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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Colorless to light yellow transparent liquid Conform Purity (GC)

Top purity Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate with high quality and best price cas:141942-85-0

Cas:141942-85-0

Min.Order:1 Gram

FOB Price: $2.0 / 5.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ats-5(For Atorvastatin) supplier in China

Cas:141942-85-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Assay: 99% up; Stable supply with over 50Mt annually; Appearance:Transparent to light-yellow liquid Storage:room temprature Package:25kg/drum Application:Intermediate of Atrovastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate, Atrovastatin Intermediate A5, 141942-85-0

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $28.0 / 45.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply ethyl (3R)-4-cyano-3-hydroxybutanoate

Cas:141942-85-0

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 141942-85-0 Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Manufacturer

Cas:141942-85-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-(-)-4-Cyano-3-hydroxybutyric acid ethyl ester

Cas:141942-85-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate/Atorvastatin Intermediates/cas no 141942-85-0

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Product Name: Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Synonyms: (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;

141942-85-0 (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER

Cas:141942-85-0

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Technical Details Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties alpha -5 º (neat) Boiling point 2

China Largest factory Manufacturer Supply Ethyl (R)-(-)-4-cyano-3-hydroxybutyate/ATS-5 CAS 141942-85-0

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate CAS NO 141942-85-0

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 141942-85-0 with best quality

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name:Ethyl (R)-(-)-4-cyano-3-hydroxybutyate CAS No.:141942-85-0 EINECS: 430-220-6 Molecular Formula: C7H11NO3 Molecular Weight: 157.17 Appearance:Colorless liquid Appearance: Colorless Transparent Liquid Storage: Preserve in well-clos

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 141942-85-0 Ethyl (R)-(-)-4-cyano-3-hydroxybutyate with best price

Cas:141942-85-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 141942-85-0

Cas:141942-85-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Atorvastatin Intermediate Ethyl (R)-(-)-4-cyano-3-hydroxybutyate with CAS:141942-85-0

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $76.0 / 80.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate CAS:141942-85-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate CAS:141942-85-0

Cas:141942-85-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Cas:141942-85-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Cas:141942-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Synonyms: (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(S)-4-CYANO

Atorvastatin Intermediates Ethyl (R)-(-)-4-cyano-3-hydroxybutyate free sample available best quality

Cas:141942-85-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl (R)-(-)-4-Cyano-3-Hydroxybutyate

Cas:141942-85-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:Colorless to yellowish transparent liq... Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application: Pharmaceutical intermediates Transportation:Common products:

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate

Cas:141942-85-0

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Cas:141942-85-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Cas:141942-85-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. Kind Pharma has its own laboratory, we can do analytical testing for API (Active Pharmaceutical Ingredient), pharmaceutical intermediate, pesticide intermediate, additive and other chemical products, so it

Ethyl (R)-(-)-4-Cyano-3-Hydroxybutyate

Cas:141942-85-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Cas:141942-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate CAS 141942-85-0

Cas:141942-85-0

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(R)-(-)-4-Cyano-3-hydroxybutyric acid ethyl ester CAS NO.141942-85-0

Cas:141942-85-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

(3R)-4-cyano-3-hydroxybutyric acid ethyl esterAppearance:Colorless to light yellow liquid Storage:Kept in a cool, dry and ventilated place Package:according to customers' requirements Application:research chemicals Transportation:By air(EMS or EUB or

(3R)-4-cyano-3-hydroxybutyric acid ethyl ester

Cas:141942-85-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Colorless to light yellow transparent liquid Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:For

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Cas:141942-85-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

ethyl (2-chloroaceto)acetate
638-07-3

ethyl (2-chloroaceto)acetate

sodium cyanide
143-33-9

sodium cyanide

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With glucose dehydrogenase; ketoreductase In acetic acid butyl ester; water at 30 - 40℃; for 16h; Product distribution / selectivity; Aqueous phosphate buffer;98%
sodium cyanide
143-33-9

sodium cyanide

(S)-4-bromo-3-hydroxy-butyric acid ethyl ester
32224-01-4, 95310-94-4, 128052-98-2, 95537-36-3

