As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:287714-41-4
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryRosuvastatin CAS No.:287714-41-4 Name: Rosuvastatin Synonyms: 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid Molecular Structure Molecul
Cas:287714-41-4
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:287714-41-4
Min.Order:1 Gram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Rosuvastatin The alias:7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid;Rosuvastatin;Rosuvastatin Acid; CAS NO:287714-41-4 EINECS NO:689-191-5 Molecular formula:C25H28O3
Cas:287714-41-4
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryProduct Name: Rosuvastatin Synonyms: ROSUVASTATIN-D3 SODIUM SALT;7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid;Rosuvastatin;Rosuvastatin Acid;(3R,5S,6E)-7-[4-(4-fluoro
Cas:287714-41-4
Min.Order:1 Gram
FOB Price: $8900.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:287714-41-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:287714-41-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Product Name: Rosuvastatin Synonyms: 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid CAS: 287714-41-4 MF: C22H28FN3O6S
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:287714-41-4
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:287714-41-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryRosuvastatin CAS:287714-41-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:287714-41-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Product Name: Rosuvastatin Synonyms: (3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid;Rosuvastatin Impurity 21;ROSUVASTATIN-D3 SODIUM SALT;7-[4-(4-Fluorophenyl)-6-(1-methyleth
Cas:287714-41-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:287714-41-4
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:287714-41-4
Min.Order:100 Milligram
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Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:287714-41-4
Min.Order:0
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Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Our service We have our own research and development team, laboratory, pilot workshop and production plant. Factory produc
Cas:287714-41-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:287714-41-4
Min.Order:10 Gram
FOB Price: $100.0
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:20g/bag, or as per your request. Application:Used as Pharmaceutical Intermediates Tran
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product name: Rosuvastatin CAS No.:287714-41-4 Molecule Formula:C22H28FN3O6S Molecule Weight:481.54 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:287714-41-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:287714-41-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiry2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
rosuvastatin
Conditions | Yield |
---|---|
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With acetic acid In tetrahydrofuran at 5 - 35℃; Stage #2: With lithium hydroxide In tetrahydrofuran at 5 - 35℃; | 93% |
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With hydrogenchloride In water; acetonitrile at 35 - 40℃; for 4h; Inert atmosphere; Darkness; Stage #2: With sodium hydroxide In acetonitrile at 20 - 25℃; for 2h; Stage #3: With hydrogenchloride In water pH=3 - 4; Time; | 74.4% |
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With hydrogenchloride; water In methanol at 25℃; Stage #2: With water; sodium hydroxide In methanol at 30℃; for 7.5 - 8.5h; Stage #3: With hydrogenchloride In water pH=3.5 - 4; |
tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
rosuvastatin
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 2h; Product distribution / selectivity; | 81% |
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 2h; Product distribution / selectivity; | 81% |
(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester
rosuvastatin
Conditions | Yield |
---|---|
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With ethanol; sodium hydroxide at 0 - 20℃; Stage #2: With hydrogenchloride In water; ethyl acetate pH=3.5 - 4.0; Product distribution / selectivity; | |
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With water; sodium hydroxide In ethanol at 0 - 20℃; Stage #2: With hydrogenchloride In ethanol; Isopropyl acetate; water Product distribution / selectivity; | |
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With sodium hydroxide; water In acetonitrile at 0 - 30℃; for 1.25h; Stage #2: With hydrogenchloride; water at 0 - 5℃; |
rosuvastatin
