4-Aminobenzotrifluoride supplier

Name
4-Aminobenzotrifluoride
EINECS 207-236-5
CAS No. 455-14-1
Article Data154
CAS DataBase
Density 1.286 g/cm³
Solubility <0.1 g/100 mL in water
Melting Point 3-8 °C
Formula C₇H₆F₃N
Boiling Point 190 °C at 760 mmHg
Molecular Weight 161.127
Flash Point 86.7 °C
Transport Information UN 2810 6.1/PG 3
Appearance clear colorless to yellow liquid
Safety 26-45-60-61-36/37/39-36
Risk Codes 25-36-50/53-36/37/38-33-20/21/22
Molecular Structure
Hazard Symbols T, N, Xi, Xn
Synonyms p-Toluidine,a,a,a-trifluoro-(6CI,7CI,8CI);(4-(Trifluoromethyl)phenyl)amine;1-Amino-4-(trifluoromethyl)benzene;4-(Trifluoromethyl)aniline;4-(Trifluoromethyl)benzenamine;4-Amino-a,a,a-benzotrifluoride;NSC 10337;p-(Trifluoromethyl)aniline;p-Amino-a,a,a-trifluorotoluene;p-Aminobenzotrifluoride;p-Trifluoromethylphenylamine;a,a,a-Trifluoro-p-toluidine;4-Aminotrifluorotoluene;
PSA 26.02000
LogP 2.86880

Synthetic route

: 402-54-0
p-nitrobenzotrifluoride

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With Zr12(μ3-O)5[(μ3-O)CoCl]8[(μ2-O)2(μ3-O)CoCl]3Li3(triphenyldicarboxylate)9; hydrogen; sodium triethylborohydride In toluene at 110℃; under 30003 Torr; for 42h; Catalytic behavior; Inert atmosphere; Schlenk technique;	100%
With hydrazine hydrate In ethanol at 40℃; for 0.5h;	99%
With LaCu0.67Si1.33; hydrogen In isopropyl alcohol at 120℃; under 22502.3 Torr; for 54h; Autoclave;	99%

: 368-90-1
4-(trifluoromethyl)phenylhydrazine

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
nickel In methanol for 1h; Heating / reflux;	100%
With hydrogen; nickel In methanol at 20℃; under 3750.38 Torr; for 2h;	75%

: 402-43-7
p-trifluoromethylphenyl bromide

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 90℃; under 5171.62 Torr; for 24h; Inert atmosphere;	95%
With ammonium hydroxide; copper(l) iodide; potassium carbonate; 4R-4-hydroxyproline In dimethyl sulfoxide at 50℃; for 24h;	91%
Stage #1: p-trifluoromethylphenyl bromide With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 50℃; for 4h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether	90%

: 455-13-0
4-Iodobenzotrifluoride

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With ammonium hydroxide; caesium carbonate In water for 1h; Reflux; Green chemistry;	92%
With ammonium hydroxide; caesium carbonate In water for 1h; Catalytic behavior; Reflux;	92%
With ammonium hydroxide; caesium carbonate In acetonitrile for 1h; Reflux; Green chemistry;	91%

: 5586-13-0
1-azido-4-(trifluoromethyl)benzene

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With water for 5h; Inert atmosphere; UV-irradiation; Sealed tube; chemoselective reaction;	92%
With C36H44CuN8(1+)*BF4(1-) In water; toluene at 100℃; for 20h; Sealed tube; chemoselective reaction;	64%
With sodium tetrahydroborate In methanol; water at 20℃; for 0.333333h; Green chemistry;	> 99 %Chromat.
With sodium tetrahydroborate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In methanol; water at 20℃; for 0.166667h;
With sodium tetrahydroborate In water at 20℃; for 0.416667h; Green chemistry;	> 99 %Chromat.

