Products

Refine

Country

Business Type

Certificate

Display

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethylisobutyrulpentanoate

Cas:7152-15-0

Min.Order:1

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Ethyl isobutyrylacetate Manufacturer/High quality/Best price/In stock

Cas:7152-15-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Isobutyrylacetic acid ethyl ester

Cas:7152-15-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 7152-15-0 with best quality

Cas:7152-15-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name: Ethyl isobutyrylacetate CAS NO. : 7152-15-0 Structural formula: Molecular formula: C8H14O3 Molecular weight: 158.195 Appearance: colorless transparent liquid

Ethyl isobutyrylacetate CAS:7152-15-0

Cas:7152-15-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 7152-15-0 Ethyl isobutyrylacetate with best price

Cas:7152-15-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Pentanoic acid,4-methyl-3-oxo-, ethyl ester

Cas:7152-15-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Kilogram

FOB Price: $85.0 / 96.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:7152-15-0

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Kilogram

FOB Price: $30.0 / 40.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethylisobutyrulpentanoate

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

supplier in China Appearance:clear colorless to yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Used for the synthesis if heter

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Ethyl Isobutyl Acetate CAS No.:7152-15-0 Molecule Formula:C8H14O3 Molecule Weight:158.20 Purity: 99.0% Package: 200kg/drum Description:Colorless liquid Manufacture Standards:Enterprise Standard TESTIN

Best Quality Ethyl Isobutyl Acetate

Cas:7152-15-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Ethyl isobutyrylacetate Synonyms: Ethyl isobutyrylacetate, Ethyl 4-methyl-3-oxovalerate;Ethyl isobutyrylacetate 95%;4-METHYL-3-OXO-PENTANOIC ACID ETHYL ESTER;ETHYL ISOBUTYROYL ACETATE;ETHYL ISOBUTYRYLACETATE;ETHYL 4-METHYL-3-OXOPE

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates Appearance:Colorless liquid Storage:Stored in the ventilated, low temperature and dry room away f

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyl Isobutyrylacetate

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers

Ethyl isobutyrylacetate 7152-15-0

Cas:7152-15-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Ethyl isobutyrylacetate cas no. 7152-15-0 98%

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Ethyl 4-Methyl-3-oxopentanoate

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Ethyl isobutyrylacetate

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Ethyl Isobutyrylacetate

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Ethylisobutyrulpentanoate

Cas:7152-15-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

isobutyryl chloride
79-30-1

isobutyryl chloride

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
Stage #1: ethyl potassium malonate With triethylamine; magnesium chloride In ethyl acetate at 0 - 35℃; for 6.5h;
Stage #2: isobutyryl chloride In ethyl acetate at 0 - 20℃; for 13h; Time;
61%
With triethylamine; magnesium chloride In acetonitrile
diethyl isobutyrylmalonate
21633-78-3

diethyl isobutyrylmalonate

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In water for 8h; Reflux;54%
With isobutyric Acid; copper diacetate; magnesium oxide Heating;
With copper diacetate; magnesium oxide; isobutyric Acid at 145℃; for 14h;
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

Diethyl carbonate
105-58-8

Diethyl carbonate

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With sodium hydride In toluene; mineral oil Reflux;60%
With sodium hydride at 60 - 90℃;
With sodium hydride In benzene
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

N,N,N,N,N,N-hexamethylphosphoric triamide
680-31-9

N,N,N,N,N,N-hexamethylphosphoric triamide

Diethyl carbonate
105-58-8

Diethyl carbonate

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
In methanol; paraffin oil; benzene81%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

isobutyryl chloride
79-30-1

isobutyryl chloride

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran99%
Stage #1: hydrogen ethyl malonate With [2,2]bipyridinyl; n-butyllithium In tetrahydrofuran; hexane at -70 - -10℃; Inert atmosphere;
Stage #2: isobutyryl chloride In tetrahydrofuran; hexane at -65℃; for 0.166667h; Inert atmosphere;
80%
2-isobutyryl-acetoacetic acid ester

