1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquirySimagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our customers
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
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Type:Manufacturers
inquiryUnique advantages for Oxcarbazepine Cas28721-07-5 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Light orange to creamish white or off-white powder Storage:Store at RT Package:
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inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:28721-07-5
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name: Occarbazepine Alias: Oxytongxinning; 10,11-dihydro-10-oxo-5H-dibenzo [b, f] aza-5-formamide; English Name: Oxcarbapezine English aliases: Oxcarbapezine; Ocarbazepine; OXACARBAZEPINE; Oxetol; Oxecarb; CAS No. 28721-07-5 Molecular formula:
Cas:28721-07-5
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:28721-07-5
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:28721-07-5
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:28721-07-5
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:28721-07-5
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Type:Lab/Research institutions
inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:28721-07-5
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:28721-07-5
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:28721-07-5
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inquiryEOxcarbazepine CAS:28721-07-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
Cas:28721-07-5
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Type:Lab/Research institutions
inquiryWe generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o
Cas:28721-07-5
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Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:28721-07-5
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:28721-07-5
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of h
Cas:28721-07-5
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Negotiable
Type:Lab/Research institutions
inquiryOxcarbazepine CAS: 28721-07-5 Specification Items Specification Appearance pale yellow to reddish brown oily transparent liquid Assay 99% min
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:28721-07-5
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FOB Price: $30.0 / 50.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : 10,11-DIHYDRO-10-OXO-5H-DIBENZ[B,
Appearance:Pale Yellow Powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/
Cas:28721-07-5
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:28721-07-5
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiry10,11-dihydro-10-methoxy-5H-dibenzo[b,f]azepine-5-carboxamide
oxcarbazepine
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water for 1.3h; Solvent; | 95.7% |
isocyanate de chlorosulfonyle
10,11-dihydro-5H-dibenzo[b,f]azepin-10-one
oxcarbazepine
Conditions | Yield |
---|---|
In dichloromethane at 0 - 5℃; Inert atmosphere; | 93% |
80% | |
Stage #1: isocyanate de chlorosulfonyle; 10,11-dihydro-5H-dibenzo[b,f]azepin-10-one In dichloromethane at 25℃; for 17h; Stage #2: With water Further stages.; | 70% |
Stage #1: isocyanate de chlorosulfonyle; 10,11-dihydro-5H-dibenzo[b,f]azepin-10-one In chloroform at 20℃; Stage #2: With water at 20℃; | 56% |
10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
oxcarbazepine
Conditions | Yield |
---|---|
With peracetic acid; potassium dichromate; hydrogen In 1,2-dichloro-ethane at 20℃; for 1h; | 90% |
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In dichloromethane at 25 - 30℃; for 0.25h; | 65.5% |
Stage #1: 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In dichloromethane at 25 - 30℃; for 0.25h; Stage #2: With sodium hypochlorite; sodium hydrogencarbonate In dichloromethane; water at 0 - 5℃; for 1h; pH=9.7; | 1.3 g |
10-methoxy-5H-dibenz[b,f]azepine-5-carboxamide
oxcarbazepine
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 40℃; for 2h; | 88.5% |
With hydrogenchloride In water at 25 - 85℃; for 4 - 6h; | 73% |
With sulfuric acid at 25℃; for 17h; |
oxcarbazepine
Conditions | Yield |
---|---|
