The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:7152-15-0
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryProduct name: Ethyl isobutyrylacetate CAS NO. : 7152-15-0 Structural formula: Molecular formula: C8H14O3 Molecular weight: 158.195 Appearance: colorless transparent liquid
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquirysupplier in China Appearance:clear colorless to yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Used for the synthesis if heter
Product name: Ethyl Isobutyl Acetate CAS No.:7152-15-0 Molecule Formula:C8H14O3 Molecule Weight:158.20 Purity: 99.0% Package: 200kg/drum Description:Colorless liquid Manufacture Standards:Enterprise Standard TESTIN
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inquiryProduct Name: Ethyl isobutyrylacetate Synonyms: Ethyl isobutyrylacetate, Ethyl 4-methyl-3-oxovalerate;Ethyl isobutyrylacetate 95%;4-METHYL-3-OXO-PENTANOIC ACID ETHYL ESTER;ETHYL ISOBUTYROYL ACETATE;ETHYL ISOBUTYRYLACETATE;ETHYL 4-METHYL-3-OXOPE
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Min.Order:1 Gram
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inquiryAgrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates Appearance:Colorless liquid Storage:Stored in the ventilated, low temperature and dry room away f
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Cas:7152-15-0
Min.Order:1 Gram
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
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Cas:7152-15-0
Min.Order:1 Kilogram
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:7152-15-0
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:7152-15-0
Min.Order:0
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Type:Lab/Research institutions
inquiryR & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
Conditions | Yield |
---|---|
Stage #1: ethyl potassium malonate With triethylamine; magnesium chloride In ethyl acetate at 0 - 35℃; for 6.5h; Stage #2: isobutyryl chloride In ethyl acetate at 0 - 20℃; for 13h; Time; | 61% |
With triethylamine; magnesium chloride In acetonitrile |
diethyl isobutyrylmalonate
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In water for 8h; Reflux; | 54% |
With isobutyric Acid; copper diacetate; magnesium oxide Heating; | |
With copper diacetate; magnesium oxide; isobutyric Acid at 145℃; for 14h; |
Conditions | Yield |
---|---|
With sodium hydride In toluene; mineral oil Reflux; | 60% |
With sodium hydride at 60 - 90℃; | |
With sodium hydride In benzene |
3-methyl-butan-2-one
N,N,N,N,N,N-hexamethylphosphoric triamide
Diethyl carbonate
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
In methanol; paraffin oil; benzene | 81% |
hydrogen ethyl malonate
isobutyryl chloride
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran | 99% |
Stage #1: hydrogen ethyl malonate With [2,2]bipyridinyl; n-butyllithium In tetrahydrofuran; hexane at -70 - -10℃; Inert atmosphere; Stage #2: isobutyryl chloride In tetrahydrofuran; hexane at -65℃; for 0.166667h; Inert atmosphere; | 80% |
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With sodium hydroxide | |
With diethyl ether; ammonia at 25℃; | |
With ammonium hydroxide at 40℃; |
Ethyl (+/-)-3-hydroxy-4-methyl-4-pentenoate
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In water; acetone at 60℃; for 16h; chemoselective reaction; | 91% |
ethyl 2-diazo-3-hydroxy-4-methylpentanoate
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride In neat (no solvent) at 20℃; for 9h; | 60% |
ethyl bromoacetate
N-(methylpropionyl)oxazolidin-2-one
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With zinc In tetrahydrofuran 1) 30 deg C, 2 h, 2) reflux, 18 h; | 83% |
cycl-isopropylidene malonate
ethanol
isobutyric Acid
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: cycl-isopropylidene malonate; isobutyric Acid With dmap In dichloromethane at 20℃; for 0.25h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃; Stage #3: ethanol In toluene for 3h; Reflux; | 48% |
ethyl bromoacetate
1-(2'-Methyl)propanoyl-3,5-dimethylpyrazole
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With zinc In tetrahydrofuran for 1h; Heating; | 73% |
