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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Rosuvastatin

Cas:287714-41-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

12 rosuvastatin CAS NO.287714-41-4

Cas:287714-41-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Rosuvastatin CAS No.:287714-41-4 Name: Rosuvastatin Synonyms: 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid Molecular Structure Molecul

High purity Rosuvastatin CAS No.:287714-41-4

Cas:287714-41-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Rosuvastatin 287714-41-4 GMP Manufacturer

Cas:287714-41-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Rosuvastatin

Cas:287714-41-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Rosuvastatin The alias:7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid;Rosuvastatin;Rosuvastatin Acid; CAS NO:287714-41-4 EINECS NO:689-191-5 Molecular formula:C25H28O3

Rosuvastatin/CAS:287714-41-4/with favorable price

Cas:287714-41-4

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Rosuvastatin Synonyms: ROSUVASTATIN-D3 SODIUM SALT;7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid;Rosuvastatin;Rosuvastatin Acid;(3R,5S,6E)-7-[4-(4-fluoro

287714-41-4 Rosuvastatin

Cas:287714-41-4

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Rosuvastatin// Ezetimibe CAS No. 287714-41-4

Cas:287714-41-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 287714-41-4 with competitive price

Cas:287714-41-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

rosuvastatin

Cas:287714-41-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Rosuvastatin Synonyms: 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid CAS: 287714-41-4 MF: C22H28FN3O6S

Rosuvastatin

Cas:287714-41-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Rosuvastatin For Anti-atherosclerosis

Cas:287714-41-4

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Rosuvastatin 287714-41-4

Cas:287714-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Rosuvastatin CAS:287714-41-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Rosuvastatin CAS:287714-41-4

Cas:287714-41-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Rosuvastatin

Cas:287714-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Rosuvastatin Synonyms: (3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid;Rosuvastatin Impurity 21;ROSUVASTATIN-D3 SODIUM SALT;7-[4-(4-Fluorophenyl)-6-(1-methyleth

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Rosuvastatin

Cas:287714-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

Rosuvastatin 287714-41-4

Cas:287714-41-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Rosuvastatin 287714-41-4

Cas:287714-41-4

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Rosuvastatin

Cas:287714-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply rosuvastatin

Cas:287714-41-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Wuhan Xinhao Biotechnology Co., Ltd.

Our service We have our own research and development team, laboratory, pilot workshop and production plant. Factory produc

Raw material Rosuvastatin intermediates powder

Cas:287714-41-4

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Rosuvastatin

Cas:287714-41-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:20g/bag, or as per your request. Application:Used as Pharmaceutical Intermediates Tran

Rosuvastatin

Cas:287714-41-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Rosuvastatin

Cas:287714-41-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Rosuvastatin CAS No.:287714-41-4 Molecule Formula:C22H28FN3O6S Molecule Weight:481.54 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Best Quality Rosuvastatin with good supplier

Cas:287714-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Rosuvastatin

Cas:287714-41-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Top Purity Rosuvastatin

Cas:287714-41-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

rosuvastatin

Cas:287714-41-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
289042-12-2

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With acetic acid In tetrahydrofuran at 5 - 35℃;
Stage #2: With lithium hydroxide In tetrahydrofuran at 5 - 35℃;
93%
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With hydrogenchloride In water; acetonitrile at 35 - 40℃; for 4h; Inert atmosphere; Darkness;
Stage #2: With sodium hydroxide In acetonitrile at 20 - 25℃; for 2h;
Stage #3: With hydrogenchloride In water pH=3 - 4; Time;
74.4%
Stage #1: 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester With hydrogenchloride; water In methanol at 25℃;
Stage #2: With water; sodium hydroxide In methanol at 30℃; for 7.5 - 8.5h;
Stage #3: With hydrogenchloride In water pH=3.5 - 4;
tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
1007871-85-3

tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 2h; Product distribution / selectivity;81%
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 2h; Product distribution / selectivity;81%
(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester
147118-40-9

