The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
Cas:147118-37-4
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryAssay: 99% up; Stable supply with over 50Mt annually; Appearance:white to off-white powder Storage:room temprature Package:25kg/drum Application:Intermediate of Rosuvastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou
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inquiry4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl CAS No.:147118-37-4 Name: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Synon
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:147118-37-4
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiry1 Factory price 2 High quality 3 Good service 4 Prompt service Triclosan, scientific name "two chlorobenzene oxygen chlorophenol", the chemical formula for C12H7Cl3O2, also known as its "new", "triclosan", etc.,
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1033.html Product Name 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-f
Cas:147118-37-4
Min.Order:1 Gram
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inquiryProduct Name: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Synonyms: Methyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-sulfonyl-amino)-pyrimidin-5-yl]carboxylate;4-(4-Fluorophenyl)-5-brom
Cas:147118-37-4
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
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Type:Trading Company
inquiryEmpagliflozin CAS:864070-44-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
Cas:147118-37-4
Min.Order:1 Gram
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Name: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Synonyms: Z8(Rosuvastatin intermediate);4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)-5-pyriMidinecarboxaldehyde;4-(4-Flu
Cas:147118-37-4
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiry4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White solid Storage:Room temperature, Kee
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryMethanesulfonamide, N-[4-(4-fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-Appearance:white powder Storage:Kept in a cool, dry and ventilated place Package:according to customers' requirements Application:research chemicals Transpor
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Min.Order:1 Gram
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inquirySuperior quality, moderate price & quick delivery. Appearance:white to off white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide inter
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Min.Order:1 Gram
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Type:Trading Company
inquiryN-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; [2,2]bipyridinyl; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; 9-azabicyclo<3.3.1>nonane-N-oxyl In acetonitrile at 20 - 50℃; for 2h; Sealed tube; | 99% |
With fluorosulfonyl fluoride; potassium carbonate; dimethyl sulfoxide at 20℃; for 2h; Sealed tube; chemoselective reaction; | 99% |
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(II) nitrate trihydrate In 2-methyltetrahydrofuran at 40℃; for 18h; Temperature; Reagent/catalyst; Solvent; | 99% |
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With formic acid for 2h; Time; Reflux; | 95% |
With diisobutylaluminium hydride In toluene at -5℃; for 1h; | 81% |
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile With diisobutylaluminium hydride In dichloromethane at 0 - 5℃; Inert atmosphere; Stage #2: With hydrogenchloride In dichloromethane; water at 0 - 30℃; | 80.3% |
N-[5-[1,3]dioxolane-2-yl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With acetic acid In water at 60 - 70℃; for 0.166667h; | 93% |
N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide With sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide for 25h; Kornblum Oxydation; Stage #2: With acetic anhydride; dimethyl sulfoxide at 70℃; | 93% |
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 2: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme | |
Multi-step reaction with 2 steps 1: water / tetrahydrofuran / 6 h / Reflux 2: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C View Scheme |
A
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
B
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: C29H40FN3O6S With ozone In methanol; dichloromethane at 25℃; for 5h; Stage #2: With thiourea In methanol; dichloromethane; water Temperature; Time; | A n/a B 82.2% |
ethyl 2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-carboxylic acid
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With lithium borohydride In tetrahydrofuran at 0 - 5℃; for 4h; | 80% |
Multi-step reaction with 2 steps 1: 277 mg / DIBAL-H / toluene / 1 h / -74 °C 2: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h View Scheme |
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine
N,N-dimethyl-formamide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With trichlorophosphate at 90 - 108℃; Temperature; | 72% |
With trichlorophosphate at 90 - 108℃; | 72% |
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With N,N-dimethyl-formamide; trichlorophosphate at 90 - 108℃; Temperature; Concentration; | 72% |
4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde
methanesulfonyl chloride
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: methanesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h; | 55% |
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: methanesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h; Product distribution / selectivity; | 55% |
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Product distribution / selectivity; | 30% |
N-(4-(4-fluorophenyl)-6-isopropyl-5-(prop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With oxone; water; sodium hydrogencarbonate; ruthenium(III) trichloride hydrate In acetonitrile at 20℃; for 24h; | 40% |
