidine In pyridine at 100℃; for 18h; Inert atmosphere;100%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

C20H32N2
1616724-87-8

C20H32N2

C25H38N2O3
1616724-88-9

C25H38N2O3

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0.25℃; for 12h;100%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ethyl 2-((cyclopropylmethyl)amino)benzoate

ethyl 2-((cyclopropylmethyl)amino)benzoate

ethyl 2-(N-(cyclopropylmethyl)-3-ethoxy-3-oxopropanamido)benzoate

ethyl 2-(N-(cyclopropylmethyl)-3-ethoxy-3-oxopropanamido)benzoate

Conditions
ConditionsYield
With pyridine; trichlorophosphate In acetonitrile at 0 - 5℃; for 2h;100%
piperonal
120-57-0

piperonal

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate
24393-66-6

ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate

Conditions
ConditionsYield
With poly{styrene-co-[4-(N-methyl-N-vinylbenzyl-amino)pyridine]-co-[1-phenyl-3-(4-vinylbenzyl)piperazine]} In N,N-dimethyl-formamide at 50℃; decarboxylative Doebner-Knoevenagel condensation reaction; optical yield given as %de; stereoselective reaction;99%
With piperidine; pyridine
With piperidine; pyridine at 70℃; for 9h;
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

(E)-4-(4-Isopropoxy-phenyl)-but-3-en-2-one
70685-50-6

(E)-4-(4-Isopropoxy-phenyl)-but-3-en-2-one

3-Hydroxy-5-(4-isopropoxy-phenyl)-cyclohex-2-enone
111973-93-4

3-Hydroxy-5-(4-isopropoxy-phenyl)-cyclohex-2-enone

Conditions
ConditionsYield
With sodium methylate In methanol99%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

isobutyryl chloride
79-30-1

isobutyryl chloride

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran99%
Stage #1: hydrogen ethyl malonate With [2,2]bipyridinyl; n-butyllithium In tetrahydrofuran; hexane at -70 - -10℃; Inert atmosphere;
Stage #2: isobutyryl chloride In tetrahydrofuran; hexane at -65℃; for 0.166667h; Inert atmosphere;
80%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate
24393-56-4

ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 25℃; Doebner-Knoevenagel reaction;99%
With dmap In N,N-dimethyl-formamide at 25℃; Knoevenagel reaction;99%
piperidine; dmap In N,N-dimethyl-formamide at 10 - 20℃; for 24h; Product distribution / selectivity;99%
With poly{styrene-co-[4-(N-methyl-N-vinylbenzyl-amino)pyridine]-co-[1-phenyl-3-(4-vinylbenzyl)piperazine]} In N,N-dimethyl-formamide at 50℃; decarboxylative Doebner-Knoevenagel condensation reaction; optical yield given as %de;97%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ethyl (E)-3-(thiophen-2-yl)acrylate
13979-15-2

ethyl (E)-3-(thiophen-2-yl)acrylate

Conditions
ConditionsYield
With poly{styrene-co-[4-(N-methyl-N-vinylbenzyl-amino)pyridine]-co-[1-phenyl-3-(4-vinylbenzyl)piperazine]} In N,N-dimethyl-formamide at 50℃; decarboxylative Doebner-Knoevenagel condensation reaction; optical yield given as %de; stereoselective reaction;99%
With dmap
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

glycine ethyl ester hydrochloride
623-33-6

glycine ethyl ester hydrochloride

ethyl 3-((2-ethoxy-2-oxoethyl)amino)-3-oxopropanoate
51925-56-5

ethyl 3-((2-ethoxy-2-oxoethyl)amino)-3-oxopropanoate

Conditions
ConditionsYield
With dmap; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 6.5h; Inert atmosphere;99%
Stage #1: hydrogen ethyl malonate; glycine ethyl ester hydrochloride With dmap; triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 7h;
79%
With dicyclohexyl-carbodiimide; trimethylamine In dichloromethane at 0 - 20℃; for 4.5h;78%
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 20℃;70%
3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ethyl (E)-3-(pyridin-3-yl)acrylate
59607-99-7, 28447-17-8