: 98-56-6
4-chlorobenzotrifluoride

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
Stage #1: 4-chlorobenzotrifluoride With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 90℃; for 18h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether	88%
With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;	86%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; ammonia; sodium t-butanolate In 1,4-dioxane at 110℃; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;	62%

: 75092-01-2
4-trifluoromethylcyclohexanone oxime

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With Pd(OH)x/LDH In N,N-dimethyl acetamide at 150℃; for 1h; Schlenk technique; Inert atmosphere;	85%

: 349-97-3
4-(trifluromethyl)acetanilide

A: 455-14-1
4-trifluoromethylphenylamine

B: (4-trifluoromethylphenyl)ethylamine

Conditions

Conditions	Yield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); formic acid; bis(trifluoromethanesulfonyl)amide; triethylamine; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In dibutyl ether at 130℃; for 24h;	A 79% B n/a

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With O-(2,4-dinitrophenyl)hydroxylamine In toluene at 80℃; for 96h; Inert atmosphere;	78%
With copper(I) oxide; ammonium hydroxide; oxygen; sodium hydroxide In water at 25℃; for 24h;	70%
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 5h; Reflux;	57%

: 120120-28-7
4-(triethylsiloxy)-4-(trifluoromethyl)-2,5-cyclohexadien-1-one

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With glycine ethyl ester hydrochloride; sodium hydrogencarbonate In ethanol for 6h; Heating;	73%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 106-40-1
4-bromo-aniline

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; sodium dodecyl-sulfate; cesium fluoride In toluene at 110℃; for 12h; Inert atmosphere;	71%

: 5-((4-(trifluoromethyl)phenyl)imino)-5H-5λ4-dibenzo[b,d]thiophene 5-oxide

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane In toluene at 100℃; Sealed tube;	69%

: 887144-94-7
Togni's reagent II

: 62-53-3
aniline

A: 455-14-1
4-trifluoromethylphenylamine

B: 88-17-5
2-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 75℃; for 6h; Schlenk technique; Inert atmosphere;	A 20% B 66%
With potassium carbonate; nickel(II) hydroxide In dimethyl sulfoxide at 35℃; for 2h; Reagent/catalyst; Solvent; Temperature; Overall yield = 89 %;	A 20% B 61%
With potassium carbonate; nickel(II) hydroxide In dimethyl sulfoxide at 35℃; for 2h; Reagent/catalyst; Solvent; Inert atmosphere;	A 20% B 49%

...Expand

: 349-97-3
4-(trifluromethyl)acetanilide

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With [RuCl2(2-(diphenylphosphino)-N-((6-((diphenylphosphino)methyl)pyridin-2-yl)methyl)ethan-1-amine)]; potassium tert-butylate; hydrogen In tetrahydrofuran at 100℃; under 37503.8 Torr; for 20h; Catalytic behavior; Autoclave; chemoselective reaction;	65%

: 570-05-8
2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
With trifluoroacetic acid for 48h; Reflux;	56%

: 2314-97-8
iodotrifluoromethane

: 62-53-3
aniline

A: 455-14-1
4-trifluoromethylphenylamine

B: 88-17-5
2-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
With fac-tris(2-phenylpyridinato-N,C2')iridium(III); potassium carbonate In 1,2-dichloro-ethane at 20℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation; regioselective reaction;	A 34% B 54%
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide In water at 40 - 50℃; for 0.333333h;	A 7.2 %Spectr. B 8.5 %Spectr.
With dihydrogen peroxide; iron(II) sulfate In water; dimethyl sulfoxide	A 13 %Spectr. B 22 %Spectr.

...Expand

: tert-butyl 2-(4-methoxyphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazine-1-carboxylate

A: 455-14-1
4-trifluoromethylphenylamine

B: 104-94-9
4-methoxy-aniline

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; regioselective reaction;	A 24% B 54%

: [1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-(4-trifluoromethyl-phenyl)-amine

A: 8,9-dimethoxy-2-(trifluoromethyl)phenanthridine

B: 455-14-1
4-trifluoromethylphenylamine

C: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With vanadium(V) oxytrifluoride; trifluoroacetic acid In dichloromethane; ethyl acetate at -30℃; for 0.166667h;	A 52% B 75 mg C 220 mg

...Expand

: 2,3,7,8-tetrafluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

: 62-53-3
aniline

A: 455-14-1
4-trifluoromethylphenylamine

B: 88-17-5
2-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;	A 23% B 44%

...Expand

: 129922-39-0
3,7-dinitro-Se-(trifluoromethyl)dibenzoselenophenium triflate

: 62-53-3
aniline

A: 455-14-1
4-trifluoromethylphenylamine

B: 88-17-5
2-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.5h; Ambient temperature; Title compound not separated from byproducts;	A 16 % Spectr. B 39%
In N,N-dimethyl-formamide for 0.5h; Ambient temperature; Title compound not separated from byproducts;	A 16 % Spectr. B 39 % Spectr.