With Oxone; sodium hydrogencarbonate; ruthenium(III) trichloride hydrate In water; acetonitrile at 20℃; for 24h; | 40% |
4-fluorobenzaldehyde
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 86.7 percent / piperidine, AcOH / benzene / Heating 2: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min 3: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature 4: 46.9 g / ethanol / 1 h / Ambient temperature 5: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h 6: 277 mg / DIBAL-H / toluene / 1 h / -74 °C 7: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h View Scheme |
(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min 2: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature 3: 46.9 g / ethanol / 1 h / Ambient temperature 4: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h 5: 277 mg / DIBAL-H / toluene / 1 h / -74 °C 6: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h View Scheme |
ethyl 4-methyl-3-oxo-pentanoate
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 86.7 percent / piperidine, AcOH / benzene / Heating 2: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min 3: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature 4: 46.9 g / ethanol / 1 h / Ambient temperature 5: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h 6: 277 mg / DIBAL-H / toluene / 1 h / -74 °C 7: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h View Scheme |
5-ethoxycarbonyl-6-(4'-fluorophenyl)-4-isopropyl-2-(methylamino)pyrimidine
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h 2: 277 mg / DIBAL-H / toluene / 1 h / -74 °C 3: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h View Scheme |
ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature 2: 46.9 g / ethanol / 1 h / Ambient temperature 3: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h 4: 277 mg / DIBAL-H / toluene / 1 h / -74 °C 5: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h View Scheme |
ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 46.9 g / ethanol / 1 h / Ambient temperature 2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h 3: 277 mg / DIBAL-H / toluene / 1 h / -74 °C 4: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h View Scheme |
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium carbonate / acetone / 24 h / 20 °C 2: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 5: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 6: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / acetone / 24 h / 20 °C 2.1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C 3.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 5.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h 5.2: 70 °C View Scheme | |
Multi-step reaction with 5 steps 1: potassium carbonate / acetone / 4.17 h / 20 °C 2: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 25 °C 3: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere 4: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C 5: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C View Scheme |
4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 2: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 3: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 4: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 2.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 3.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h 3.2: 70 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 3: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere 4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 3: water / tetrahydrofuran / 6 h / Reflux 4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 26 h / 0 - 20 °C 2: N-Bromosuccinimide / acetonitrile / 68 h / 20 °C / UV-irradiation 3: sodium hydrogencarbonate / acetonitrile / 4 h / Reflux 4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C View Scheme |
N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 2: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 3: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 2.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h 2.2: 70 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 2: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere 3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 2: water / tetrahydrofuran / 6 h / Reflux 3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / acetonitrile / 68 h / 20 °C / UV-irradiation 2: sodium hydrogencarbonate / acetonitrile / 4 h / Reflux 3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C View Scheme |
2-allyl-1-(4-fluorophenyl)-4-methylpentane-1,3-dione
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 25 °C 2: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere 3: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C 4: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: tetrahydrofuran / 0.33 h / 20 °C 1.2: 48.16 h / 25 °C 2.1: triethylamine / dichloromethane / 17 h / -5 °C 3.1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C 4.1: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C View Scheme |
5-allyl-4-(4-fluorophenyl)-6-isopropyl-N-methylpyrimidin-2-amine
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere 2: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C 3: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 17 h / -5 °C 2: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C 3: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C View Scheme |
N-(5-allyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C 2: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C 2: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C View Scheme |
1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C 2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 3: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 4: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 5: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C 2.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 3.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 4.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h 4.2: 70 °C View Scheme | |