2-isobutyryl-acetoacetic acid ester

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With sodium hydroxide
With diethyl ether; ammonia at 25℃;
With ammonium hydroxide at 40℃;
Ethyl (+/-)-3-hydroxy-4-methyl-4-pentenoate
122622-90-6

Ethyl (+/-)-3-hydroxy-4-methyl-4-pentenoate

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In water; acetone at 60℃; for 16h; chemoselective reaction;91%
ethyl 2-diazo-3-hydroxy-4-methylpentanoate
38491-54-2

ethyl 2-diazo-3-hydroxy-4-methylpentanoate

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride In neat (no solvent) at 20℃; for 9h;60%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

N-(methylpropionyl)oxazolidin-2-one
109853-52-3

N-(methylpropionyl)oxazolidin-2-one

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With zinc In tetrahydrofuran 1) 30 deg C, 2 h, 2) reflux, 18 h;83%
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

ethanol
64-17-5

ethanol

isobutyric Acid
79-31-2

isobutyric Acid

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
Stage #1: cycl-isopropylidene malonate; isobutyric Acid With dmap In dichloromethane at 20℃; for 0.25h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
Stage #3: ethanol In toluene for 3h; Reflux;
48%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

1-(2'-Methyl)propanoyl-3,5-dimethylpyrazole
155688-65-6

1-(2'-Methyl)propanoyl-3,5-dimethylpyrazole

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With zinc In tetrahydrofuran for 1h; Heating;73%
ethyl acetate
141-78-6

ethyl acetate

isobutyryl chloride
79-30-1

isobutyryl chloride

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; Condensation;
4-methyl-3-oxopentanonitrile
29509-06-6

4-methyl-3-oxopentanonitrile

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With hydrogenchloride; ethanol
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With cetyltrimethylammonium chloride; calcium carbonate; calcium oxide In 1,4-dioxane at 25℃; for 5h; Sonication;95 %Chromat.
ethyl potassium malonate
6148-64-7

ethyl potassium malonate

isobutyric Acid
79-31-2

isobutyric Acid

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
Stage #1: isobutyric Acid With 1,1'-carbonyldiimidazole In tetrahydrofuran Acylation;
Stage #2: ethyl potassium malonate With magnesium chloride In tetrahydrofuran Substitution; decarboxylation;
With 1,1'-carbonyldiimidazole; magnesium chloride In tetrahydrofuran
ethanol
64-17-5

ethanol

5-(1-hydroxy-2-methylpropylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
84794-38-7

5-(1-hydroxy-2-methylpropylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
In toluene for 3h; Reflux;43%
In toluene Heating;
In toluene for 3h; Reflux;2.24 g
ethyl bromoacetate
105-36-2

ethyl bromoacetate

isobutyryl chloride
79-30-1

isobutyryl chloride

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With zinc; tetrakis(triphenylphosphine) palladium(0) 1.) DME; 2.) DME, reflux, 1 h; Yield given. Multistep reaction;
isobutyrylacetoacetic acid ester

isobutyrylacetoacetic acid ester

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With sodium hydroxide
With sodium ethanolate
2-Benzenesulfinyl-3-hydroxy-4-methyl-pentanoic acid ethyl ester
57365-40-9

2-Benzenesulfinyl-3-hydroxy-4-methyl-pentanoic acid ethyl ester

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
In benzene
ethanol
64-17-5

ethanol

5-(1-Amino-2-methyl-propylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione
77570-22-0

5-(1-Amino-2-methyl-propylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With hydrogenchloride; sodium ethanolate 1.) ethanol, reflux, overnight; Yield given. Multistep reaction;
ethyl 2-acetyl-4-methyl-3-oxopentanoate
79322-87-5

ethyl 2-acetyl-4-methyl-3-oxopentanoate

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With ethanol; sodium ethanolate
4-methyl-2-pentynoic acid
65199-69-1

