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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

4-Aminobenzotrifluoride 455-14-1 /manufacturer/low price/high quality/in stock

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $11.0 / 12.0

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

We are Top manufacturer of Teriflunomide intermediate 4-(Trifluoromethyl)aniline CAS:455-14-1. Appearance:colorless to light yellow oil. Storage:store in well closed container Package:export worthy package Application:Teriflunomide intermediate P

high quality Teriflunomide intermediate 4-(Trifluoromethyl)aniline

Cas:455-14-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Jiangsu Huaen Energy Co., Ltd.

Yellowish Transparent Liquid

4-Aminotrifluorotoluene

Cas:455-14-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-(Trifluoromethyl) Aniline supplier in China

Cas:455-14-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Leflunomide[CAS:75706-12-6] USP Standard 4-(Trifluoromethyl)aniline CAS:455-14-1 5-Methyl-4-Isoxazolecarboxylic Acid[CAS:42831-50-5] Name 4-Aminobenzotrifluoride Synonyms 4-(Trifluoromethyl)aniline

4-(Trifluoromethyl)aniline for Leflunomide

Cas:455-14-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-(Trifluoromethyl) Aniline

Cas:455-14-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 455-14-1 Benzenamine,4-(trifluoromethyl)-

Cas:455-14-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

4-Aminobenzotrifluoride

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 4-Aminobenzotrifluoride

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

4-aminobenzotrifluoride

Cas:455-14-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

4-Aminobenzotrifluoride Factory Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for pr

4-Aminobenzotrifluoride Factory

Cas:455-14-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1101.html Product Name 4-Aminobenzotrifluoride CAS No. 455-14-1

4-Aminobenzotrifluoride

Cas:455-14-1

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--455-14-1--4-Aminobenzotrifluoride factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business

TIANFUCHEM--455-14-1--4-Aminobenzotrifluoride factory price

Cas:455-14-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

4-Aminobenzotrifluoride

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Aminotrifluorotoluene)

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Best Purity CAS 455-14-1 with best quality

Cas:455-14-1

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in t

Benzenamine,4-(trifluoromethyl)-

Cas:455-14-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: 4-Aminotrifluorotoluene Synonyms: p-Trifluoromethylaniline CAS: 455-14-1 MF: C7H6F3N Appearance:Colorless transparent liquid, Storage: Preserve in well-closed, light-resistant and airtight containers. Package: 25kgs/drum Application:Pes

4-Aminotrifluorotoluene

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99% 4-Aminobenzotrifluoride 455-14-1 For Fungicide

Cas:455-14-1

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenamine,4-(trifluoromethyl)- 455-14-1

Cas:455-14-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-Aminotrifluorotoluene 455-14-1

Cas:455-14-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

4-Aminobenzotrifluoride

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $85.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality 4-Aminobenzotrifluoride CAS 455-14-1ong technical force to ensure technical support and research capabilities. 2. Made in China and exported to many countries and regions at the most favorable price

High quality 4-Aminobenzotrifluoride CAS 455-14-1

Cas:455-14-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

4-Aminobenzotrifluoride CAS NO.455-14-1

Cas:455-14-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo

4- (Trifluoromethyl) Aniline CAS 455-14-1

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenamine,4-(trifluoromethyl)-

Cas:455-14-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Aminobenzotrifluoride

Cas:455-14-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Miheng Trading Co., Ltd.

4-Aminobenzotrifluoride CAS 455-14-1 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to as

4-Aminobenzotrifluoride CAS 455-14-1

Cas:455-14-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

4-Aminotrifluorotoluene

Cas:455-14-1

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-trifluoromethylaniline

Cas:455-14-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

p-nitrobenzotrifluoride
402-54-0

p-nitrobenzotrifluoride

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With Zr12(μ3-O)5[(μ3-O)CoCl]8[(μ2-O)2(μ3-O)CoCl]3Li3(triphenyldicarboxylate)9; hydrogen; sodium triethylborohydride In toluene at 110℃; under 30003 Torr; for 42h; Catalytic behavior; Inert atmosphere; Schlenk technique;100%
With hydrazine hydrate In ethanol at 40℃; for 0.5h;99%
With LaCu0.67Si1.33; hydrogen In isopropyl alcohol at 120℃; under 22502.3 Torr; for 54h; Autoclave;99%
4-(trifluoromethyl)phenylhydrazine
368-90-1

