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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Oxcarbazepine API Powder CAS 28721-07-5

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Oxcarbazepine Manufacturer/High quality/Best price/In stock

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our customers

high purity Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Oxcarbazepine manufacturer with low price

Cas:28721-07-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Oxcarbazepine Cas28721-07-5 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Light orange to creamish white or off-white powder Storage:Store at RT Package:

Factory supply Oxcarbazepine Cas 28721-07-5 with high purity

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $120.0 / 300.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

Factory supply Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Oxcarbazepine 28721-07-5 GMP Manufacturer

Cas:28721-07-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Oxcarbazepine

Cas:28721-07-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name: Occarbazepine Alias: Oxytongxinning; 10,11-dihydro-10-oxo-5H-dibenzo [b, f] aza-5-formamide; English Name: Oxcarbapezine English aliases: Oxcarbapezine; Ocarbazepine; OXACARBAZEPINE; Oxetol; Oxecarb; CAS No. 28721-07-5 Molecular formula:

Oxcarbapezine/Cas:28721-07-5/99.12% High purity

Cas:28721-07-5

Min.Order:25 Metric Ton

FOB Price: $4.0 / 5.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Oxcarbazepine CAS NO 28721-07-5

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 28721-07-5 with best quality

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99%min Oxcarbazepine Manufacturer For Neurological Medication

Cas:28721-07-5

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Oxcarbazepine 28721-07-5

Cas:28721-07-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

Pharmaceutical Raw Material Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

99% Purity Oxcarbazepine Antiepileptic Raw Powder Oxcarbazepine Pharmaceutical Oxcarbazepine

Cas:28721-07-5

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

An anticonvulsant and mood-stabilizing drugs Oxcarbazepine CAS:28721-07-5

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $138.0 / 157.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

EOxcarbazepine CAS:28721-07-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

Oxcarbazepine CAS:28721-07-5

Cas:28721-07-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o

Hot Selling Oxcarbazepine CAS 28721-07-5 as Anticonvulsant with Fast Delivery

Cas:28721-07-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Oxcarbazepine/ LIDE PHARMA- Factory supply / Best price

Cas:28721-07-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

TIANFUCHEM--High purity Oxcarbazepine factory price CAS NO.28721-07-5

Cas:28721-07-5

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of h

Oxcarbazepine CAS 28721-07-5

Cas:28721-07-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Oxcarbazepine CAS: 28721-07-5 Specification Items Specification Appearance pale yellow to reddish brown oily transparent liquid Assay 99% min

Factory supply Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Oxcarbazepine

Cas:28721-07-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : 10,11-DIHYDRO-10-OXO-5H-DIBENZ[B,

Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:Pale Yellow Powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/

Oxcarbazepine

Cas:28721-07-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Oxcarbazepine

Cas:28721-07-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Oxcarbazepine CAS 28721-07-5

Cas:28721-07-5

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Synthetic route

10,11-dihydro-10-methoxy-5H-dibenzo[b,f]azepine-5-carboxamide
98253-74-8

10,11-dihydro-10-methoxy-5H-dibenzo[b,f]azepine-5-carboxamide

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 1.3h; Solvent;95.7%
isocyanate de chlorosulfonyle
1189-71-5

isocyanate de chlorosulfonyle

10,11-dihydro-5H-dibenzo[b,f]azepin-10-one
21737-58-6

10,11-dihydro-5H-dibenzo[b,f]azepin-10-one

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
In dichloromethane at 0 - 5℃; Inert atmosphere;93%
80%
Stage #1: isocyanate de chlorosulfonyle; 10,11-dihydro-5H-dibenzo[b,f]azepin-10-one In dichloromethane at 25℃; for 17h;
Stage #2: With water Further stages.;
70%
Stage #1: isocyanate de chlorosulfonyle; 10,11-dihydro-5H-dibenzo[b,f]azepin-10-one In chloroform at 20℃;
Stage #2: With water at 20℃;
56%
10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
29331-92-8

