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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-(Trifluoromethyl)benzoic acid Manufacturer/High quality/Best price/In stock

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-(Trifluoromethyl)Benzoic Acid with high purity

Cas:455-24-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 99.9%min 99.9% Hangzhou Dingyan Chem is a leading manufacturer and supplier of che

High quality 455-24-3 4-trifluoromethyl benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Colorless liquid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(Trifluoromethyl)-benzoic acid

Cas:455-24-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

4-(trifluoromethyl)benzoic

Cas:455-24-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 4-(Trifluoromethyl)benzoic acid CAS No. 455-24-3

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Gram

FOB Price: $22.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CAS 455-24-3 4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: 4-Trifluoromethylbenzoic acid CAS No.: 455-24-3 Molecular Formula: C8H5F3O2 Molecular Weight: 190.12 EINEC No.: 207-242-8 Appearance:White Powder Storage:Store in cool an

4-Trifluoromethylbenzoic acid CAS:455-24-3

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 455-24-3 with fast shipping

Cas:455-24-3

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Trifluoromethyl benzoic acid 455-24-3

Cas:455-24-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, 4-(Trifluoromethyl)benzoic acid CAS:455-24-3

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $27.0 / 29.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Trifluoromethyl benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

4-(Trifluoromethyl)benzoic acid CAS NO.455-24-3

Cas:455-24-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Trifluoromethyl Benzoic Acid

Cas:455-24-3

Min.Order:0

Negotiable

Type:Manufacturers

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Alpha,Alpha,Alpha-Trifluoro-p-toluic acid

Cas:455-24-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-(Trifluoromethyl)benzoic acid/High quality/Best price

Cas:455-24-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:White to light yellow crystal powde Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediat

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

4-(Trifluoromethyl)benzoic acidCAS NO.: 455-24-3

Cas:455-24-3

Min.Order:1 Gram

FOB Price: $4.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

4-(Trifluoromethyl)benzoic acid Chemical Properties Melting point 219-220 °C(lit.) Boiling point 247°C 753mm density 1.3173 (estimate) Fp 247°C/753mm storage temp. Store below +30°C. pka 3.69±0.10(Predic

4-Trifluoromethylbenzoic acid

Cas:455-24-3

Min.Order:200 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-(Trifluoromethyl)benzoic acid

Cas:455-24-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Synthetic route

4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;99%
With 4H3N*4H(1+)*CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h;99%
With oxygen; copper(II) acetate monohydrate; cobalt(II) diacetate tetrahydrate In water at 70℃; under 760.051 Torr; for 1h;99%
1-(4-(trifluoromethyl)phenyl)ethane-1,2-diol
175605-64-8

1-(4-(trifluoromethyl)phenyl)ethane-1,2-diol

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With oxygen; sodium methylate; silver trifluoromethanesulfonate In tetrahydrofuran; methanol at 37℃; under 760.051 Torr; Sealed tube;99%
4-(trifluoromethyl)benzylic alcohol
349-95-1

4-(trifluoromethyl)benzylic alcohol

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With manganese(II) bromide; silver carbonate; potassium hydroxide In 1,3,5-trimethyl-benzene at 50 - 165℃; for 2h; Schlenk technique; Inert atmosphere;98%
With methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate; nickel dibromide at 120℃; under 760.051 Torr; for 72h;97%
With 3,5-Lutidine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; sodium persulfate; tris(2,2'‐bipyridine)ruthenium(II) hexafluorophosphate In water; acetonitrile at 20℃; for 48h; Sealed tube; Irradiation;95%
4-methylbenzotrifluoride
6140-17-6

4-methylbenzotrifluoride

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With formic acid; 1,10-ethyliden-3-octyl-7-trifluoromethylalloxazinium chloride; oxygen In acetonitrile at 40℃; for 24h; Irradiation;98%
With cerium(III) chloride; 1,1,1-trichloroethanol; oxygen In acetonitrile at 60℃; Irradiation;90%
With oxygen; Langlois reagent In acetonitrile at 25℃; for 12h; Irradiation; Green chemistry;87%
With pyridine; dipotassium peroxodisulfate; oxygen In acetonitrile at 80℃; under 760.051 Torr; for 16h; Green chemistry;72%
methyl 4-(trifluoromethyl)benzoate
2967-66-0

