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Henan Sigma Biotechnology Co., Ltd.

1. We integrate research and development, production, and sales. A 1800 square meter research and development center,The company has conducted over 50 research and development and technical service projects annually, applied for more than 10 patents,

(R)-Phenylephrine Hydrochlorid

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Phenylephrine Hcl supplier in China

Cas:61-76-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

CAS No.: 61-76-7 Other Names: Phenylephrine HCL MF: C9H13NO2.HCl EINECS No.: 200-517-3, 200-517-3 Place of Origin: Shaanxi, China (Mainland) Type: nutrition

Supply High purity 99% Phenylephrine HCL CAS no 61-76-7

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $400.0 / 500.0

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white crystalline powder Storage:Store at RT.

Good quality Phenylephrine hydrochloride CAS 61-76-7 with favorable price

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $300.0 / 350.0

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

Good quality Competitive price On time delivery Our Advantages: Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail

Good quality Phenylephrine HCL manufacturer

Cas:61-76-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Phenylephrine hydrochloride

Cas:61-76-7

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% (R)-Phenylephrine Hydrochlorid 61-76-7 GMP Manufacturer

Cas:61-76-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

(R)-Phenylephrine Hydrochlorid Mol Download Chemical properties CAS: 61-76-7 MF: C9H13NO2.ClH MW: 203.67 EINECS: 200-517-3 MDL No.: MFCD00012605 Properties Melting point: 143-145 °C(lit.) alpha -47 º (c=2, H2O) refractive

Top quality (R)-Phenylephrine Hydrochlorid 61-76-7

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $23.0 / 25.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-(-)-Phenylephrine hydrochloride

Cas:61-76-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply Phenylephrine Hydrochloride/Hcl CAS 61-76-7

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:(R)-Phenylephrine Hydrochlorid CAS NO: 61-76-7 Grade:Medical scientific research and export Molecular formula: C9H15Cl2NO2 Molecular weight:240.1269 Product Quality 12 years of chemical raw materials Mature operation of the industry

(R)-Phenylephrine Hydrochlorid/ CAS:61-76-7/ raw material/ high-quality

Cas:61-76-7

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CAS 61-76-7 Phenylephrine hydrochloride

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(R)-Phenylephrine Hydrochlorid

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 61-76-7 with best quality

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Phenylephrine hydrochloride

Cas:61-76-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Phenylephrine hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:61-76-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Phenylephrine Hydrochloride CAS 61-76-7 Phenylephrine Hydrochloride CAS 61-76-7 CAS 61-76-7 Brand: Sinotech MF C9H13NO2 · HCl MSDS: Aviable

Phenylephrine HCL

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to almost white crystalline powder Storage:R.T Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in China

API USP grade Phenylephrine Hydrochlorid cas 61-76-7

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $510.0 / 580.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-,hydrochloride (1:1), (aR)- 61-76-7

Cas:61-76-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Phenylephrine HCl CAS 61-76-7

Cas:61-76-7

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white crystalline powder Storage:Store in dry,

Phenylephrine Hydrochlorid cas 61-76-7 door to door shipping

Cas:61-76-7

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Phenylephrine hydrochloride CAS:61-76-7

Cas:61-76-7

Min.Order:1 Kilogram

FOB Price: $246.0 / 298.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(R)-Phenylephrine Hydrochlorid CAS:61-76-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ

(R)-Phenylephrine Hydrochlorid CAS:61-76-7

Cas:61-76-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o

Hot Selling CAS 61-76-7

Cas:61-76-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-,hydrochloride (1:1), (aR)-

Cas:61-76-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Phenylephrine Hydrochloride manufacturer with low price

Cas:61-76-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-,hydrochloride (1:1), (aR)-

Cas:61-76-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

L(-)-Phenylephrine hydrochloride

Cas:61-76-7

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Phenylephrine hydrochloride

Cas:61-76-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methylamine
74-89-5

methylamine

3-((R)-1-Hydroxy-2-iodo-ethyl)-phenol
603983-68-2

3-((R)-1-Hydroxy-2-iodo-ethyl)-phenol

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Stage #1: methylamine; 3-((R)-1-Hydroxy-2-iodo-ethyl)-phenol In tetrahydrofuran; water at 20℃; for 3h;
Stage #2: With hydrogenchloride at 20℃;
90%
C13H21NO4