4-methyl-2-pentynoic acid

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: alcoholic KOH-solution
2: sulfuric acid
View Scheme
ethanol
64-17-5

ethanol

isobutyrylacetic acid
5650-76-0

isobutyrylacetic acid

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With sulfuric acid
ethyl bromoacetate
105-36-2

ethyl bromoacetate

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With iodine; magnesium
diethyl isobutyrylmalonate
21633-78-3

diethyl isobutyrylmalonate

isobutyric Acid
79-31-2

isobutyric Acid

A

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

B

ethyl isobutyrate, 2,6-dimethyl-heptane-3,5-dione

ethyl isobutyrate, 2,6-dimethyl-heptane-3,5-dione

Conditions
ConditionsYield
With copper diacetate; magnesium oxide
(4-methyl-3-oxo-1-phenyl-pentyl)-malonic acid diethyl ester
5435-09-6

(4-methyl-3-oxo-1-phenyl-pentyl)-malonic acid diethyl ester

sodium ethanolate
141-52-6

sodium ethanolate

A

diethyl benzalmalonate
5292-53-5

diethyl benzalmalonate

B

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

C

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

D

diphenyl-diisobutyryl-cyclobutane

diphenyl-diisobutyryl-cyclobutane

Conditions
ConditionsYield
at 130℃;
ethyl acetate
141-78-6

ethyl acetate

C7H12O4
62763-38-6

C7H12O4

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
(i) LDA, Et2O, THF, (ii) /BRN= 6775142/; Multistep reaction;
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

sodium methylate
124-41-4

sodium methylate

Diethyl carbonate
105-58-8

Diethyl carbonate

A

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

B

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

tetrachloromethane
56-23-5

tetrachloromethane

ethyl 2-acetyl-4-methyl-3-oxopentanoate
79322-87-5

ethyl 2-acetyl-4-methyl-3-oxopentanoate

water
7732-18-5

water

A

acetic acid
64-19-7

acetic acid

B

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
Erhitzen;
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

2-bromo-4-methyl-3-oxo-pentanoic acid ethyl ester
81569-67-7

2-bromo-4-methyl-3-oxo-pentanoic acid ethyl ester

Conditions
ConditionsYield
With N-Bromosuccinimide In various solvent(s) at 20℃; for 0.916667h;92%
With bromine In tetrachloromethane; water at 0℃; for 2h;90%
With bromine In tetrachloromethane; water at 0℃; for 2h;90%
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

Ethyl 3-amino-4-methyl-2-pentenoate
70106-45-5

Ethyl 3-amino-4-methyl-2-pentenoate

Conditions
ConditionsYield
With ammonium acetate; acetic acid In water; toluene Reflux;88.6%
With ammonium acetate In methanol at 20℃; for 72h;85%
With ammonium acetate In methanol at 20℃; for 72h; Substitution;
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

methyl iodide
74-88-4

methyl iodide

ethyl 2,4-dimethyl-3-oxopentanoate
7251-96-9

ethyl 2,4-dimethyl-3-oxopentanoate

Conditions
ConditionsYield
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With potassium carbonate In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃;
89%
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With potassium carbonate In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at 0℃; Inert atmosphere;
With potassium carbonate In N,N-dimethyl-formamide Inert atmosphere;
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 4h; Inert atmosphere;
With potassium carbonate In tetrahydrofuran Inert atmosphere; Reflux;
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl 2-chloro-4-methyl-3-oxopentanoate
35391-60-7

ethyl 2-chloro-4-methyl-3-oxopentanoate

Conditions
ConditionsYield
With N-chloro-succinimide In various solvent(s) at 20℃; for 1h;92%
With sulfuryl dichloride In toluene at 20℃; for 18h;70%
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With sulfuryl dichloride In toluene at 20℃; for 18h;
Stage #2: With water In toluene
70%
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester
122930-45-4