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran at -78℃; Condensation; |
4-methyl-3-oxopentanonitrile
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With hydrogenchloride; ethanol |
3-methyl-butan-2-one
chloroformic acid ethyl ester
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With cetyltrimethylammonium chloride; calcium carbonate; calcium oxide In 1,4-dioxane at 25℃; for 5h; Sonication; | 95 %Chromat. |
ethyl potassium malonate
isobutyric Acid
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: isobutyric Acid With 1,1'-carbonyldiimidazole In tetrahydrofuran Acylation; Stage #2: ethyl potassium malonate With magnesium chloride In tetrahydrofuran Substitution; decarboxylation; | |
With 1,1'-carbonyldiimidazole; magnesium chloride In tetrahydrofuran |
ethanol
5-(1-hydroxy-2-methylpropylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
In toluene for 3h; Reflux; | 43% |
In toluene Heating; | |
In toluene for 3h; Reflux; | 2.24 g |
Conditions | Yield |
---|---|
With zinc; tetrakis(triphenylphosphine) palladium(0) 1.) DME; 2.) DME, reflux, 1 h; Yield given. Multistep reaction; |
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With sodium hydroxide | |
With sodium ethanolate |
2-Benzenesulfinyl-3-hydroxy-4-methyl-pentanoic acid ethyl ester
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
In benzene |
ethanol
5-(1-Amino-2-methyl-propylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With hydrogenchloride; sodium ethanolate 1.) ethanol, reflux, overnight; Yield given. Multistep reaction; |
ethyl 2-acetyl-4-methyl-3-oxopentanoate
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With ethanol; sodium ethanolate |
4-methyl-2-pentynoic acid
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: alcoholic KOH-solution 2: sulfuric acid View Scheme |
Conditions | Yield |
---|---|
With sulfuric acid |
Conditions | Yield |
---|---|
With iodine; magnesium |
diethyl isobutyrylmalonate
isobutyric Acid
A
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With copper diacetate; magnesium oxide |
(4-methyl-3-oxo-1-phenyl-pentyl)-malonic acid diethyl ester
sodium ethanolate
A
diethyl benzalmalonate
B
ethyl 4-methyl-3-oxo-pentanoate
C
Ethyl isobutyrate
Conditions | Yield |
---|---|
at 130℃; |
Conditions | Yield |
---|---|
(i) LDA, Et2O, THF, (ii) /BRN= 6775142/; Multistep reaction; |
3-methyl-butan-2-one
sodium methylate
Diethyl carbonate
A
Methyl 4-methyl-3-oxopentanoate
B
ethyl 4-methyl-3-oxo-pentanoate
tetrachloromethane
ethyl 2-acetyl-4-methyl-3-oxopentanoate
water
A
acetic acid
B
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Erhitzen; |
ethyl 4-methyl-3-oxo-pentanoate
2-bromo-4-methyl-3-oxo-pentanoic acid ethyl ester
Conditions | Yield |
---|---|
With N-Bromosuccinimide In various solvent(s) at 20℃; for 0.916667h; | 92% |
With bromine In tetrachloromethane; water at 0℃; for 2h; | 90% |
With bromine In tetrachloromethane; water at 0℃; for 2h; | 90% |
ethyl 4-methyl-3-oxo-pentanoate
Ethyl 3-amino-4-methyl-2-pentenoate
Conditions | Yield |
---|---|
With ammonium acetate; acetic acid In water; toluene Reflux; | 88.6% |
With ammonium acetate In methanol at 20℃; for 72h; | 85% |
With ammonium acetate In methanol at 20℃; for 72h; Substitution; |
ethyl 4-methyl-3-oxo-pentanoate
methyl iodide
ethyl 2,4-dimethyl-3-oxopentanoate
Conditions | Yield |
---|---|
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With potassium carbonate In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; | 89% |
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With potassium carbonate In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 0℃; Inert atmosphere; | |
With potassium carbonate In N,N-dimethyl-formamide Inert atmosphere; | |
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 4h; Inert atmosphere; | |
With potassium carbonate In tetrahydrofuran Inert atmosphere; Reflux; |
ethyl 4-methyl-3-oxo-pentanoate
ethyl 2-chloro-4-methyl-3-oxopentanoate
Conditions | Yield |
---|---|
With N-chloro-succinimide In various solvent(s) at 20℃; for 1h; | 92% |
With sulfuryl dichloride In toluene at 20℃; for 18h; | 70% |
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With sulfuryl dichloride In toluene at 20℃; for 18h; Stage #2: With water In toluene | 70% |