Stage #1: methyl N-cyano-N-2'-cyanophenyl-2-aminophenylacetate With potassium tert-butylate In tetrahydrofuran at 40 - 50℃; for 4h; Stage #2: With water In tetrahydrofuran at 50 - 55℃; for 3h; | 87.9% |
oxcarbazepine
Conditions | Yield |
---|---|
Stage #1: ethyl N-cyano-N-2′-cyanophenyl-2-aminophenylacetate With potassium tert-butylate In tetrahydrofuran at 40 - 50℃; for 4h; Stage #2: With water In tetrahydrofuran at 60 - 65℃; for 3h; | 86.4% |
oxcarbazepine
Conditions | Yield |
---|---|
With water; acetic acid at 15 - 25℃; for 0.5 - 1h; | 84% |
10-chloro-5H-dibenzo[b,f]azepine-5-carboxamide
oxcarbazepine
Conditions | Yield |
---|---|
With hydrogenchloride at 20℃; for 50h; | 83% |
10-Brom-5-carbamoyl-5H-dibenzazepin
oxcarbazepine
Conditions | Yield |
---|---|
With sulfuric acid at 20℃; for 50h; | 83% |
Conditions | Yield |
---|---|
With hydrogenchloride | 80% |
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; sodium isocyanate With water; Pyridine hydrobromide In toluene at 22℃; for 7 - 8h; Stage #2: With hydrogenchloride In water; toluene at 55 - 89℃; for 3 - 4h; Heating / reflux; | 44% |
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; sodium isocyanate With water; quinoline hydrochloride In toluene at 20℃; for 18h; Stage #2: With hydrogenchloride In water; toluene at 89℃; for 2h; Heating / reflux; | 35% |
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; sodium isocyanate With acetic acid at 25 - 35℃; for 1.33333 - 1.5h; Stage #2: With sulfuric acid; water at 33 - 35℃; for 1 - 2h; |
10-methoxy-5H-dibenzo[b,f]azepine
bis(trichloromethyl) carbonate
oxcarbazepine
Conditions | Yield |
---|---|
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With triethylamine In toluene at 10 - 15℃; for 6h; Stage #2: With ammonia In water; toluene at 20℃; for 1h; Stage #3: With formic acid; water for 1h; Product distribution / selectivity; Heating / reflux; | 76.6% |
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With pyridine In toluene at 10 - 15℃; for 6h; Stage #2: With ammonia In water; toluene at 20℃; for 1h; Stage #3: With sulfuric acid; water for 1h; Product distribution / selectivity; Heating / reflux; | 72.7% |
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With triethylamine In dichloromethane Heating / reflux; Stage #2: With ammonia In dichloromethane; water at 20℃; for 1h; Stage #3: With sulfuric acid; water for 1h; Product distribution / selectivity; Heating / reflux; | 68.7% |
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With 1,4-diaza-bicyclo[2.2.2]octane In toluene at 10 - 15℃; for 6h; Stage #2: With ammonia In water; toluene at 20℃; for 1h; Stage #3: With formic acid; water for 1h; Product distribution / selectivity; Heating / reflux; | 67.3% |
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine; bis(trichloromethyl) carbonate With triethylamine In toluene at 10 - 15℃; for 2 - 6h; Stage #2: With ammonia In water; toluene at 20℃; for 1h; Stage #3: With sulfuric acid; water for 1h; Product distribution / selectivity; Heating / reflux; | 64% |
Conditions | Yield |
---|---|
With oxygen In acetic acid at 20℃; under 750.075 Torr; for 7 - 17h; | 49% |
With oxygen In acetic acid at 22℃; for 7h; | 43% |
With oxygen In acetonitrile at 20℃; under 750.075 Torr; for 17h; | 36% |
10,11-Dihydrocarbamazepin
oxcarbazepine
Conditions | Yield |
---|---|
With N-hydroxyphthalimide; oxygen; benzaldehyde; chromium(III) nitrate; nickel diacetate In acetic acid at 22℃; under 750.06 Torr; for 7h; | 26% |
With oxygen at 20℃; under 750.075 Torr; | 16% |
With sodium hypochlorite; tetrabutyl-ammonium chloride; ruthenium(III)chloride; copper dichloride In chloroform at 30 - 40℃; for 5h; Reagent/catalyst; Industrial scale; | 7.23 kg |
Conditions | Yield |
---|---|
With oxygen; N-hydroxyphthalimide In acetonitrile at 20℃; under 750.075 Torr; for 17h; | 19% |
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid; palladium In water | A 5% B n/a |
10,11-Dihydrocarbamazepin
A
oxcarbazepine
B
10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
Conditions | Yield |
---|---|
With N-hydroxyphthalimide; oxygen; benzaldehyde; nickel diacetate In acetic acid at 22℃; under 750.06 Torr; for 5h; Product distribution; Further Variations:; Catalysts; Reagents; Solvents; reaction time; | A 27 % Chromat. B 9 % Chromat. C 1 % Chromat. D 10 % Chromat. |