4-(trifluoromethyl)phenylhydrazine

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
nickel In methanol for 1h; Heating / reflux;100%
With hydrogen; nickel In methanol at 20℃; under 3750.38 Torr; for 2h;75%
p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 90℃; under 5171.62 Torr; for 24h; Inert atmosphere;95%
With ammonium hydroxide; copper(l) iodide; potassium carbonate; 4R-4-hydroxyproline In dimethyl sulfoxide at 50℃; for 24h;91%
Stage #1: p-trifluoromethylphenyl bromide With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 50℃; for 4h;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether
90%
4-Iodobenzotrifluoride
455-13-0

4-Iodobenzotrifluoride

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With ammonium hydroxide; caesium carbonate In water for 1h; Reflux; Green chemistry;92%
With ammonium hydroxide; caesium carbonate In water for 1h; Catalytic behavior; Reflux;92%
With ammonium hydroxide; caesium carbonate In acetonitrile for 1h; Reflux; Green chemistry;91%
1-azido-4-(trifluoromethyl)benzene
5586-13-0

1-azido-4-(trifluoromethyl)benzene

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With water for 5h; Inert atmosphere; UV-irradiation; Sealed tube; chemoselective reaction;92%
With C36H44CuN8(1+)*BF4(1-) In water; toluene at 100℃; for 20h; Sealed tube; chemoselective reaction;64%
With sodium tetrahydroborate In methanol; water at 20℃; for 0.333333h; Green chemistry;> 99 %Chromat.
With sodium tetrahydroborate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In methanol; water at 20℃; for 0.166667h;
With sodium tetrahydroborate In water at 20℃; for 0.416667h; Green chemistry;> 99 %Chromat.
4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
Stage #1: 4-chlorobenzotrifluoride With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 90℃; for 18h;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether
88%
With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;86%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; ammonia; sodium t-butanolate In 1,4-dioxane at 110℃; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;62%
4-trifluoromethylcyclohexanone oxime
75092-01-2

4-trifluoromethylcyclohexanone oxime

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With Pd(OH)x/LDH In N,N-dimethyl acetamide at 150℃; for 1h; Schlenk technique; Inert atmosphere;85%
4-(trifluromethyl)acetanilide
349-97-3

4-(trifluromethyl)acetanilide

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

(4-trifluoromethylphenyl)ethylamine

(4-trifluoromethylphenyl)ethylamine

Conditions
ConditionsYield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); formic acid; bis(trifluoromethanesulfonyl)amide; triethylamine; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In dibutyl ether at 130℃; for 24h;A 79%
B n/a
4-trifluoromethylphenylboronic acid
128796-39-4

4-trifluoromethylphenylboronic acid

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With O-(2,4-dinitrophenyl)hydroxylamine In toluene at 80℃; for 96h; Inert atmosphere;78%
With copper(I) oxide; ammonium hydroxide; oxygen; sodium hydroxide In water at 25℃; for 24h;70%
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 5h; Reflux;57%
4-(triethylsiloxy)-4-(trifluoromethyl)-2,5-cyclohexadien-1-one
120120-28-7

4-(triethylsiloxy)-4-(trifluoromethyl)-2,5-cyclohexadien-1-one

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With glycine ethyl ester hydrochloride; sodium hydrogencarbonate In ethanol for 6h; Heating;73%
(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

4-bromo-aniline
106-40-1

4-bromo-aniline

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; sodium dodecyl-sulfate; cesium fluoride In toluene at 110℃; for 12h; Inert atmosphere;71%
5-((4-(trifluoromethyl)phenyl)imino)-5H-5λ4-dibenzo[b,d]thiophene 5-oxide

5-((4-(trifluoromethyl)phenyl)imino)-5H-5λ4-dibenzo[b,d]thiophene 5-oxide

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane In toluene at 100℃; Sealed tube;69%
Togni's reagent II
887144-94-7

Togni's reagent II

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 75℃; for 6h; Schlenk technique; Inert atmosphere;A 20%
B 66%
With potassium carbonate; nickel(II) hydroxide In dimethyl sulfoxide at 35℃; for 2h; Reagent/catalyst; Solvent; Temperature; Overall yield = 89 %;A 20%
B 61%
With potassium carbonate; nickel(II) hydroxide In dimethyl sulfoxide at 35℃; for 2h; Reagent/catalyst; Solvent; Inert atmosphere;A 20%
B 49%
4-(trifluromethyl)acetanilide
349-97-3