...Expand

: 129946-88-9
Umemoto's reagent

: 62-53-3
aniline

A: 455-14-1
4-trifluoromethylphenylamine

B: 88-17-5
2-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 5h; Title compound not separated from byproducts;	A 15% B 37%
In N,N-dimethyl-formamide at 80℃; for 7h;	A 18% B 39 % Spectr.
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;	A 2% B 5%

...Expand

: 62-53-3
aniline

: 160656-66-6
S-(Trifluoromethyl)-7-nitrodibenzothiophenium-3-sulfonate

A: 455-14-1
4-trifluoromethylphenylamine

B: 88-17-5
2-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80℃; for 0.5h;	A 18 % Spectr. B 37%
In N,N-dimethyl-formamide at 80℃; for 0.5h;	A 18% B 37 % Spectr.
In N,N-dimethyl-formamide at 80℃; for 0.5h; Product distribution; other temperature;

...Expand

: tert-butyl 2-(2,4,6-trimethylphenyl)-1-(4-trifluoromethylphenyl)hydrazinecarboxylate

A: 455-14-1
4-trifluoromethylphenylamine

B: 1-mesityl-2-[4-(trifluoromethyl)phenyl]diazene

C: 88-05-1
2,4,6-trimethylaniline

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 65 %; regioselective reaction;	A n/a B 37% C n/a

...Expand

: 2,6-difluoro-S-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

: 62-53-3
aniline

A: 455-14-1
4-trifluoromethylphenylamine

B: 88-17-5
2-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 30℃; for 3h; Inert atmosphere;	A 17% B 37%

...Expand

: 75-63-8
Bromotrifluoromethane

: 62-53-3
aniline

A: 455-14-1
4-trifluoromethylphenylamine

B: 88-17-5
2-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
With α-picoline; sodium metabisulfite; sulfur dioxide; zinc In N,N-dimethyl-formamide at 20℃; under 2250.2 - 3750.3 Torr; for 2h; Product distribution; other alkylating reagents, other method, other pressure, temp.; various substrates;	A 20% B 36%
With α-picoline; sodium metabisulfite; sulfur dioxide; zinc In N,N-dimethyl-formamide at 20℃; under 2250.2 - 3750.3 Torr; for 2h; also with NaS2O4;	A 20% B 36%
With sulfur dioxide; zinc In N,N-dimethyl-formamide under 2250.2 - 3750.3 Torr; for 2h; Ambient temperature;	A 20% B 36%

...Expand

: 740-69-2
1,2-bis(4-(trifluoromethyl)phenyl)hydrazine

: 135-19-3
β-naphthol

A: 455-14-1
4-trifluoromethylphenylamine

B: 1-(4-(trifluoromethyl)phenylamino)naphthalen-2-ol

Conditions

Conditions	Yield
In neat (no solvent) at 120℃; Inert atmosphere;	A n/a B 34%

...Expand

: 455-24-3
4-trifluoromethylbenzoic acid

: 455-14-1
4-trifluoromethylphenylamine

Conditions

Conditions	Yield
Stage #1: 4-trifluoromethylbenzoic acid With trifluorormethanesulfonic acid; trimethylsilylazide In chloroform at 90℃; for 0.0583333h; Schmidt Reaction; Flow reactor; Stage #2: With water In methanol; chloroform at 20℃; Schmidt Reaction; Flow reactor;	24%

: 1616514-64-7
tert-butyl 2-(2,6-dimethylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate

A: 455-14-1
4-trifluoromethylphenylamine

B: 1616514-72-7
3′,5′-dimethyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine

C: 1616514-78-3
3,5-dimethyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine

D: 150370-02-8
2,6-Dimethyl-4'-(trifluoromethyl)azobenzene

E: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 20℃; for 2h; Inert atmosphere; Reflux;	A 9% B 21% C 18% D 10% E 6%
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 58 %; regioselective reaction;	A 9% B 21% C 18% D 10% E 6%

...Expand

: 1616514-65-8
tert-butyl 2-(2-ethyl-6-methylphenyl)-1-(4-(trifluoromethyl)phenyl)hydrazinecarboxylate

A: 455-14-1
4-trifluoromethylphenylamine

B: 24549-06-2
6-ethyl-o-toluidine

C: 1616514-73-8
3′-ethyl-5′-methyl-5-trifluoromethyl-1,1′-biphenyl-2,4′-diamine

D: 1616514-79-4
3-ethyl-5-methyl-N1-[4-(trifluoromethyl)phenyl]benzene-1,4-diamine