carbamazepine 10,11-epoxide
oxcarbazepine
Conditions | Yield |
---|---|
With lithium iodide In chloroform | |
Multi-step reaction with 2 steps 1: triethylamine; 5%-palladium/activated carbon; hydrogen / water; methanol / 2 h / 750.08 Torr 2: peracetic acid; hydrogen; potassium dichromate / 1,2-dichloro-ethane / 1 h / 20 °C View Scheme |
oxcarbazepine
Conditions | Yield |
---|---|
With sulfuric acid In acetic acid at 20℃; for 0.0833333 - 0.166667h; |
1-(2-aminophenyl)-2-(2-bromophenyll)ethanone
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 91 percent / Pd(OAc)2; BINAP; K3PO4 / toluene; H2O / 5 h / 130 °C 2.1: CHCl3 / 20 °C 2.2: 56 percent / H2O / 20 °C View Scheme |
2-(2-bromophenyl)-1-[2-N-(4-methylbenzenesulfonamido)phenyl]ethanone
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 95 percent / H2SO4 / 0.17 h / 20 °C 2.1: 91 percent / Pd(OAc)2; BINAP; K3PO4 / toluene; H2O / 5 h / 130 °C 3.1: CHCl3 / 20 °C 3.2: 56 percent / H2O / 20 °C View Scheme |
N-(2-acetylphenyl)-4-methylbenzenesulfonamide
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 86 percent / Pd(OAc)2; Xantphos; Cs2CO3 / toluene; H2O / 48 h / 120 °C 2.1: 95 percent / H2SO4 / 0.17 h / 20 °C 3.1: 91 percent / Pd(OAc)2; BINAP; K3PO4 / toluene; H2O / 5 h / 130 °C 4.1: CHCl3 / 20 °C 4.2: 56 percent / H2O / 20 °C View Scheme |
2-aminoacetophenone
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 96 percent / pyridine / CH2Cl2 2.1: 86 percent / Pd(OAc)2; Xantphos; Cs2CO3 / toluene; H2O / 48 h / 120 °C 3.1: 95 percent / H2SO4 / 0.17 h / 20 °C 4.1: 91 percent / Pd(OAc)2; BINAP; K3PO4 / toluene; H2O / 5 h / 130 °C 5.1: CHCl3 / 20 °C 5.2: 56 percent / H2O / 20 °C View Scheme |
1-phenyl-1,3-dihydro-indol-2-one
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 97 percent / aq. NaOH / 6 h / 100 °C 2.1: 98 percent / dimethylformamide / 4 h / 24 °C 3.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C 4.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C 5.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C 6.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C 7.1: CH2Cl2 / 17 h / 25 °C 7.2: 70 percent / H2O View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydroxide / tetrahydrofuran / 5 h / 67 °C 1.2: 2 h / -10 °C 2.1: polyphosphoric acid / 3 h / 90 - 95 °C 3.1: water / 0 - 98 °C 4.1: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C 5.1: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 6.1: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydroxide / tetrahydrofuran / 5 h / 67 °C 1.2: 2 h / -40 °C 2.1: polyphosphoric acid / 3 h / 90 - 95 °C 3.1: water / 0 - 98 °C 4.1: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C 5.1: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 6.1: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: sodium hydroxide / water; ethanol / 1 h / 50 °C 1.2: 4 h / 20 °C 2.1: pyridine / toluene / 24 h / 50 °C 3.1: pyridine / 22 h / 100 °C 4.1: sodium hydroxide / water; methanol / 24 h / 20 °C 5.1: polyphosphoric acid / 3 h / 90 - 95 °C 6.1: water / 0 - 98 °C 7.1: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C 8.1: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 9.1: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme |
10-methoxy-5H-dibenzo[b,f]azepine
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: AcOH / 7 h / 25 °C 2: H2SO4 / 17 h / 25 °C View Scheme | |
With hydrogenchloride; benzoic acid In water; toluene | |
With sulfuric acid In water; toluene | |
Multi-step reaction with 2 steps 1: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 2: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme |
(2-phenylamino-phenyl)-acetic acid methyl ester
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: pyridine / toluene / 24 h / 50 °C 1.2: pyridine / 22 h / 100 °C 2.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C 3.1: polyphosphoric acid / 3 h / 95 °C 4.1: 97 percent / aq. NaOH / 6 h / 100 °C 5.1: 98 percent / dimethylformamide / 4 h / 24 °C 6.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C 7.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C 8.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C 9.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C 10.1: CH2Cl2 / 17 h / 25 °C 10.2: 70 percent / H2O View Scheme | |
