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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Methyl isobutyrylacetate Manufacturer/High quality/Best price/In stock

Cas:42558-54-3

Min.Order:1 Kilogram

FOB Price: $3.0

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Methyl Isobutyryl Acetate supplier in China

Cas:42558-54-3

Min.Order:0 Metric Ton

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Jinan Finer Chemical Co., Ltd

Product Description

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Kilogram

FOB Price: $5.0 / 30.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Metric Ton

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Methyl 4-methyl-3-oxopentanoate

Cas:42558-54-3

Min.Order:1

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 42558-54-3 Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Gram

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Isobutyrylacetic acid methyl ester

Cas:42558-54-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Kilogram

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Gram

FOB Price: $12.0 / 15.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 42558-54-3 with fast shipping

Cas:42558-54-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

China Sell Chemicals Methyl Isobutyrylacetate Ibem CAS 42558-54-3

Cas:42558-54-3

Min.Order:10 Kilogram

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Henan Sinotech Import&Export Corporation

CAS Number 42558-54-3 Product Name Isobutyrylacetic Acid Methyl Ester Synonyms 2-methylpropanoic Propanoic Anhydride; 4-methy

Methyl isobutyryl acetate CAS: 42558-54-3

Cas:42558-54-3

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 42558-54-3 Methyl isobutyrylacetate with best price

Cas:42558-54-3

Min.Order:10 Gram

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:colorless to yellowish Oil Storage:Store below +30°C. Package:25kg/Barrel Application:pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in china

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methyl isobutyrylacetate 42558-54-3

Cas:42558-54-3

Min.Order:1 Kilogram

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Shanghai Minstar Chemical Co., Ltd

Product Name: Methyl isobutyrylacetate CAS: 42558-54-3 MF: C7H12O3 MW: 144.17 EINECS: 418-900-0 Mol File: 42558-54-3.mol Methyl isobutyrylacetate Structure Methyl isobutyrylacetate Chemical Properties Melting point -75°C B

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Gram

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EAST CHEMSOURCES LIMITED

Pharmaceutical intermediate, atorvastatin intermediate Appearance:Colorless liquid Storage:Stored in the ventilated, low temperature and dry room away from direct sunlight. Package:200kg/drum Application:Pharmaceutical intermediate, atorvastatin int

Methyl isobutyrylacetate(IBEM)

Cas:42558-54-3

Min.Order:1 Metric Ton

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Kilogram

FOB Price: $76.0 / 85.0

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Methyl Isobutyrylacetate CAS 42558-54-3 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made

High quality Methyl Isobutyrylacetate CAS 42558-54-3

Cas:42558-54-3

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Kilogram

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:42558-54-3

Cas:42558-54-3

Min.Order:0

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Lonwin Chemical Group Limited

Methyl isobutyrylacetate CAS:42558-54-3 Specification Item name Methyl Isobutyrylacetate Molecular Weight 144.17 Package 200kg/drum Purity 99%min Color Colorness Transperant App

Factory supply Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Kilogram

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Type:Other

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Methyl isobutyrylacetate Synonyms: ISO-BUTYRYL METHYL ACETATE;ISOBUTYRYLACETIC ACID METHYL ESTER;BUTTPARK 30\10-63;4-METHYL-3-OXO-PENTANOIC ACID METHYL ESTER;4-METHYL-3-OXOVALERIC ACID METHYL ESTER;MIBA;Methyl Isobutyryacetate;M1 M

Atorvastatin Intermediates Methyl isobutyrylacetate supplier best quality

Cas:42558-54-3

Min.Order:100 Gram

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Methyl Isobutyryl Acetate

Cas:42558-54-3

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Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao

Methyl isobutyrylacetate 42558-54-3

Cas:42558-54-3

Min.Order:1 Kilogram

FOB Price: $16.0 / 20.0

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Kilogram

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Methyl isobutyryl acetate

Cas:42558-54-3

Min.Order:0 Metric Ton

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:0

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Methyl isobutyrylacetate

Cas:42558-54-3

Min.Order:1 Gram

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Synthetic route

3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

A

2,5,6-trimethylhept-4-en-3-one
16466-21-0

2,5,6-trimethylhept-4-en-3-one

B

2,5,6-trimethylhept-5-en-3-one
101459-87-4

2,5,6-trimethylhept-5-en-3-one

C

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
Stage #1: 3-methyl-butan-2-one With sodium hydride In 1,4-dioxane; mineral oil at 20℃; for 0.166667h;
Stage #2: carbonic acid dimethyl ester In 1,4-dioxane; mineral oil at 50℃; for 3h; Reagent/catalyst; Solvent; Temperature; Time;
A n/a
B n/a
C 88%
methyl diazoacetate
6832-16-2

methyl diazoacetate

isobutyraldehyde
78-84-2

isobutyraldehyde

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
yttria-stabilized zirconia In 1,2-dichloro-ethane for 10h; Heating;85%
With Cu(II)-Mont K 10 clay In benzene at 80℃; for 3h; Condensation;62%
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
Stage #1: 3-methyl-butan-2-one With sodium hydride In tetrahydrofuran for 0.333333h;
Stage #2: carbonic acid dimethyl ester In tetrahydrofuran at 30℃; Further stages.;
85%
Stage #1: 3-methyl-butan-2-one; carbonic acid dimethyl ester With sodium hydride In toluene at 80℃; for 5h;
Stage #2: With water; acetic acid In toluene
62.72%
Stage #1: carbonic acid dimethyl ester With sodium hydride In toluene Reflux; Inert atmosphere;
Stage #2: 3-methyl-butan-2-one In toluene Reflux; Inert atmosphere;
methanol
67-56-1

methanol

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

isobutyryl chloride
79-30-1

isobutyryl chloride

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
Stage #1: cycl-isopropylidene malonate; isobutyryl chloride With pyridine In dichloromethane at 20℃; for 2h;
Stage #2: methanol In dichloromethane for 2h; Further stages.;
75%
methyl 4-methyl-2-pentenoate
50652-78-3

methyl 4-methyl-2-pentenoate

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
With tert.-butylhydroperoxide; sodium tetrachloropalladate(II) In acetic acid; tert-butyl alcohol at 50℃; for 3h;64%
With methanol; water; oxygen; toluene-4-sulfonic acid; palladium dichloride In N,N-dimethyl acetamide at 80℃; under 4560.31 Torr; for 10h; Autoclave; regioselective reaction;68 %Chromat.
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

sodium methylate
124-41-4

sodium methylate

Diethyl carbonate
105-58-8

Diethyl carbonate

A

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

B

ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

(1R,3aS,8aS)-7-isopropyl-1,4-dimethyl-1,2,3,3a,6,8a-hexahydroazulene
36577-33-0

(1R,3aS,8aS)-7-isopropyl-1,4-dimethyl-1,2,3,3a,6,8a-hexahydroazulene

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
(i) O3, AcOEt, (ii) aq. H2O2, KHCO3, (iii) /BRN= 102415/, Et2O; Multistep reaction;
ethyl 2-acetyl-4-methyl-3-oxopentanoate
79322-87-5

ethyl 2-acetyl-4-methyl-3-oxopentanoate

sodium methylate
124-41-4

sodium methylate

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
In methanol
isobutyrylacetic acid
5650-76-0

isobutyrylacetic acid

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
In diethyl ether Yield given;
methanol
67-56-1

methanol

5-(1-hydroxy-2-methylpropylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
84794-38-7