4-(trifluromethyl)acetanilide

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With [RuCl2(2-(diphenylphosphino)-N-((6-((diphenylphosphino)methyl)pyridin-2-yl)methyl)ethan-1-amine)]; potassium tert-butylate; hydrogen In tetrahydrofuran at 100℃; under 37503.8 Torr; for 20h; Catalytic behavior; Autoclave; chemoselective reaction;65%
2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole
570-05-8

2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
With trifluoroacetic acid for 48h; Reflux;56%
iodotrifluoromethane
2314-97-8

iodotrifluoromethane

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
With fac-tris(2-phenylpyridinato-N,C2')iridium(III); potassium carbonate In 1,2-dichloro-ethane at 20℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation; regioselective reaction;A 34%
B 54%
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water at 40 - 50℃; for 0.333333h;A 7.2 %Spectr.
B 8.5 %Spectr.
With dihydrogen peroxide; iron(II) sulfate In water; dimethyl sulfoxideA 13 %Spectr.
B 22 %Spectr.
tert-butyl 2-(4-methoxyphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazine-1-carboxylate

tert-butyl 2-(4-methoxyphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazine-1-carboxylate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

4-methoxy-aniline
104-94-9

4-methoxy-aniline

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; regioselective reaction;A 24%
B 54%
[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-(4-trifluoromethyl-phenyl)-amine

[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-(4-trifluoromethyl-phenyl)-amine

A

8,9-dimethoxy-2-(trifluoromethyl)phenanthridine

8,9-dimethoxy-2-(trifluoromethyl)phenanthridine

B

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

C

3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

Conditions
ConditionsYield
With vanadium(V) oxytrifluoride; trifluoroacetic acid In dichloromethane; ethyl acetate at -30℃; for 0.166667h;A 52%
B 75 mg
C 220 mg
2,3,7,8-tetrafluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

2,3,7,8-tetrafluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;A 23%
B 44%
3,7-dinitro-Se-(trifluoromethyl)dibenzoselenophenium triflate
129922-39-0

3,7-dinitro-Se-(trifluoromethyl)dibenzoselenophenium triflate

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.5h; Ambient temperature; Title compound not separated from byproducts;A 16 % Spectr.
B 39%
In N,N-dimethyl-formamide for 0.5h; Ambient temperature; Title compound not separated from byproducts;A 16 % Spectr.
B 39 % Spectr.
Umemoto's reagent
129946-88-9

Umemoto's reagent

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 5h; Title compound not separated from byproducts;A 15%
B 37%
In N,N-dimethyl-formamide at 80℃; for 7h;A 18%
B 39 % Spectr.
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;A 2%
B 5%
aniline
62-53-3

aniline

S-(Trifluoromethyl)-7-nitrodibenzothiophenium-3-sulfonate
160656-66-6

S-(Trifluoromethyl)-7-nitrodibenzothiophenium-3-sulfonate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 0.5h;A 18 % Spectr.
B 37%
In N,N-dimethyl-formamide at 80℃; for 0.5h;A 18%
B 37 % Spectr.
In N,N-dimethyl-formamide at 80℃; for 0.5h; Product distribution; other temperature;
tert-butyl 2-(2,4,6-trimethylphenyl)-1-(4-trifluoromethylphenyl)hydrazinecarboxylate

tert-butyl 2-(2,4,6-trimethylphenyl)-1-(4-trifluoromethylphenyl)hydrazinecarboxylate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

1-mesityl-2-[4-(trifluoromethyl)phenyl]diazene

1-mesityl-2-[4-(trifluoromethyl)phenyl]diazene

C

2,4,6-trimethylaniline
88-05-1

2,4,6-trimethylaniline

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 65 %; regioselective reaction;A n/a
B 37%
C n/a
2,6-difluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