(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester

Conditions
ConditionsYield
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 22h;95%
With piperidine; acetic acid In benzene Heating;86.7%
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 22h; Inert atmosphere;83.9%
With piperidine; acetic acid In toluene for 8h; Heating;75%
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 22h; Inert atmosphere;
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl 3-amino-4-methyl-pent-2-enoate
78168-82-8

ethyl 3-amino-4-methyl-pent-2-enoate

Conditions
ConditionsYield
With ammonium acetate In cyclohexane; isopropyl alcohol98%
With ammonium acetate In methanol at 20℃; for 72h;85%
With ammonia In ethanol at 25℃; for 42h;
With ammonium acetate In cyclohexane
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl (3R)-3-hydroxy-4-methylpentanoate
95614-86-1

ethyl (3R)-3-hydroxy-4-methylpentanoate

Conditions
ConditionsYield
With hydrogen; (S)-BinapRuBr2 at 50℃; under 760 Torr; for 48h;100%
With C32H40F6O6P2Pd; hydrogen In acetone at 0℃; under 23272.3 Torr; for 12h; Autoclave; enantioselective reaction;99%
With (2R,2'R,3R,3'R)-3,3'-di-tert-butyl-2,2'-diisopropyl-2,2',3,3'-tetrahydro-4,4'-bibenzo[d][1,3]oxaphosphole; hydrogen; palladium diacetate In acetone at 0 - 20℃; under 225023 Torr; for 20h; Glovebox;99%
6-bromo-1H-indole-2-carbaldehyde
105191-12-6

6-bromo-1H-indole-2-carbaldehyde

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(2Z)-2-((6-bromo-1H-indol-2-yl)methylidene)-4-methyl-3-oxopentanoic acid ethyl ester

(2Z)-2-((6-bromo-1H-indol-2-yl)methylidene)-4-methyl-3-oxopentanoic acid ethyl ester

Conditions
ConditionsYield
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Aldol Condensation; Inert atmosphere;95%
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere;95%
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere;95%
8-bromo-quinoline-4-carbaldehyde
898391-87-2

8-bromo-quinoline-4-carbaldehyde

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl (Z)-2-((8-bromo-quinolin-4-yl)methylene)-4-methyl-3-oxopentanoate

ethyl (Z)-2-((8-bromo-quinolin-4-yl)methylene)-4-methyl-3-oxopentanoate

Conditions
ConditionsYield
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere;89%
With pyridine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere;89%
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 12h; Inert atmosphere;89%
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

isobutyrylacetic acid
5650-76-0

isobutyrylacetic acid

Conditions
ConditionsYield
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With sodium hydroxide; water at 20℃; for 16h;
Stage #2: With hydrogenchloride In water pH=1 - 2;
95%
With water; sodium hydroxide at 0 - 20℃; for 16h;
3-(4-fluoro-phenyl)-propenal
51791-26-5, 24654-55-5

3-(4-fluoro-phenyl)-propenal

thiourea
17356-08-0

thiourea

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(S)-ethyl 4-(4-fluorostyryl)-6-isopropyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-ethyl 4-(4-fluorostyryl)-6-isopropyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 3-(4-fluoro-phenyl)-propenal; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
92%
Stage #1: 3-(4-fluoro-phenyl)-propenal; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
92%
Stage #1: 3-(4-fluoro-phenyl)-propenal; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction;
92%
4-chlorocinnamaldehyde
1075-77-0

4-chlorocinnamaldehyde

thiourea
17356-08-0

thiourea

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(S)-ethyl 4-(4-chlorostyryl)-6-isopropyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-ethyl 4-(4-chlorostyryl)-6-isopropyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 4-chlorocinnamaldehyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
93%
Stage #1: 4-chlorocinnamaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
93%
Stage #1: 4-chlorocinnamaldehyde; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction;
93%
4-bromocinnamaldeyde
49678-04-8, 3893-18-3

4-bromocinnamaldeyde

thiourea
17356-08-0

thiourea

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(S)-ethyl 4-(4-bromostyryl)-6-isopropyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-ethyl 4-(4-bromostyryl)-6-isopropyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 4-bromocinnamaldeyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
93%
Stage #1: 4-bromocinnamaldeyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
93%
Stage #1: 4-bromocinnamaldeyde; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction;
93%
4-(trifluoromethyl)cinnamaldehyde
95123-61-8, 41917-83-3

