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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply High Quality Emtricitabine powder CAS 143491-57-0

Cas:143491-57-0

Min.Order:1 Kilogram

FOB Price: $350.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Emtricitabine Manufacturer/High quality/Best price/In stock

Cas:143491-57-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:-20°C Freezer Package:1kg/foil bag;

High quality Emtricitabine CAS 143491-57-0 supplied by manufacturer

Cas:143491-57-0

Min.Order:25 Kilogram

FOB Price: $100.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Emtricitabine

Cas:143491-57-0

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Emtricitabine 143491-57-0 GMP Manufacturer

Cas:143491-57-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Emtricitabine

Cas:143491-57-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

Active pharmaceutical ingredient,Anti-retroviral, EmtricitabineCAS No.: 143491-57-0.

Cas:143491-57-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Emtricitabine

Cas:143491-57-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

CAS No.143491-57-0 Emtricitabine

Cas:143491-57-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 143491-57-0 with best quality

Cas:143491-57-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Emtricitabine/ LIDE PHARMA- Factory supply / Best price

Cas:143491-57-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

[English Name] Emtricitabine [Test Method]HPLC [Purity]≥99% [CAS No.] 143491-57-0 [Mol. Formula]C8H10FN3O3S [Purity]> 99% by HPLC [Packaging]Package and quantity according to customer's detail requirement [Remark] In stock,

Emtricitabine

Cas:143491-57-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp

Emtricitabine 99%

Cas:143491-57-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quality 99% purity Pharmaceuticals Powder Emtricitabine raw powder emtricitabine

Cas:143491-57-0

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: Emtricitabine CAS: 143491-57-0 MF: C8H10FN3O3S MW: 247.25 EINECS: 604-363-1 Mol File: 143491-57-0.mol Emtricitabine Structure Emtricitabine Chemical Properties Melting point 136-140°C alpha D25 -133.60&de

Emtricitabine

Cas:143491-57-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

143491-57-0 cas 99.5% BP USP Emtricitabine

Cas:143491-57-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Emtricitabine CAS:143491-57-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

Emtricitabine CAS:143491-57-0

Cas:143491-57-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Chinese suppliers CAS 143491-57-0 Emtricitabine

Cas:143491-57-0

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Emtricitabine

Cas:143491-57-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Emtricitabine manufacturer with low price

Cas:143491-57-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:143491-57-0

Cas:143491-57-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Emtricitabine

Cas:143491-57-0

Min.Order:1 Gram

FOB Price: $109.0

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Emtricitabine

Cas:143491-57-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Emtricitabine 143491-57-0

Cas:143491-57-0

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Emtricitabine

Cas:143491-57-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

EMtricitabine

Cas:143491-57-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Emtricitabine

Cas:143491-57-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Emtricitabine

Cas:143491-57-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

Emtricitabine

Cas:143491-57-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Emtricitabine

Cas:143491-57-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Synthetic route

2',3'-dideoxy-5-fluoro-3'-thiacytidine hydrochloride
258832-61-0

2',3'-dideoxy-5-fluoro-3'-thiacytidine hydrochloride

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With triethylamine In methanol at 15 - 60℃;93.2%
With triethylamine In methanol at 25 - 65℃; for 0.25h; Heating / reflux;82%
With tributyl-amine In dichloromethane at 25 - 35℃; for 5.5h;
Amberlite LA2 liquid ion-exchange resin;25 g
(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine salicylate

(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine salicylate

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With triethylamine In ethanol at 50℃; for 1h;91.88%
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one; benzoic acid

4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one; benzoic acid

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With Isopropyl acetate; triethylamine at 15 - 30℃; for 4h; Reagent/catalyst;90%
In acetone for 2h; Reflux;87%
C8H10FN3O3S*BrH

C8H10FN3O3S*BrH

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In methanol at 15 - 60℃;88.9%
(+/-)-cis-2',3'-dideoxy-5-fluoro-3'-thiacytidine

(+/-)-cis-2',3'-dideoxy-5-fluoro-3'-thiacytidine

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
Stage #1: (+/-)-cis-2',3'-dideoxy-5-fluoro-3'-thiacytidine With 1,1'-bi-2-naphthol In methanol Reflux;
Stage #2: With hydrogenchloride In water; ethyl acetate for 0.5h; pH=2 - 3;
88.9%
C23H20FN3O6S