(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With ethanol; sodium hydroxide at 0 - 20℃;
Stage #2: With hydrogenchloride In water; ethyl acetate pH=3.5 - 4.0; Product distribution / selectivity;
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With water; sodium hydroxide In ethanol at 0 - 20℃;
Stage #2: With hydrogenchloride In ethanol; Isopropyl acetate; water Product distribution / selectivity;
Stage #1: (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid methyl ester With sodium hydroxide; water In acetonitrile at 0 - 30℃; for 1.25h;
Stage #2: With hydrogenchloride; water at 0 - 5℃;
(E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt

(E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride In water; acetonitrile at 20℃; for 1h; Product distribution / selectivity;
With hydrogenchloride In water at 20℃; for 1h; Product distribution / selectivity;
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine
852820-97-4

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With sodium hydroxide; water In ethanol at 20℃; for 2h;
crestor

crestor

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride; sodium chloride In water; acetonitrile at 0 - 20℃; pH=2.8 - 3.4;
With monosodium salt of ethylenediaminetetraacetic acid In water
With hydrogenchloride In water; ethyl acetate at 20 - 25℃; pH=3.5 - 3.7; Product distribution / selectivity;
With hydrogenchloride; water In ethyl acetate for 0.166667h; Product distribution / selectivity;
With water; edetate disodium
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With sodium hydroxide; ethanol; water at 20℃; for 2h; Product distribution / selectivity;
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 50 - 55℃; for 1h;
Stage #2: With phosphoric acid; water Product distribution / selectivity;
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 30℃; for 2h;
Stage #2: With hydrogenchloride; water at 20℃; Product distribution / selectivity;
rosuvastatin methylamine salt
355805-96-8

rosuvastatin methylamine salt

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate at 25 - 30℃; pH=4.0;
With hydrogenchloride; water In ethyl acetate at 25 - 30℃; pH=4.0;
rosuvastatin sodium

rosuvastatin sodium

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride; water at 20℃; Product distribution / selectivity;
With phosphoric acid; water In 2-methylpropyl acetate Product distribution / selectivity;
With hydrogenchloride In diethyl ether; water for 0.5h; pH=5; Product distribution / selectivity;
rosuvastatin α,α-dimethylphenethyl ester
925705-14-2

rosuvastatin α,α-dimethylphenethyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With sodium hydroxide; water In tetrahydrofuran at 50℃; for 3h;
methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate
147118-39-6

methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Stage #1: methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate With diethyl methoxy borane In tetrahydrofuran; methanol at -100 - -98℃; for 1.5h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -100℃; for 1h;
Stage #3: With water; sodium hydrogencarbonate; acetic acid more than 3 stages;
Multi-step reaction with 3 steps
1.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1.5 h / -85 °C / Inert atmosphere
1.2: 12.5 h / -85 - 30 °C
2.1: water / acetonitrile / 2.75 h / 40 °C
3.1: hydrogenchloride / diethyl ether; water / 0.5 h / pH 5
View Scheme
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine
917805-74-4

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; water at 0 - 5℃; pH=3 - 3.5; Product distribution / selectivity;
(E)-(6-(2-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-vinyl)-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid

(E)-(6-(2-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-vinyl)-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 0.5h; Product distribution / selectivity;
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 0.5h; Product distribution / selectivity;
ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate
851443-04-4

ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Stage #1: ethyl (3R),(5S),(6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoate With sodium hydroxide; ethanol; water at 60℃; for 0.833333h;
Stage #2: With hydrogenchloride; water In ethanol at 0 - 10℃; for 0.166667h; Product distribution / selectivity;
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetonitrile / 12 h / 84 °C
2.1: hydrogen fluoride / acetonitrile / 6.5 h / 0 - 28 °C
2.2: 0.33 h / pH 8
3.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1.5 h / -85 °C / Inert atmosphere
3.2: 12.5 h / -85 - 30 °C
4.1: water / acetonitrile / 2.75 h / 40 °C
5.1: hydrogenchloride / diethyl ether; water / 0.5 h / pH 5
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / 0 - 35 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
3: water; sodium hydroxide / 0 - 35 °C
View Scheme
methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
147118-35-2

methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetonitrile / 12 h / 84 °C
2.1: hydrogen fluoride / acetonitrile / 6.5 h / 0 - 28 °C
2.2: 0.33 h / pH 8
3.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1.5 h / -85 °C / Inert atmosphere
3.2: 12.5 h / -85 - 30 °C
4.1: water / acetonitrile / 2.75 h / 40 °C
5.1: hydrogenchloride / diethyl ether; water / 0.5 h / pH 5
View Scheme
7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)-pyrimidin-5-yl)-(3R)-3-tert-butyldimethylsiloxy-5-oxo-(E)-6-heptenoic acid methyl ester
147118-38-5

7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)-pyrimidin-5-yl)-(3R)-3-tert-butyldimethylsiloxy-5-oxo-(E)-6-heptenoic acid methyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen fluoride / acetonitrile / 6.5 h / 0 - 28 °C
1.2: 0.33 h / pH 8
2.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1.5 h / -85 °C / Inert atmosphere
2.2: 12.5 h / -85 - 30 °C
3.1: water / acetonitrile / 2.75 h / 40 °C
4.1: hydrogenchloride / diethyl ether; water / 0.5 h / pH 5
View Scheme
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
124655-09-0

1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane
2: N,N-dimethyl-formamide / 25 - 130 °C
3: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol
4: sodium hydride / tetrahydrofuran / 0 - 35 °C
5: hydrogenchloride / water; acetonitrile / 35 - 40 °C
6: water; sodium hydroxide / 0 - 35 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate
2: potassium carbonate / dimethyl sulfoxide / 2.16 h / 20 °C
3: hydrogenchloride / acetonitrile; water / 8 h / 20 °C
View Scheme
(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester
135054-68-1

(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N,N-dimethyl-formamide / 25 - 130 °C
2: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol
3: sodium hydride / tetrahydrofuran / 0 - 35 °C
4: hydrogenchloride / water; acetonitrile / 35 - 40 °C
5: water; sodium hydroxide / 0 - 35 °C
View Scheme
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
380460-39-9

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol
2: sodium hydride / tetrahydrofuran / 0 - 35 °C
3: hydrogenchloride / water; acetonitrile / 35 - 40 °C
4: water; sodium hydroxide / 0 - 35 °C
View Scheme
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
380460-37-7

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / 0 - 35 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
3: water; sodium hydroxide / 0 - 35 °C
View Scheme
tert-butyl 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
1054627-26-7

tert-butyl 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / 0 - 35 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
3: water; sodium hydroxide / 0 - 35 °C
View Scheme
[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl(methyl)amino)pyrimidin-5-yl-methyl]triphenylphosphonium triflate

[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl(methyl)amino)pyrimidin-5-yl-methyl]triphenylphosphonium triflate

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / -15 - 0 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
3: water; sodium hydroxide / 0 - 35 °C
View Scheme
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
124752-23-4

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / -15 - 0 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
3: water; sodium hydroxide / 0 - 35 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -80 - -75 °C / Inert atmosphere
1.2: 1 h / -80 - -75 °C / Inert atmosphere
2.1: hydrogenchloride / acetonitrile; water / 35 - 42 °C / Inert atmosphere
2.2: 0.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / dimethyl sulfoxide / 2 h / 25 - 75 °C
2.1: hydrogenchloride / acetonitrile; water / 4 h / 35 - 40 °C / Inert atmosphere; Darkness
2.2: 2 h / 20 - 25 °C
2.3: pH 3 - 4
View Scheme
C25H34FN3O5S2

C25H34FN3O5S2

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With water; sodium hydroxide at 0 - 35℃;
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
154026-95-6