10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With peracetic acid; potassium dichromate; hydrogen In 1,2-dichloro-ethane at 20℃; for 1h;90%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In dichloromethane at 25 - 30℃; for 0.25h;65.5%
Stage #1: 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In dichloromethane at 25 - 30℃; for 0.25h;
Stage #2: With sodium hypochlorite; sodium hydrogencarbonate In dichloromethane; water at 0 - 5℃; for 1h; pH=9.7;
1.3 g
10-methoxy-5H-dibenz[b,f]azepine-5-carboxamide
28721-09-7

10-methoxy-5H-dibenz[b,f]azepine-5-carboxamide

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 40℃; for 2h;88.5%
With hydrogenchloride In water at 25 - 85℃; for 4 - 6h;73%
With sulfuric acid at 25℃; for 17h;
methyl N-cyano-N-2'-cyanophenyl-2-aminophenylacetate

methyl N-cyano-N-2'-cyanophenyl-2-aminophenylacetate

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Stage #1: methyl N-cyano-N-2'-cyanophenyl-2-aminophenylacetate With potassium tert-butylate In tetrahydrofuran at 40 - 50℃; for 4h;
Stage #2: With water In tetrahydrofuran at 50 - 55℃; for 3h;
87.9%
ethyl N-cyano-N-2′-cyanophenyl-2-aminophenylacetate

ethyl N-cyano-N-2′-cyanophenyl-2-aminophenylacetate

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Stage #1: ethyl N-cyano-N-2′-cyanophenyl-2-aminophenylacetate With potassium tert-butylate In tetrahydrofuran at 40 - 50℃; for 4h;
Stage #2: With water In tetrahydrofuran at 60 - 65℃; for 3h;
86.4%
C16H13ClN2O4S

C16H13ClN2O4S

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With water; acetic acid at 15 - 25℃; for 0.5 - 1h;84%
10-chloro-5H-dibenzo[b,f]azepine-5-carboxamide
59690-92-5

10-chloro-5H-dibenzo[b,f]azepine-5-carboxamide

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 50h;83%
10-Brom-5-carbamoyl-5H-dibenzazepin
59690-97-0

10-Brom-5-carbamoyl-5H-dibenzazepin

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With sulfuric acid at 20℃; for 50h;83%
10-methoxy-5H-dibenzo[b,f]azepine
4698-11-7

10-methoxy-5H-dibenzo[b,f]azepine

sodium isocyanate
917-61-3

sodium isocyanate

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With hydrogenchloride80%
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; sodium isocyanate With water; Pyridine hydrobromide In toluene at 22℃; for 7 - 8h;
Stage #2: With hydrogenchloride In water; toluene at 55 - 89℃; for 3 - 4h; Heating / reflux;
44%
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; sodium isocyanate With water; quinoline hydrochloride In toluene at 20℃; for 18h;
Stage #2: With hydrogenchloride In water; toluene at 89℃; for 2h; Heating / reflux;
35%
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; sodium isocyanate With acetic acid at 25 - 35℃; for 1.33333 - 1.5h;
Stage #2: With sulfuric acid; water at 33 - 35℃; for 1 - 2h;
10-methoxy-5H-dibenzo[b,f]azepine
4698-11-7

10-methoxy-5H-dibenzo[b,f]azepine

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With triethylamine In toluene at 10 - 15℃; for 6h;
Stage #2: With ammonia In water; toluene at 20℃; for 1h;
Stage #3: With formic acid; water for 1h; Product distribution / selectivity; Heating / reflux;
76.6%
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With pyridine In toluene at 10 - 15℃; for 6h;
Stage #2: With ammonia In water; toluene at 20℃; for 1h;
Stage #3: With sulfuric acid; water for 1h; Product distribution / selectivity; Heating / reflux;
72.7%
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With triethylamine In dichloromethane Heating / reflux;
Stage #2: With ammonia In dichloromethane; water at 20℃; for 1h;
Stage #3: With sulfuric acid; water for 1h; Product distribution / selectivity; Heating / reflux;
68.7%
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With 1,4-diaza-bicyclo[2.2.2]octane In toluene at 10 - 15℃; for 6h;
Stage #2: With ammonia In water; toluene at 20℃; for 1h;
Stage #3: With formic acid; water for 1h; Product distribution / selectivity; Heating / reflux;
67.3%
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With triethylamine In toluene at 10 - 15℃; for 2 - 6h;
Stage #2: With ammonia In water; toluene at 20℃; for 1h;
Stage #3: With sulfuric acid; water for 1h; Product distribution / selectivity; Heating / reflux;
64%
10,11-Dihydrocarbamazepin
3564-73-6