5-(1-hydroxy-2-methylpropylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
for 4h; Heating; Yield given;
methanol
67-56-1

methanol

2,2-dimethyl-5-(2-methylpropanoyl)-1,3-dioxane-4,6-dione
74965-86-9

2,2-dimethyl-5-(2-methylpropanoyl)-1,3-dioxane-4,6-dione

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
for 4h; Heating;
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide / 6 h / 110 °C
2: diethyl ether
View Scheme
Multi-step reaction with 2 steps
1: dimethylformamide / 3 h / 110 °C
2: diethyl ether
View Scheme
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

methyl (S)-3-hydroxy-4-methylvalerate

methyl (S)-3-hydroxy-4-methylvalerate

Conditions
ConditionsYield
With cat; hydrogen In methanol; dichloromethane at 25℃; under 77572.2 Torr; for 48h;100%
With hydrogen In methanol at 50℃; under 31029.7 Torr; for 24h; optical yield given as %ee; enantioselective reaction;99%
With C50H46Cl2N2O2P2Ru; hydrogen In methanol at 50℃; under 30003 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Autoclave; enantioselective reaction;97.8%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

2-[(4-fluorophenyl)methylene]-4-methyl-3-oxopentanoic acid methyl ester

2-[(4-fluorophenyl)methylene]-4-methyl-3-oxopentanoic acid methyl ester

Conditions
ConditionsYield
With piperidine; acetic acid In hexane at 20℃; for 12 - 16h; Heating / reflux;100%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

C8H11F3O5S

C8H11F3O5S

Conditions
ConditionsYield
With lithium hydroxide In water at 0℃; for 0.3h;100%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-methoxycarbonyl aniline
619-45-4

4-methoxycarbonyl aniline

methyl 4-(4-methyl-3-oxopentanamido)benzoate
936847-59-5

methyl 4-(4-methyl-3-oxopentanamido)benzoate

Conditions
ConditionsYield
With ethylenediamine In toluene for 20 - 25h; Heating / reflux;99.45%
In toluene for 24h; Reflux; Dean-Stark;85%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

(R)-3-Hydroxy-3-methylpentansaeure-methylester
76835-65-9

(R)-3-Hydroxy-3-methylpentansaeure-methylester

Conditions
ConditionsYield
With hydrogen; (S)-BinapRuBr2 In methanol at 60℃; under 760.051 Torr; for 18h; Noyori reduction;99%
With RuBr2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl}; hydrogen In methanol at 60℃; under 760.051 Torr;94%
With hydrogen In methanol at 80℃; under 15001.5 Torr; for 10h; enantioselective reaction;91.9%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-acetamidobenzenesulfonyl azide
2158-14-7

4-acetamidobenzenesulfonyl azide

methyl 2-diazo-4-methyl-3-oxopentanoate
402568-04-1

methyl 2-diazo-4-methyl-3-oxopentanoate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 16h;99%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

urea
57-13-6

urea

methyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

methyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
With sulfuric acid In methanol at 65℃; for 48h; Reagent/catalyst;98%
With sulfuric acid; copper(l) chloride In methanol at 78℃; for 9h;94.5%
With sulfuric acid; copper(l) chloride In methanol at 80℃; for 24h; Biginelli Pyrimidone Synthesis; Inert atmosphere;86%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

3-isopropylisoxazol-5(4H)-one
29068-23-3

3-isopropylisoxazol-5(4H)-one

Conditions
ConditionsYield
Stage #1: Methyl 4-methyl-3-oxopentanoate With hydroxylamine hydrochloride; sodium acetate In ethanol Reflux;
Stage #2: With hydrogenchloride In ethanol; water Reflux;
98%
With hydroxylamine hydrochloride; sodium acetate In ethanol at 78℃;78%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

formamidine
463-52-5

formamidine

6-(difluoromethyl)pyrimidin-4-ol

6-(difluoromethyl)pyrimidin-4-ol

Conditions
ConditionsYield
With sodium methylate In methanol at 20℃; for 18h;98%
nitrostyrene
5153-67-3

nitrostyrene

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

methyl 4-methyl-2-(2-nitro-1-phenylethyl)-3-oxopentanoate

methyl 4-methyl-2-(2-nitro-1-phenylethyl)-3-oxopentanoate

Conditions
ConditionsYield
[(S,S)-N-(pentamethylbenzenesulfonyl)-1,2-diphenylethylenediamine] (hexamethylbenzene)ruthenium at -20℃; for 48h; Michael Condensation;97%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

