The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
Cas:355806-00-7
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:355806-00-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:355806-00-7
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------
Cas:355806-00-7
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquiryAssay: 99% up; Stable supply with over 50Mt annually; Appearance:white to off-white powder Storage:room temprature Package:25kg/drum Application:Intermediate of Rosuvastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou
Cas:355806-00-7
Min.Order:1 Kilogram
FOB Price: $75.0 / 85.0
Type:Trading Company
inquiryUnique advantages of tert-Butyl rosuvastatin Cas 355806-00-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:Cool dry place Package:100g,
Cas:355806-00-7
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:355806-00-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryProduct Name: tert-Butyl rosuvastatin Synonyms: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester;tert-butyl rosuvastatin;tert-Butyl (6E)-7-[4-(4-fluo
Cas:355806-00-7
Min.Order:1 Gram
FOB Price: $8900.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:355806-00-7
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:355806-00-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:355806-00-7
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:355806-00-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquirytert-Butyl rosuvastatin CAS:355806-00-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:355806-00-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:355806-00-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: tert-Butyl rosuvastatin Synonyms: Rosuvastatin calcium-001;R1.5;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester;tert-butyl rosuvastatin;te
Cas:355806-00-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:355806-00-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:355806-00-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater
Cas:355806-00-7
Min.Order:0 Metric Ton
FOB Price: $18.0 / 20.0
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:355806-00-7
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:355806-00-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:355806-00-7
Min.Order:100 Gram
Negotiable
Type:Other
inquirylow price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat
Cas:355806-00-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:355806-00-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryRosuvastatin tert-Butyl EsterAppearance:off-white crystalline powder Storage:Kept in a cool, dry and ventilated place Package:according to customers' requirements Application:research chemicals Transportation:By air(EMS or EUB or FedEx or TNT ect...)
Superior quality, moderate price & quick delivery. Appearance:White to off-white crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pes
Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
Cas:355806-00-7
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Trading Company
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat
Cas:355806-00-7
Min.Order:1 Kilogram
FOB Price: $200.0 / 300.0
Type:Lab/Research institutions
inquiry2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 10℃; for 4h; Temperature; | 95% |
With water; trifluoroacetic acid at 30 - 40℃; | 86% |
With camphor-10-sulfonic acid In water; acetonitrile at 20℃; for 0.5h; | 57% |
tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2-phenyl-1,3-dioxan-4-yl)acetate With water; acetic acid at 40 - 60℃; for 3h; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate | 95% |
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 1h; | 95% |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 1h; | 95% |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 1h; | 95% |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester With triethyl borane In tetrahydrofuran; methanol at -78℃; for 0.25h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78℃; for 0.5h; Inert atmosphere; | 90.6% |
Stage #1: (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78℃; for 0.5h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol for 3h; | 86% |
With sodium hydroxide; water In ethanol at 20℃; for 2h; | |
With sodium tetrahydroborate; diethyl methoxy borane In tetrahydrofuran; methanol at -78 - -75℃; for 1.5h; | 10.5 g |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
With glucose dehydrogenase; D-Glucose; carbonyl reductase; NADP; sodium carbonate In ethanol; water at 30 - 50℃; pH=6.9 - 7.2; Enzymatic reaction; | 86.7% |
tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran at 20℃; for 2.5h; Stage #2: With sodium hydroxide; water In water at 0 - 15℃; pH=6; Product distribution / selectivity; | 81% |