C13H21NO4

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol for 1h; Reflux;90%
3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride
94240-17-2

3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
With hydrogen; [Rh(cod)(R-Binapine)]BF4 In methanol at 65℃; under 21752.2 - 24752.5 Torr; for 18.25h; Product distribution / selectivity;85%
Phenylephrin
59-42-7

Phenylephrin

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 55 - 65℃; for 0.5h; Product distribution / selectivity;84.5%
With hydrogenchloride In water; isopropyl alcohol pH=7 - 8; enantioselective reaction;3.35 g
(1R)-2-bromo-1-(3-hydroxylphenyl)ethanol

(1R)-2-bromo-1-(3-hydroxylphenyl)ethanol

methylamine
74-89-5

methylamine

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Stage #1: (1R)-2-bromo-1-(3-hydroxylphenyl)ethanol; methylamine In methanol for 6h; Inert atmosphere;
Stage #2: With hydrogenchloride In methanol for 0.5h; Inert atmosphere;
74.8%
(R)-2-(Benzyl-methyl-amino)-1-(3-benzyloxy-phenyl)-ethanol; hydrochloride
122709-71-1

(R)-2-(Benzyl-methyl-amino)-1-(3-benzyloxy-phenyl)-ethanol; hydrochloride

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal at 3℃; under 7600 Torr; for 3h; Yield given;
With hydrogen; palladium on activated charcoal In ethanol at 50℃; under 7600 Torr; for 3h; Yield given;
3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde
96013-95-5

3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 90 percent / tetrahydrofuran / 6 h / 20 °C
2.1: 97 percent / (DHQD)2PHAL; K3Fe(CH)6; K2CO3 / OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
3.1: 98 percent / dibutyltin oxide; NEt3 / CH2Cl2 / 0.75 h / 20 °C
4.1: 90 percent / AcOH / H2O; tetrahydrofuran / 10 h / 60 °C
5.1: 98 percent / NaI / acetone / 6 h / Heating
6.1: H2O; tetrahydrofuran / 3 h / 20 °C
6.2: 90 percent / methanolic HCl / 20 °C
View Scheme
meta-hydroxybenzaldehyde
100-83-4

meta-hydroxybenzaldehyde

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 90 percent / imidazole / CH2Cl2 / 5 h / 0 - 20 °C
2.1: 90 percent / tetrahydrofuran / 6 h / 20 °C
3.1: 97 percent / (DHQD)2PHAL; K3Fe(CH)6; K2CO3 / OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
4.1: 98 percent / dibutyltin oxide; NEt3 / CH2Cl2 / 0.75 h / 20 °C
5.1: 90 percent / AcOH / H2O; tetrahydrofuran / 10 h / 60 °C
6.1: 98 percent / NaI / acetone / 6 h / Heating
7.1: H2O; tetrahydrofuran / 3 h / 20 °C
7.2: 90 percent / methanolic HCl / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C
2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 0 °C
2.2: 0.5 h / 20 °C
3.1: (R,R)-Jacobsen catalyst / water / 61 h / 0 - 20 °C / Resolution of racemate
4.1: methanol / 2 h / 20 °C
5.1: hydrogenchloride / methanol / 1 h / Reflux
View Scheme
tert-butyldimethyl-(3-vinylphenoxy)silane
149274-04-4

tert-butyldimethyl-(3-vinylphenoxy)silane

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 97 percent / (DHQD)2PHAL; K3Fe(CH)6; K2CO3 / OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
2.1: 98 percent / dibutyltin oxide; NEt3 / CH2Cl2 / 0.75 h / 20 °C
3.1: 90 percent / AcOH / H2O; tetrahydrofuran / 10 h / 60 °C
4.1: 98 percent / NaI / acetone / 6 h / Heating
5.1: H2O; tetrahydrofuran / 3 h / 20 °C
5.2: 90 percent / methanolic HCl / 20 °C
View Scheme
1-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethane-1,2-diol
603983-65-9

1-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethane-1,2-diol

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 98 percent / dibutyltin oxide; NEt3 / CH2Cl2 / 0.75 h / 20 °C
2.1: 90 percent / AcOH / H2O; tetrahydrofuran / 10 h / 60 °C
3.1: 98 percent / NaI / acetone / 6 h / Heating
4.1: H2O; tetrahydrofuran / 3 h / 20 °C
4.2: 90 percent / methanolic HCl / 20 °C
View Scheme
Toluene-4-sulfonic acid (R)-2-hydroxy-2-(3-hydroxy-phenyl)-ethyl ester
603983-67-1

