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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

High quality/Best price/Key global supplier/In stock/Express shipment/ R-2/CAS No.355806-00-7

Cas:355806-00-7

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Tert-Butyl Rosuvastatin supplier in China

Cas:355806-00-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------

High purity 355806-00-7 tert-butyl rosuvastatin

Cas:355806-00-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Sinoway Industrial Co., Ltd.

Assay: 99% up; Stable supply with over 50Mt annually; Appearance:white to off-white powder Storage:room temprature Package:25kg/drum Application:Intermediate of Rosuvastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou

tert-Butyl rosuvastatin, Rosuvastatin Intermediate R1, 355806-00-7

Cas:355806-00-7

Min.Order:1 Kilogram

FOB Price: $75.0 / 85.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of tert-Butyl rosuvastatin Cas 355806-00-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:Cool dry place Package:100g,

Factory supply tert-Butyl rosuvastatin Cas 355806-00-7 with high quality and best price

Cas:355806-00-7

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tert-Butyl Rosuvastatin

Cas:355806-00-7

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Product Name: tert-Butyl rosuvastatin Synonyms: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester;tert-butyl rosuvastatin;tert-Butyl (6E)-7-[4-(4-fluo

355806-00-7 tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

tert-Butyl rosuvastatin CAS :355806-00-7

Cas:355806-00-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 355806-00-7 with competitive price

Cas:355806-00-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Rosuvastatin Intermediates Manufacturer 355806-00-7

Cas:355806-00-7

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

tert-Butyl rosuvastatin 355806-00-7

Cas:355806-00-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

tert-Butyl rosuvastatin CAS:355806-00-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

tert-Butyl rosuvastatin CAS:355806-00-7

Cas:355806-00-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: tert-Butyl rosuvastatin Synonyms: Rosuvastatin calcium-001;R1.5;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester;tert-butyl rosuvastatin;te

tert-Butyl rosuvastatin supplier best quality

Cas:355806-00-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

R1.5

Cas:355806-00-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:0

Negotiable

Type:Trading Company

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products tert-Butyl rosuvastatin(355806-00-7)

Cas:355806-00-7

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat

tert-Butyl rosuvastatin 355806-00-7

Cas:355806-00-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Tert-Butyl Rosuvastatin

Cas:355806-00-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

Rosuvastatin tert-Butyl EsterAppearance:off-white crystalline powder Storage:Kept in a cool, dry and ventilated place Package:according to customers' requirements Application:research chemicals Transportation:By air(EMS or EUB or FedEx or TNT ect...)

Rosuvastatin tert-Butyl Ester

Cas:355806-00-7

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White to off-white crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pes

tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

Rosuvastatin tert-butyl ester

Cas:355806-00-7

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat

Enke tert-Butyl rosuvastatin

Cas:355806-00-7

Min.Order:1 Kilogram

FOB Price: $200.0 / 300.0

Type:Lab/Research institutions

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Synthetic route

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
289042-12-2

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 10℃; for 4h; Temperature;95%
With water; trifluoroacetic acid at 30 - 40℃;86%
With camphor-10-sulfonic acid In water; acetonitrile at 20℃; for 0.5h;57%
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate
1235588-97-2

tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Stage #1: tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate With water; acetic acid at 40 - 60℃; for 3h;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate
95%
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 1h;95%
tert-butyl 2-((2R,4S)-4-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-1,5-dioxaspiro[5.5]undecan-2-yl)acetate

tert-butyl 2-((2R,4S)-4-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-1,5-dioxaspiro[5.5]undecan-2-yl)acetate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 1h;95%
tert-butyl 2-((7R,9S)-9-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-6,10-dioxaspiro[4.5]decan-7-yl)acetate

tert-butyl 2-((7R,9S)-9-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-6,10-dioxaspiro[4.5]decan-7-yl)acetate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 1h;95%
(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester

(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Stage #1: (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester With triethyl borane In tetrahydrofuran; methanol at -78℃; for 0.25h; Inert atmosphere;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78℃; for 0.5h; Inert atmosphere;
90.6%
Stage #1: (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78℃; for 0.5h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol for 3h;
86%
With sodium hydroxide; water In ethanol at 20℃; for 2h;
With sodium tetrahydroborate; diethyl methoxy borane In tetrahydrofuran; methanol at -78 - -75℃; for 1.5h;10.5 g
tert-butyl (6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]-3,5-dioxohept-6-enoate

tert-butyl (6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]-3,5-dioxohept-6-enoate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
With glucose dehydrogenase; D-Glucose; carbonyl reductase; NADP; sodium carbonate In ethanol; water at 30 - 50℃; pH=6.9 - 7.2; Enzymatic reaction;86.7%
tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
1007871-85-3

tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Stage #1: tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran at 20℃; for 2.5h;
Stage #2: With sodium hydroxide; water In water at 0 - 15℃; pH=6; Product distribution / selectivity;
81%
Stage #1: tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran at 20℃; for 1 - 2.5h;
Stage #2: With sodium hydroxide In tetrahydrofuran; water at 15℃; pH=6; Product distribution / selectivity;
81%
(5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester
910867-13-9

(5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78℃; for 0.583333h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78℃; for 3 - 4h;
Stage #3: With methanol; water; acetic acid In tetrahydrofuran; ethyl acetate at -78℃; for 0.166667h;
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78 - -75℃; for 1.16667h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78 - -75℃; for 2.25h;
Stage #3: With acetic acid In tetrahydrofuran; methanol at -78℃;
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78 - -75℃; for 1.16667h; Inert atmosphere;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78 - -75℃; Inert atmosphere;
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78℃; for 0.583333h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78℃; for 3 - 4h;
Stage #3: With acetic acid In tetrahydrofuran; methanol; water; ethyl acetate at -78 - 28℃; for 0.166667h;
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With sodium tetrahydroborate; diethyl methoxy borane In tetrahydrofuran; methanol at -90 - 85℃; for 14.5h;
Stage #2: With acetic acid In tetrahydrofuran; methanol
tert-butyl 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
1054627-26-7

tert-butyl 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C
2: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 0 - 35 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
View Scheme
tert-butyl 2-[(4R,6S)-2,2-dimethyl-6-[(4-nitrophenylsulfonyloxy)methyl]-1,3-dioxan-4-yl]acetate
141942-89-4

tert-butyl 2-[(4R,6S)-2,2-dimethyl-6-[(4-nitrophenylsulfonyloxy)methyl]-1,3-dioxan-4-yl]acetate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 4-methyl-morpholine / 80 - 90 °C
2: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / dichloromethane; isopropyl alcohol / 16.5 h / 0 - 30 °C
3: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C
4: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5
View Scheme
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
124655-09-0

1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 - 5 °C
1.2: 10 - 15 °C
2.1: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C
3.1: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / toluene / 3 h / 0 - 30 °C / Inert atmosphere
2: 4-methyl-morpholine / 80 - 90 °C
3: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / dichloromethane; isopropyl alcohol / 16.5 h / 0 - 30 °C
4: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C
5: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane
2: N,N-dimethyl-formamide / 25 - 130 °C
3: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol
4: sodium hydride / tetrahydrofuran / 0 - 35 °C
5: hydrogenchloride / water; acetonitrile / 35 - 40 °C
View Scheme
(4R,6S)-6-(benzothiazol-2-mercapto)methyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
1353750-24-9

(4R,6S)-6-(benzothiazol-2-mercapto)methyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / dichloromethane; isopropyl alcohol / 16.5 h / 0 - 30 °C
2: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C
3: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5
View Scheme
(R)-tert-butyl 4-cyano-3-(tert-butyldimethylsilyloxy)butyrate

(R)-tert-butyl 4-cyano-3-(tert-butyldimethylsilyloxy)butyrate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 20 h / 10 - 30 °C
2.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C
3.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C
4.2: 1.5 h / -60 - 0 °C
5.1: cyclohexane / 30 h / 20 - 82 °C
6.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C
7.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere
View Scheme
(R)-tert-butyl 4-carbamoyl-3-(tert-butyldimethylsilyloxy)butyrate

(R)-tert-butyl 4-carbamoyl-3-(tert-butyldimethylsilyloxy)butyrate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C
2.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C
3.2: 1.5 h / -60 - 0 °C
4.1: cyclohexane / 30 h / 20 - 82 °C
5.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C
6.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere
View Scheme
(R)-5-tert-butoxy-3-(tert-butyldimethylsilyloxy)-5-oxopentanoic acid