10,11-Dihydrocarbamazepin

benzaldehyde
100-52-7

benzaldehyde

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With oxygen In acetic acid at 20℃; under 750.075 Torr; for 7 - 17h;49%
With oxygen In acetic acid at 22℃; for 7h;43%
With oxygen In acetonitrile at 20℃; under 750.075 Torr; for 17h;36%
10,11-Dihydrocarbamazepin
3564-73-6

10,11-Dihydrocarbamazepin

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With N-hydroxyphthalimide; oxygen; benzaldehyde; chromium(III) nitrate; nickel diacetate In acetic acid at 22℃; under 750.06 Torr; for 7h;26%
With oxygen at 20℃; under 750.075 Torr;16%
With sodium hypochlorite; tetrabutyl-ammonium chloride; ruthenium(III)chloride; copper dichloride In chloroform at 30 - 40℃; for 5h; Reagent/catalyst; Industrial scale;7.23 kg
10,11-Dihydrocarbamazepin
3564-73-6

10,11-Dihydrocarbamazepin

acetaldehyde
75-07-0

acetaldehyde

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With oxygen; N-hydroxyphthalimide In acetonitrile at 20℃; under 750.075 Torr; for 17h;19%
BIA 2-256
78880-64-5

BIA 2-256

A

platinum-on-carbon

platinum-on-carbon

B

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With hydrogenchloride; acetic acid; palladium In waterA 5%
B n/a
10,11-Dihydrocarbamazepin
3564-73-6

10,11-Dihydrocarbamazepin

A

oxcarbazepine
28721-07-5

oxcarbazepine

B

10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
29331-92-8

10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide

C

10,11-dioxo-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

10,11-dioxo-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

D

10-hydroperoxy-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

10-hydroperoxy-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

Conditions
ConditionsYield
With N-hydroxyphthalimide; oxygen; benzaldehyde; nickel diacetate In acetic acid at 22℃; under 750.06 Torr; for 5h; Product distribution; Further Variations:; Catalysts; Reagents; Solvents; reaction time;A 27 % Chromat.
B 9 % Chromat.
C 1 % Chromat.
D 10 % Chromat.
carbamazepine 10,11-epoxide
36507-30-9

carbamazepine 10,11-epoxide

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With lithium iodide In chloroform
Multi-step reaction with 2 steps
1: triethylamine; 5%-palladium/activated carbon; hydrogen / water; methanol / 2 h / 750.08 Torr
2: peracetic acid; hydrogen; potassium dichromate / 1,2-dichloro-ethane / 1 h / 20 °C
View Scheme
10-methoxy-5H-dibenz[b,f]azepine-5-carbonitrile

10-methoxy-5H-dibenz[b,f]azepine-5-carbonitrile

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
With sulfuric acid In acetic acid at 20℃; for 0.0833333 - 0.166667h;
1-(2-aminophenyl)-2-(2-bromophenyll)ethanone
869668-73-5

1-(2-aminophenyl)-2-(2-bromophenyll)ethanone

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 91 percent / Pd(OAc)2; BINAP; K3PO4 / toluene; H2O / 5 h / 130 °C
2.1: CHCl3 / 20 °C
2.2: 56 percent / H2O / 20 °C
View Scheme
2-(2-bromophenyl)-1-[2-N-(4-methylbenzenesulfonamido)phenyl]ethanone
869668-71-3

2-(2-bromophenyl)-1-[2-N-(4-methylbenzenesulfonamido)phenyl]ethanone

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 95 percent / H2SO4 / 0.17 h / 20 °C
2.1: 91 percent / Pd(OAc)2; BINAP; K3PO4 / toluene; H2O / 5 h / 130 °C
3.1: CHCl3 / 20 °C
3.2: 56 percent / H2O / 20 °C
View Scheme
N-(2-acetylphenyl)-4-methylbenzenesulfonamide
1859-70-7

