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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Quality Factory Supply 147118-37-4 In Stock

Cas:147118-37-4

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Sinoway Industrial Co., Ltd.

Assay: 99% up; Stable supply with over 50Mt annually; Appearance:white to off-white powder Storage:room temprature Package:25kg/drum Application:Intermediate of Rosuvastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou

Hangzhou Think Chemical Co. Ltd

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl CAS No.:147118-37-4 Name: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Synon

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl) amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidine-2-yl]-N-methymethane-sulfonamide

Cas:147118-37-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

1 Factory price 2 High quality 3 Good service 4 Prompt service Triclosan, scientific name "two chlorobenzene oxygen chlorophenol", the chemical formula for C12H7Cl3O2, also known as its "new", "triclosan", etc.,

N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-meth...

Cas:147118-37-4

Min.Order:500 Kilogram

FOB Price: $9000.0 / 10000.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1033.html Product Name 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-f

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Product Name: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Synonyms: Methyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-sulfonyl-amino)-pyrimidin-5-yl]carboxylate;4-(4-Fluorophenyl)-5-brom

147118-37-4 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 147118-37-4 with fast shipping

Cas:147118-37-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Rosuvastatin Calcium Intermediate Manufacturer 147118-37-4

Cas:147118-37-4

Min.Order:10 Gram

Negotiable

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl 147118-37-4

Cas:147118-37-4

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl 147118-37-4

Cas:147118-37-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Rosuvastatin Z-9 CAS Number:147118-37-4

Cas:147118-37-4

Min.Order:1 Gram

FOB Price: $10.0 / 12.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Empagliflozin CAS:864070-44-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl CAS:147118-37-4

Cas:147118-37-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:147118-37-4

Cas:147118-37-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Synonyms: Z8(Rosuvastatin intermediate);4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)-5-pyriMidinecarboxaldehyde;4-(4-Flu

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White solid Storage:Room temperature, Kee

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Z-8: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Z-8: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Z-8: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Methanesulfonamide, N-[4-(4-fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-Appearance:white powder Storage:Kept in a cool, dry and ventilated place Package:according to customers' requirements Application:research chemicals Transpor

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white to off white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide inter

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

Cas:147118-37-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Synthetic route

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; [2,2]bipyridinyl; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; 9-azabicyclo<3.3.1>nonane-N-oxyl In acetonitrile at 20 - 50℃; for 2h; Sealed tube;99%
With fluorosulfonyl fluoride; potassium carbonate; dimethyl sulfoxide at 20℃; for 2h; Sealed tube; chemoselective reaction;99%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(II) nitrate trihydrate In 2-methyltetrahydrofuran at 40℃; for 18h; Temperature; Reagent/catalyst; Solvent;99%
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile
1092844-00-2

4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With formic acid for 2h; Time; Reflux;95%
With diisobutylaluminium hydride In toluene at -5℃; for 1h;81%
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile With diisobutylaluminium hydride In dichloromethane at 0 - 5℃; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water at 0 - 30℃;
80.3%
N-[5-[1,3]dioxolane-2-yl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
916480-94-9

N-[5-[1,3]dioxolane-2-yl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With acetic acid In water at 60 - 70℃; for 0.166667h;93%
N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
799842-07-2

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide With sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide for 25h; Kornblum Oxydation;
Stage #2: With acetic anhydride; dimethyl sulfoxide at 70℃;
93%
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
2: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 2 steps
1: water / tetrahydrofuran / 6 h / Reflux
2: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
C29H40FN3O6S

C29H40FN3O6S

A

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
124752-23-4

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: C29H40FN3O6S With ozone In methanol; dichloromethane at 25℃; for 5h;
Stage #2: With thiourea In methanol; dichloromethane; water Temperature; Time;
A n/a
B 82.2%
ethyl 2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-carboxylic acid
147118-30-7

ethyl 2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-carboxylic acid

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With lithium borohydride In tetrahydrofuran at 0 - 5℃; for 4h;80%
Multi-step reaction with 2 steps
1: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
2: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine
1031246-43-1

4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With trichlorophosphate at 90 - 108℃; Temperature;72%
With trichlorophosphate at 90 - 108℃;72%
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine
1031246-43-1

4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With N,N-dimethyl-formamide; trichlorophosphate at 90 - 108℃; Temperature; Concentration;72%
4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde
147118-41-0

4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: methanesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h;
55%
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: methanesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h; Product distribution / selectivity;
55%
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Product distribution / selectivity;30%
N-(4-(4-fluorophenyl)-6-isopropyl-5-(prop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide
1356998-77-0

N-(4-(4-fluorophenyl)-6-isopropyl-5-(prop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With oxone; water; sodium hydrogencarbonate; ruthenium(III) trichloride hydrate In acetonitrile at 20℃; for 24h;40%
With Oxone; sodium hydrogencarbonate; ruthenium(III) trichloride hydrate In water; acetonitrile at 20℃; for 24h;40%
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