C23H20FN3O6S

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With methanol; potassium carbonate at 0 - 25℃; for 3h;87.34%
5S-(5'-fluorocytosinyl)-1,3-oxathiolane-2R-methyl-L-menthol carbonate

5S-(5'-fluorocytosinyl)-1,3-oxathiolane-2R-methyl-L-menthol carbonate

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With potassium carbonate In methanol at 0 - 25℃; for 3h;86%
With potassium carbonate In methanol at 0 - 25℃; for 3.5h;82%
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-[5-fluoro-2-oxo-4-(phenylcarboxamido)-1,2-dihydro-1-pyrimidinyl]-1,3-oxathiolane-2-carboxylate

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-[5-fluoro-2-oxo-4-(phenylcarboxamido)-1,2-dihydro-1-pyrimidinyl]-1,3-oxathiolane-2-carboxylate

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
Stage #1: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-[5-fluoro-2-oxo-4-(phenylcarboxamido)-1,2-dihydro-1-pyrimidinyl]-1,3-oxathiolane-2-carboxylate With methanol at 40℃; Inert atmosphere;
Stage #2: With sodium tetrahydroborate; dipotassium hydrogenphosphate; water; sodium hydroxide In methanol at 20℃; for 1h; diastereoselective reaction;
75%
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathialane-2-carboxylate
764659-72-5

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathialane-2-carboxylate

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With sodium tetrahydroborate; dipotassium hydrogenphosphate; water; sodium hydroxide In ethanol at 20℃; Temperature;70%
Stage #1: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate With sodium tetrahydroborate In methanol at -5℃; for 5h; Inert atmosphere;
Stage #2: With isopropyl alcohol In water at 60℃; for 1h;
Stage #3: With methanol In water Product distribution / selectivity;
65%
With methanol; sodium tetrahydroborate at -7 - -5℃; for 6h; Product distribution / selectivity; Inert atmosphere;65%
N-[5-Fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

N-[5-Fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With ammonia Ambient temperature; Yield given;
(-)-(2R,5S)-5-fluoro-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N4-benzoylcytosine
145913-69-5

(-)-(2R,5S)-5-fluoro-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N4-benzoylcytosine

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetra-n-butylammonium fluoride / tetrahydrofuran / 4 h / Ambient temperature
2: methanolic NH3 / Ambient temperature
View Scheme
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-[1,3]-oxathiolan-5-yl]-(1H)-pyrimidin-2-one monosuccinate
1313482-37-9

4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-[1,3]-oxathiolan-5-yl]-(1H)-pyrimidin-2-one monosuccinate

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 20℃; for 5h;
5-(4-acetylamino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid 2-isopropyl-5-methyl-cyclohexyl ester
1321928-75-9

5-(4-acetylamino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid 2-isopropyl-5-methyl-cyclohexyl ester

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: methanesulfonic acid / methanol / 4 h
1.2: 0.17 h
2.1: sodium hydroxide; dipotassium hydrogenphosphate; sodium tetrahydroborate / water; industrially methylated spirit / 4 h / 18 - 22 °C
2.2: 22 - 42 °C
3.1: triethylamine / isopropyl alcohol; water / 6 h / 6 - 20 °C
View Scheme
4-amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolane-5-yl)-1H-pyrimidin-2-one 2-fluorobenzoic acid salt
1321928-76-0

4-amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolane-5-yl)-1H-pyrimidin-2-one 2-fluorobenzoic acid salt

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
With triethylamine In water; isopropyl alcohol at 6 - 20℃; for 6h;
C15H14FN3O4S

C15H14FN3O4S

emtricitabine
143491-57-0

emtricitabine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: (S)-2-phenylglycine / methanol / Reflux
1.2: 8 h / 20 °C
2.1: 1,1'-bi-2-naphthol / methanol / Reflux
2.2: 0.5 h / pH 2 - 3
View Scheme
N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

emtricitabine
143491-57-0

emtricitabine

(Z)-N’-(5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide

(Z)-N’-(5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide

Conditions
ConditionsYield
In methanol at 20℃; for 21h;100%
emtricitabine
143491-57-0

emtricitabine

C18H26FN3O4S*ClH

C18H26FN3O4S*ClH

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 10 - 20℃; for 2h; Solvent; Temperature;93.6%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

emtricitabine
143491-57-0

emtricitabine

4-amino-1-((2R,5S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoropyrimidin-2(1H)-one
1365246-84-9