methyl 4-(trifluoromethyl)benzoate

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With iodine; aluminium In acetonitrile at 80℃; for 18h;98%
With lithium hydroxide monohydrate; water In ethanol at 25℃; for 12h;94.8%
With methanol; water; sodium hydroxide at 20℃; for 2h;68.4%
carbon dioxide
124-38-9

carbon dioxide

5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane
501374-30-7

5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane With [Ni(N,N'-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)(allyl)Cl]; potassium tert-butylate In toluene at 100℃; under 760.051 Torr; for 15h; Schlenk technique; Inert atmosphere;
Stage #2: With hydrogenchloride In water; ethyl acetate; toluene at 20℃;
97%
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h;92%
With (1,3-bis(2,6-diisopropyl-4-(morpholinomethyl)phenyl)imidazolidin-2-ylidene)copper(I) bromide; potassium tert-butylate In tetrahydrofuran under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Reflux; Green chemistry;90%
With 1,3-bis-(diphenylphosphino)propane; cesium fluoride; [Rh(OH)(cod)]2 In 1,4-dioxane at 60℃;76%
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In 1,4-dioxane at 100℃; under 15201 Torr; for 8h; Inert atmosphere; Autoclave;
Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere;
74%
methyl 3-oxo-3-(4-(trifluoromethyl)phenyl) propanedithioate
1448887-34-0

methyl 3-oxo-3-(4-(trifluoromethyl)phenyl) propanedithioate

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 100℃; for 9h; Reflux; chemoselective reaction;97%
carbon monoxide
201230-82-2

carbon monoxide

4-Iodobenzotrifluoride
455-13-0

4-Iodobenzotrifluoride

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With amphiphilic resin-supported phosphine-palladium; water; potassium carbonate at 25℃; under 760 Torr; for 12h; hydroxycarbonylation;96%
With water; potassium carbonate In acetonitrile; tert-butyl alcohol at 100℃; under 3750.38 Torr; for 0.0161111h;96%
With water; palladium diacetate; potassium carbonate at 20℃; under 760.051 Torr; for 7h;82%
With water; palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; under 11251.1 Torr; Flow reactor;78%
With water; sodium carbonate; palladium diacetate at 20 - 165℃; under 10501.1 - 22502.3 Torr; for 0.333333h; microwave irradiation;59%
1-(4-trifluorophenyl)ethanol
1737-26-4

1-(4-trifluorophenyl)ethanol

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With sodium nitrate; water; oxygen In dimethyl sulfoxide at 130℃; for 24h;96%
4-trifluoromethyl-benzoyl fluoride
368-94-5

4-trifluoromethyl-benzoyl fluoride

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With water at 20℃; Temperature; Reflux;95.4%
1-(4-methoxyphenyl)-2-[4-(trifluoromethyl)phenyl]ethanone
181308-89-4

1-(4-methoxyphenyl)-2-[4-(trifluoromethyl)phenyl]ethanone

A

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

B

4-methoxybenzoic acid
100-09-4

4-methoxybenzoic acid

Conditions
ConditionsYield
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;A 90%
B 93%
carbon monoxide
201230-82-2

carbon monoxide

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With 1,3-bis(dicyclohexylphosphino)propane bis(tetrafluoroborate) salt; water; palladium diacetate; potassium carbonate In dimethyl sulfoxide at 100℃; under 760.051 Torr; for 15h;92%
With potassium hydroxide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride In water for 48h; Heating;500 % Turnov.
carbon dioxide
124-38-9

carbon dioxide

p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; 2-(diphenylphosphino)-2’(3-(dimethylamino)-3-oxopropyl)-6’-(3-(icosyloxy)-3-oxopropyl)biphenyl; water; palladium diacetate; N-ethyl-N,N-diisopropylamine In toluene under 760.051 Torr; for 16h; Inert atmosphere; Schlenk technique; Irradiation;92%
Stage #1: p-trifluoromethylphenyl bromide With bromobenzene; trifluoroacetic acid; cobalt(II) bromide; zinc dibromide; zinc In acetonitrile Inert atmosphere;
Stage #2: carbon dioxide With palladium diacetate; tricyclohexylphosphine In tetrahydrofuran; acetonitrile at 0℃; under 760.051 Torr; Inert atmosphere;
Stage #3: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate; acetonitrile
90%
With tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 4h; Electrolysis;78%
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

