Leflunomide[CAS:75706-12-6] USP Standard 5-Methyl-4-Isoxazolecarboxylic Acid[CAS:42831-50-5] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years o
Cas:75706-12-6
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inquiryWe are the only one manufacturer in China who can produce it as USP34. We have produced it for more than 13 years. Appearance:White or off-white crystalline powder Storage:normal Package:25kgs net carton drums Application:API for arthritis;75706-12
Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryItems Standard Result Assay 98%min ---------------------------------------------------------------------------------------------
Cas:75706-12-6
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:75706-12-6
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inquiryUnique advantages of Leflunomide Cas 75706-12-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Cool dry place Package:100g,1kg
Cas:75706-12-6
Min.Order:100 Gram
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:75706-12-6
Min.Order:1 Gram
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inquiry1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Package:as request Application:active pharmaceutical ingredient Transportation:as request Port:any port
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:75706-12-6
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:75706-12-6
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Cas:75706-12-6
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inquiryChemical Name leflunomide Synonyms N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide;Leflunomidum;Arava;lefunamide;5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide;Expan
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Cas:75706-12-6
Min.Order:1 Kilogram
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Beluga chemical professional supply High quality Leflunomide CAS 75706-12-6 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and
Cas:75706-12-6
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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Cas:75706-12-6
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inquiryHubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)
Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo
Cas:75706-12-6
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Cas:75706-12-6
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual
Cas:75706-12-6
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
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inquiryLeflunomide
Conditions | Yield |
---|---|
With tris(pentafluorophenyl)borate In dichloromethane at 40℃; | 98% |
5-methyl-1,2-oxazole-4-carboxylic acid
4-trifluoromethylphenylamine
Leflunomide
Conditions | Yield |
---|---|
With triethylamine; 1,1'-carbonyldiimidazole In dichloromethane at 0℃; Reagent/catalyst; Heating; | 94% |
5-methylisoxazole-4-carbonyl chloride
4-trifluoromethylphenylamine
Leflunomide
Conditions | Yield |
---|---|
In diethyl ether for 0.5h; Ambient temperature; | 93% |
With sodium hydrogencarbonate In N,N-dimethyl acetamide; toluene | 86% |
With sodium hydrogencarbonate In water; toluene at 20 - 60℃; for 18h; | 43% |
4-trifluoromethylphenylamine
Leflunomide
Conditions | Yield |
---|---|
Stage #1: 5-methyl-1,2-oxazole-4-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide In toluene at 25 - 70℃; for 6h; Stage #2: 4-trifluoromethylphenylamine In toluene at 0 - 30℃; for 6h; | 62.34% |
N-(4-aminophenyl)-5-methylisoxazole-4-carboxamide
Leflunomide
Conditions | Yield |
---|---|
With copper; isopentyl nitrite In acetonitrile at 0 - 15℃; for 8h; Sandmeyer Reaction; Schlenk technique; Inert atmosphere; | 58% |
With copper; isopentyl nitrite In acetonitrile at 0 - 15℃; Sandmeyer Reaction; Inert atmosphere; | 58% |
5-methyl-1,2-oxazole-4-carboxylic acid
Leflunomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 96 percent / SOCl2 / 1 h / 70 °C 2: 93 percent / diethyl ether / 0.5 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 4 h / 40 °C 2: triethylamine / dichloromethane / 0 °C 3: copper; isopentyl nitrite / acetonitrile / 8 h / 0 - 15 °C / Schlenk technique; Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / 4 h / 50 °C / Inert atmosphere 2: sodium hydrogencarbonate / water; toluene / 18 h / 20 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / 45 °C 2: caesium carbonate / butanone; water / 1 h / 45 - 55 °C View Scheme |