Multi-step reaction with 7 steps 1.1: pyridine / toluene / 24 h / 50 °C 1.2: pyridine / 22 h / 100 °C 2.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C 3.1: 70 percent / polyphosphoric acid / 3 h / 95 °C 4.1: 81 percent / p-TsOH / methanol / 5 h / Heating 5.1: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C 6.1: AcOH / 7 h / 25 °C 7.1: H2SO4 / 17 h / 25 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: pyridine / toluene / 24 h / 50 °C 1.2: pyridine / 22 h / 100 °C 2.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C 3.1: 70 percent / polyphosphoric acid / 3 h / 95 °C 4.1: 72 percent / KOH / ethane-1,2-diol / 0.5 h / 108 °C 5.1: CH2Cl2 / 17 h / 25 °C 5.2: 70 percent / H2O View Scheme | |
Multi-step reaction with 8 steps 1: pyridine / toluene / 24 h / 50 °C 2: pyridine / 22 h / 100 °C 3: sodium hydroxide / water; methanol / 24 h / 20 °C 4: polyphosphoric acid / 3 h / 90 - 95 °C 5: water / 0 - 98 °C 6: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C 7: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 8: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme |
10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 81 percent / p-TsOH / methanol / 5 h / Heating 2: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C 3: AcOH / 7 h / 25 °C 4: H2SO4 / 17 h / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 72 percent / KOH / ethane-1,2-diol / 0.5 h / 108 °C 2.1: CH2Cl2 / 17 h / 25 °C 2.2: 70 percent / H2O View Scheme | |
Multi-step reaction with 4 steps 1: water / 0 - 98 °C 2: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C 3: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 4: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme |
[2-(methoxycarbonyl-phenyl-amino)-phenyl]-acetic acid methyl ester
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C 2.1: polyphosphoric acid / 3 h / 95 °C 3.1: 97 percent / aq. NaOH / 6 h / 100 °C 4.1: 98 percent / dimethylformamide / 4 h / 24 °C 5.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C 6.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C 7.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C 8.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C 9.1: CH2Cl2 / 17 h / 25 °C 9.2: 70 percent / H2O View Scheme | |
Multi-step reaction with 6 steps 1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C 2: 70 percent / polyphosphoric acid / 3 h / 95 °C 3: 81 percent / p-TsOH / methanol / 5 h / Heating 4: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C 5: AcOH / 7 h / 25 °C 6: H2SO4 / 17 h / 25 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 90 percent / aq. NaOH / methanol / 24 h / 25 °C 2.1: 70 percent / polyphosphoric acid / 3 h / 95 °C 3.1: 72 percent / KOH / ethane-1,2-diol / 0.5 h / 108 °C 4.1: CH2Cl2 / 17 h / 25 °C 4.2: 70 percent / H2O View Scheme | |
Multi-step reaction with 6 steps 1: sodium hydroxide / water; methanol / 24 h / 20 °C 2: polyphosphoric acid / 3 h / 90 - 95 °C 3: water / 0 - 98 °C 4: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C 5: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 6: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme |
10-methoxy-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C 2: AcOH / 7 h / 25 °C 3: H2SO4 / 17 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C 2: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 3: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme |
2-[(methoxycarbonyl)phenylamino]benzeneacetic acid
oxcarbazepine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: polyphosphoric acid / 3 h / 95 °C 2.1: 97 percent / aq. NaOH / 6 h / 100 °C 3.1: 98 percent / dimethylformamide / 4 h / 24 °C 4.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C 5.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C 6.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C 7.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C 8.1: CH2Cl2 / 17 h / 25 °C 8.2: 70 percent / H2O View Scheme | |