Multi-step reaction with 5 steps 1: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C 2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere 5: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C View Scheme |
N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide
A
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
B
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 2: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme |
N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
A
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
B
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide at 20℃; for 71h; Kornblum oxidation; Inert atmosphere; |
1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
A
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
B
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C 2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: caesium carbonate / 2-methyltetrahydrofuran / 24 h / 70 °C 2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme |
4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine
A
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
B
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 3: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme |
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione
A
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
B
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere 2: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere 2: caesium carbonate / 2-methyltetrahydrofuran / 24 h / 70 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme |
Methyl 4-methyl-3-oxopentanoate
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: dmap; ammonia / toluene; water / 0 - 35 °C / Inert atmosphere 2.1: copper(l) chloride; sulfuric acid / methanol / 30 - 70 °C / Inert atmosphere; Reflux 3.1: potassium carbonate; tert.-butylhydroperoxide; copper(II) choride dihydrate / dichloromethane / 25 - 30 °C / Inert atmosphere 4.1: trichlorophosphate / dichloromethane / 0 - 105 °C / Inert atmosphere 5.1: potassium carbonate / toluene / 25 - 115 °C / Inert atmosphere; Reflux 6.1: diisobutylaluminium hydride / dichloromethane / 0 - 5 °C / Inert atmosphere 6.2: 0 - 30 °C View Scheme |
methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)-pyrimidin-5-yl)-(3R)-3-tert-butyldimethylsiloxy-5-oxo-(E)-6-heptenoic acid methyl ester
Conditions | Yield |
---|---|
In toluene for 30h; Wittig condensation; Heating / reflux; | 100% |
Stage #1: methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate; N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In acetonitrile for 10 - 12h; Heating / reflux; Stage #2: With acetic acid In di-isopropyl ether; water at 20℃; for 0.25h; Stage #3: With water; sodium hydrogencarbonate In di-isopropyl ether Product distribution / selectivity; | 100% |
In acetonitrile for 10 - 12h; Product distribution / selectivity; Heating / reflux; | 100% |
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate In tetrahydrofuran at 5 - 25℃; for 2h; | 98% |
With methanol; sodium tetrahydroborate In tetrahydrofuran at 5 - 10℃; | |
With methanol; sodium tetrahydroborate In tetrahydrofuran at 0 - 20℃; for 1h; |
methyl (triphenylphosphoranylidene)acetate
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
methyl 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoate
Conditions | Yield |
---|---|
In acetonitrile at 20 - 81℃; | 96% |
thiosemicarbazide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: thiosemicarbazide; allyl halide In ethanol for 3h; Reflux; Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 5h; Reflux; | 93% |
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 3h; Wittig Olefination; | 92.9% |
thiosemicarbazide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: thiosemicarbazide; isopentyl halide In ethanol for 3h; Reflux; Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux; | 92% |
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran; water at -15 - 42℃; for 1h; Temperature; Inert atmosphere; | 91% |
With sodium hydride In tetrahydrofuran at 0 - 35℃; Solvent; Temperature; Reagent/catalyst; | 120 g |
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 3h; Wittig Olefination; | 90.6% |
(R)-methyl 3-(tert-butyldimethylsilyloxy)-5-oxohexanoate
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide With tin(IV) chloride In tetrahydrofuran; dichloromethane at 0℃; for 0.25h; Inert atmosphere; Stage #2: (R)-methyl 3-(tert-butyldimethylsilyloxy)-5-oxohexanoate With 4-methyl-morpholine In tetrahydrofuran; dichloromethane at 0℃; for 3h; Reagent/catalyst; Inert atmosphere; | 87% |
thiosemicarbazide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: thiosemicarbazide; benzyl halide In ethanol for 3h; Reflux; Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux; | 85% |
thiosemicarbazide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: thiosemicarbazide; n-heptyl halide In ethanol for 3h; Reflux; Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux; | 85% |
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol at -40℃; for 4h; | 85% |
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran at 42℃; Inert atmosphere; | 84.5% |
thiosemicarbazide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: thiosemicarbazide; isopropyl halide In ethanol for 3h; Reflux; Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 5.5h; Reflux; | 83% |
allyl bromide
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
N-[4-(4-fluorophenyl)-5-(1-hydroxybut-3-enyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Conditions | Yield |
---|---|
Stage #1: allyl bromide With magnesium In diethyl ether for 0.5h; Inert atmosphere; Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In tetrahydrofuran; diethyl ether at -5 - 5℃; Stage #3: With hydrogenchloride; water In tetrahydrofuran; diethyl ether for 0.5h; | 81% |
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