4-trifluoromethylphenylamine
A
5-methylisoxazole-4-carbonyl chloride
B
Leflunomide
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water |
Conditions | Yield |
---|---|
In acetonitrile |
5-methyl-1,2-oxazole-4-carboxylic acid
4-aminobenzotrifluoride hydrochloride
Leflunomide
Conditions | Yield |
---|---|
Stage #1: 5-methyl-1,2-oxazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In neat (no solvent) for 0.333333h; Milling; Stage #2: 4-aminobenzotrifluoride hydrochloride In neat (no solvent) for 5h; Milling; | |
Stage #1: 5-methyl-1,2-oxazole-4-carboxylic acid With 1,1'-carbonyldiimidazole for 0.333333h; Milling; Green chemistry; Stage #2: 4-aminobenzotrifluoride hydrochloride for 5h; Milling; Green chemistry; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane 2: copper; isopentyl nitrite / acetonitrile / 8 h / 0 - 15 °C / Schlenk technique; Inert atmosphere View Scheme |
5-methylisoxazole-4-carbonyl chloride
Leflunomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 °C 2: copper; isopentyl nitrite / acetonitrile / 8 h / 0 - 15 °C / Schlenk technique; Inert atmosphere View Scheme |
2-ethoxymethyleneacetoacetyl-(4-trifluoromethyl)aniline
Leflunomide
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium hydroxide In ethanol for 1h; Reflux; |
3-oxo-N-(4-(trifluoromethyl)phenyl)butanamide
Leflunomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic anhydride / 2 h / 105 °C 2: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 1 h / Reflux View Scheme |
diphenylzinc
Leflunomide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: toluene / 40 °C 2: tetramethylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 0 °C 3: triethylamine / dichloromethane 4: tris(pentafluorophenyl)borate / dichloromethane / 40 °C View Scheme |
Leflunomide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetramethylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 0 °C 2: triethylamine / dichloromethane 3: tris(pentafluorophenyl)borate / dichloromethane / 40 °C View Scheme |
Leflunomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane 2: tris(pentafluorophenyl)borate / dichloromethane / 40 °C View Scheme |
ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate
Leflunomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride / ethanol / -5 - 20 °C 2: triethylamine; 1,1'-carbonyldiimidazole / dichloromethane / 0 °C / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydroxylamine / methanol; water / -5 - 15 °C 2: acetic acid; hydrogenchloride / water / Reflux 3: triethylamine; 1,1'-carbonyldiimidazole / dichloromethane / 0 °C / Heating View Scheme |
Leflunomide
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; for 2h; Reagent/catalyst; Temperature; | 98% |
Leflunomide
Conditions | Yield |
---|---|
Stage #1: Leflunomide With sodium hydroxide In water; isopropyl alcohol at 30℃; pH=12; Stage #2: With hydrogenchloride at 30℃; | 95% |
With sodium hydroxide In methanol; water; butanone at 50℃; for 1h; Concentration; Temperature; Solvent; | 94% |
With water |
Leflunomide
N,N-dimethyl-formamide dimethyl acetal
C12H8F3N2O2(1-)*C4H12N(1+)
Conditions | Yield |
---|---|
In 1,4-dioxane 1) 72 h, r.t. 2) 1 h, 65-75 deg C; | 60% |
Leflunomide
Conditions | Yield |
---|---|
With bis(methanesulfonyl)peroxide at 23℃; for 24h; Inert atmosphere; Schlenk technique; | 60% |
Leflunomide
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; lithium carbonate In 1,2-dichloro-ethane; acetonitrile at 60℃; for 20h; Sealed tube; | 32% |
Leflunomide
Conditions | Yield |
---|---|
With tetra(n-butyl)ammonium hydroxide; 1,2-dichloro-ethane In methanol at 60℃; for 10h; Electrochemical reaction; Green chemistry; | 31% |
Leflunomide
Conditions | Yield |
---|---|
With hydrogenchloride; n-butyllithium In tetrahydrofuran; hexane; water; ethyl acetate |
Leflunomide
Leflunomide
Conditions | Yield |
---|---|
In methanol; dichloromethane; toluene | |
In methanol; dichloromethane; toluene |
Leflunomide
Conditions | Yield |
---|---|
With hydrogenchloride In water for 24h; pH=1; | 0.297 g |
Conditions | Yield |
---|---|
In water at 21.84℃; under 750.075 Torr; |
Conditions | Yield |
---|---|
In water at 21.84℃; under 750.075 Torr; |
Conditions | Yield |
---|---|
In water at 21.84℃; under 750.075 Torr; |
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