A

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

B

ethyl (E)-4-trifluoromethylcinnamate
101466-85-7, 128408-03-7

ethyl (E)-4-trifluoromethylcinnamate

Conditions
ConditionsYield
Stage #1: 4-Trifluoromethylbenzaldehyde; diethoxyphosphoryl-acetic acid ethyl ester With potassium carbonate for 6h; Horner-Wadsworth-Emmons olefination; Neat (no solvent); high-speed ball milling;
Stage #2: With Oxone for 12h; Neat (no solvent); high-speed ball milling; optical yield given as %de; diastereoselective reaction;
A n/a
B 91%
carbon dioxide
124-38-9

carbon dioxide

4-(trifluoromethyl)phenylsulfurofluoridate

4-(trifluoromethyl)phenylsulfurofluoridate

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With manganese; bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 20h; Schlenk technique; Inert atmosphere; Glovebox;91%
ethyl 4-(trifluoromethyl)benzoate
583-02-8

ethyl 4-(trifluoromethyl)benzoate

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With water; potassium hydroxide at 115℃; for 1h;90%
(±)-1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-diol
199166-26-2

(±)-1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-diol

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
Stage #1: (±)-1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-diol With oxygen; sodium t-butanolate In tetrahydrofuran at 20℃; under 760.051 Torr; for 3.5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=1; chemoselective reaction;
89%
Stage #1: (±)-1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-diol With 2,3,4,5,6-pentamethyliodobenzene; oxygen; isobutyraldehyde In 1,2-dichloro-ethane under 760.051 Torr; for 24h;
Stage #2: With sodium chlorite; 2-methyl-but-2-ene In aq. phosphate buffer; 1,2-dichloro-ethane; tert-butyl alcohol at 25℃; for 14h;
79%
With oxygen In dichloromethane at 20℃; under 760.051 Torr; for 12h; Irradiation;78%
carbon dioxide
124-38-9

carbon dioxide

4-Iodobenzotrifluoride
455-13-0

4-Iodobenzotrifluoride

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With 3,4-benzo-1,1,2,2-tetraethyl-1,2-disilacyclobut-3-ene; cesium fluoride In N,N-dimethyl-formamide at 0 - 20℃; under 760.051 Torr; for 2h;88%
p-trifluoromethylbenzamide
1891-90-3

p-trifluoromethylbenzamide

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With acetic acid; isopentyl nitrite at 80℃; for 24h; Inert atmosphere;86%
2-(4-trifluoromethylphenyl)ethanol
2968-93-6

2-(4-trifluoromethylphenyl)ethanol

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With oxygen; sodium t-butanolate In tetrahydrofuran at 20℃; under 750.075 Torr; for 12h; chemoselective reaction;86%
carbon monoxide
201230-82-2

carbon monoxide

p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With water; potassium carbonate In acetonitrile; tert-butyl alcohol at 120℃; under 30003 Torr; for 7h;85%
carbon dioxide
124-38-9

carbon dioxide

p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

A

α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

B

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide for 10h; Ambient temperature; electrochemically;A 2.4 mmol
B 84%
formic acid
64-18-6

formic acid

p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube;84%
With N,N,N,N,-tetramethylethylenediamine; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium diacetate In N,N-dimethyl-formamide at 115℃; for 24h; Temperature; Inert atmosphere;80%
4-(trifluoromethyl)mandelic acid
395-35-7

4-(trifluoromethyl)mandelic acid

A

4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

B

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; oxygen; CoCl2 In water; dimethyl sulfoxide at 125℃; under 760.051 Torr; for 24h; Title compound not separated from byproducts.;A 17%
B 83%
carbon dioxide
124-38-9

carbon dioxide

sodium 4-trifluoromethylbenzenesulfinate

sodium 4-trifluoromethylbenzenesulfinate

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate In dimethyl sulfoxide at 140℃; under 750.075 Torr; for 3h; Schlenk technique; Sealed tube;83%
carbon dioxide
124-38-9