4-fluorobenzaldehyde
ethyl 4-methyl-3-oxo-pentanoate
(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester
Conditions | Yield |
---|---|
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 22h; | 95% |
With piperidine; acetic acid In benzene Heating; | 86.7% |
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 22h; Inert atmosphere; | 83.9% |
With piperidine; acetic acid In toluene for 8h; Heating; | 75% |
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 22h; Inert atmosphere; |
ethyl 4-methyl-3-oxo-pentanoate
ethyl 3-amino-4-methyl-pent-2-enoate
Conditions | Yield |
---|---|
With ammonium acetate In cyclohexane; isopropyl alcohol | 98% |
With ammonium acetate In methanol at 20℃; for 72h; | 85% |
With ammonia In ethanol at 25℃; for 42h; | |
With ammonium acetate In cyclohexane |
ethyl 4-methyl-3-oxo-pentanoate
ethyl (3R)-3-hydroxy-4-methylpentanoate
Conditions | Yield |
---|---|
With hydrogen; (S)-BinapRuBr2 at 50℃; under 760 Torr; for 48h; | 100% |
With C32H40F6O6P2Pd; hydrogen In acetone at 0℃; under 23272.3 Torr; for 12h; Autoclave; enantioselective reaction; | 99% |
With (2R,2'R,3R,3'R)-3,3'-di-tert-butyl-2,2'-diisopropyl-2,2',3,3'-tetrahydro-4,4'-bibenzo[d][1,3]oxaphosphole; hydrogen; palladium diacetate In acetone at 0 - 20℃; under 225023 Torr; for 20h; Glovebox; | 99% |
6-bromo-1H-indole-2-carbaldehyde
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Aldol Condensation; Inert atmosphere; | 95% |
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere; | 95% |
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere; | 95% |
8-bromo-quinoline-4-carbaldehyde
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere; | 89% |
With pyridine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere; | 89% |
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere; | 89% |
Conditions | Yield |
---|---|
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With sodium hydroxide; water at 20℃; for 16h; Stage #2: With hydrogenchloride In water pH=1 - 2; | 95% |
With water; sodium hydroxide at 0 - 20℃; for 16h; |
3-(4-fluoro-phenyl)-propenal
thiourea
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: 3-(4-fluoro-phenyl)-propenal; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction; | 92% |
Stage #1: 3-(4-fluoro-phenyl)-propenal; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction; | 92% |
Stage #1: 3-(4-fluoro-phenyl)-propenal; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction; | 92% |
Conditions | Yield |
---|---|
Stage #1: 4-chlorocinnamaldehyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction; | 93% |
Stage #1: 4-chlorocinnamaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction; | 93% |
Stage #1: 4-chlorocinnamaldehyde; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction; | 93% |
4-bromocinnamaldeyde
thiourea
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: 4-bromocinnamaldeyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction; | 93% |
Stage #1: 4-bromocinnamaldeyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction; | 93% |
Stage #1: 4-bromocinnamaldeyde; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction; | 93% |
4-(trifluoromethyl)cinnamaldehyde
thiourea
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: 4-(trifluoromethyl)cinnamaldehyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction; | 90% |
Stage #1: 4-(trifluoromethyl)cinnamaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction; | 90% |
Stage #1: 4-(trifluoromethyl)cinnamaldehyde; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction; | 90% |
3-(4-nitrophenyl)-2-propenal
thiourea
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: 3-(4-nitrophenyl)-2-propenal; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction; | 91% |
Stage #1: 3-(4-nitrophenyl)-2-propenal; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction; | 91% |
Stage #1: 3-(4-nitrophenyl)-2-propenal; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction; | 91% |
thiourea
3-(4-methylphenyl)acrylaldehyde
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: thiourea; 4-methyl cinnamaldehyde With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction; | 96% |