Multi-step reaction with 5 steps 1: 70 percent / polyphosphoric acid / 3 h / 95 °C 2: 81 percent / p-TsOH / methanol / 5 h / Heating 3: 98 percent / aq. NaOH / various solvent(s) / 4 h / 100 °C 4: AcOH / 7 h / 25 °C 5: H2SO4 / 17 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 70 percent / polyphosphoric acid / 3 h / 95 °C 2.1: 72 percent / KOH / ethane-1,2-diol / 0.5 h / 108 °C 3.1: CH2Cl2 / 17 h / 25 °C 3.2: 70 percent / H2O View Scheme | |
Multi-step reaction with 5 steps 1: polyphosphoric acid / 3 h / 90 - 95 °C 2: water / 0 - 98 °C 3: sodium hydroxide / water; methanol / 2.5 h / 105 - 110 °C 4: acetic acid / 6.17 h / 20 - 45 °C / Inert atmosphere 5: hydrogenchloride / water; acetone / 2 h / 40 °C View Scheme |
oxcarbazepine
S-licarbazepine
Conditions | Yield |
---|---|
With C32H39BrMnN2O2P; potassium tert-butylate; hydrogen In methanol at 20℃; under 22502.3 Torr; for 16h; Glovebox; Autoclave; enantioselective reaction; | 99% |
Stage #1: oxcarbazepine With triethylammonium formate; C33H40ClN2O4RuS In ethyl acetate; N,N-dimethyl-formamide pH=6.8 - 7.45; Heating / reflux; Stage #2: With formic acid In water; ethyl acetate; N,N-dimethyl-formamide for 23h; pH=7.4 - 7.8; Heating / reflux; | 94% |
Stage #1: oxcarbazepine With triethylamine; C33H40ClN2O4RuS In water; ethyl acetate; N,N-dimethyl-formamide at 72 - 77℃; pH=8.8; Heating / reflux; Stage #2: With formic acid In water; ethyl acetate; N,N-dimethyl-formamide for 20 - 27h; pH=7.4; Heating / reflux; | 88% |
oxcarbazepine
10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol; water at 20 - 45℃; for 1.5h; | 97.3% |
With sodium tetrahydroborate In ethanol; water at 45 - 50℃; | 94% |
With sodium tetrahydroborate; water In methanol at 25 - 65℃; for 2.75h; | 93.8% |
oxcarbazepine
carbamazepin
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate at 45 - 50℃; for 3h; | 91.5% |
oxcarbazepine
5H-dibenzazepine-10(11H),11-dione
Conditions | Yield |
---|---|
With selenium(IV) oxide In 1,4-dioxane for 7h; Reflux; | 90% |
With dihydrogen peroxide; methyltrioxorhenium(VII) In water; tert-butyl alcohol at 40℃; for 16h; | 27% |
Multi-step reaction with 2 steps 1: 73.4 percent / Br2 / acetic acid / 60 h / 15 °C 2: 2.4 percent / acetic acid / 0.75 h / Heating View Scheme |
oxcarbazepine
acetic anhydride
10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane at 20℃; for 4.16h; | 88% |
oxcarbazepine
N-methoxylamine hydrochloride
Conditions | Yield |
---|---|
With pyridine In ethanol for 4h; Heating; | 87% |
oxcarbazepine
B
10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f]azepine-5-carboxamide
Conditions | Yield |
---|---|
With pyridine; hydroxylamine hydrochloride In ethanol for 4h; Heating; Title compound not separated from byproducts; | A n/a B 86% |
Conditions | Yield |
---|---|
With aluminium trichloride In chloroform for 5h; Heating; | 85% |
oxcarbazepine
Conditions | Yield |
---|---|
With bromine In acetic acid at 15℃; for 60h; | 73.4% |
oxcarbazepine
phenylhydrazine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium acetate In ethanol; water at 60℃; for 0.5h; | 72.5% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 48h; Ambient temperature; | 72% |
oxcarbazepine
methyl glyoxylate methyl hemi-acetal
Conditions | Yield |
---|---|
In chloroform for 2h; Heating; | 70% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium acetate In ethanol; water at 60℃; for 0.5h; | 68% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium acetate In ethanol; water at 60℃; for 0.5h; | 61% |
oxcarbazepine
10,11-dihydro-5H-dibenzo[b,f]azepin-10-one
Conditions | Yield |
---|---|
With hydrogenchloride; 1-amino-3-(dimethylamino)propane In water; dimethyl sulfoxide at 120℃; for 1h; | 59% |
With water |
oxcarbazepine
1-butanethiol
Conditions | Yield |
---|---|
With aluminium trichloride In chloroform at 40℃; for 5h; | 58% |
oxcarbazepine
O-benzylhydoxylamine hydrochloride
Conditions | Yield |
---|---|
With pyridine In ethanol for 4h; Heating; | 58% |
oxcarbazepine
ethanethiol
Conditions | Yield |
---|---|
With aluminium trichloride In chloroform at 40℃; for 5h; | 55.2% |
oxcarbazepine
methylamine
10-(methylamino)-5H-dibenzo[b,f]azepine-5-carboxamide
Conditions | Yield |
---|---|
Stage #1: oxcarbazepine; methylamine With titanium(IV) isopropylate In ethanol for 6h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In ethanol for 3h; Inert atmosphere; | 52% |
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