(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium carbonate / methanol / -2 - 2 °C
2: triethylamine / dichloromethane
3: N,N-dimethyl-formamide / 25 - 130 °C
4: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol
5: sodium hydride / tetrahydrofuran / 0 - 35 °C
6: hydrogenchloride / water; acetonitrile / 35 - 40 °C
7: water; sodium hydroxide / 0 - 35 °C
View Scheme
N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
799842-07-2

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: toluene / 3 h / 120 °C
2: potassium carbonate / dimethyl sulfoxide / 2.16 h / 20 °C
3: hydrogenchloride / acetonitrile; water / 8 h / 20 °C
View Scheme
4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3,4-dihydropyrimidine-2(1H)-one

4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3,4-dihydropyrimidine-2(1H)-one

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: pyridine / dichloromethane / 4 h / 0 - 20 °C
2.1: diisobutylaluminium hydride / toluene / 3 h / -10 °C
2.2: 0.25 h
3.1: phosphorus tribromide / dichloromethane / 1 h / 20 °C
4.1: triphenylphosphine / dimethyl sulfoxide / 2 h / 20 °C
4.2: 60 °C
5.1: sulfuric acid / 1,4-dioxane / 5 h / 20 °C
6.1: acetic acid butyl ester / 4 h / Reflux
7.1: sodium hydroxide / methanol / 5 h / 20 °C
View Scheme
C16H17FN2O5S

C16H17FN2O5S

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / toluene / 3 h / -10 °C
1.2: 0.25 h
2.1: phosphorus tribromide / dichloromethane / 1 h / 20 °C
3.1: triphenylphosphine / dimethyl sulfoxide / 2 h / 20 °C
3.2: 60 °C
4.1: sulfuric acid / 1,4-dioxane / 5 h / 20 °C
5.1: acetic acid butyl ester / 4 h / Reflux
6.1: sodium hydroxide / methanol / 5 h / 20 °C
View Scheme
C15H17FN2O4S

C15H17FN2O4S

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: phosphorus tribromide / dichloromethane / 1 h / 20 °C
2.1: triphenylphosphine / dimethyl sulfoxide / 2 h / 20 °C
2.2: 60 °C
3.1: sulfuric acid / 1,4-dioxane / 5 h / 20 °C
4.1: acetic acid butyl ester / 4 h / Reflux
5.1: sodium hydroxide / methanol / 5 h / 20 °C
View Scheme
tert-butylamine
75-64-9

tert-butylamine

rosuvastatin
287714-41-4

rosuvastatin

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine
917805-74-4

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; Product distribution / selectivity;100%
methylamine
74-89-5

methylamine

rosuvastatin
287714-41-4

rosuvastatin

rosuvastatin methylamine salt
355805-96-8

rosuvastatin methylamine salt

Conditions
ConditionsYield
In water; acetonitrile at 0 - 5℃; Inert atmosphere;98%
rosuvastatin
287714-41-4

rosuvastatin

(E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt

(E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt

Conditions
ConditionsYield
With hydrogenchloride; calcium chloride In methanol; water at 15 - 20℃; pH=7; Solvent;97.9%
With calcium chloride In water at 20℃; for 2h;
rosuvastatin
287714-41-4

rosuvastatin

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide
1431473-61-8

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-isopropylpyrimidin-5-yl]-3,5-dihydroxy-N-hydroxy-6-heptenamide

Conditions
ConditionsYield
With hydroxylamine In tetrahydrofuran; water at 20℃; for 1h;95%
(S)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

rosuvastatin
287714-41-4

rosuvastatin

C30H37FN4O5S

C30H37FN4O5S

Conditions
ConditionsYield
In toluene at 100 - 110℃; for 10h;95%
piperazine
110-85-0

piperazine

rosuvastatin
287714-41-4

rosuvastatin

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid piperazinium salt

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid piperazinium salt

Conditions
ConditionsYield
In Isopropyl acetate at 20 - 60℃; for 4.5h; Product distribution / selectivity;94%
bis(2,4-pentanedionato)zinc

bis(2,4-pentanedionato)zinc

rosuvastatin
287714-41-4

rosuvastatin

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

Conditions
ConditionsYield
In methanol at 20℃; for 8h; Product distribution / selectivity;93%
(-)-1-<(4-chlorophenyl)phenylmethyl>piperazine