Toluene-4-sulfonic acid (R)-2-hydroxy-2-(3-hydroxy-phenyl)-ethyl ester

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 98 percent / NaI / acetone / 6 h / Heating
2.1: H2O; tetrahydrofuran / 3 h / 20 °C
2.2: 90 percent / methanolic HCl / 20 °C
View Scheme
toluene-4-sulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl ester
603983-66-0

toluene-4-sulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl ester

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 90 percent / AcOH / H2O; tetrahydrofuran / 10 h / 60 °C
2.1: 98 percent / NaI / acetone / 6 h / Heating
3.1: H2O; tetrahydrofuran / 3 h / 20 °C
3.2: 90 percent / methanolic HCl / 20 °C
View Scheme
3'-benzyloxy-2-(N-benzyl-N-methyl)aminoacetophenone hydrochloride
122709-70-0

3'-benzyloxy-2-(N-benzyl-N-methyl)aminoacetophenone hydrochloride

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2, 2, (2R,4R)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine, triethylamine / methanol / 20 h / 50 °C / 15200 Torr
2: H2 / 10percent Pd/C / ethanol / 3 h / 50 °C / 7600 Torr
View Scheme
Multi-step reaction with 2 steps
1: 100 percent / H2, triethylamine / <(Rh(COD)Cl>2, (2R,4R)-MCCPM / CH2Cl2 / 20 h / 50 °C / 15200 Torr
2: H2 / 10percent Pd/C / 3 h / 3 °C / 7600 Torr
View Scheme
2-(benzyl(methyl)amino)-1-(3'-hydroxyphenyl)ethanol
1159977-09-9

2-(benzyl(methyl)amino)-1-(3'-hydroxyphenyl)ethanol

2-(benzyl(methyl)amino)-1-(3'-hydroxyphenyl)ethanone hydrochloride
71786-67-9

2-(benzyl(methyl)amino)-1-(3'-hydroxyphenyl)ethanone hydrochloride

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
With hydrogen; triethylamine In methanol
3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride
94240-17-2

3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride

A

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

B

(+)-Phenylephrine hydrochloride
939-38-8

(+)-Phenylephrine hydrochloride

Conditions
ConditionsYield
With hydrogen; [(S)-Xyl-P-Phos RuCl(p-cymene)]Cl In methanol at 80 - 85℃; under 18751.9 - 23252.3 Torr; for 21h; Product distribution / selectivity;A n/a
B n/a
phenylephrine hydrochloride
154-86-9

phenylephrine hydrochloride

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / methanol / 0.5 h / 20 °C
1.2: 1.5 h / 25 - 60 °C / Resolution of racemate
2.1: hydrogenchloride / toluene; water / 0.5 h / 75 - 80 °C / pH < 2
2.2: 1 - 15 °C / pH ~ 9
3.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 55 - 65 °C
View Scheme
Phenylephrine
1477-63-0

Phenylephrine

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: methanol / 2 h / 20 - 65 °C / Resolution of racemate
2.1: hydrogenchloride / toluene; water / 0.5 h / 75 - 80 °C / pH < 2
2.2: 1 - 15 °C / pH ~ 9
3.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 55 - 65 °C
View Scheme
(R)-phenylephrine-(R)-naproxen
1280541-42-5

(R)-phenylephrine-(R)-naproxen

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / toluene; water / 0.5 h / 75 - 80 °C / pH < 2
1.2: 1 - 15 °C / pH ~ 9
2.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 55 - 65 °C
View Scheme
(3-methoxyethoxymethyloxy)benzaldehyde
139461-72-6

(3-methoxyethoxymethyloxy)benzaldehyde

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 0 °C
1.2: 0.5 h / 20 °C
2.1: (R,R)-Jacobsen catalyst / water / 61 h / 0 - 20 °C / Resolution of racemate
3.1: methanol / 2 h / 20 °C
4.1: hydrogenchloride / methanol / 1 h / Reflux
View Scheme
1-(3-methoxyethoxymethyloxy)phenylethylene oxide