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetonitrile at 20℃; for 1h; Product distribution / selectivity; | |
With hydrogenchloride In water at 20℃; for 1h; Product distribution / selectivity; |
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine
rosuvastatin
Conditions | Yield |
---|---|
With sodium hydroxide; water In ethanol at 20℃; for 2h; |
rosuvastatin
Conditions | Yield |
---|---|
With hydrogenchloride; sodium chloride In water; acetonitrile at 0 - 20℃; pH=2.8 - 3.4; | |
With monosodium salt of ethylenediaminetetraacetic acid In water | |
With hydrogenchloride In water; ethyl acetate at 20 - 25℃; pH=3.5 - 3.7; Product distribution / selectivity; | |
With hydrogenchloride; water In ethyl acetate for 0.166667h; Product distribution / selectivity; | |
With water; edetate disodium |
rosuvastatin tert-butyl ester
rosuvastatin
Conditions | Yield |
---|---|
With sodium hydroxide; ethanol; water at 20℃; for 2h; Product distribution / selectivity; | |
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 50 - 55℃; for 1h; Stage #2: With phosphoric acid; water Product distribution / selectivity; | |
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 30℃; for 2h; Stage #2: With hydrogenchloride; water at 20℃; Product distribution / selectivity; |
rosuvastatin methylamine salt
rosuvastatin
Conditions | Yield |
---|---|
With hydrogenchloride In water; ethyl acetate at 25 - 30℃; pH=4.0; | |
With hydrogenchloride; water In ethyl acetate at 25 - 30℃; pH=4.0; |
rosuvastatin
Conditions | Yield |
---|---|
With hydrogenchloride; water at 20℃; Product distribution / selectivity; | |
With phosphoric acid; water In 2-methylpropyl acetate Product distribution / selectivity; | |
With hydrogenchloride In diethyl ether; water for 0.5h; pH=5; Product distribution / selectivity; |
rosuvastatin α,α-dimethylphenethyl ester
rosuvastatin
Conditions | Yield |
---|---|
With sodium hydroxide; water In tetrahydrofuran at 50℃; for 3h; |
methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate
rosuvastatin
Conditions | Yield |
---|---|
Stage #1: methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate With diethyl methoxy borane In tetrahydrofuran; methanol at -100 - -98℃; for 1.5h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -100℃; for 1h; Stage #3: With water; sodium hydrogencarbonate; acetic acid more than 3 stages; | |
Multi-step reaction with 3 steps 1.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1.5 h / -85 °C / Inert atmosphere 1.2: 12.5 h / -85 - 30 °C 2.1: water / acetonitrile / 2.75 h / 40 °C 3.1: hydrogenchloride / diethyl ether; water / 0.5 h / pH 5 View Scheme |
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine
rosuvastatin
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; water at 0 - 5℃; pH=3 - 3.5; Product distribution / selectivity; |
rosuvastatin
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 0.5h; Product distribution / selectivity; | |
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 0.5h; Product distribution / selectivity; |
ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate
rosuvastatin
Conditions | Yield |
---|---|
Stage #1: ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate With sodium hydroxide; ethanol; water at 60℃; for 0.833333h; Stage #2: With hydrogenchloride; water In ethanol at 0 - 10℃; for 0.166667h; Product distribution / selectivity; |
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: acetonitrile / 12 h / 84 °C 2.1: hydrogen fluoride / acetonitrile / 6.5 h / 0 - 28 °C 2.2: 0.33 h / pH 8 3.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1.5 h / -85 °C / Inert atmosphere 3.2: 12.5 h / -85 - 30 °C 4.1: water / acetonitrile / 2.75 h / 40 °C 5.1: hydrogenchloride / diethyl ether; water / 0.5 h / pH 5 View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / 0 - 35 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C 3: water; sodium hydroxide / 0 - 35 °C View Scheme |
methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: acetonitrile / 12 h / 84 °C 2.1: hydrogen fluoride / acetonitrile / 6.5 h / 0 - 28 °C 2.2: 0.33 h / pH 8 3.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1.5 h / -85 °C / Inert atmosphere 3.2: 12.5 h / -85 - 30 °C 4.1: water / acetonitrile / 2.75 h / 40 °C 5.1: hydrogenchloride / diethyl ether; water / 0.5 h / pH 5 View Scheme |
7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)-pyrimidin-5-yl)-(3R)-3-tert-butyldimethylsiloxy-5-oxo-(E)-6-heptenoic acid methyl ester