(-)-1-<(4-chlorophenyl)phenylmethyl>piperazine

rosuvastatin
287714-41-4

rosuvastatin

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid (-)-1-[(4-chlorophenyl)-phenyl-methyl]piperazinium salt

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid (-)-1-[(4-chlorophenyl)-phenyl-methyl]piperazinium salt

Conditions
ConditionsYield
In Isopropyl acetate at 20 - 60℃; for 4.5h; Product distribution / selectivity;93%
N-(4-chlorobenzhydryl)piperazine
303-26-4

N-(4-chlorobenzhydryl)piperazine

rosuvastatin
287714-41-4

rosuvastatin

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid 1-[(4-chlorophenyl)-phenyl-methyl]piperazinium salt
1235588-98-3

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid 1-[(4-chlorophenyl)-phenyl-methyl]piperazinium salt

Conditions
ConditionsYield
In Isopropyl acetate at 20 - 60℃; for 4.5h; Product distribution / selectivity;93%
rac-methylbenzylamine
618-36-0

rac-methylbenzylamine

rosuvastatin
287714-41-4

rosuvastatin

C30H37FN4O5S

C30H37FN4O5S

Conditions
ConditionsYield
In toluene at 100 - 110℃;92%
zinc(II) acetylacetonate
14024-63-6

zinc(II) acetylacetonate

rosuvastatin
287714-41-4

rosuvastatin

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

Conditions
ConditionsYield
In methanol at 20℃; for 4 - 8h; Product distribution / selectivity;91%
berberine chloride
633-65-8

berberine chloride

rosuvastatin
287714-41-4

rosuvastatin

C22H27FN3O6S(1-)*C20H18NO4(1+)

C22H27FN3O6S(1-)*C20H18NO4(1+)

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 60 - 70℃; pH=7 - 8; Concentration;89.6%
tert-Octylamine
107-45-9

tert-Octylamine

rosuvastatin
287714-41-4

rosuvastatin

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid tert-octylammonium salt
917805-85-7

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid tert-octylammonium salt

Conditions
ConditionsYield
In acetonitrile at 20℃; for 0.183333h;89.4%
In acetonitrile at 20℃; for 0.183333h; Product distribution / selectivity;
SEC-BUTYLAMINE
33966-50-6

SEC-BUTYLAMINE

rosuvastatin
287714-41-4

rosuvastatin

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid sec-butylammonium salt
917805-75-5

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid sec-butylammonium salt

Conditions
ConditionsYield
In acetonitrile at 50℃; for 0.0833333h; Product distribution / selectivity;88%
rosuvastatin
287714-41-4

rosuvastatin

C22H26FN3O5S

C22H26FN3O5S

Conditions
ConditionsYield
With sulfuric acid In tetrahydrofuran at 5 - 20℃; Inert atmosphere;84%
cyclohexylamine
108-91-8

cyclohexylamine

rosuvastatin
287714-41-4

rosuvastatin

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid cyclohexylammonium salt
852820-98-5

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid cyclohexylammonium salt

Conditions
ConditionsYield
In ethyl acetate at 0 - 30℃; for 3.5h;83.5%
In tert-butyl methyl ether Product distribution / selectivity;
In Isopropyl acetate Product distribution / selectivity;
C21H19BrNO4(1+)*Br(1-)

C21H19BrNO4(1+)*Br(1-)

rosuvastatin
287714-41-4

rosuvastatin

C43H46FN4O10S(1+)*Br(1-)

C43H46FN4O10S(1+)*Br(1-)