E: 1616514-85-2
1-(2-ethyl-6-methylphenyl)-2-(4-(trifluoromethyl)phenyl)diazene

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 20℃; for 2h; Inert atmosphere; Reflux;	A 10% B 6% C 10% D 18% E 12%
With hydrogenchloride In ethanol for 2h; Inert atmosphere; Reflux; Overall yield = 50 %; regioselective reaction;	A 10% B 6% C 10% D 18% E 12%

...Expand

: 455-14-1
4-trifluoromethylphenylamine

: 4755-77-5
Ethyl oxalyl chloride

: 69066-00-8
ethyl 2-oxo-2-((4-(trifluoromethyl)phenyl)amino)acetate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 8h;	100%
With triethylamine In tetrahydrofuran at 20℃;	99%
With pyridine In dichloromethane at 0 - 20℃; for 43h; Reflux; Inert atmosphere; Schlenk technique;	96%

: 455-14-1
4-trifluoromethylphenylamine

: 163444-17-5
2-iodo-4-(trifluoromethyl)aniline

Conditions

Conditions	Yield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate In methanol; dichloromethane at 20℃; for 2h;	100%
With Iodine monochloride In methanol; dichloromethane at 0 - 20℃;	97%
With Iodine monochloride In methanol; dichloromethane at 0 - 20℃; for 1h;	97%

: 455-14-1
4-trifluoromethylphenylamine

: 108-24-7
acetic anhydride

: 349-97-3
4-(trifluromethyl)acetanilide

Conditions

Conditions	Yield
In dichloromethane at 20℃; Inert atmosphere;	100%
In dichloromethane; water at 25℃; for 1h; Temperature;	99.3%
With pyridine at 0 - 20℃; for 0.5h;	99%

: 455-14-1
4-trifluoromethylphenylamine

: 5586-13-0
1-azido-4-(trifluoromethyl)benzene

Conditions

Conditions	Yield
With tert.-butylnitrite; trimethylsilylazide In acetonitrile at 20℃; for 1h; Inert atmosphere;	100%
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In water at 0℃; for 2h; Stage #2: With sodium azide In water at 0 - 20℃;	95%
Stage #1: 4-trifluoromethylphenylamine With hydrogenchloride; sodium nitrite In water at 0℃; for 2h; Stage #2: With sodium azide In water at 0℃; for 2h;	95%

: 455-14-1
4-trifluoromethylphenylamine

: 98-88-4
benzoyl chloride

: 350-98-1
N-(4-(trifluoromethyl)phenyl)benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h;	100%
With dmap In dichloromethane at 20℃; Inert atmosphere;	91%
With triethylamine In dichloromethane at 0 - 40℃; Inert atmosphere;	75%

: 98-01-1
furfural

: 455-14-1
4-trifluoromethylphenylamine

: 325139-72-8
1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In diethyl ether at 20℃; Molecular sieve; Inert atmosphere;	100%
In benzene at 20℃; for 20h;	70%

: 455-14-1
4-trifluoromethylphenylamine

: 13529-12-9
5-triethylsilylfuran-2-carbaldehyde

: N-(5-triethylsilyl-2-furylmethylidene)-4-trifluoromethylaniline

Conditions

Conditions	Yield
With 4 A molecular sieve In benzene at 20℃; for 20h;	100%

: 455-14-1
4-trifluoromethylphenylamine

: 98-59-9
p-toluenesulfonyl chloride

: 4-methyl-N-(4-(trifluoromethyl)phenyl)benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With pyridine In dichloromethane at 20℃; for 24h;	98%
for 0.1h; microwave irradiation;	92%

: 455-14-1
4-trifluoromethylphenylamine

: 830324-69-1
3,4-dihydro-4-oxo-3-(2-chloro-3-pyridyl)-2-quinazolinecarbothioic acid S-p-tolyl ester

: 830324-75-9
3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid (4-trifluoromethyl-phenyl)-amide

Conditions

Conditions	Yield
With silver trifluoroacetate In tetrahydrofuran; toluene at 60℃; for 1.5h;	100%

: 872-85-5
pyridine-4-carbaldehyde

: 455-14-1
4-trifluoromethylphenylamine

: C13H9F3N2

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h;	100%

: 455-14-1
4-trifluoromethylphenylamine

: 333-20-0
potassium thioacyanate

: 1736-72-7
1-(4-(trifluoromethyl)phenyl)thiourea

Conditions

Conditions	Yield
With hydrogenchloride In water Heating / reflux;	100%

: 916222-27-0
(3R)-5-methoxy-3-[(trifluoroacetyl)amino]chromane-8-sulfonyl chloride