ethyl (E)-3-(pyridin-3-yl)acrylate

Conditions
ConditionsYield
With poly{styrene-co-[4-(N-methyl-N-vinylbenzyl-amino)pyridine]-co-[1-phenyl-3-(4-vinylbenzyl)piperazine]} In N,N-dimethyl-formamide at 50℃; decarboxylative Doebner-Knoevenagel condensation reaction; optical yield given as %de; stereoselective reaction;99%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

ethyl (E)-3-(4-bromophenyl)-2-propenoate
24393-53-1, 136265-11-7, 15795-20-7

ethyl (E)-3-(4-bromophenyl)-2-propenoate

Conditions
ConditionsYield
With poly{styrene-co-[4-(N-methyl-N-vinylbenzyl-amino)pyridine]-co-[1-phenyl-3-(4-vinylbenzyl)piperazine]} In N,N-dimethyl-formamide at 50℃; decarboxylative Doebner-Knoevenagel condensation reaction; optical yield given as %de; stereoselective reaction;99%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ortho-anisaldehyde
135-02-4

ortho-anisaldehyde

ethyl 3-(2-methoxyphenyl)prop-2-enoate
24393-54-2

ethyl 3-(2-methoxyphenyl)prop-2-enoate

Conditions
ConditionsYield
With poly{styrene-co-[4-(N-methyl-N-vinylbenzyl-amino)pyridine]-co-[1-phenyl-3-(4-vinylbenzyl)piperazine]} In N,N-dimethyl-formamide at 50℃; decarboxylative Doebner-Knoevenagel condensation reaction; optical yield given as %de; stereoselective reaction;99%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

N-methylaniline
100-61-8

N-methylaniline

ethyl 3-(N-methyl-N-phenylamino)-3-oxopropionate
59050-15-6

ethyl 3-(N-methyl-N-phenylamino)-3-oxopropionate

Conditions
ConditionsYield
With 2-chloro-1-methyl-pyridinium iodide; triethylamine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;99%
With dicyclohexyl-carbodiimide In dichloromethane at 20℃;90%
With 2-chloro-1-methyl-pyridinium iodide; triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;77%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

DL-alanine ethyl ester hydrochloride
617-27-6

DL-alanine ethyl ester hydrochloride

N-Aethoxycarbonylacetylsarcosinaethylester

N-Aethoxycarbonylacetylsarcosinaethylester

Conditions
ConditionsYield
With dmap; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 2.5h; Inert atmosphere;99%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

vanillin
121-33-5

vanillin

ethyl 4-hydroxy-3-methoxycinnamate
4046-02-0

ethyl 4-hydroxy-3-methoxycinnamate

Conditions
ConditionsYield
Stage #1: hydrogen ethyl malonate; vanillin With piperidine; pyridine at 100℃; for 24h; Knoevenagel Condensation;
Stage #2: With hydrogenchloride In water at -10 - 0℃; for 24h;
98%
With piperidine In pyridine at 100℃; for 8h; Knoevenagel Condensation;97%
With piperidine; pyridine; aniline
With pyridine Knoevenagel Condensation; Reflux;
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

(S)-N-[1-(5-oxazoyl)ethyl]-1H-indole-3-ethanamine
196819-38-2

(S)-N-[1-(5-oxazoyl)ethyl]-1H-indole-3-ethanamine

(S)-3-[[2-(1H-indol-3-yl)ethyl][1-(5-oxazoyl)ethyl]amino]-3-oxopropanoic acid ethyl ester
196819-50-8

(S)-3-[[2-(1H-indol-3-yl)ethyl][1-(5-oxazoyl)ethyl]amino]-3-oxopropanoic acid ethyl ester

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide for 2h; Ambient temperature;98%
With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h; Condensation;98%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

benzyl chloroformate
501-53-1

benzyl chloroformate

A

benzyl ethyl malonate
42998-51-6

benzyl ethyl malonate

B

CO2

CO2

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 4℃; for 0.5h;A 98%
B n/a
2,2-dimethylbut-3-enoyl chloride
57690-96-7