Conditions
ConditionsYield
Stage #1: rosuvastatin With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: C21H19BrNO4(1+)*Br(1-) In N,N-dimethyl-formamide at 70℃;
83%
rosuvastatin
287714-41-4

rosuvastatin

crestor

crestor

Conditions
ConditionsYield
With calcium chloride; sodium hydroxide In water at 20 - 25℃; for 0.333333h; pH=8 - 9;82.7%
With calcium chloride In water at 20℃; for 1.01667 - 1.16667h; Product distribution / selectivity;
With calcium acetate In water at 20℃; for 1.01667h; Product distribution / selectivity;
Multi-step reaction with 2 steps
1.1: ethyl acetate / 0 - 35 °C
2.1: sodium hydroxide / water / 1 h / 9 - 35 °C
2.2: 0.5 h / 36 - 40 °C
View Scheme
zinc(II) sulfate
7733-02-0

zinc(II) sulfate

rosuvastatin
287714-41-4

rosuvastatin

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

Conditions
ConditionsYield
With sodium ethanolate In water; ethyl acetate at 20℃; for 2.5h; Product distribution / selectivity;81%
Cyclopentamine
1003-03-8

Cyclopentamine

rosuvastatin
287714-41-4

rosuvastatin

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid cyclopentylammonium salt
1235589-01-1

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid cyclopentylammonium salt

Conditions
ConditionsYield
In Isopropyl acetate at 50℃; for 0.0833333h;81%
tert-butylamine
75-64-9

tert-butylamine

rosuvastatin
287714-41-4

rosuvastatin

crestor

crestor

Conditions
ConditionsYield
Stage #1: tert-butylamine; rosuvastatin In acetonitrile at 5 - 45℃; for 1h;
Stage #2: With sodium hydroxide In water at 25 - 30℃;
Stage #3: With calcium(II) chloride dihydrate In water at 25 - 30℃;
80%
zinc(II) chloride
7646-85-7

zinc(II) chloride

rosuvastatin
287714-41-4

rosuvastatin

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

Conditions
ConditionsYield
With sodium ethanolate In ethanol; ethyl acetate at 20 - 50℃; for 2.5h; Product distribution / selectivity;77%
With sodium ethanolate In ethanol; ethyl acetate at 20 - 50℃; for 2.5h; Product distribution / selectivity;
cycloheptanamine
5452-35-7

cycloheptanamine

rosuvastatin
287714-41-4

rosuvastatin

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid cycloheptylammonium salt
1235589-02-2

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid cycloheptylammonium salt

Conditions
ConditionsYield
In Isopropyl acetate at 50℃; for 0.0833333h;76%
zinc(II) ethanolate
3851-22-7

zinc(II) ethanolate

rosuvastatin
287714-41-4

rosuvastatin

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonyl-amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenecarboxylic acid zinc salt

Conditions
ConditionsYield
In ethanol; ethyl acetate for 2h; Product distribution / selectivity; Heating / reflux;75%
In ethanol; ethyl acetate at 20℃; for 2 - 16h; Product distribution / selectivity; Heating / reflux;68%
isopropylamine
75-31-0

isopropylamine

rosuvastatin
287714-41-4

rosuvastatin

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine
852820-97-4

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine

Conditions
ConditionsYield
In ethyl acetate at 0 - 30℃; for 3.5h; Product distribution / selectivity;61.7%
In acetonitrile at 0 - 30℃; for 3.5h; Product distribution / selectivity;49.4%
allyl bromide
106-95-6

allyl bromide

rosuvastatin
287714-41-4

rosuvastatin

rosuvastatin allyl ester
1352945-05-1

rosuvastatin allyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 25℃; for 16h;59%
2,3-diethynylquinoxaline
91-19-0

2,3-diethynylquinoxaline

rosuvastatin
287714-41-4

rosuvastatin

rosuvastatin quinoxaline

rosuvastatin quinoxaline

Conditions
ConditionsYield
In toluene at 20℃; for 20.5h; Sonication;55%
1,4-pyrazine
290-37-9

1,4-pyrazine

rosuvastatin
287714-41-4

rosuvastatin

rosuvastatin pyrazine

rosuvastatin pyrazine

Conditions
ConditionsYield
In water at 20℃; for 3h; Sonication;50%

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