Stage #1: thiourea; 4-methyl cinnamaldehyde With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction; | 96% |
Stage #1: thiourea; 4-methyl cinnamaldehyde With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction; | 96% |
Conditions | Yield |
---|---|
Stage #1: 4-methoxycinnamaldehyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction; | 95% |
Stage #1: 4-methoxycinnamaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction; | 95% |
Stage #1: 4-methoxycinnamaldehyde; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction; | 95% |
ethyl 4-methyl-3-oxo-pentanoate
ethyl 2-diazo-4-methyl-3-oxopentanoate
Conditions | Yield |
---|---|
With 4-toluenesulfonyl azide; caesium carbonate In tetrahydrofuran at 25℃; for 3h; Inert atmosphere; | 87% |
With sodium azide; 3-Carboxybenzenesulfonyl chloride; potassium carbonate In water; acetonitrile at 20℃; for 2h; | 85% |
With 4-toluenesulfonyl azide; triethylamine |
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h; Inert atmosphere; | 86% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h; Molecular sieve; | 86% |
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With sulfur tetrafluoride; hydrogen fluoride at 20℃; Cooling with liquid nitrogen; Autoclave; Stage #2: With potassium permanganate In dichloromethane; water for 1h; | 78% |
Conditions | Yield |
---|---|
With sodium methylate In methanol; ethanol at 100℃; Sealed tube; | 76% |
With sodium methylate In ethanol for 2h; Heating; | 71.5% |
ethyl 4-methyl-3-oxo-pentanoate
benzylamine
ethyl 5-(propan-2-yl)-2-phenyl-1,3-oxazole-4-carboxylate
Conditions | Yield |
---|---|
With tert-butyl hydroxyperoxide; tetra-(n-butyl)ammonium iodide In water; ethyl acetate at 40℃; for 10h; | 76% |
With [Cu(1,10-phenanthroline)2Cl]Cl; iodine; oxygen In acetonitrile at 60℃; for 24h; Molecular sieve; | 75% |
Conditions | Yield |
---|---|
With sulfuric acid In ethanol at 80℃; for 48h; | 99% |
With cerium(III) chloride heptahydrate In ethanol at 80℃; for 24h; Biginelli Pyrimidone Synthesis; | 38% |
Conditions | Yield |
---|---|
Stage #1: thiourea; 3-phenyl-propenal With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction; | 96% |
Stage #1: thiourea; 3-phenyl-propenal With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube; Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction; | 96% |
ammonium thiocyanate
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With fluorescein free acid In acetonitrile at 20℃; UV-irradiation; | 80% |
With fluorescein In acetonitrile at 20℃; for 6h; Irradiation; | 80% |
ethyl 4-methyl-3-oxo-pentanoate
ethyl 2-hydroxyimino-4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite In water at 0℃; | 100% |
With sodium nitrite In acetic acid at 0 - 20℃; | 90% |
With sodium nitrite In water; acetic acid at 0 - 20℃; | 90% |
With sodium nitrite In water; acetic acid at 5 - 20℃; for 2h; | |
With acetic acid; sodium nitrite In water at 0 - 20℃; |
Conditions | Yield |
---|---|
With potassium tert-butylate In methanol at 0℃; for 4.5h; Reflux; | 78.2% |
With potassium carbonate In water at 20℃; for 0.25h; Microwave irradiation; | 54% |
Conditions | Yield |
---|---|
With copper(I) oxide; tert.-butylhydroperoxide; ammonium acetate In water at 120℃; for 24h; | 68% |
With copper(I) oxide; tert.-butylhydroperoxide; ammonium acetate at 120℃; for 24h; Schlenk technique; | 58% |
[5-bromo-3-methylpent-2-en-1-yl]benzene
ethyl 4-methyl-3-oxo-pentanoate
Conditions | Yield |
---|---|
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With sodium hydride In tetrahydrofuran; mineral oil for 1h; Cooling; Stage #2: [5-bromo-3-methylpent-2-en-1-yl]benzene In tetrahydrofuran; mineral oil at 0 - 20℃; for 18h; | 98% |
Conditions | Yield |
---|---|
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With lithium hydroxide In water; toluene at 5 - 10℃; Stage #2: trifluoromethylsulfonic anhydride In water; toluene at 5 - 15℃; | 67% |
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With water; lithium hydroxide In toluene at 10℃; for 0.0833333h; Stage #2: trifluoromethylsulfonic anhydride In toluene at 10 - 25℃; for 2h; |
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