2,6-difluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;A 17%
B 37%
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

aniline
62-53-3

aniline

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

2-(trifluoromethyl)benzenamine
88-17-5

2-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
With α-picoline; sodium metabisulfite; sulfur dioxide; zinc In N,N-dimethyl-formamide at 20℃; under 2250.2 - 3750.3 Torr; for 2h; Product distribution; other alkylating reagents, other method, other pressure, temp.; various substrates;A 20%
B 36%
With α-picoline; sodium metabisulfite; sulfur dioxide; zinc In N,N-dimethyl-formamide at 20℃; under 2250.2 - 3750.3 Torr; for 2h; also with NaS2O4;A 20%
B 36%
With sulfur dioxide; zinc In N,N-dimethyl-formamide under 2250.2 - 3750.3 Torr; for 2h; Ambient temperature;A 20%
B 36%
1,2-bis(4-(trifluoromethyl)phenyl)hydrazine
740-69-2

1,2-bis(4-(trifluoromethyl)phenyl)hydrazine

β-naphthol
135-19-3

β-naphthol

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

1-(4-(trifluoromethyl)phenylamino)naphthalen-2-ol

1-(4-(trifluoromethyl)phenylamino)naphthalen-2-ol

Conditions
ConditionsYield
In neat (no solvent) at 120℃; Inert atmosphere;A n/a
B 34%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylbenzoic acid With trifluorormethanesulfonic acid; trimethylsilylazide In chloroform at 90℃; for 0.0583333h; Schmidt Reaction; Flow reactor;
Stage #2: With water In methanol; chloroform at 20℃; Schmidt Reaction; Flow reactor;
24%
tert-butyl 2-(2,6-dimethylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate
1616514-64-7

tert-butyl 2-(2,6-dimethylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

3′,5′-dimethyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine
1616514-72-7

3′,5′-dimethyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine

C

3,5-dimethyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine
1616514-78-3

3,5-dimethyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine

D

2,6-Dimethyl-4'-(trifluoromethyl)azobenzene
150370-02-8

2,6-Dimethyl-4'-(trifluoromethyl)azobenzene

E

2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20℃; for 2h; Inert atmosphere; Reflux;A 9%
B 21%
C 18%
D 10%
E 6%
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 58 %; regioselective reaction;A 9%
B 21%
C 18%
D 10%
E 6%
tert-butyl 2-(2-ethyl-6-methylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate
1616514-65-8

tert-butyl 2-(2-ethyl-6-methylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate

A

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

B

6-ethyl-o-toluidine
24549-06-2

6-ethyl-o-toluidine

C

3′-ethyl-5′-methyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine
1616514-73-8

3′-ethyl-5′-methyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine

D

3-ethyl-5-methyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine
1616514-79-4

3-ethyl-5-methyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine

E

1-(2-ethyl-6-methylphenyl)-2-(4-(trifluoromethyl)phenyl)diazene
1616514-85-2

1-(2-ethyl-6-methylphenyl)-2-(4-(trifluoromethyl)phenyl)diazene

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20℃; for 2h; Inert atmosphere; Reflux;A 10%
B 6%
C 10%
D 18%
E 12%
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 50 %; regioselective reaction;A 10%
B 6%
C 10%
D 18%
E 12%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

ethyl 2-oxo-2-((4-(trifluoromethyl)phenyl)amino)acetate
69066-00-8

ethyl 2-oxo-2-((4-(trifluoromethyl)phenyl)amino)acetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 8h;100%
With triethylamine In tetrahydrofuran at 20℃;99%
With pyridine In dichloromethane at 0 - 20℃; for 43h; Reflux; Inert atmosphere; Schlenk technique;96%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

2-iodo-4-(trifluoromethyl)aniline
163444-17-5

2-iodo-4-(trifluoromethyl)aniline

Conditions
ConditionsYield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate In methanol; dichloromethane at 20℃; for 2h;100%
With Iodine monochloride In methanol; dichloromethane at 0 - 20℃;97%
With Iodine monochloride In methanol; dichloromethane at 0 - 20℃; for 1h;97%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

acetic anhydride
108-24-7

acetic anhydride

4-(trifluromethyl)acetanilide
349-97-3

4-(trifluromethyl)acetanilide

Conditions
ConditionsYield
In dichloromethane at 20℃; Inert atmosphere;100%
In dichloromethane; water at 25℃; for 1h; Temperature;99.3%
With pyridine at 0 - 20℃; for 0.5h;99%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