N-(2-acetylphenyl)-4-methylbenzenesulfonamide

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 86 percent / Pd(OAc)2; Xantphos; Cs2CO3 / toluene; H2O / 48 h / 120 °C
2.1: 95 percent / H2SO4 / 0.17 h / 20 °C
3.1: 91 percent / Pd(OAc)2; BINAP; K3PO4 / toluene; H2O / 5 h / 130 °C
4.1: CHCl3 / 20 °C
4.2: 56 percent / H2O / 20 °C
View Scheme
2-aminoacetophenone
551-93-9

2-aminoacetophenone

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 96 percent / pyridine / CH2Cl2
2.1: 86 percent / Pd(OAc)2; Xantphos; Cs2CO3 / toluene; H2O / 48 h / 120 °C
3.1: 95 percent / H2SO4 / 0.17 h / 20 °C
4.1: 91 percent / Pd(OAc)2; BINAP; K3PO4 / toluene; H2O / 5 h / 130 °C
5.1: CHCl3 / 20 °C
5.2: 56 percent / H2O / 20 °C
View Scheme
1-phenyl-1,3-dihydro-indol-2-one
3335-98-6

1-phenyl-1,3-dihydro-indol-2-one

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 97 percent / aq. NaOH / 6 h / 100 °C
2.1: 98 percent / dimethylformamide / 4 h / 24 °C
3.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C
4.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C
5.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C
6.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C
7.1: CH2Cl2 / 17 h / 25 °C
7.2: 70 percent / H2O
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydroxide / tetrahydrofuran / 5 h / 67 °C
1.2: 2 h / -10 °C
2.1: polyphosphoric acid / 3 h / 90 - 95 °C
3.1: water / 0 - 98 °C
4.1: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C
5.1: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
6.1: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydroxide / tetrahydrofuran / 5 h / 67 °C
1.2: 2 h / -40 °C
2.1: polyphosphoric acid / 3 h / 90 - 95 °C
3.1: water / 0 - 98 °C
4.1: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C
5.1: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
6.1: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
Multi-step reaction with 9 steps
1.1: sodium hydroxide / water; ethanol / 1 h / 50 °C
1.2: 4 h / 20 °C
2.1: pyridine / toluene / 24 h / 50 °C
3.1: pyridine / 22 h / 100 °C
4.1: sodium hydroxide / water; methanol / 24 h / 20 °C
5.1: polyphosphoric acid / 3 h / 90 - 95 °C
6.1: water / 0 - 98 °C
7.1: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C
8.1: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
9.1: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
10-methoxy-5H-dibenzo[b,f]azepine
4698-11-7

10-methoxy-5H-dibenzo[b,f]azepine

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AcOH / 7 h / 25 °C
2: H2SO4 / 17 h / 25 °C
View Scheme
With hydrogenchloride; benzoic acid In water; toluene
With sulfuric acid In water; toluene
Multi-step reaction with 2 steps
1: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
2: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
(2-phenylamino-phenyl)-acetic acid methyl ester
39507-06-7

(2-phenylamino-phenyl)-acetic acid methyl ester

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: pyridine / toluene / 24 h / 50 °C
1.2: pyridine / 22 h / 100 °C
2.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C
3.1: polyphosphoric acid / 3 h / 95 °C
4.1: 97 percent / aq. NaOH / 6 h / 100 °C
5.1: 98 percent / dimethylformamide / 4 h / 24 °C
6.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C
7.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C
8.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C
9.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C
10.1: CH2Cl2 / 17 h / 25 °C
10.2: 70 percent / H2O
View Scheme
Multi-step reaction with 7 steps
1.1: pyridine / toluene / 24 h / 50 °C
1.2: pyridine / 22 h / 100 °C
2.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C
3.1: 70 percent / polyphosphoric acid / 3 h / 95 °C
4.1: 81 percent / p-TsOH / methanol / 5 h / Heating
5.1: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C
6.1: AcOH / 7 h / 25 °C
7.1: H2SO4 / 17 h / 25 °C
View Scheme
Multi-step reaction with 5 steps
1.1: pyridine / toluene / 24 h / 50 °C
1.2: pyridine / 22 h / 100 °C
2.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C
3.1: 70 percent / polyphosphoric acid / 3 h / 95 °C
4.1: 72 percent / KOH / ethane-1,2-diol / 0.5 h / 108 °C
5.1: CH2Cl2 / 17 h / 25 °C
5.2: 70 percent / H2O
View Scheme
Multi-step reaction with 8 steps
1: pyridine / toluene / 24 h / 50 °C
2: pyridine / 22 h / 100 °C
3: sodium hydroxide / water; methanol / 24 h / 20 °C
4: polyphosphoric acid / 3 h / 90 - 95 °C
5: water / 0 - 98 °C
6: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C
7: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
8: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester
353497-31-1