(R)-5-tert-butoxy-3-(tert-butyldimethylsilyloxy)-5-oxopentanoic acid

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C
2.2: 1.5 h / -60 - 0 °C
3.1: cyclohexane / 30 h / 20 - 82 °C
4.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C
5.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: dicyclohexyl-carbodiimide / dichloromethane / 25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
5.1: triethyl borane / tetrahydrofuran; methanol / 0.25 h / -78 °C / Inert atmosphere
5.2: 0.5 h / -78 °C / Inert atmosphere
View Scheme
(R)-3-(tert-butyldimethylsilyloxy)-5-ethoxycarbonyloxy-5-oxopentanoic acid tert-butyl ester

(R)-3-(tert-butyldimethylsilyloxy)-5-ethoxycarbonyloxy-5-oxopentanoic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C
1.2: 1.5 h / -60 - 0 °C
2.1: cyclohexane / 30 h / 20 - 82 °C
3.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C
4.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere
View Scheme
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 1H-imidazole / dichloromethane / 21 h / 20 - 30 °C
2.1: sodium hydroxide; water / methanol / 3 h / 0 - 15 °C
3.1: sodium hydroxide; dmap / tert-butyl alcohol / 8 - 30 °C
4.1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 20 h / 10 - 30 °C
5.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C
6.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere
7.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C
7.2: 1.5 h / -60 - 0 °C
8.1: cyclohexane / 30 h / 20 - 82 °C
9.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C
10.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere
View Scheme
tert-butyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphorylidenehexanoate

tert-butyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphorylidenehexanoate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cyclohexane / 30 h / 20 - 82 °C
2: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C
3: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere
View Scheme
tertiary butyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenoate

tertiary butyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenoate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; diethyl methoxy borane In tetrahydrofuran; methanol at -80 - 25℃; for 4h; Inert atmosphere;
(R)-(-)-ethyl 4-cyano-3-(tert-butyldimethylsilyloxy)butyrate
141942-82-7

(R)-(-)-ethyl 4-cyano-3-(tert-butyldimethylsilyloxy)butyrate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: sodium hydroxide; water / methanol / 3 h / 0 - 15 °C
2.1: sodium hydroxide; dmap / tert-butyl alcohol / 8 - 30 °C
3.1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 20 h / 10 - 30 °C
4.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C
5.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C
6.2: 1.5 h / -60 - 0 °C
7.1: cyclohexane / 30 h / 20 - 82 °C
8.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C
9.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere
View Scheme
(R)-4-cyano-3-(tert-butyldimethylsilyloxy)butyric acid
105876-28-6

(R)-4-cyano-3-(tert-butyldimethylsilyloxy)butyric acid

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium hydroxide; dmap / tert-butyl alcohol / 8 - 30 °C
2.1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 20 h / 10 - 30 °C
3.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C
4.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C
5.2: 1.5 h / -60 - 0 °C
6.1: cyclohexane / 30 h / 20 - 82 °C
7.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C
8.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere
View Scheme
3-oxo-propionic acid tert-butyl ester
108350-21-6

3-oxo-propionic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 25 - 30 °C
2: sodium hydroxide / ethanol; water / 25 - 30 °C
3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / water; dichloromethane / 5 - 10 °C
4: sodium carbonate; D-Glucose; NADP; glucose dehydrogenase; carbonyl reductase / ethanol; water / 30 - 50 °C / pH 6.9 - 7.2 / Enzymatic reaction
View Scheme
3-hydroxy-5-oxo-hexanoic acid t-butyl ester

3-hydroxy-5-oxo-hexanoic acid t-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / ethanol; water / 25 - 30 °C
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / water; dichloromethane / 5 - 10 °C
3: sodium carbonate; D-Glucose; NADP; glucose dehydrogenase; carbonyl reductase / ethanol; water / 30 - 50 °C / pH 6.9 - 7.2 / Enzymatic reaction
View Scheme
tert-butyl (6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate

tert-butyl (6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / water; dichloromethane / 5 - 10 °C
2: sodium carbonate; D-Glucose; NADP; glucose dehydrogenase; carbonyl reductase / ethanol; water / 30 - 50 °C / pH 6.9 - 7.2 / Enzymatic reaction
View Scheme
(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester
135054-68-1