1-(3-methoxyethoxymethyloxy)phenylethylene oxide

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (R,R)-Jacobsen catalyst / water / 61 h / 0 - 20 °C / Resolution of racemate
2: methanol / 2 h / 20 °C
3: hydrogenchloride / methanol / 1 h / Reflux
View Scheme
3-acetylphenyl acetate
2454-35-5

3-acetylphenyl acetate

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: bromine; aluminum (III) chloride / diethyl ether / -10 °C
2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
3.1: methanol / 6 h / Inert atmosphere
3.2: 0.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: bromine; aluminum (III) chloride / diethyl ether / -10 °C
2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
3.1: methanol / 6 h / Inert atmosphere
3.2: 0.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: bromine; aluminum (III) chloride / diethyl ether / -10 °C
2.1: sodium hydrogencarbonate / methanol
3.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
3.2: 0 °C / Inert atmosphere
4.1: methanol / 6 h / Inert atmosphere
4.2: 0.5 h / Inert atmosphere
View Scheme
2-bromo-3-acetyloxylacetophenone
38396-89-3

2-bromo-3-acetyloxylacetophenone

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
1.2: 0 °C / Inert atmosphere
2.1: methanol / 6 h / Inert atmosphere
2.2: 0.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
1.2: 0 °C / Inert atmosphere
2.1: methanol / 6 h / Inert atmosphere
2.2: 0.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / methanol
2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
3.1: methanol / 6 h / Inert atmosphere
3.2: 0.5 h / Inert atmosphere
View Scheme
3-Hydroxyacetophenone
121-71-1

3-Hydroxyacetophenone

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 1.5 h / 0 °C / pH 7 - 8
2.1: bromine; aluminum (III) chloride / diethyl ether / -10 °C
3.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
3.2: 0 °C / Inert atmosphere
4.1: methanol / 6 h / Inert atmosphere
4.2: 0.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 1.5 h / 0 °C / pH 7 - 8
2.1: bromine; aluminum (III) chloride / diethyl ether / -10 °C
3.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
3.2: 0 °C / Inert atmosphere
4.1: methanol / 6 h / Inert atmosphere
4.2: 0.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 1.5 h / 0 °C / pH 7 - 8
2.1: bromine; aluminum (III) chloride / diethyl ether / -10 °C
3.1: sodium hydrogencarbonate / methanol
4.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 20 °C / Inert atmosphere
4.2: 0 °C / Inert atmosphere
5.1: methanol / 6 h / Inert atmosphere
5.2: 0.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuryl dichloride / dichloromethane / 2 h / 5 - 25 °C
2.1: (1R,2S)-1-Amino-2-indanol; borane-THF / tetrahydrofuran / 0.5 h / 20 - 25 °C
3.1: water; methanol / 30 - 40 °C
3.2: 0.5 h / 0 - 50 °C
View Scheme
methylamine
74-89-5

methylamine

(R)-2-chloro-1-(3-hydroxyphenyl)ethanol
925430-39-3

(R)-2-chloro-1-(3-hydroxyphenyl)ethanol

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Conditions
ConditionsYield
Stage #1: methylamine; (R)-2-chloro-1-(3-hydroxyphenyl)ethanol In methanol; water at 30 - 40℃;
Stage #2: With hydrogenchloride In methanol; water at 0 - 50℃; for 0.5h;
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate
79060-88-1

sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate

C9H13NO2*C32H12BF24(1-)*H(1+)

C9H13NO2*C32H12BF24(1-)*H(1+)

Conditions
ConditionsYield
In chloroform at 20℃; for 1h;97%
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

(-)-m-octopamine
636-87-3

(-)-m-octopamine

Conditions
ConditionsYield
for 9h; Irradiation;96.1%
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

N,N-diethylcarbamyl chloride
88-10-8

N,N-diethylcarbamyl chloride

(1R)-1-(3-hydroxyphenyl)-2-ethanol
112023-62-8

(1R)-1-(3-hydroxyphenyl)-2-ethanol

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;76%
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

propargyl bromide
106-96-7

propargyl bromide

(R)-3-hydroxy-α-<(methyl-2-propanoylamino)methyl>benzenemethanol
110193-52-7

(R)-3-hydroxy-α-<(methyl-2-propanoylamino)methyl>benzenemethanol

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; toluene for 16h;64%
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Diethyl carbonate
105-58-8