Stage #1: tert-butyl-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran at 20℃; for 1 - 2.5h; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 15℃; pH=6; Product distribution / selectivity; | 81% |
(5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78℃; for 0.583333h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78℃; for 3 - 4h; Stage #3: With methanol; water; acetic acid In tetrahydrofuran; ethyl acetate at -78℃; for 0.166667h; | |
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78 - -75℃; for 1.16667h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78 - -75℃; for 2.25h; Stage #3: With acetic acid In tetrahydrofuran; methanol at -78℃; | |
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78 - -75℃; for 1.16667h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78 - -75℃; Inert atmosphere; | |
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With diethyl methoxy borane In tetrahydrofuran; methanol at -78℃; for 0.583333h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at -78℃; for 3 - 4h; Stage #3: With acetic acid In tetrahydrofuran; methanol; water; ethyl acetate at -78 - 28℃; for 0.166667h; | |
Stage #1: (5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester With sodium tetrahydroborate; diethyl methoxy borane In tetrahydrofuran; methanol at -90 - 85℃; for 14.5h; Stage #2: With acetic acid In tetrahydrofuran; methanol |
tert-butyl 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C 2: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5 View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 0 - 35 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C View Scheme |
tert-butyl 2-[(4R,6S)-2,2-dimethyl-6-[(4-nitrophenylsulfonyloxy)methyl]-1,3-dioxan-4-yl]acetate
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 4-methyl-morpholine / 80 - 90 °C 2: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / dichloromethane; isopropyl alcohol / 16.5 h / 0 - 30 °C 3: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C 4: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5 View Scheme |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 - 5 °C 1.2: 10 - 15 °C 2.1: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C 3.1: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5 View Scheme | |
Multi-step reaction with 5 steps 1: triethylamine / toluene / 3 h / 0 - 30 °C / Inert atmosphere 2: 4-methyl-morpholine / 80 - 90 °C 3: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / dichloromethane; isopropyl alcohol / 16.5 h / 0 - 30 °C 4: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C 5: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5 View Scheme | |
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane 2: N,N-dimethyl-formamide / 25 - 130 °C 3: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol 4: sodium hydride / tetrahydrofuran / 0 - 35 °C 5: hydrogenchloride / water; acetonitrile / 35 - 40 °C View Scheme |
(4R,6S)-6-(benzothiazol-2-mercapto)methyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / dichloromethane; isopropyl alcohol / 16.5 h / 0 - 30 °C 2: potassium tert-butylate / tetrahydrofuran / 1.75 h / -80 - 45 °C 3: hydrogenchloride; water / acetonitrile / 25 - 55 °C / pH 2.5 View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 20 h / 10 - 30 °C 2.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C 3.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere 4.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C 4.2: 1.5 h / -60 - 0 °C 5.1: cyclohexane / 30 h / 20 - 82 °C 6.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C 7.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C 2.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C 3.2: 1.5 h / -60 - 0 °C 4.1: cyclohexane / 30 h / 20 - 82 °C 5.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C 6.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C 2.2: 1.5 h / -60 - 0 °C 3.1: cyclohexane / 30 h / 20 - 82 °C 4.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C 5.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: dicyclohexyl-carbodiimide / dichloromethane / 25 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere 3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere 3.2: 20 °C / Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere 5.1: triethyl borane / tetrahydrofuran; methanol / 0.25 h / -78 °C / Inert atmosphere 5.2: 0.5 h / -78 °C / Inert atmosphere View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C 1.2: 1.5 h / -60 - 0 °C 2.1: cyclohexane / 30 h / 20 - 82 °C 3.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C 4.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere View Scheme |
(R)-ethyl 4-cyano-3-hydroxybutyrate