(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 25 - 130 °C
2: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol
3: sodium hydride / tetrahydrofuran / 0 - 35 °C
4: hydrogenchloride / water; acetonitrile / 35 - 40 °C
View Scheme
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
380460-39-9

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol
2: sodium hydride / tetrahydrofuran / 0 - 35 °C
3: hydrogenchloride / water; acetonitrile / 35 - 40 °C
View Scheme
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
380460-37-7

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 0 - 35 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
View Scheme
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 0 - 35 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
View Scheme
[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl(methyl)amino)pyrimidin-5-yl-methyl]triphenylphosphonium triflate

[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl(methyl)amino)pyrimidin-5-yl-methyl]triphenylphosphonium triflate

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / -15 - 0 °C
2: hydrogenchloride / water; acetonitrile / 35 - 40 °C
View Scheme
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

rosuvastatin sodium

rosuvastatin sodium

Conditions
ConditionsYield
With sodium hydroxide; water In tetrahydrofuran at 30 - 50℃; for 1 - 2h; Product distribution / selectivity;100%
With water; sodium hydroxide In acetonitrile at 20℃; for 7h; Temperature;97%
With sodium hydroxide In ethanol at 0 - 20℃; for 1h;92%
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

(E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt

(E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt

Conditions
ConditionsYield
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In ethanol; water at 20℃; for 1h;
Stage #2: With calcium chloride In ethanol; water at 0 - 20℃;
94%
Stage #1: rosuvastatin tert-butyl ester With lithium hydroxide In ethanol at 60℃; for 8h;
Stage #2: With calcium chloride In water for 0.5h;
90%
Stage #1: rosuvastatin tert-butyl ester With water; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 50℃; for 2h;
Stage #2: With calcium chloride In water at 0℃; for 0.25h; Product distribution / selectivity;
Stage #1: rosuvastatin tert-butyl ester With water; isopropylamine In tetrahydrofuran at 95 - 100℃; for 2h;
Stage #2: With calcium hydroxide In water at 20℃; for 1h; Product distribution / selectivity;
sodium hydroxide
1310-73-2

sodium hydroxide

rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

rosuvastatin sodium

rosuvastatin sodium

Conditions
ConditionsYield
With ethanol; water at 20 - 60℃; for 4.5h; Product distribution / selectivity;91%
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

rac-methylbenzylamine
618-36-0

rac-methylbenzylamine

C30H37FN4O5S

C30H37FN4O5S

Conditions
ConditionsYield
In toluene at 100 - 110℃; for 12h;91%
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

diisobutylamine
110-96-3

diisobutylamine

rosuvastatin diisobutylamine salt

rosuvastatin diisobutylamine salt

Conditions
ConditionsYield
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In tetrahydrofuran; water at 5 - 10℃; for 5h;
Stage #2: With citric acid In dichloromethane; water at 5 - 20℃; for 0.5h;
Stage #3: diisobutylamine In acetonitrile at 45 - 50℃; for 0.5h;
90%
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

tert-butylamine
75-64-9

tert-butylamine

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine
917805-74-4

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine

Conditions
ConditionsYield
In water; acetonitrile at 25 - 80℃; Product distribution / selectivity;85%
With water at 95 - 100℃; for 2 - 4h; Product distribution / selectivity;
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In water; acetonitrile at 17 - 22℃; for 3h;
Stage #2: tert-butylamine In dichloromethane for 1h; Temperature; Solvent; Reflux;
9.3 g
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

crestor

crestor

Conditions
ConditionsYield
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In methanol; water at 0 - 10℃; for 5h;
Stage #2: With calcium chloride In water at 10 - 15℃;
83.5%
Stage #1: rosuvastatin tert-butyl ester With water; sodium hydroxide at 40 - 45℃; Inert atmosphere;
Stage #2: With calcium chloride at 15 - 20℃; Micron filter;
38%
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In acetonitrile at 20℃; for 2h;
Stage #2: With calcium chloride In water at 20℃; for 15h; Product distribution / selectivity;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester

(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester

Conditions
ConditionsYield
With manganese(IV) oxide In dichloromethane at 40℃; for 18h; Temperature;80%
With manganese(IV) oxide for 20h; Reflux;17.6 g
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

rosuvastatin
287714-41-4

rosuvastatin

Conditions
ConditionsYield
With sodium hydroxide; ethanol; water at 20℃; for 2h; Product distribution / selectivity;
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 50 - 55℃; for 1h;
Stage #2: With phosphoric acid; water Product distribution / selectivity;
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 30℃; for 2h;
Stage #2: With hydrogenchloride; water at 20℃; Product distribution / selectivity;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

diethylamine
109-89-7

diethylamine

C4H11N*C22H28FN3O6S
917805-73-3

C4H11N*C22H28FN3O6S

Conditions
ConditionsYield
With water at 95 - 100℃; for 3.5h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

N-methylpropan-2-amine
4747-21-1

N-methylpropan-2-amine

C4H11N*C22H28FN3O6S
917805-72-2

C4H11N*C22H28FN3O6S

Conditions
ConditionsYield
With water at 95 - 100℃; for 2h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

tetramethyl ammoniumhydroxide
75-59-2

tetramethyl ammoniumhydroxide

rosuvastatin tetramethyl ammonium salt
917805-79-9

rosuvastatin tetramethyl ammonium salt

Conditions
ConditionsYield
With water at 40 - 45℃; for 1h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

diisopropylamine
108-18-9

diisopropylamine

E-7-[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt
862994-56-7

E-7-[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

Conditions
ConditionsYield
With water at 95 - 100℃; for 3h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

isopropylamine
75-31-0

isopropylamine

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine
852820-97-4

(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine

Conditions
ConditionsYield
With water at 95 - 100℃; for 2 - 3h; Product distribution / selectivity;
In water at 98 - 100℃; for 2h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

SEC-BUTYLAMINE
33966-50-6

SEC-BUTYLAMINE

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid sec-butylammonium salt
917805-75-5

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid sec-butylammonium salt

Conditions
ConditionsYield
With water at 95 - 100℃; for 4h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

Rosuvastatin lactone
503610-43-3

Rosuvastatin lactone

Conditions
ConditionsYield
Stage #1: rosuvastatin tert-butyl ester With potassium hydroxide; water In tetrahydrofuran at 40 - 45℃; for 1.5h;
Stage #2: With phosphoric acid; water In ethyl acetate for 0.333333h; Heating / reflux;
Stage #3: With sodium hydrogencarbonate In water; ethyl acetate
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

rosuvastatin triol t-butyl ester
1058749-22-6

rosuvastatin triol t-butyl ester

Conditions
ConditionsYield
Stage #1: rosuvastatin tert-butyl ester With boron dimethyl-trifluoro sulphide In tetrahydrofuran at 20℃; for 3h;
Stage #2: With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 50℃; for 0.5h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

rosuvastatin triol t-butyl ester
1058749-22-6

rosuvastatin triol t-butyl ester

A

rosuvastatin triol calcium

rosuvastatin triol calcium

B

crestor

crestor

Conditions
ConditionsYield
Stage #1: rosuvastatin tert-butyl ester; rosuvastatin triol t-butyl ester With sodium hydroxide; water In ethanol at 20℃; for 2h;
Stage #2: With calcium chloride In water at 20 - 40℃; for 1h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

N,N'-dibenzylethylenediamine diacetate
122-75-8

N,N'-dibenzylethylenediamine diacetate

N,N'-dibenzylethylenediamine rosuvastatin
1045601-12-4

N,N'-dibenzylethylenediamine rosuvastatin

Conditions
ConditionsYield
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In ethanol; water at 25 - 30℃; for 1h;
Stage #2: N,N'-dibenzylethylenediamine diacetate In water for 2h;
rosuvastatin tert-butyl ester
355806-00-7

rosuvastatin tert-butyl ester

N,N'-dibenzylethylenediamine diacetate
122-75-8

N,N'-dibenzylethylenediamine diacetate

(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)]-2-[methyl(methylsulfonyl)amino-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid N,N'-dibenzylethylenediamine

(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)]-2-[methyl(methylsulfonyl)amino-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid N,N'-dibenzylethylenediamine

Conditions
ConditionsYield
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; ethanol; water at 25 - 30℃; for 1h;
Stage #2: N,N'-dibenzylethylenediamine diacetate In water for 2h; Product distribution / selectivity;
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