methyl-2-[(dimethylamino)methylidene]-4-methyl-3-oxopentanoate

methyl-2-[(dimethylamino)methylidene]-4-methyl-3-oxopentanoate

Conditions
ConditionsYield
at 80℃; for 1h;97%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

propionamidine hydrochloride
3599-89-1

propionamidine hydrochloride

2‐ethyl‐6‐isopropylpyrimidin‐4(3H)‐one
34127-00-9

2‐ethyl‐6‐isopropylpyrimidin‐4(3H)‐one

Conditions
ConditionsYield
With sodium methylate In methanol at 20℃; Inert atmosphere;97%
oct-1-ene
111-66-0

oct-1-ene

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

methyl 2-isobutyryl-3-methylnonanoate

methyl 2-isobutyryl-3-methylnonanoate

Conditions
ConditionsYield
With [Ir(cod)2]SbF6; 2,2'-bis(diphenylphosphino)biphenyl for 24h; Catalytic behavior; Reagent/catalyst; Reflux; diastereoselective reaction;97%
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide
757251-39-1

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

regorafenib
755037-03-7

regorafenib

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 140℃; for 4h; Temperature; Green chemistry;96.8%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

aniline
62-53-3

aniline

4-methyl-3-oxo-N-phenylpentanamide
124401-38-3

4-methyl-3-oxo-N-phenylpentanamide

Conditions
ConditionsYield
With dmap at 100℃; for 16h;96.4%
With triethylamine at 80 - 125℃;92.7%
With sodium hydroxide In neat (no solvent) at 135℃; for 12h;92%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

thiourea
17356-08-0

thiourea

3-(4-methylphenyl)acrylaldehyde
1504-75-2

3-(4-methylphenyl)acrylaldehyde

(S)-methyl 6-isopropyl-4-(4-methylstyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-methyl 6-isopropyl-4-(4-methylstyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: thiourea; 4-methyl cinnamaldehyde With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: Methyl 4-methyl-3-oxopentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
96%
4-methoxycinnamaldehyde
1963-36-6

4-methoxycinnamaldehyde

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

thiourea
17356-08-0

thiourea

(S)-methyl 6-isopropyl-4-(4-methoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

(S)-methyl 6-isopropyl-4-(4-methoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 4-methoxycinnamaldehyde; thiourea With quinidine thiourea A; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis; Sealed tube;
Stage #2: Methyl 4-methyl-3-oxopentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; Sealed tube; enantioselective reaction;
96%
Stage #1: 4-methoxycinnamaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In dichloromethane at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: Methyl 4-methyl-3-oxopentanoate In dichloromethane at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
96%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

methyl 2-(4-fluorophenyl)methylidene-3-oxo-4-methylpentanoate
122549-26-2

methyl 2-(4-fluorophenyl)methylidene-3-oxo-4-methylpentanoate

Conditions
ConditionsYield
With piperidine; acetic acid In isopropyl alcohol at 20℃; for 22h; Inert atmosphere;95.4%
With piperidine; acetic acid In isopropyl alcohol at 25 - 35℃; for 20h; Knoevenagel Condensation;86.11%
With piperidine; acetic acid In isopropyl alcohol at 30℃; for 0.5h; Temperature;80%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

benzylamine
100-46-9

benzylamine

methyl 5-isopropyl-2-phenyloxazole-4-carboxylate
1225057-22-6

methyl 5-isopropyl-2-phenyloxazole-4-carboxylate

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iodine In N,N-dimethyl-formamide at 80℃; for 6h;95%
With tert.-butylhydroperoxide; iodine; copper(II) acetate monohydrate In N,N-dimethyl-formamide at 20℃;91%
With tert-butyl hydroxyperoxide; tetra-(n-butyl)ammonium iodide In water; ethyl acetate at 40℃; for 8h;69%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

thiourea
17356-08-0

thiourea

(S)-4-(4-nitrophenyl)-6-isopropyl-5-methoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2(1H)-thione

(S)-4-(4-nitrophenyl)-6-isopropyl-5-methoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2(1H)-thione