1-azido-4-(trifluoromethyl)benzene
5586-13-0

1-azido-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
With tert.-butylnitrite; trimethylsilylazide In acetonitrile at 20℃; for 1h; Inert atmosphere;100%
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In water at 0℃; for 2h;
Stage #2: With sodium azide In water at 0 - 20℃;
95%
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In water at 0℃; for 2h;
Stage #2: With sodium azide In water at 0℃; for 2h;
95%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

benzoyl chloride
98-88-4

benzoyl chloride

N-(4-(trifluoromethyl)phenyl)benzamide
350-98-1

N-(4-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane for 2h;100%
With dmap In dichloromethane at 20℃; Inert atmosphere;91%
With triethylamine In dichloromethane at 0 - 40℃; Inert atmosphere;75%
furfural
98-01-1

furfural

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine
325139-72-8

1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In diethyl ether at 20℃; Molecular sieve; Inert atmosphere;100%
In benzene at 20℃; for 20h;70%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

5-triethylsilylfuran-2-carbaldehyde
13529-12-9

5-triethylsilylfuran-2-carbaldehyde

N-(5-triethylsilyl-2-furylmethylidene)-4-trifluoromethylaniline

N-(5-triethylsilyl-2-furylmethylidene)-4-trifluoromethylaniline

Conditions
ConditionsYield
With 4 A molecular sieve In benzene at 20℃; for 20h;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-methyl-N-(4-(trifluoromethyl)phenyl)benzenesulfonamide

4-methyl-N-(4-(trifluoromethyl)phenyl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 4℃;100%
With pyridine In dichloromethane at 20℃; for 24h;98%
for 0.1h; microwave irradiation;92%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

3,4-dihydro-4-oxo-3-(2-chloro-3-pyridyl)-2-quinazolinecarbothioic acid S-p-tolyl ester
830324-69-1

3,4-dihydro-4-oxo-3-(2-chloro-3-pyridyl)-2-quinazolinecarbothioic acid S-p-tolyl ester

3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid (4-trifluoromethyl-phenyl)-amide
830324-75-9

3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid (4-trifluoromethyl-phenyl)-amide

Conditions
ConditionsYield
With silver trifluoroacetate In tetrahydrofuran; toluene at 60℃; for 1.5h;100%
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

C13H9F3N2

C13H9F3N2

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 20℃; for 12h;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

potassium thioacyanate
333-20-0

potassium thioacyanate

1-(4-(trifluoromethyl)phenyl)thiourea
1736-72-7

1-(4-(trifluoromethyl)phenyl)thiourea

Conditions
ConditionsYield
With hydrogenchloride In water Heating / reflux;100%
(3R)-5-methoxy-3-[(trifluoroacetyl)amino]chromane-8-sulfonyl chloride
916222-27-0

(3R)-5-methoxy-3-[(trifluoroacetyl)amino]chromane-8-sulfonyl chloride

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

2,2,2-trifluoro-N-[(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl]acetamide
916223-31-9

2,2,2-trifluoro-N-[(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl]acetamide

Conditions
ConditionsYield
With pyridine In dichloromethane for 8h;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

propionaldehyde
123-38-6

propionaldehyde

N-propyl-4-(trifluoromethyl)benzenamine
190843-72-2

N-propyl-4-(trifluoromethyl)benzenamine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 18℃; for 0.0833333h; Solvent; Green chemistry;100%
2,6-Pyridinedicarboxaldehyde
5431-44-7

2,6-Pyridinedicarboxaldehyde

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

C21H13F6N3

C21H13F6N3

Conditions
ConditionsYield
In dichloromethane for 4h; Molecular sieve;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

2-methyl-N-(4-(trifluoromethyl)phenyl)benzamide

2-methyl-N-(4-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3h;100%
4-chloro-5-bromopyrimidine
56181-39-6

4-chloro-5-bromopyrimidine

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

C11H7BrF3N3

C11H7BrF3N3

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate In 1-methyl-pyrrolidin-2-one at 60℃; for 2h;100%
With toluene-4-sulfonic acid In 1-methyl-pyrrolidin-2-one at 60℃; for 2h;51%
furfural
98-01-1

furfural

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

(E)-1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine
1185039-73-9

(E)-1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine

Conditions
ConditionsYield
In toluene Inert atmosphere; Reflux; Dean-Stark;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