Diethyl carbonate

(R)-5-(3-hydroxyphenyl)-3-methyl-2-oxazolidone
110193-49-2

(R)-5-(3-hydroxyphenyl)-3-methyl-2-oxazolidone

Conditions
ConditionsYield
With potassium carbonate for 4h; Heating;51%
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

Diethyl carbonate
105-58-8

Diethyl carbonate

5-(3-hydroxyphenyl)-3-methyl-2-oxazolidone
112710-46-0

5-(3-hydroxyphenyl)-3-methyl-2-oxazolidone

Conditions
ConditionsYield
With potassium carbonate In acetone51%
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

N,N-Dimethylthiocarbamoyl chloride
16420-13-6

N,N-Dimethylthiocarbamoyl chloride

(R)-1-(3-hydroxyphenyl)-2-ethanol
110193-50-5

(R)-1-(3-hydroxyphenyl)-2-ethanol

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 2h;47%
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

N,N-Dimethylthiocarbamoyl chloride
16420-13-6

N,N-Dimethylthiocarbamoyl chloride

1-(3-Hydroxyphenyl)-2-(N-methyl-N-dimethylthiocarbamoyl)amino ethanol
112636-20-1

1-(3-Hydroxyphenyl)-2-(N-methyl-N-dimethylthiocarbamoyl)amino ethanol

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; hexane; dichloromethane47%
sodium cyanide
773837-37-9

sodium cyanide

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

(R)-2-((2-hydroxy-2-(3-hydroxyphenyl)ethyl)amino)acetonitrile

(R)-2-((2-hydroxy-2-(3-hydroxyphenyl)ethyl)amino)acetonitrile

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; acetic acid In acetonitrile at 20℃; for 24h; Irradiation; Sealed tube;26%
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

7α-hydroxyendesm-4-en-6,12-olide
105578-87-8

7α-hydroxyendesm-4-en-6,12-olide

(3aR,5aR,9bS)-3a-hydroxy-3-((((2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl)(methyl)amino)methyl)-5a,9-dimethyl-3,3a,4,5,5a,6,7,8-octahydronaphtho[1,2-b]furan-2(9bH)-one
1109276-29-0

(3aR,5aR,9bS)-3a-hydroxy-3-((((2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl)(methyl)amino)methyl)-5a,9-dimethyl-3,3a,4,5,5a,6,7,8-octahydronaphtho[1,2-b]furan-2(9bH)-one

Conditions
ConditionsYield
With triethylamine In ethanol at 25℃; for 15h;21.3%
4-(chlorocarbonyl)pyridine
14254-57-0

4-(chlorocarbonyl)pyridine

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

N-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-N-methyl-isonicotinamide

N-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-N-methyl-isonicotinamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;
propionyl chloride
79-03-8

propionyl chloride

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

N-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-N-methyl-propionamide

N-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-N-methyl-propionamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-methyl-carbamic acid ethyl ester

[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-methyl-carbamic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

(S)-methyl 1-(chlorocarbonyl)pyrrolidine-2-carboxylate
85665-59-4

(S)-methyl 1-(chlorocarbonyl)pyrrolidine-2-carboxylate

(S)-1-{[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-2-carboxylic acid methyl ester

(S)-1-{[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

diphenylcarbamic chloride
83-01-2

diphenylcarbamic chloride

1-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-1-methyl-3,3-diphenyl-urea

1-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-1-methyl-3,3-diphenyl-urea

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

dimethylamino sulfonyl chloride
13360-57-1

dimethylamino sulfonyl chloride

C11H18N2O4S

C11H18N2O4S

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;
phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

N,N-Dimethylcarbamoyl chloride
79-44-7

N,N-Dimethylcarbamoyl chloride

1-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-1,3,3-trimethyl-urea

1-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-1,3,3-trimethyl-urea

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;
aqueous potassium hydroxide

aqueous potassium hydroxide

phenylephrine hydrochloride
61-76-7

phenylephrine hydrochloride

phosphorous acid
10294-56-1

phosphorous acid

butan-1-ol
71-36-3

butan-1-ol

2-(3-Hydroxyphenyl)-methylaminoethane
51674-33-0

2-(3-Hydroxyphenyl)-methylaminoethane

Conditions
ConditionsYield
With hydrogen iodide; sodium sulfate23.72 g (62.7%)

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