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogen fluoride / acetonitrile / 6.5 h / 0 - 28 °C 1.2: 0.33 h / pH 8 2.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1.5 h / -85 °C / Inert atmosphere 2.2: 12.5 h / -85 - 30 °C 3.1: water / acetonitrile / 2.75 h / 40 °C 4.1: hydrogenchloride / diethyl ether; water / 0.5 h / pH 5 View Scheme |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: triethylamine / dichloromethane 2: N,N-dimethyl-formamide / 25 - 130 °C 3: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol 4: sodium hydride / tetrahydrofuran / 0 - 35 °C 5: hydrogenchloride / water; acetonitrile / 35 - 40 °C 6: water; sodium hydroxide / 0 - 35 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydrogencarbonate 2: potassium carbonate / dimethyl sulfoxide / 2.16 h / 20 °C 3: hydrogenchloride / acetonitrile; water / 8 h / 20 °C View Scheme |
(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: N,N-dimethyl-formamide / 25 - 130 °C 2: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol 3: sodium hydride / tetrahydrofuran / 0 - 35 °C 4: hydrogenchloride / water; acetonitrile / 35 - 40 °C 5: water; sodium hydroxide / 0 - 35 °C View Scheme |
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol 2: sodium hydride / tetrahydrofuran / 0 - 35 °C 3: hydrogenchloride / water; acetonitrile / 35 - 40 °C 4: water; sodium hydroxide / 0 - 35 °C View Scheme |
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / 0 - 35 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C 3: water; sodium hydroxide / 0 - 35 °C View Scheme |
tert-butyl 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / 0 - 35 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C 3: water; sodium hydroxide / 0 - 35 °C View Scheme |
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / -15 - 0 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C 3: water; sodium hydroxide / 0 - 35 °C View Scheme |
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / -15 - 0 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C 3: water; sodium hydroxide / 0 - 35 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -80 - -75 °C / Inert atmosphere 1.2: 1 h / -80 - -75 °C / Inert atmosphere 2.1: hydrogenchloride / acetonitrile; water / 35 - 42 °C / Inert atmosphere 2.2: 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium carbonate / dimethyl sulfoxide / 2 h / 25 - 75 °C 2.1: hydrogenchloride / acetonitrile; water / 4 h / 35 - 40 °C / Inert atmosphere; Darkness 2.2: 2 h / 20 - 25 °C 2.3: pH 3 - 4 View Scheme |
rosuvastatin
Conditions | Yield |
---|---|
With water; sodium hydroxide at 0 - 35℃; |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: potassium carbonate / methanol / -2 - 2 °C 2: triethylamine / dichloromethane 3: N,N-dimethyl-formamide / 25 - 130 °C 4: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol 5: sodium hydride / tetrahydrofuran / 0 - 35 °C 6: hydrogenchloride / water; acetonitrile / 35 - 40 °C 7: water; sodium hydroxide / 0 - 35 °C View Scheme |
N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene / 3 h / 120 °C 2: potassium carbonate / dimethyl sulfoxide / 2.16 h / 20 °C 3: hydrogenchloride / acetonitrile; water / 8 h / 20 °C View Scheme |
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: pyridine / dichloromethane / 4 h / 0 - 20 °C 2.1: diisobutylaluminium hydride / toluene / 3 h / -10 °C 2.2: 0.25 h 3.1: phosphorus tribromide / dichloromethane / 1 h / 20 °C 4.1: triphenylphosphine / dimethyl sulfoxide / 2 h / 20 °C 4.2: 60 °C 5.1: sulfuric acid / 1,4-dioxane / 5 h / 20 °C 6.1: acetic acid butyl ester / 4 h / Reflux 7.1: sodium hydroxide / methanol / 5 h / 20 °C View Scheme |
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: diisobutylaluminium hydride / toluene / 3 h / -10 °C 1.2: 0.25 h 2.1: phosphorus tribromide / dichloromethane / 1 h / 20 °C 3.1: triphenylphosphine / dimethyl sulfoxide / 2 h / 20 °C 3.2: 60 °C 4.1: sulfuric acid / 1,4-dioxane / 5 h / 20 °C 5.1: acetic acid butyl ester / 4 h / Reflux 6.1: sodium hydroxide / methanol / 5 h / 20 °C View Scheme |
rosuvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: phosphorus tribromide / dichloromethane / 1 h / 20 °C 2.1: triphenylphosphine / dimethyl sulfoxide / 2 h / 20 °C 2.2: 60 °C 3.1: sulfuric acid / 1,4-dioxane / 5 h / 20 °C 4.1: acetic acid butyl ester / 4 h / Reflux 5.1: sodium hydroxide / methanol / 5 h / 20 °C View Scheme |
tert-butylamine
rosuvastatin
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; Product distribution / selectivity; | 100% |
Conditions | Yield |
---|---|
In water; acetonitrile at 0 - 5℃; Inert atmosphere; | 98% |
rosuvastatin
Conditions | Yield |
---|---|
With hydrogenchloride; calcium chloride In methanol; water at 15 - 20℃; pH=7; Solvent; | 97.9% |
With calcium chloride In water at 20℃; for 2h; |
rosuvastatin
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide
Conditions | Yield |
---|---|
With hydroxylamine In tetrahydrofuran; water at 20℃; for 1h; | 95% |
Conditions | Yield |
---|---|
In toluene at 100 - 110℃; for 10h; | 95% |
piperazine
rosuvastatin
Conditions | Yield |
---|---|
In Isopropyl acetate at 20 - 60℃; for 4.5h; Product distribution / selectivity; | 94% |
rosuvastatin
Conditions | Yield |
---|---|
In methanol at 20℃; for 8h; Product distribution / selectivity; | 93% |
rosuvastatin
Conditions | Yield |
---|---|
In Isopropyl acetate at 20 - 60℃; for 4.5h; Product distribution / selectivity; | 93% |
N-(4-chlorobenzhydryl)piperazine
rosuvastatin
(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid 1-[(4-chlorophenyl)-phenyl-methyl]piperazinium salt
Conditions | Yield |
---|---|
In Isopropyl acetate at 20 - 60℃; for 4.5h; Product distribution / selectivity; | 93% |
Conditions | Yield |
---|---|
In toluene at 100 - 110℃; | 92% |
zinc(II) acetylacetonate
rosuvastatin
Conditions | Yield |
---|---|
In methanol at 20℃; for 4 - 8h; Product distribution / selectivity; | 91% |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 60 - 70℃; pH=7 - 8; Concentration; | 89.6% |
tert-Octylamine
rosuvastatin
(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid tert-octylammonium salt
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 0.183333h; | 89.4% |
In acetonitrile at 20℃; for 0.183333h; Product distribution / selectivity; |
SEC-BUTYLAMINE
rosuvastatin
(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid sec-butylammonium salt
Conditions | Yield |
---|---|
In acetonitrile at 50℃; for 0.0833333h; Product distribution / selectivity; | 88% |
rosuvastatin
Conditions | Yield |
---|---|
With sulfuric acid In tetrahydrofuran at 5 - 20℃; Inert atmosphere; | 84% |
cyclohexylamine
rosuvastatin
(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid cyclohexylammonium salt
Conditions | Yield |
---|---|
In ethyl acetate at 0 - 30℃; for 3.5h; | 83.5% |
In tert-butyl methyl ether Product distribution / selectivity; | |
In Isopropyl acetate Product distribution / selectivity; |
Conditions | Yield |
---|---|
Stage #1: rosuvastatin With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: C21H19BrNO4(1+)*Br(1-) In N,N-dimethyl-formamide at 70℃; | 83% |
rosuvastatin
Conditions | Yield |
---|---|
With calcium chloride; sodium hydroxide In water at 20 - 25℃; for 0.333333h; pH=8 - 9; | 82.7% |
With calcium chloride In water at 20℃; for 1.01667 - 1.16667h; Product distribution / selectivity; | |
With calcium acetate In water at 20℃; for 1.01667h; Product distribution / selectivity; | |
Multi-step reaction with 2 steps 1.1: ethyl acetate / 0 - 35 °C 2.1: sodium hydroxide / water / 1 h / 9 - 35 °C 2.2: 0.5 h / 36 - 40 °C View Scheme |
zinc(II) sulfate
rosuvastatin
Conditions | Yield |
---|---|
With sodium ethanolate In water; ethyl acetate at 20℃; for 2.5h; Product distribution / selectivity; | 81% |
Cyclopentamine
rosuvastatin
(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid cyclopentylammonium salt
Conditions | Yield |
---|---|
In Isopropyl acetate at 50℃; for 0.0833333h; | 81% |
Conditions | Yield |
---|---|
Stage #1: tert-butylamine; rosuvastatin In acetonitrile at 5 - 45℃; for 1h; Stage #2: With sodium hydroxide In water at 25 - 30℃; Stage #3: With calcium(II) chloride dihydrate In water at 25 - 30℃; | 80% |
zinc(II) chloride
rosuvastatin
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol; ethyl acetate at 20 - 50℃; for 2.5h; Product distribution / selectivity; | 77% |
With sodium ethanolate In ethanol; ethyl acetate at 20 - 50℃; for 2.5h; Product distribution / selectivity; |
cycloheptanamine
rosuvastatin
(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid cycloheptylammonium salt
Conditions | Yield |
---|---|
In Isopropyl acetate at 50℃; for 0.0833333h; | 76% |
zinc(II) ethanolate
rosuvastatin
Conditions | Yield |
---|---|
In ethanol; ethyl acetate for 2h; Product distribution / selectivity; Heating / reflux; | 75% |
In ethanol; ethyl acetate at 20℃; for 2 - 16h; Product distribution / selectivity; Heating / reflux; | 68% |
isopropylamine
rosuvastatin
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine
Conditions | Yield |
---|---|
In ethyl acetate at 0 - 30℃; for 3.5h; Product distribution / selectivity; | 61.7% |
In acetonitrile at 0 - 30℃; for 3.5h; Product distribution / selectivity; | 49.4% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 25℃; for 16h; | 59% |
Conditions | Yield |
---|---|
In toluene at 20℃; for 20.5h; Sonication; | 55% |
Conditions | Yield |
---|---|
In water at 20℃; for 3h; Sonication; | 50% |
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