7-isoselenocyanato-4-methyl-2H-chromen-2-one

7-isoselenocyanato-4-methyl-2H-chromen-2-one

N-(4-methyl-2-oxo-2H-chromen-7-yl)-N'-(4-trifluoromethyl)selenourea

N-(4-methyl-2-oxo-2H-chromen-7-yl)-N'-(4-trifluoromethyl)selenourea

Conditions
ConditionsYield
In tetrahydrofuran at 40℃; for 2h; Inert atmosphere; Darkness;100%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

benzaldehyde
100-52-7

benzaldehyde

N-benzylidene-4-(trifluoromethyl)aniline
351-98-4

N-benzylidene-4-(trifluoromethyl)aniline

Conditions
ConditionsYield
at 50℃; Condensation;99.1%
In water at 20℃; for 12h; Inert atmosphere;95%
In toluene for 0.5h; Heating;84%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

4-nitro-N-(4-(trifluoromethyl)phenyl)benzamide
7607-41-2

4-nitro-N-(4-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;99%
With pyridine for 4h; Heating;95%
With pyridine at 20℃; Inert atmosphere; Reflux;95%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

potassium thioacyanate
333-20-0

potassium thioacyanate

2-amino-6-trifluoromethyl-1,3-benzothiazole
777-12-8

2-amino-6-trifluoromethyl-1,3-benzothiazole

Conditions
ConditionsYield
With sodium iodide dichloride at 70℃; for 2h;99%
With 6-methylbenzothiazol-2-ylamine; N,N,N,N,-tetramethylethylenediamine; oxygen; copper(II) bis(trifluoromethanesulfonate) In dimethyl sulfoxide at 100℃; for 24h; regioselective reaction;80%
With bromine In acetic acid for 24h;20%
With bromine; acetic acid for 21h; Ambient temperature;
With bromine In acetic acid Cooling with ice;
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

acetonitrile
75-05-8

acetonitrile

(4-trifluoromethylphenyl)ethylamine

(4-trifluoromethylphenyl)ethylamine

Conditions
ConditionsYield
With ammonium acetate; hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h;99%
With palladium 10% on activated carbon; hydrogen; acetic acid In methanol at 20℃; under 760.051 Torr; for 18h;99%
4-(chlorocarbonyl)pyridine
14254-57-0

4-(chlorocarbonyl)pyridine

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

N-[4-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

N-[4-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran at 0 - 65℃; for 1.58333h;99%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Cp*Ni(PEt3)S(OMe)
198903-09-2

Cp*Ni(PEt3)S(OMe)

Cp*Ni(PEt3)NHC6H4(p-CF3)
198903-17-2

Cp*Ni(PEt3)NHC6H4(p-CF3)

Conditions
ConditionsYield
In diethyl ether inert atmosphere; stirring (10 min); removal of volatile materials (vac.), crystn. (pentane);99%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

5-nitrosalicylic acid
96-97-9

5-nitrosalicylic acid

2-hydroxy-5-nitro-N-[4-(trifluoromethyl)phenyl]benzamide
198774-77-5

2-hydroxy-5-nitro-N-[4-(trifluoromethyl)phenyl]benzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;99%
With phosphorus trichloride Microwave irradiation; Reflux;76%
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 3h; Inert atmosphere;66.2%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;
3-Chloropropyl isocyanate
13010-19-0

3-Chloropropyl isocyanate

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

1-(3-chloropropyl)-3-(4-(trifluoromethyl)phenyl)urea
1422166-44-6

1-(3-chloropropyl)-3-(4-(trifluoromethyl)phenyl)urea

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃;99%
In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 20℃; for 72h;87%
In dichloromethane at 20℃; for 72h;
In dichloromethane at 20℃;
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

4-((4-trifluoromethylphenyl)amino)-7-chloroquinolinium chloride

4-((4-trifluoromethylphenyl)amino)-7-chloroquinolinium chloride

Conditions
ConditionsYield
In ethanol Reflux;99%
tetrafluoroboric acid

tetrafluoroboric acid

4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

p-(trifluoromethyl)benzenediazonium tetrafluoroborate

p-(trifluoromethyl)benzenediazonium tetrafluoroborate

Conditions
ConditionsYield
Stage #1: tetrafluoroboric acid; 4-trifluoromethylphenylamine In water at 0℃; for 0.166667h;
Stage #2: With sodium nitrite In water at 0℃; for 0.283333h;
99%
With isopentyl nitrite In ethanol; water at -20 - 20℃; for 1h; Inert atmosphere;77%
With sodium nitrite In water at 0℃; for 0.5h;70%
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