: 455-14-1
4-trifluoromethylphenylamine

: 916223-31-9
2,2,2-trifluoro-N-[(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl]acetamide

Conditions

Conditions	Yield
With pyridine In dichloromethane for 8h;	100%

: 455-14-1
4-trifluoromethylphenylamine

: 123-38-6
propionaldehyde

: 190843-72-2
N-propyl-4-(trifluoromethyl)benzenamine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 18℃; for 0.0833333h; Solvent; Green chemistry;	100%

: 5431-44-7
2,6-Pyridinedicarboxaldehyde

: 455-14-1
4-trifluoromethylphenylamine

: C21H13F6N3

Conditions

Conditions	Yield
In dichloromethane for 4h; Molecular sieve;	100%

: 455-14-1
4-trifluoromethylphenylamine

: 933-88-0
ortho-toluoyl chloride

: 2-methyl-N-(4-(trifluoromethyl)phenyl)benzamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3h;	100%

: 56181-39-6
4-chloro-5-bromopyrimidine

: 455-14-1
4-trifluoromethylphenylamine

: C11H7BrF3N3

Conditions

Conditions	Yield
With p-toluenesulfonic acid monohydrate In 1-methyl-pyrrolidin-2-one at 60℃; for 2h;	100%
With toluene-4-sulfonic acid In 1-methyl-pyrrolidin-2-one at 60℃; for 2h;	51%

: 98-01-1
furfural

: 455-14-1
4-trifluoromethylphenylamine

: 1185039-73-9
(E)-1-(furan-2-yl)-N-(4-(trifluoromethyl)phenyl)methanimine

Conditions

Conditions	Yield
In toluene Inert atmosphere; Reflux; Dean-Stark;	100%

: 455-14-1
4-trifluoromethylphenylamine

: 7-isoselenocyanato-4-methyl-2H-chromen-2-one

: N-(4-methyl-2-oxo-2H-chromen-7-yl)-N'-(4-trifluoromethyl)selenourea

Conditions

Conditions	Yield
In tetrahydrofuran at 40℃; for 2h; Inert atmosphere; Darkness;	100%

: 455-14-1
4-trifluoromethylphenylamine

: 100-52-7
benzaldehyde

: 351-98-4
N-benzylidene-4-(trifluoromethyl)aniline

Conditions

Conditions	Yield
at 50℃; Condensation;	99.1%
In water at 20℃; for 12h; Inert atmosphere;	95%
In toluene for 0.5h; Heating;	84%

: 455-14-1
4-trifluoromethylphenylamine

: 122-04-3
4-nitro-benzoyl chloride

: 7607-41-2
4-nitro-N-(4-(trifluoromethyl)phenyl)benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;	99%
With pyridine for 4h; Heating;	95%
With pyridine at 20℃; Inert atmosphere; Reflux;	95%

: 455-14-1
4-trifluoromethylphenylamine

: 333-20-0
potassium thioacyanate

: 777-12-8
2-amino-6-trifluoromethyl-1,3-benzothiazole

Conditions

Conditions	Yield
With sodium iodide dichloride at 70℃; for 2h;	99%
With 6-methylbenzothiazol-2-ylamine; N,N,N,N,-tetramethylethylenediamine; oxygen; copper(II) bis(trifluoromethanesulfonate) In dimethyl sulfoxide at 100℃; for 24h; regioselective reaction;	80%
With bromine In acetic acid for 24h;	20%
With bromine; acetic acid for 21h; Ambient temperature;
With bromine In acetic acid Cooling with ice;

: 455-14-1
4-trifluoromethylphenylamine

: 75-05-8
acetonitrile

: (4-trifluoromethylphenyl)ethylamine

Conditions

Conditions	Yield
With ammonium acetate; hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h;	99%
With palladium 10% on activated carbon; hydrogen; acetic acid In methanol at 20℃; under 760.051 Torr; for 18h;	99%

: 14254-57-0
4-(chlorocarbonyl)pyridine

: 455-14-1
4-trifluoromethylphenylamine

: N-[4-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran at 0 - 65℃; for 1.58333h;	99%

: 455-14-1
4-trifluoromethylphenylamine

: 198903-09-2
Cp*Ni(PEt3)S(OMe)