PhCH2CH2MgHal

PhCH2CH2MgHal

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86.7 percent / piperidine, AcOH / benzene / Heating
2: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min
3: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature
4: 46.9 g / ethanol / 1 h / Ambient temperature
5: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
6: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
7: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester
122930-45-4

(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min
2: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature
3: 46.9 g / ethanol / 1 h / Ambient temperature
4: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
5: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
6: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86.7 percent / piperidine, AcOH / benzene / Heating
2: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min
3: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature
4: 46.9 g / ethanol / 1 h / Ambient temperature
5: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
6: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
7: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
5-ethoxycarbonyl-6-(4'-fluorophenyl)-4-isopropyl-2-(methylamino)pyrimidine
147118-32-9

5-ethoxycarbonyl-6-(4'-fluorophenyl)-4-isopropyl-2-(methylamino)pyrimidine

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
2: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
3: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate
147118-27-2

ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature
2: 46.9 g / ethanol / 1 h / Ambient temperature
3: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
4: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
5: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate
147118-28-3

ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 46.9 g / ethanol / 1 h / Ambient temperature
2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
3: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
4: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione
114433-94-2

1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium carbonate / acetone / 24 h / 20 °C
2: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C
3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
4: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
5: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
6: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 24 h / 20 °C
2.1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C
3.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
4.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
5.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h
5.2: 70 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / acetone / 4.17 h / 20 °C
2: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 25 °C
3: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere
4: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
5: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C
View Scheme
4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine
1207460-34-1

4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
3: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
4: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
3.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h
3.2: 70 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
3: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
3: water / tetrahydrofuran / 6 h / Reflux
4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 26 h / 0 - 20 °C
2: N-Bromosuccinimide / acetonitrile / 68 h / 20 °C / UV-irradiation
3: sodium hydrogencarbonate / acetonitrile / 4 h / Reflux
4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide
953776-62-0

N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
2: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
3: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
2.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h
2.2: 70 °C
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
2: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
2: water / tetrahydrofuran / 6 h / Reflux
3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 68 h / 20 °C / UV-irradiation
2: sodium hydrogencarbonate / acetonitrile / 4 h / Reflux
3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
2-allyl-1-(4-fluorophenyl)-4-methylpentane-1,3-dione
1356998-74-7

2-allyl-1-(4-fluorophenyl)-4-methylpentane-1,3-dione

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 25 °C
2: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere
3: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
4: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 0.33 h / 20 °C
1.2: 48.16 h / 25 °C
2.1: triethylamine / dichloromethane / 17 h / -5 °C
3.1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
4.1: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C
View Scheme
5-allyl-4-(4-fluorophenyl)-6-isopropyl-N-methylpyrimidin-2-amine
1356998-75-8

5-allyl-4-(4-fluorophenyl)-6-isopropyl-N-methylpyrimidin-2-amine

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere
2: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
3: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 17 h / -5 °C
2: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
3: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C
View Scheme
N-(5-allyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
1356998-76-9

N-(5-allyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
2: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
2: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C
View Scheme
1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
1354455-77-8

1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C
2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
4: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
5: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 4 steps
1.1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C
2.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
4.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h
4.2: 70 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C
2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
5: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide
953776-62-0

N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
2: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
799842-07-2

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide at 20℃; for 71h; Kornblum oxidation; Inert atmosphere;
1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
1354455-77-8

1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C
2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: caesium carbonate / 2-methyltetrahydrofuran / 24 h / 70 °C
2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine
1207460-34-1

4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
3: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione
114433-94-2

1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere
2: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C
3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
4: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere
2: caesium carbonate / 2-methyltetrahydrofuran / 24 h / 70 °C
3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
4: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dmap; ammonia / toluene; water / 0 - 35 °C / Inert atmosphere
2.1: copper(l) chloride; sulfuric acid / methanol / 30 - 70 °C / Inert atmosphere; Reflux
3.1: potassium carbonate; tert.-butylhydroperoxide; copper(II) choride dihydrate / dichloromethane / 25 - 30 °C / Inert atmosphere
4.1: trichlorophosphate / dichloromethane / 0 - 105 °C / Inert atmosphere
5.1: potassium carbonate / toluene / 25 - 115 °C / Inert atmosphere; Reflux
6.1: diisobutylaluminium hydride / dichloromethane / 0 - 5 °C / Inert atmosphere
6.2: 0 - 30 °C
View Scheme
methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
147118-35-2

methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)-pyrimidin-5-yl)-(3R)-3-tert-butyldimethylsiloxy-5-oxo-(E)-6-heptenoic acid methyl ester
147118-38-5

7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)-pyrimidin-5-yl)-(3R)-3-tert-butyldimethylsiloxy-5-oxo-(E)-6-heptenoic acid methyl ester