4-(trifluoromethyl)cinnamaldehyde

thiourea
17356-08-0

thiourea

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(S)-ethyl 6-isopropyl-2-thioxo-4-(4-(trifluoromethyl)styryl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-ethyl 6-isopropyl-2-thioxo-4-(4-(trifluoromethyl)styryl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 4-(trifluoromethyl)cinnamaldehyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
90%
Stage #1: 4-(trifluoromethyl)cinnamaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
90%
Stage #1: 4-(trifluoromethyl)cinnamaldehyde; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction;
90%
3-(4-nitrophenyl)-2-propenal
1734-79-8

3-(4-nitrophenyl)-2-propenal

thiourea
17356-08-0

thiourea

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(S)-ethyl 6-isopropyl-4-(4-nitrostyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-ethyl 6-isopropyl-4-(4-nitrostyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 3-(4-nitrophenyl)-2-propenal; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
91%
Stage #1: 3-(4-nitrophenyl)-2-propenal; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
91%
Stage #1: 3-(4-nitrophenyl)-2-propenal; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction;
91%
thiourea
17356-08-0

thiourea

3-(4-methylphenyl)acrylaldehyde
1504-75-2

3-(4-methylphenyl)acrylaldehyde

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(S)-ethyl 6-isopropyl-4-(4-methylstyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-ethyl 6-isopropyl-4-(4-methylstyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: thiourea; 4-methyl cinnamaldehyde With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
96%
Stage #1: thiourea; 4-methyl cinnamaldehyde With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
96%
Stage #1: thiourea; 4-methyl cinnamaldehyde With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction;
96%
4-methoxycinnamaldehyde
1963-36-6

4-methoxycinnamaldehyde

thiourea
17356-08-0

thiourea

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(S)-ethyl 6-isopropyl-4-(4-methoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-ethyl 6-isopropyl-4-(4-methoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 4-methoxycinnamaldehyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
95%
Stage #1: 4-methoxycinnamaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
95%
Stage #1: 4-methoxycinnamaldehyde; thiourea With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction;
95%
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl 2-diazo-4-methyl-3-oxopentanoate
402568-02-9

ethyl 2-diazo-4-methyl-3-oxopentanoate

Conditions
ConditionsYield
With 4-toluenesulfonyl azide; caesium carbonate In tetrahydrofuran at 25℃; for 3h; Inert atmosphere;87%
With sodium azide; 3-Carboxybenzenesulfonyl chloride; potassium carbonate In water; acetonitrile at 20℃; for 2h;85%
With 4-toluenesulfonyl azide; triethylamine
3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid ethyl ester

3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid ethyl ester

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

3,5-diethyl 4-(4-bromophenyl)-2-fluoro-6-(propan-2-yl)-4H-pyran-3,5-dicarboxylate

3,5-diethyl 4-(4-bromophenyl)-2-fluoro-6-(propan-2-yl)-4H-pyran-3,5-dicarboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h; Inert atmosphere;86%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h; Molecular sieve;86%
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl 3,3-difluoro-4-methylpentanoate

ethyl 3,3-difluoro-4-methylpentanoate

Conditions
ConditionsYield
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With sulfur tetrafluoride; hydrogen fluoride at 20℃; Cooling with liquid nitrogen; Autoclave;
Stage #2: With potassium permanganate In dichloromethane; water for 1h;
78%
guanidine hydrochloride
50-01-1

guanidine hydrochloride

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

2-amino-6-isopropyl-4(3H)-pyrimidinone

2-amino-6-isopropyl-4(3H)-pyrimidinone

Conditions
ConditionsYield
With sodium methylate In methanol; ethanol at 100℃; Sealed tube;76%
With sodium methylate In ethanol for 2h; Heating;71.5%
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

benzylamine
100-46-9

benzylamine

ethyl 5-(propan-2-yl)-2-phenyl-1,3-oxazole-4-carboxylate
1354790-43-4

ethyl 5-(propan-2-yl)-2-phenyl-1,3-oxazole-4-carboxylate

Conditions
ConditionsYield
With tert-butyl hydroxyperoxide; tetra-(n-butyl)ammonium iodide In water; ethyl acetate at 40℃; for 10h;76%
With [Cu(1,10-phenanthroline)2Cl]Cl; iodine; oxygen In acetonitrile at 60℃; for 24h; Molecular sieve;75%
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