(S)-4-bromo-3-hydroxy-butyric acid ethyl ester

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
at 50℃; for 3h;95%
In N,N-dimethyl-formamide at 20℃;50%
sodium cyanide
773837-37-9

sodium cyanide

ethyl (S)-4-chloro-3-hydroxybutanoate
10488-69-4, 86728-85-0, 87068-18-6, 90866-33-4

ethyl (S)-4-chloro-3-hydroxybutanoate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid; sodium hydroxide In water at 40℃; pH=7.3; Enzymatic reaction;93%
With halohydrindehalogenase from parvibaculum lavamentivorans at 40℃; for 14h; pH=8; Kinetics; Enzymatic reaction;85%
In water; N,N-dimethyl-formamide at 50℃; for 3h;70%
(R)-3-hydroxy-4-cyano-butyric acid
287955-93-5

(R)-3-hydroxy-4-cyano-butyric acid

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid In ethanol90%
cyanoacetoacetic acid ethyl ester
1715-68-0

cyanoacetoacetic acid ethyl ester

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With D-glucose In phosphate buffer at 30℃; for 24h; pH=7;83.1%
sodium cyanide
143-33-9

sodium cyanide

(S)-4-iodo-3-hydroxy-butyric acid ethyl ester
112100-39-7

(S)-4-iodo-3-hydroxy-butyric acid ethyl ester

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
In ethanol; water at 45℃; for 3h;81%
(S)-4-bromo-3-hydroxybutyric acid,ethyl ester
32224-01-4

(S)-4-bromo-3-hydroxybutyric acid,ethyl ester

sodium cyanide
143-33-9

sodium cyanide

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
In water at 25 - 35℃; for 7.33h; pH=8 - 9.5;80%
sodium cyanide
143-33-9

sodium cyanide

ethyl (S)-4-chloro-3-hydroxybutanoate
10488-69-4, 86728-85-0, 87068-18-6, 90866-33-4

ethyl (S)-4-chloro-3-hydroxybutanoate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With acetic acid In water at 105 - 110℃; for 0.02125h;80%
With sodium dihydrogen phosphate monohydrate In formamide at 65℃; for 1.25h;76.4%
In water at 105℃; for 0.0133333h;67.4%
ethanol
64-17-5

ethanol

(R)-3-hydroxy-4-cyano-butyric acid
287955-93-5

(R)-3-hydroxy-4-cyano-butyric acid

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid at 80℃; for 1h;62%
hydrogenchloride In diethyl ether; ethanol at 20℃; for 30h;
With hydrogenchloride In diethyl ether; ethanol at 20℃; for 30h; Inert atmosphere;
With hydrogenchloride In diethyl ether at 20℃; for 30h; Inert atmosphere;
ethanol
64-17-5

ethanol

(R)-3-hydroxy-4-cyano-butyric acid
287955-93-5

(R)-3-hydroxy-4-cyano-butyric acid

A

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

B

(S)-3-hydroxy-4-cyanobutyric acid ethyl ester
312745-91-8

(S)-3-hydroxy-4-cyanobutyric acid ethyl ester

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 0.5h; Title compound not separated from byproducts.;
3-hydroxyglutaronitrile
13880-89-2

3-hydroxyglutaronitrile

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nitrilase III; phosphate buffer / 22 h / 22 °C / pH 7
2: HCl / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: water / 22 h / 22 °C / pH 7
2: hydrogenchloride / ethanol; diethyl ether / 30 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: water; A190H / aq. phosphate buffer / 21 °C / pH 7 / Enzymatic reaction
2: hydrogenchloride / diethyl ether / 30 h / 20 °C / Inert atmosphere
View Scheme
(R)-4-cyano-3-hydroxybutyric acid calcium salt

(R)-4-cyano-3-hydroxybutyric acid calcium salt

ethanol
64-17-5

ethanol

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid at 0℃; for 1h; Heating / reflux; Neat (no solvent);
(R)-potassium 3-hydroxy-4-cyano-butyrate
635680-93-2

(R)-potassium 3-hydroxy-4-cyano-butyrate

ethanol
64-17-5

ethanol

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid at 0℃;n/a
diethyl sulfate
64-67-5

diethyl sulfate

(S)-(-)-methyl-(3-hydroxy-4-bromo)-butanoate
88759-56-2

(S)-(-)-methyl-(3-hydroxy-4-bromo)-butanoate

(R)-3-hydroxy-4-cyano-butyric acid
287955-93-5

(R)-3-hydroxy-4-cyano-butyric acid

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With hydrogenchloride; calcium hydroxide; sodium bicarbonate; calcium chloride; triethylamine In water; ethyl acetate
(S)-4-bromo-3-hydroxy-butyric acid ethyl ester
32224-01-4, 95310-94-4, 128052-98-2, 95537-36-3