Conditions
ConditionsYield
Stage #1: 4-nitrobenzaldehdye; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In toluene at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: Methyl 4-methyl-3-oxopentanoate In toluene at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
95%
5-Chloroisatoic anhydride
4743-17-3

5-Chloroisatoic anhydride

N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

C15H13ClF3NO5S

C15H13ClF3NO5S

Conditions
ConditionsYield
Stage #1: 5-Chloroisatoic anhydride; Methyl 4-methyl-3-oxopentanoate With sodium hydride In N,N-dimethyl acetamide at 0 - 120℃; for 1h;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h;
95%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

C20H18ClNO2

C20H18ClNO2

Conditions
ConditionsYield
With ZnCl2 supported on Fe3O4 (at) SiO2 nanocatalyst In neat (no solvent) at 60℃; for 4h;95%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

2-amino-4'-fluorobenzophenone
3800-06-4

2-amino-4'-fluorobenzophenone

methyl 4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinecarboxylate
130954-89-1

methyl 4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinecarboxylate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 0.00833333h; Friedlaender condensation; microwave irradiation;94%
With toluene-4-sulfonic acid In toluene for 5h; Heating;28%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

(E)-3-benbenzylidene-5-phenylpent-4-yn-2-one
771477-49-7

(E)-3-benbenzylidene-5-phenylpent-4-yn-2-one

C25H26O4
1175095-87-0

C25H26O4

Conditions
ConditionsYield
With [Pd(dppp)(H2O)2](2+)*2(OTf)(1-) In 1,2-dichloro-ethane at 20℃; for 10h; tandem Michael addition-cyclization; optical yield given as %de; diastereoselective reaction;94%
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

thiourea
17356-08-0

thiourea

(S)-4-(4-trifluoromethylphenyl)-6-isopropyl-5-methoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2(1H)-thione

(S)-4-(4-trifluoromethylphenyl)-6-isopropyl-5-methoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2(1H)-thione

Conditions
ConditionsYield
Stage #1: 4-Trifluoromethylbenzaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In toluene at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: Methyl 4-methyl-3-oxopentanoate In toluene at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
94%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

malononitrile
109-77-3

malononitrile

C17H17FN2O3
954153-13-0

C17H17FN2O3

Conditions
ConditionsYield
With piperidine In ethanol at 20 - 76℃; for 1h;93%
4-acetyl-2-iodotrifluoroacetanilide

4-acetyl-2-iodotrifluoroacetanilide

Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

5-acetyl-2-trifluoromethyl-1H-indole-3-carboxylic acid methyl ester

5-acetyl-2-trifluoromethyl-1H-indole-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate; L-proline In dimethyl sulfoxide at 60℃; for 12h;93%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

p-methoxyphenylisocyanide
10349-38-9

p-methoxyphenylisocyanide

C15H19NO4

C15H19NO4

Conditions
ConditionsYield
With silver carbonate In 1,4-dioxane at 80℃;93%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

thiourea
17356-08-0

thiourea

(S)-4-(4-chlorophenyl)-6-isopropyl-5-methoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2(1H)-thione

(S)-4-(4-chlorophenyl)-6-isopropyl-5-methoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2(1H)-thione

Conditions
ConditionsYield
Stage #1: 4-chlorobenzaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In toluene at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: Methyl 4-methyl-3-oxopentanoate In toluene at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
93%
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

thiourea
17356-08-0

thiourea

(S)-4-(4-hydroxyphenyl)-6-isopropyl-5-methoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2(1H)-thione

(S)-4-(4-hydroxyphenyl)-6-isopropyl-5-methoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2(1H)-thione

Conditions
ConditionsYield
Stage #1: 4-hydroxy-benzaldehyde; thiourea With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea; (1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3 -carboxylic acid In toluene at 20℃; for 3h; Biginelli Pyrimidone Synthesis;
Stage #2: Methyl 4-methyl-3-oxopentanoate In toluene at 50℃; for 15h; Biginelli Pyrimidone Synthesis; enantioselective reaction;
93%
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