10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 81 percent / p-TsOH / methanol / 5 h / Heating
2: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C
3: AcOH / 7 h / 25 °C
4: H2SO4 / 17 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 72 percent / KOH / ethane-1,2-diol / 0.5 h / 108 °C
2.1: CH2Cl2 / 17 h / 25 °C
2.2: 70 percent / H2O
View Scheme
Multi-step reaction with 4 steps
1: water / 0 - 98 °C
2: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C
3: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
4: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
[2-(methoxycarbonyl-phenyl-amino)-phenyl]-acetic acid methyl ester
805236-74-2

[2-(methoxycarbonyl-phenyl-amino)-phenyl]-acetic acid methyl ester

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C
2.1: polyphosphoric acid / 3 h / 95 °C
3.1: 97 percent / aq. NaOH / 6 h / 100 °C
4.1: 98 percent / dimethylformamide / 4 h / 24 °C
5.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C
6.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C
7.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C
8.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C
9.1: CH2Cl2 / 17 h / 25 °C
9.2: 70 percent / H2O
View Scheme
Multi-step reaction with 6 steps
1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C
2: 70 percent / polyphosphoric acid / 3 h / 95 °C
3: 81 percent / p-TsOH / methanol / 5 h / Heating
4: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C
5: AcOH / 7 h / 25 °C
6: H2SO4 / 17 h / 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C
2.1: 70 percent / polyphosphoric acid / 3 h / 95 °C
3.1: 72 percent / KOH / ethane-1,2-diol / 0.5 h / 108 °C
4.1: CH2Cl2 / 17 h / 25 °C
4.2: 70 percent / H2O
View Scheme
Multi-step reaction with 6 steps
1: sodium hydroxide / water; methanol / 24 h / 20 °C
2: polyphosphoric acid / 3 h / 90 - 95 °C
3: water / 0 - 98 °C
4: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C
5: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
6: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
10-methoxy-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester
353497-37-7

10-methoxy-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C
2: AcOH / 7 h / 25 °C
3: H2SO4 / 17 h / 25 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C
2: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
3: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
2-[(methoxycarbonyl)phenylamino]benzeneacetic acid
353497-35-5

2-[(methoxycarbonyl)phenylamino]benzeneacetic acid

oxcarbazepine
28721-07-5

oxcarbazepine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: polyphosphoric acid / 3 h / 95 °C
2.1: 97 percent / aq. NaOH / 6 h / 100 °C
3.1: 98 percent / dimethylformamide / 4 h / 24 °C
4.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C
5.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C
6.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C
7.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C
8.1: CH2Cl2 / 17 h / 25 °C
8.2: 70 percent / H2O
View Scheme
Multi-step reaction with 5 steps
1: 70 percent / polyphosphoric acid / 3 h / 95 °C
2: 81 percent / p-TsOH / methanol / 5 h / Heating
3: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C
4: AcOH / 7 h / 25 °C
5: H2SO4 / 17 h / 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 70 percent / polyphosphoric acid / 3 h / 95 °C
2.1: 72 percent / KOH / ethane-1,2-diol / 0.5 h / 108 °C
3.1: CH2Cl2 / 17 h / 25 °C
3.2: 70 percent / H2O
View Scheme
Multi-step reaction with 5 steps
1: polyphosphoric acid / 3 h / 90 - 95 °C
2: water / 0 - 98 °C
3: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C
4: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere
5: hydrogenchloride / water; acetone / 2 h / 40 °C
View Scheme
oxcarbazepine
28721-07-5