(S)-4-bromo-3-hydroxy-butyric acid ethyl ester

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With NaCN In ethanol; water29.8 g (95%)
sodium cyanide
143-33-9

sodium cyanide

ethyl (S)-4-chloro-3-hydroxybutanoate
10488-69-4, 86728-85-0, 87068-18-6, 90866-33-4

ethyl (S)-4-chloro-3-hydroxybutanoate

A

(E)-ethyl 4-hydroxybut-2-enoate
10080-68-9

(E)-ethyl 4-hydroxybut-2-enoate

B

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
In water at 55℃; for 3h; pH=8.5 - 9; Product distribution / selectivity;
hydrogen cyanide
74-90-8

hydrogen cyanide

ethyl (S)-4-chloro-3-hydroxybutanoate
10488-69-4, 86728-85-0, 87068-18-6, 90866-33-4

ethyl (S)-4-chloro-3-hydroxybutanoate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
Stage #1: hydrogen cyanide With halohydrin dehalogenase In water at 40℃; for 0.5h; pH=7;
Stage #2: ethyl (S)-4-chloro-3-hydroxybutanoate In water for 21h; pH=7; Product distribution / selectivity;
sodium cyanide
773837-37-9

sodium cyanide

(S)-4-bromo-3-hydroxy-butyric acid ethyl ester
32224-01-4, 95310-94-4, 128052-98-2, 95537-36-3

(S)-4-bromo-3-hydroxy-butyric acid ethyl ester

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
In ethanol; water
sodium cyanide
773837-37-9

sodium cyanide

ethyl (-)-(2S)-oxirane-2-acetate
112083-63-3

ethyl (-)-(2S)-oxirane-2-acetate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With ammonia; nickel dichloride In aq. phosphate buffer; water at 30℃; pH=8; Kinetics; Enzymatic reaction;
sodium cyanide
773837-37-9

sodium cyanide

ethyl (2-chloroaceto)acetate
638-07-3

ethyl (2-chloroaceto)acetate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With vector pACYCDuet-RB and vector pET30-halohydrin dehalogenase in Escherichia coli BL21 (DE3) In aq. buffer at 30℃; for 2h; pH=7; Enzymatic reaction; stereoselective reaction;n/a
sodium cyanide
773837-37-9

sodium cyanide

ethyl (2-chloroaceto)acetate
638-07-3

ethyl (2-chloroaceto)acetate

A

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

B

(S)-3-hydroxy-4-cyanobutyric acid ethyl ester
312745-91-8

(S)-3-hydroxy-4-cyanobutyric acid ethyl ester

Conditions
ConditionsYield
With vector pCDFDuet-HF and vector pET30-(S)-alcohol dehydrogenase in Escherichia coli BL21(DE3) In aq. buffer at 30℃; for 10h; pH=7; Enzymatic reaction; stereoselective reaction;A n/a
B n/a
With halohydrin dehalogenase; NAD; magnesium chloride; alcohol dehydrogenase In tert-butyl methyl ether at 40℃; under 760.051 Torr; for 10h; pH=8; Solvent; Reagent/catalyst; Concentration; Time; Electrolysis; Sealed tube; Inert atmosphere; Enzymatic reaction;A n/a
B n/a
ethyl (S)-4-chloro-3-hydroxybutanoate
10488-69-4, 86728-85-0, 87068-18-6, 90866-33-4

ethyl (S)-4-chloro-3-hydroxybutanoate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
With sodium cyanide; halohydrin dehalogenase In aq. phosphate buffer at 30℃; for 4h; pH=8; Enzymatic reaction;
ethyl (2-chloroaceto)acetate
638-07-3

ethyl (2-chloroaceto)acetate

A

(E)-ethyl 4-hydroxybut-2-enoate
10080-68-9

(E)-ethyl 4-hydroxybut-2-enoate

B

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ketoreductase / acetic acid butyl ester; water / 11 h / pH 7
2: water / 3 h / 55 °C / pH 8.5 - 9
View Scheme
ethyl (2-chloroaceto)acetate
638-07-3

ethyl (2-chloroaceto)acetate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ketoreductase / acetic acid butyl ester; water / 11 h / pH 7
2: water / 3 h / 55 °C / pH 8
View Scheme
O-(4-methoxybenzyl)-trichloroacetimidate
89238-99-3