2,2-dimethylbut-3-enoyl chloride

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ethyl 4,4-dimethyl-3-oxo-hex-5-enoate
66248-79-1

ethyl 4,4-dimethyl-3-oxo-hex-5-enoate

Conditions
ConditionsYield
Stage #1: hydrogen ethyl malonate With [2,2]bipyridinyl; n-butyllithium In tetrahydrofuran; hexane at -70 - -10℃;
Stage #2: 2,2-dimethylbut-3-enoyl chloride In tetrahydrofuran; hexane at -60 - 0℃; for 3h;
98%
With n-butyllithium In tetrahydrofuran; hexane at -65℃; for 1h;8.1 g
Stage #1: hydrogen ethyl malonate With n-butyllithium In tetrahydrofuran; hexanes at -70 - -10℃; Inert atmosphere;
Stage #2: 2,2-dimethylbut-3-enoyl chloride In tetrahydrofuran; hexanes at -60 - 0℃; for 3h;
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

para-acetamidobenzaldehyde
122-85-0

para-acetamidobenzaldehyde

ethyl 3-(4-acetylaminophenyl)-2-propenoate
215258-04-1

ethyl 3-(4-acetylaminophenyl)-2-propenoate

Conditions
ConditionsYield
With poly{styrene-co-[4-(N-methyl-N-vinylbenzyl-amino)pyridine]-co-[1-phenyl-3-(4-vinylbenzyl)piperazine]} In N,N-dimethyl-formamide at 50℃; decarboxylative Doebner-Knoevenagel condensation reaction; optical yield given as %de; stereoselective reaction;98%
With dmap In N,N-dimethyl-formamide at 25℃; for 168h; Knoevenagel reaction;92%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ethyl (+/-)-trans-2-oxo-1,4-diphenyl-azetidine-3-carboxylate

ethyl (+/-)-trans-2-oxo-1,4-diphenyl-azetidine-3-carboxylate

Conditions
ConditionsYield
Stage #1: hydrogen ethyl malonate With 1,1'-carbonyldiimidazole In dichloromethane at 25℃; for 1h;
Stage #2: (E)-N-benzylidenebenzenamine In dichloromethane at 25℃; for 1h;
98%
Stage #1: hydrogen ethyl malonate With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Staudinger reaction; Inert atmosphere;
Stage #2: (E)-N-benzylidenebenzenamine In dichloromethane at 20℃; for 1h; Staudinger reaction; Inert atmosphere; stereoselective reaction;
79%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

ethyl (E)-3-(4-chlorophenyl)prop-2-enoate
24393-52-0

ethyl (E)-3-(4-chlorophenyl)prop-2-enoate

Conditions
ConditionsYield
With poly{styrene-co-[4-(N-methyl-N-vinylbenzyl-amino)pyridine]-co-[1-phenyl-3-(4-vinylbenzyl)piperazine]} In N,N-dimethyl-formamide at 50℃; decarboxylative Doebner-Knoevenagel condensation reaction; optical yield given as %de; stereoselective reaction;98%
With dmap
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ethyl 2-(butoxyamino)benzoate

ethyl 2-(butoxyamino)benzoate

ethyl 2-(N-butoxy-3-ethoxy-3-oxopropanamido)benzoate

ethyl 2-(N-butoxy-3-ethoxy-3-oxopropanamido)benzoate

Conditions
ConditionsYield
With pyridine; trichlorophosphate In acetonitrile at 0 - 5℃; for 2h;98%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

4-(p-isopropylphenyl)-3-buten-2-one
74389-78-9

4-(p-isopropylphenyl)-3-buten-2-one

3-Hydroxy-5-(4-isopropyl-phenyl)-cyclohex-2-enone
111945-86-9

3-Hydroxy-5-(4-isopropyl-phenyl)-cyclohex-2-enone

Conditions
ConditionsYield
With sodium methylate In methanol97%

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