urea
57-13-6

urea

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate

ethyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate

Conditions
ConditionsYield
With sulfuric acid In ethanol at 80℃; for 48h;99%
With cerium(III) chloride heptahydrate In ethanol at 80℃; for 24h; Biginelli Pyrimidone Synthesis;38%
thiourea
17356-08-0

thiourea

3-phenyl-propenal
104-55-2

3-phenyl-propenal

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(S)-ethyl 6-isopropyl-4-styryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-ethyl 6-isopropyl-4-styryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: thiourea; 3-phenyl-propenal With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
96%
Stage #1: thiourea; 3-phenyl-propenal With C30H29F6N3OS; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Sealed tube;
Stage #2: ethyl 4-methyl-3-oxo-pentanoate at 50℃; for 15h; enantioselective reaction;
96%
ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(E)-3-amino-4-methyl-2-thiocyanatopent-2-enoic acid ethyl ester

(E)-3-amino-4-methyl-2-thiocyanatopent-2-enoic acid ethyl ester

Conditions
ConditionsYield
With fluorescein free acid In acetonitrile at 20℃; UV-irradiation;80%
With fluorescein In acetonitrile at 20℃; for 6h; Irradiation;80%
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl 2-hydroxyimino-4-methyl-3-oxo-pentanoate
38603-76-8

ethyl 2-hydroxyimino-4-methyl-3-oxo-pentanoate

Conditions
ConditionsYield
With acetic acid; sodium nitrite In water at 0℃;100%
With sodium nitrite In acetic acid at 0 - 20℃;90%
With sodium nitrite In water; acetic acid at 0 - 20℃;90%
With sodium nitrite In water; acetic acid at 5 - 20℃; for 2h;
With acetic acid; sodium nitrite In water at 0 - 20℃;
benzamidine monohydrochloride
1670-14-0

benzamidine monohydrochloride

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

6-isopropyl-2-phenylpyrimidin-4-ol

6-isopropyl-2-phenylpyrimidin-4-ol

Conditions
ConditionsYield
With potassium tert-butylate In methanol at 0℃; for 4.5h; Reflux;78.2%
With potassium carbonate In water at 20℃; for 0.25h; Microwave irradiation;54%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

diethyl 2,6-diisopropylpyridine-3,5-dicarboxylate

diethyl 2,6-diisopropylpyridine-3,5-dicarboxylate

Conditions
ConditionsYield
With copper(I) oxide; tert.-butylhydroperoxide; ammonium acetate In water at 120℃; for 24h;68%
With copper(I) oxide; tert.-butylhydroperoxide; ammonium acetate at 120℃; for 24h; Schlenk technique;58%
[5-bromo-3-methylpent-2-en-1-yl]benzene
1001653-19-5

[5-bromo-3-methylpent-2-en-1-yl]benzene

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl 5-methyl-2-(2-methylpropanoyl)-7-phenylhept-4-enoate

ethyl 5-methyl-2-(2-methylpropanoyl)-7-phenylhept-4-enoate

Conditions
ConditionsYield
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With sodium hydride In tetrahydrofuran; mineral oil for 1h; Cooling;
Stage #2: [5-bromo-3-methylpent-2-en-1-yl]benzene In tetrahydrofuran; mineral oil at 0 - 20℃; for 18h;
98%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

ethyl 4-methyl-3-{[(trifluoromethyl)sulfonyl]oxy}pent-2-enoate

ethyl 4-methyl-3-{[(trifluoromethyl)sulfonyl]oxy}pent-2-enoate

Conditions
ConditionsYield
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With lithium hydroxide In water; toluene at 5 - 10℃;
Stage #2: trifluoromethylsulfonic anhydride In water; toluene at 5 - 15℃;
67%
Stage #1: ethyl 4-methyl-3-oxo-pentanoate With water; lithium hydroxide In toluene at 10℃; for 0.0833333h;
Stage #2: trifluoromethylsulfonic anhydride In toluene at 10 - 25℃; for 2h;

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View