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: 1H-imidazole / dichloromethane / 21 h / 20 - 30 °C 2.1: sodium hydroxide; water / methanol / 3 h / 0 - 15 °C 3.1: sodium hydroxide; dmap / tert-butyl alcohol / 8 - 30 °C 4.1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 20 h / 10 - 30 °C 5.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C 6.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere 7.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C 7.2: 1.5 h / -60 - 0 °C 8.1: cyclohexane / 30 h / 20 - 82 °C 9.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C 10.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: cyclohexane / 30 h / 20 - 82 °C 2: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C 3: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
With sodium tetrahydroborate; diethyl methoxy borane In tetrahydrofuran; methanol at -80 - 25℃; for 4h; Inert atmosphere; |
(R)-(-)-ethyl 4-cyano-3-(tert-butyldimethylsilyloxy)butyrate
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: sodium hydroxide; water / methanol / 3 h / 0 - 15 °C 2.1: sodium hydroxide; dmap / tert-butyl alcohol / 8 - 30 °C 3.1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 20 h / 10 - 30 °C 4.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C 5.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere 6.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C 6.2: 1.5 h / -60 - 0 °C 7.1: cyclohexane / 30 h / 20 - 82 °C 8.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C 9.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere View Scheme |
(R)-4-cyano-3-(tert-butyldimethylsilyloxy)butyric acid
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: sodium hydroxide; dmap / tert-butyl alcohol / 8 - 30 °C 2.1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 20 h / 10 - 30 °C 3.1: sodium hypochlorite / dichloromethane / 8 h / 0 - 5 °C 4.1: triethylamine / toluene / 4 h / -45 - 0 °C / Inert atmosphere 5.1: n-butyllithium / tetrahydrofuran / 1.5 h / -60 - 0 °C 5.2: 1.5 h / -60 - 0 °C 6.1: cyclohexane / 30 h / 20 - 82 °C 7.1: hydrogenchloride; water / methanol / 4.5 h / 10 - 25 °C 8.1: diethyl methoxy borane; sodium tetrahydroborate / methanol; tetrahydrofuran / 4 h / -80 - 25 °C / Inert atmosphere View Scheme |
3-oxo-propionic acid tert-butyl ester
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 25 - 30 °C 2: sodium hydroxide / ethanol; water / 25 - 30 °C 3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / water; dichloromethane / 5 - 10 °C 4: sodium carbonate; D-Glucose; NADP; glucose dehydrogenase; carbonyl reductase / ethanol; water / 30 - 50 °C / pH 6.9 - 7.2 / Enzymatic reaction View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / ethanol; water / 25 - 30 °C 2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / water; dichloromethane / 5 - 10 °C 3: sodium carbonate; D-Glucose; NADP; glucose dehydrogenase; carbonyl reductase / ethanol; water / 30 - 50 °C / pH 6.9 - 7.2 / Enzymatic reaction View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / water; dichloromethane / 5 - 10 °C 2: sodium carbonate; D-Glucose; NADP; glucose dehydrogenase; carbonyl reductase / ethanol; water / 30 - 50 °C / pH 6.9 - 7.2 / Enzymatic reaction View Scheme |
(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide / 25 - 130 °C 2: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol 3: sodium hydride / tetrahydrofuran / 0 - 35 °C 4: hydrogenchloride / water; acetonitrile / 35 - 40 °C View Scheme |
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol 2: sodium hydride / tetrahydrofuran / 0 - 35 °C 3: hydrogenchloride / water; acetonitrile / 35 - 40 °C View Scheme |
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 0 - 35 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C View Scheme |
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 0 - 35 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / -15 - 0 °C 2: hydrogenchloride / water; acetonitrile / 35 - 40 °C View Scheme |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
With sodium hydroxide; water In tetrahydrofuran at 30 - 50℃; for 1 - 2h; Product distribution / selectivity; | 100% |
With water; sodium hydroxide In acetonitrile at 20℃; for 7h; Temperature; | 97% |
With sodium hydroxide In ethanol at 0 - 20℃; for 1h; | 92% |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In ethanol; water at 20℃; for 1h; Stage #2: With calcium chloride In ethanol; water at 0 - 20℃; | 94% |
Stage #1: rosuvastatin tert-butyl ester With lithium hydroxide In ethanol at 60℃; for 8h; Stage #2: With calcium chloride In water for 0.5h; | 90% |
Stage #1: rosuvastatin tert-butyl ester With water; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 50℃; for 2h; Stage #2: With calcium chloride In water at 0℃; for 0.25h; Product distribution / selectivity; | |
Stage #1: rosuvastatin tert-butyl ester With water; isopropylamine In tetrahydrofuran at 95 - 100℃; for 2h; Stage #2: With calcium hydroxide In water at 20℃; for 1h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With ethanol; water at 20 - 60℃; for 4.5h; Product distribution / selectivity; | 91% |