4-amino-1-((2R,5S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoropyrimidin-2(1H)-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 18h;90%
With 1H-imidazole In tetrahydrofuran at 20℃; for 2h; Concentration; Inert atmosphere; Cooling;
emtricitabine
143491-57-0

emtricitabine

isobutyl chloroformate
543-27-1

isobutyl chloroformate

isobutyl (5-fluoro-1-((2S,5R)-2-(((isobutoxycarbonyl)oxy)methyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

isobutyl (5-fluoro-1-((2S,5R)-2-(((isobutoxycarbonyl)oxy)methyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;83%
emtricitabine
143491-57-0

emtricitabine

methyl chloroformate
79-22-1

methyl chloroformate

methyl (5-fluoro-1-((2R,5S)-2-(((methoxycarbonyl)oxy)methyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

methyl (5-fluoro-1-((2R,5S)-2-(((methoxycarbonyl)oxy)methyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;68%
dodecyl 1H-imidazole-1-carboxylate
148204-50-6

dodecyl 1H-imidazole-1-carboxylate

emtricitabine
143491-57-0

emtricitabine

dodecyl (1-((2S,5R)-2-((((dodecyloxy)carbonyl)oxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

dodecyl (1-((2S,5R)-2-((((dodecyloxy)carbonyl)oxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Conditions
ConditionsYield
With pyridine; potassium hydroxide In dichloromethane at 20℃; for 18h; Inert atmosphere;67%
emtricitabine
143491-57-0

emtricitabine

carbonochloridic acid, butyl ester
592-34-7

carbonochloridic acid, butyl ester

butyl (5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

butyl (5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;60%
C17H21F5NO8P

C17H21F5NO8P

emtricitabine
143491-57-0

emtricitabine

isopropyl (2S)‐2‐{[(R)‐[(2R,5S)‐5‐(4‐amino‐5‐fluoro‐2‐oxopyrimidin‐1‐yl)‐1,3‐oxathiolan‐2‐yl]methoxy([(isopropoxycarbonyl)oxy]methoxy)phosphoryl]amino}propanoate

isopropyl (2S)‐2‐{[(R)‐[(2R,5S)‐5‐(4‐amino‐5‐fluoro‐2‐oxopyrimidin‐1‐yl)‐1,3‐oxathiolan‐2‐yl]methoxy([(isopropoxycarbonyl)oxy]methoxy)phosphoryl]amino}propanoate

Conditions
ConditionsYield
Stage #1: emtricitabine With tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: C17H21F5NO8P In tetrahydrofuran at 0 - 20℃; for 20h;
53%
tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

emtricitabine
143491-57-0

emtricitabine

emtricitabine monophosphate 1.6*nBu4N+ salt

emtricitabine monophosphate 1.6*nBu4N+ salt

Conditions
ConditionsYield
Stage #1: emtricitabine With trichlorophosphate at 0℃; for 1h; Inert atmosphere;
Stage #2: With water for 1h; Cooling with ice;
Stage #3: tetra(n-butyl)ammonium hydroxide In water pH=7.0;
36%
3-Phenylpropan-1-amine
2038-57-5

3-Phenylpropan-1-amine

emtricitabine
143491-57-0

emtricitabine

C17H19FN4O3S

C17H19FN4O3S

Conditions
ConditionsYield
With copper(l) iodide; 9-azabicyclo<3.3.1>nonane-N-oxyl; oxygen; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 4h; Sealed tube;35%
emtricitabine
143491-57-0

emtricitabine

Allyl chloroformate
2937-50-0

Allyl chloroformate

allyl (5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

allyl (5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 15h; Inert atmosphere;23%
emtricitabine
143491-57-0

emtricitabine

β-L-2',3'-dideoxy-3'-thia-5-fluoro-N4-hydroxycytidine

β-L-2',3'-dideoxy-3'-thia-5-fluoro-N4-hydroxycytidine

Conditions
ConditionsYield
With hydroxylamine hydrochloride In water for 24h; pH=6.0;16%
emtricitabine
143491-57-0

emtricitabine

salicylic acid
69-72-7

salicylic acid

(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine salicylate

(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine salicylate

Conditions
ConditionsYield
In water at 80℃;13%
emtricitabine
143491-57-0

emtricitabine

(-)-5'-O-(t-butyldimethylsilyl)-N4-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine
1365246-85-0

(-)-5'-O-(t-butyldimethylsilyl)-N4-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C
2: pyridine / 0 - 20 °C
View Scheme

Raw Materials

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