O-(4-methoxybenzyl)-trichloroacetimidate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

ethyl (R)-4-cyano-3-[(4-methoxybenzyl)oxy]butanoate
1031883-60-9

ethyl (R)-4-cyano-3-[(4-methoxybenzyl)oxy]butanoate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane; cyclohexane at 25℃; for 3h;99%
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

(R)-ethyl-5-amino-3-hydroxy-5-oxopentanoate
717127-73-6

(R)-ethyl-5-amino-3-hydroxy-5-oxopentanoate

Conditions
ConditionsYield
With Wilkinson's catalyst; 2,2-dimethylpropionaldehyde oxime In toluene at 110℃; for 4h;99%
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

4-hydroxy-δ-valerolactam
1051316-41-6

4-hydroxy-δ-valerolactam

Conditions
ConditionsYield
With platinum(IV) oxide; hydrogen In methanol99%
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

(R)-4-cyano-3-hydroxybutyric acid hydrazide

(R)-4-cyano-3-hydroxybutyric acid hydrazide

Conditions
ConditionsYield
With hydrazine In ethanol for 2h;98%
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

(R)-4-cyano-3-hydroxybutyramide

(R)-4-cyano-3-hydroxybutyramide

Conditions
ConditionsYield
With ammonium hydroxide In methanol for 10h;83%
With ammonium hydroxide In methanol
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

methyl iodide
74-88-4

methyl iodide

(R) 4-cyano-3-methoxyl butyric acid ethyl ester

(R) 4-cyano-3-methoxyl butyric acid ethyl ester

Conditions
ConditionsYield
With silver(l) oxide at 20℃;63.1%
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

1,2-dibromomethane
74-95-3

1,2-dibromomethane

(R)-6,6-dibromo-3-hydroxy-5-oxohexanenitrile

(R)-6,6-dibromo-3-hydroxy-5-oxohexanenitrile

Conditions
ConditionsYield
Stage #1: 1,2-dibromomethane With lithium diisopropyl amide In tetrahydrofuran at -90℃; for 0.0666667h; Inert atmosphere; Flow reactor;
Stage #2: (R)-ethyl 4-cyano-3-hydroxybutyrate In tetrahydrofuran at -90℃; Inert atmosphere; Flow reactor;
22%
t-butyl lithioacetate
150942-98-6

t-butyl lithioacetate

(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

tert-butyl (5R)-6-cyano-5-hydroxy-3-carbonylhexanoate
125988-01-4

tert-butyl (5R)-6-cyano-5-hydroxy-3-carbonylhexanoate

Conditions
ConditionsYield
In tetrahydrofuran; hexane Yield given;
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

(R)-5-Amino-pentane-1,3-diol

(R)-5-Amino-pentane-1,3-diol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

(R)-3-hydroxy-4-cyano-butyric acid
287955-93-5

(R)-3-hydroxy-4-cyano-butyric acid

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 2h;
With sodium hydroxide; water for 2h;
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

[3-((R)-4-Cyano-3-hydroxy-butyrylamino)-propyl]-carbamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
669013-16-5

[3-((R)-4-Cyano-3-hydroxy-butyrylamino)-propyl]-carbamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NaOH / 2 h / 20 °C
2: 64 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; aq. NaH2PO4 / dimethylformamide; tetrahydrofuran / 16 h / 20 °C / pH 5.7 - 6.0
View Scheme
(R)-ethyl 4-cyano-3-hydroxybutyrate
141942-85-0

(R)-ethyl 4-cyano-3-hydroxybutyrate

(3-{(R)-4-Cyano-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-butyrylamino}-propyl)-carbamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
669013-14-3

(3-{(R)-4-Cyano-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-butyrylamino}-propyl)-carbamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. NaOH / 2 h / 20 °C
2: 64 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; aq. NaH2PO4 / dimethylformamide; tetrahydrofuran / 16 h / 20 °C / pH 5.7 - 6.0
3: 63 percent / N,N-diisopropylethylamine / CH2Cl2 / 3 h / 20 °C
View Scheme
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