Conditions | Yield |
---|---|
In toluene at 100 - 110℃; for 12h; | 91% |
rosuvastatin tert-butyl ester
diisobutylamine
Conditions | Yield |
---|---|
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In tetrahydrofuran; water at 5 - 10℃; for 5h; Stage #2: With citric acid In dichloromethane; water at 5 - 20℃; for 0.5h; Stage #3: diisobutylamine In acetonitrile at 45 - 50℃; for 0.5h; | 90% |
rosuvastatin tert-butyl ester
tert-butylamine
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine
Conditions | Yield |
---|---|
In water; acetonitrile at 25 - 80℃; Product distribution / selectivity; | 85% |
With water at 95 - 100℃; for 2 - 4h; Product distribution / selectivity; | |
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In water; acetonitrile at 17 - 22℃; for 3h; Stage #2: tert-butylamine In dichloromethane for 1h; Temperature; Solvent; Reflux; | 9.3 g |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In methanol; water at 0 - 10℃; for 5h; Stage #2: With calcium chloride In water at 10 - 15℃; | 83.5% |
Stage #1: rosuvastatin tert-butyl ester With water; sodium hydroxide at 40 - 45℃; Inert atmosphere; Stage #2: With calcium chloride at 15 - 20℃; Micron filter; | 38% |
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In acetonitrile at 20℃; for 2h; Stage #2: With calcium chloride In water at 20℃; for 15h; Product distribution / selectivity; |
rosuvastatin tert-butyl ester
Conditions | Yield |
---|---|
With manganese(IV) oxide In dichloromethane at 40℃; for 18h; Temperature; | 80% |
With manganese(IV) oxide for 20h; Reflux; | 17.6 g |
rosuvastatin tert-butyl ester
rosuvastatin
Conditions | Yield |
---|---|
With sodium hydroxide; ethanol; water at 20℃; for 2h; Product distribution / selectivity; | |
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 50 - 55℃; for 1h; Stage #2: With phosphoric acid; water Product distribution / selectivity; | |
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; water In tetrahydrofuran at 30℃; for 2h; Stage #2: With hydrogenchloride; water at 20℃; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With water at 95 - 100℃; for 3.5h; |
rosuvastatin tert-butyl ester
N-methylpropan-2-amine
C4H11N*C22H28FN3O6S
Conditions | Yield |
---|---|
With water at 95 - 100℃; for 2h; |
rosuvastatin tert-butyl ester
tetramethyl ammoniumhydroxide
rosuvastatin tetramethyl ammonium salt
Conditions | Yield |
---|---|
With water at 40 - 45℃; for 1h; |
rosuvastatin tert-butyl ester
diisopropylamine
E-7-[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt
Conditions | Yield |
---|---|
With water at 95 - 100℃; for 3h; |
rosuvastatin tert-butyl ester
isopropylamine
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidine-5-yl]-3,5-dihydroxyhept-6-enoic acid isopropylamine
Conditions | Yield |
---|---|
With water at 95 - 100℃; for 2 - 3h; Product distribution / selectivity; | |
In water at 98 - 100℃; for 2h; |
rosuvastatin tert-butyl ester
SEC-BUTYLAMINE
(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid sec-butylammonium salt
Conditions | Yield |
---|---|
With water at 95 - 100℃; for 4h; |
rosuvastatin tert-butyl ester
Rosuvastatin lactone
Conditions | Yield |
---|---|
Stage #1: rosuvastatin tert-butyl ester With potassium hydroxide; water In tetrahydrofuran at 40 - 45℃; for 1.5h; Stage #2: With phosphoric acid; water In ethyl acetate for 0.333333h; Heating / reflux; Stage #3: With sodium hydrogencarbonate In water; ethyl acetate |
rosuvastatin tert-butyl ester
rosuvastatin triol t-butyl ester
Conditions | Yield |
---|---|
Stage #1: rosuvastatin tert-butyl ester With boron dimethyl-trifluoro sulphide In tetrahydrofuran at 20℃; for 3h; Stage #2: With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 50℃; for 0.5h; |
rosuvastatin tert-butyl ester
rosuvastatin triol t-butyl ester
Conditions | Yield |
---|---|
Stage #1: rosuvastatin tert-butyl ester; rosuvastatin triol t-butyl ester With sodium hydroxide; water In ethanol at 20℃; for 2h; Stage #2: With calcium chloride In water at 20 - 40℃; for 1h; |
rosuvastatin tert-butyl ester
N,N'-dibenzylethylenediamine diacetate
N,N'-dibenzylethylenediamine rosuvastatin
Conditions | Yield |
---|---|
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide In ethanol; water at 25 - 30℃; for 1h; Stage #2: N,N'-dibenzylethylenediamine diacetate In water for 2h; |
rosuvastatin tert-butyl ester
N,N'-dibenzylethylenediamine diacetate
Conditions | Yield |
---|---|
Stage #1: rosuvastatin tert-butyl ester With sodium hydroxide; ethanol; water at 25 - 30℃; for 1h; Stage #2: N,N'-dibenzylethylenediamine diacetate In water for 2h; Product distribution / selectivity; |
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