: 198903-17-2
Cp*Ni(PEt3)NHC6H4(p-CF3)

Conditions

Conditions	Yield
In diethyl ether inert atmosphere; stirring (10 min); removal of volatile materials (vac.), crystn. (pentane);	99%

: 455-14-1
4-trifluoromethylphenylamine

: 96-97-9
5-nitrosalicylic acid

: 198774-77-5
2-hydroxy-5-nitro-N-[4-(trifluoromethyl)phenyl]benzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	99%
With phosphorus trichloride Microwave irradiation; Reflux;	76%
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 3h; Inert atmosphere;	66.2%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;

: 13010-19-0
3-Chloropropyl isocyanate

: 455-14-1
4-trifluoromethylphenylamine

: 1422166-44-6
1-(3-chloropropyl)-3-(4-(trifluoromethyl)phenyl)urea

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃;	99%
In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 20℃; for 72h;	87%
In dichloromethane at 20℃; for 72h;
In dichloromethane at 20℃;

: 86-98-6
4,7-dichloroquinoline

: 455-14-1
4-trifluoromethylphenylamine

: 4-((4-trifluoromethylphenyl)amino)-7-chloroquinolinium chloride

Conditions

Conditions	Yield
In ethanol Reflux;	99%

: tetrafluoroboric acid

: 455-14-1
4-trifluoromethylphenylamine

: p-(trifluoromethyl)benzenediazonium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: tetrafluoroboric acid; 4-trifluoromethylphenylamine In water at 0℃; for 0.166667h; Stage #2: With sodium nitrite In water at 0℃; for 0.283333h;	99%
With isopentyl nitrite In ethanol; water at -20 - 20℃; for 1h; Inert atmosphere;	77%
With sodium nitrite In water at 0℃; for 0.5h;	70%

4-Aminobenzotrifluoride Chemical Properties

Product Name: 4-Aminobenzotrifluoride
Synonyms: TIMTEC-BB SBB003956;P-(TRIFLUOROMETHYL)ANILINE;P-AMINOBENZOTRIFLUORIDE;1-AMINO-4-(TRIFLUOROMETHYL)BENZENE;4-(TRIFLUOROMETHYL)ANILINE;4-AMINOBENZOTRIFLUORIDE;4-AMINO-A,A,A-TRIFLUOROTOLUENE;A,A,A-TRIFLUORO-P-TOLUIDINE
Molecular formula: C₇H₆F₃N
Molar mass: 161.12
EINECS: 207-236-5
Melting point:3-8 °C
Boiling point :83 °C12 mm Hg(lit.)
density:1.283 g/mL at 25 °C(lit.)
refractive index:n20/D 1.483(lit.)
Fp :188 °F
Water Solubility:<0.1 g/100 mL

4-Aminobenzotrifluoride Uses

p-TRIFLUOROMETHYLANILINE is a kind of intermediates in medicine, dyestuff, pesticide aspect.

4-Aminobenzotrifluoride Toxicity Data With Reference

1.	mmo-sat 10 mg/L	ENMUDM Environmental Mutagenesis. 5 (1983),803.
2.	mmo-esc 10 mg/L	ENMUDM Environmental Mutagenesis. 5 (1983),803.
3.	ipr-mus LD50:101 mg/kg	JMCMAR Journal of Medicinal Chemistry. 17 (1974),900.

4-Aminobenzotrifluoride Consensus Reports

Reported in EPA TSCA Inventory.

4-Aminobenzotrifluoride Safety Profile

Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x. See also FLUORIDES.
Hazard Codes: T, N, Xi, Xn
Hazard Note: Toxic/Irritant
The Risk Statements information of p-TRIFLUOROMETHYLANILINE:
25: Toxic if swallowed
33: Danger of cumulative effects
36: Irritating to the eyes
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
The Safety Statements information of p-TRIFLUOROMETHYLANILINE:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
60: This material and/or its container must be disposed of as hazardous waste
61: Avoid release to the environment. Refer to special instructions safety data sheet
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 3
RTECS: XU9260000

Product Name

4-Aminobenzotrifluoride

Synthetic route

4-Aminobenzotrifluoride Chemical Properties

4-Aminobenzotrifluoride Uses

4-Aminobenzotrifluoride Toxicity Data With Reference

4-Aminobenzotrifluoride Consensus Reports

4-Aminobenzotrifluoride Safety Profile

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