oxcarbazepine

S-licarbazepine
104746-04-5

S-licarbazepine

Conditions
ConditionsYield
With C32H39BrMnN2O2P; potassium tert-butylate; hydrogen In methanol at 20℃; under 22502.3 Torr; for 16h; Glovebox; Autoclave; enantioselective reaction;99%
Stage #1: oxcarbazepine With triethylammonium formate; C33H40ClN2O4RuS In ethyl acetate; N,N-dimethyl-formamide pH=6.8 - 7.45; Heating / reflux;
Stage #2: With formic acid In water; ethyl acetate; N,N-dimethyl-formamide for 23h; pH=7.4 - 7.8; Heating / reflux;
94%
Stage #1: oxcarbazepine With triethylamine; C33H40ClN2O4RuS In water; ethyl acetate; N,N-dimethyl-formamide at 72 - 77℃; pH=8.8; Heating / reflux;
Stage #2: With formic acid In water; ethyl acetate; N,N-dimethyl-formamide for 20 - 27h; pH=7.4; Heating / reflux;
88%
oxcarbazepine
28721-07-5

oxcarbazepine

10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
29331-92-8

10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol; water at 20 - 45℃; for 1.5h;97.3%
With sodium tetrahydroborate In ethanol; water at 45 - 50℃;94%
With sodium tetrahydroborate; water In methanol at 25 - 65℃; for 2.75h;93.8%
oxcarbazepine
28721-07-5

oxcarbazepine

carbamazepin
298-46-4

carbamazepin

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate at 45 - 50℃; for 3h;91.5%
oxcarbazepine
28721-07-5

oxcarbazepine

5H-dibenzazepine-10(11H),11-dione
19579-83-0

5H-dibenzazepine-10(11H),11-dione

Conditions
ConditionsYield
With selenium(IV) oxide In 1,4-dioxane for 7h; Reflux;90%
With dihydrogen peroxide; methyltrioxorhenium(VII) In water; tert-butyl alcohol at 40℃; for 16h;27%
Multi-step reaction with 2 steps
1: 73.4 percent / Br2 / acetic acid / 60 h / 15 °C
2: 2.4 percent / acetic acid / 0.75 h / Heating
View Scheme
oxcarbazepine
28721-07-5

oxcarbazepine

acetic anhydride
108-24-7

acetic anhydride

10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide
952740-00-0

10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide

Conditions
ConditionsYield
With pyridine; dmap In dichloromethane at 20℃; for 4.16h;88%
oxcarbazepine
28721-07-5

oxcarbazepine

N-methoxylamine hydrochloride
593-56-6

N-methoxylamine hydrochloride

10-methoxyimino-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

10-methoxyimino-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

Conditions
ConditionsYield
With pyridine In ethanol for 4h; Heating;87%
oxcarbazepine
28721-07-5

oxcarbazepine

A

(Z)-10,11-dihydro-10-hydroxyimino-5H-dibenzo[b,f]azepine-5-carboxamide

(Z)-10,11-dihydro-10-hydroxyimino-5H-dibenzo[b,f]azepine-5-carboxamide

B

10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f]azepine-5-carboxamide
461670-31-5

10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f]azepine-5-carboxamide

Conditions
ConditionsYield
With pyridine; hydroxylamine hydrochloride In ethanol for 4h; Heating; Title compound not separated from byproducts;A n/a
B 86%
oxcarbazepine
28721-07-5

oxcarbazepine

methylthiol
74-93-1

methylthiol

10-Methylthio-5H-dibenzoazepin-5-carboxamid
92483-89-1

10-Methylthio-5H-dibenzoazepin-5-carboxamid

Conditions
ConditionsYield
With aluminium trichloride In chloroform for 5h; Heating;85%
oxcarbazepine
28721-07-5