Conditions
ConditionsYield
In toluene for 30h; Wittig condensation; Heating / reflux;100%
Stage #1: methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate; N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In acetonitrile for 10 - 12h; Heating / reflux;
Stage #2: With acetic acid In di-isopropyl ether; water at 20℃; for 0.25h;
Stage #3: With water; sodium hydrogencarbonate In di-isopropyl ether Product distribution / selectivity;
100%
In acetonitrile for 10 - 12h; Product distribution / selectivity; Heating / reflux;100%
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate In tetrahydrofuran at 5 - 25℃; for 2h;98%
With methanol; sodium tetrahydroborate In tetrahydrofuran at 5 - 10℃;
With methanol; sodium tetrahydroborate In tetrahydrofuran at 0 - 20℃; for 1h;
methyl (triphenylphosphoranylidene)acetate
21204-67-1

methyl (triphenylphosphoranylidene)acetate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

methyl 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoate
1024024-26-7

methyl 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoate

Conditions
ConditionsYield
In acetonitrile at 20 - 81℃;96%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

allyl halide

allyl halide

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-allylisothiourea

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-allylisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; allyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 5h; Reflux;
93%
ethyl 2-((4R,6S)-6-triphenylphosphinomethylidene-2,2-dimethyl-1,3-dioxan-4-yl)acetate

ethyl 2-((4R,6S)-6-triphenylphosphinomethylidene-2,2-dimethyl-1,3-dioxan-4-yl)acetate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

C27H36FN3O6S

C27H36FN3O6S

Conditions
ConditionsYield
In acetonitrile at 50℃; for 3h; Wittig Olefination;92.9%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

isopentyl halide

isopentyl halide

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-isopentylisothiourea

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-isopentylisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; isopentyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux;
92%
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
380460-37-7

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
289042-12-2

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; water at -15 - 42℃; for 1h; Temperature; Inert atmosphere;91%
With sodium hydride In tetrahydrofuran at 0 - 35℃; Solvent; Temperature; Reagent/catalyst;120 g
ethyl 2-((4R,6S)-6-triphenylphosphinemethylidene-2-ethoxycarbonylmethyl-1,3-dioxane-4-yl)acetate

ethyl 2-((4R,6S)-6-triphenylphosphinemethylidene-2-ethoxycarbonylmethyl-1,3-dioxane-4-yl)acetate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

C29H38FN3O8S

C29H38FN3O8S

Conditions
ConditionsYield
In acetonitrile at 50℃; for 3h; Wittig Olefination;90.6%
(R)-methyl 3-(tert-butyldimethylsilyloxy)-5-oxohexanoate
1622874-01-4

(R)-methyl 3-(tert-butyldimethylsilyloxy)-5-oxohexanoate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

methyl (3R,6E)-3-[[(1,1-dimethylethyl)dimethylsilyl]-oxo]-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidyl]-5-oxo-6-heptenoate

methyl (3R,6E)-3-[[(1,1-dimethylethyl)dimethylsilyl]-oxo]-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidyl]-5-oxo-6-heptenoate

Conditions
ConditionsYield
Stage #1: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide With tin(IV) chloride In tetrahydrofuran; dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #2: (R)-methyl 3-(tert-butyldimethylsilyloxy)-5-oxohexanoate With 4-methyl-morpholine In tetrahydrofuran; dichloromethane at 0℃; for 3h; Reagent/catalyst; Inert atmosphere;
87%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

benzyl halide

benzyl halide

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-benzylisothiourea

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-benzylisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; benzyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux;
85%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

n-heptyl halide

n-heptyl halide

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-hepteneisothiourea

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-hepteneisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; n-heptyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux;
85%
C19H23N5O7S

C19H23N5O7S

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

C28H35FN4O7S

C28H35FN4O7S

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol at -40℃; for 4h;85%
1,1-dimethylethyl 2,4,6-trideoxy-3,5-O-(1-methylethylidene)-6-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]-D-erythro-hexonate

1,1-dimethylethyl 2,4,6-trideoxy-3,5-O-(1-methylethylidene)-6-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]-D-erythro-hexonate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
289042-12-2

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 42℃; Inert atmosphere;84.5%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

isopropyl halide

isopropyl halide

2-[N-methyl(methylsulphanamid)] - 4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-isopropylisothiourea

2-[N-methyl(methylsulphanamid)] - 4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-isopropylisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; isopropyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 5.5h; Reflux;
83%
allyl bromide
106-95-6

allyl bromide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-(1-hydroxybut-3-enyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
1352138-41-0

N-[4-(4-fluorophenyl)-5-(1-hydroxybut-3-enyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: allyl bromide With magnesium In diethyl ether for 0.5h; Inert atmosphere;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In tetrahydrofuran; diethyl ether at -5 - 5℃;
Stage #3: With hydrogenchloride; water In tetrahydrofuran; diethyl ether for 0.5h;
81%
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