oxcarbazepine

10-bromo-10,11-dihydro-11-oxo-5H-dibenzazepine-5-carboxamide

10-bromo-10,11-dihydro-11-oxo-5H-dibenzazepine-5-carboxamide

Conditions
ConditionsYield
With bromine In acetic acid at 15℃; for 60h;73.4%
oxcarbazepine
28721-07-5

oxcarbazepine

phenylhydrazine
100-63-0

phenylhydrazine

10-phenylhydrazono-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide

10-phenylhydrazono-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide

Conditions
ConditionsYield
With hydrogenchloride; sodium acetate In ethanol; water at 60℃; for 0.5h;72.5%
oxcarbazepine
28721-07-5

oxcarbazepine

acetic acid
64-19-7

acetic acid

2-hydroxyethanethiol
60-24-2

2-hydroxyethanethiol

10-(2-Acetoxyethylthio)-5H-dibenzoazepin-5-carboxamid

10-(2-Acetoxyethylthio)-5H-dibenzoazepin-5-carboxamid

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 48h; Ambient temperature;72%
oxcarbazepine
28721-07-5

oxcarbazepine

methyl glyoxylate methyl hemi-acetal
109745-70-2, 19757-97-2

methyl glyoxylate methyl hemi-acetal

Hydroxy-[(10-oxo-10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl)-amino]-acetic acid methyl ester

Hydroxy-[(10-oxo-10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl)-amino]-acetic acid methyl ester

Conditions
ConditionsYield
In chloroform for 2h; Heating;70%
oxcarbazepine
28721-07-5

oxcarbazepine

hydrazine carboxamide
4426-72-6, 51433-48-8

hydrazine carboxamide

C16H15N5O2

C16H15N5O2

Conditions
ConditionsYield
With hydrogenchloride; sodium acetate In ethanol; water at 60℃; for 0.5h;68%
oxcarbazepine
28721-07-5

oxcarbazepine

thiosemicarbazide
79-19-6

thiosemicarbazide

C16H15N5OS

C16H15N5OS

Conditions
ConditionsYield
With hydrogenchloride; sodium acetate In ethanol; water at 60℃; for 0.5h;61%
oxcarbazepine
28721-07-5

oxcarbazepine

10,11-dihydro-5H-dibenzo[b,f]azepin-10-one
21737-58-6

10,11-dihydro-5H-dibenzo[b,f]azepin-10-one

Conditions
ConditionsYield
With hydrogenchloride; 1-amino-3-(dimethylamino)propane In water; dimethyl sulfoxide at 120℃; for 1h;59%
With water
oxcarbazepine
28721-07-5

oxcarbazepine

1-butanethiol
109-79-5

1-butanethiol

10-Butylsulfanyl-dibenzo[b,f]azepine-5-carboxylic acid amide

10-Butylsulfanyl-dibenzo[b,f]azepine-5-carboxylic acid amide

Conditions
ConditionsYield
With aluminium trichloride In chloroform at 40℃; for 5h;58%
oxcarbazepine
28721-07-5

oxcarbazepine

O-benzylhydoxylamine hydrochloride
2687-43-6

O-benzylhydoxylamine hydrochloride

10-benzyloxyimino-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

10-benzyloxyimino-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

Conditions
ConditionsYield
With pyridine In ethanol for 4h; Heating;58%
oxcarbazepine
28721-07-5

oxcarbazepine

ethanethiol
75-08-1

ethanethiol

10-Ethylsulfanyl-dibenzo[b,f]azepine-5-carboxylic acid amide

10-Ethylsulfanyl-dibenzo[b,f]azepine-5-carboxylic acid amide

Conditions
ConditionsYield
With aluminium trichloride In chloroform at 40℃; for 5h;55.2%
oxcarbazepine
28721-07-5

oxcarbazepine

methylamine
74-89-5

methylamine

10-(methylamino)-5H-dibenzo[b,f]azepine-5-carboxamide
1548175-75-2

10-(methylamino)-5H-dibenzo[b,f]azepine-5-carboxamide

Conditions
ConditionsYield
Stage #1: oxcarbazepine; methylamine With titanium(IV) isopropylate In ethanol for 6h; Inert atmosphere;
Stage #2: With sodium tetrahydroborate In ethanol for 3h; Inert atmosphere;
52%
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