carbon dioxide

Sodium; 4-trifluoromethyl-benzenesulfonate
360-27-0

Sodium; 4-trifluoromethyl-benzenesulfonate

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide; Sodium; 4-trifluoromethyl-benzenesulfonate With copper(l) iodide; potassium tert-butylate; o-phenanthroline In dimethyl sulfoxide at 140℃; under 760.051 Torr; for 12h; Schlenk technique;
Stage #2: With hydrogenchloride In water; dimethyl sulfoxide Schlenk technique;
81%
carbon dioxide
124-38-9

carbon dioxide

dimethyl(4-(trifluoromethyl)phenyl)sulfonium trifluoromethanesulfonate

dimethyl(4-(trifluoromethyl)phenyl)sulfonium trifluoromethanesulfonate

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With 2.9-dimethyl-1,10-phenanthroline; neocuproine; zinc In dimethyl sulfoxide at 20℃; under 760.051 Torr; for 16h;81%
1-(4-(trifluoromethyl)phenyl)cyclohexanol
29480-13-5

1-(4-(trifluoromethyl)phenyl)cyclohexanol

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With iron(III) chloride; cerium(III) chloride; tetrabutyl-ammonium chloride; oxygen In acetonitrile at 20℃; under 760.051 Torr; for 24h; Schlenk technique; Irradiation;81%
carbon dioxide
124-38-9

carbon dioxide

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

A

α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

B

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Conditions
ConditionsYield
With tetrabutylammomium bromide In N,N-dimethyl-formamide at 5℃; electrolysis (I=0.4 A);A 3 % Chromat.
B 80%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

4-trifluoromethyl-phenyl acetyl chloride
329-15-7

4-trifluoromethyl-phenyl acetyl chloride

Conditions
ConditionsYield
With thionyl chloride Reflux;100%
With thionyl chloride for 2h; Reflux;100%
Stage #1: 4-trifluoromethylbenzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h;
Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h;
100%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-4-trifluoromethylbenzamide
116332-61-7

N-methoxy-N-methyl-4-trifluoromethylbenzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 2h;100%
Stage #1: 4-trifluoromethylbenzoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 23℃;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 0℃; for 2h;
95%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;95%
n-heptan1ol
111-70-6

n-heptan1ol

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

heptyl 4-(trifluoromethyl)benzoate
959086-76-1

heptyl 4-(trifluoromethyl)benzoate

Conditions
ConditionsYield
With Candida antarctica lipase B immobilised in a macroporous DVB crosslinked polymer (Novozym 435) In cyclohexane at 80℃; for 24h; Enzymatic reaction;100%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

C21H33N3O
1619984-56-3

C21H33N3O

N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)nicotinamide
1619983-84-4

N-((2R,3S,4S,4aS)-3,4a,8,8-tetramethyl-4-((4-(trifluoromethyl)benzamido)methyl)-decahydronaphthalen-2-yl)nicotinamide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Inert atmosphere;100%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

tetramethyl ammoniumhydroxide
75-59-2

tetramethyl ammoniumhydroxide

C8H4F3O2(1-)*C4H12N(1+)

C8H4F3O2(1-)*C4H12N(1+)

Conditions
ConditionsYield
With water In ethanol at 0 - 20℃; for 0.0833333h;100%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

4-(trifluoromethyl)benzylic alcohol
349-95-1

4-(trifluoromethyl)benzylic alcohol

Conditions
ConditionsYield
With C25H42N6Rh(1+)*CF3O3S(1-); phenylsilane In tetrahydrofuran at 30℃; for 20h; Inert atmosphere;99%
Stage #1: 4-trifluoromethylbenzoic acid With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 0℃; for 0.166667h;
Stage #2: With sodium tetrahydroborate In water; ethyl acetate at 0℃; for 0.466667h;
90%
With cobalt(II) tetrafluoroborate hexahydrate; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 100℃; under 60006 Torr; for 22h;82%
2,2-dimethyl-propanol-1
75-84-3

2,2-dimethyl-propanol-1

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

2,2-dimethyl-1-propanol-mono(p-trifluoro-methylbenzoate)

2,2-dimethyl-1-propanol-mono(p-trifluoro-methylbenzoate)

Conditions
ConditionsYield
With sulfuric acid In toluene99%
With sulfuric acid In toluene99%
With sulfuric acid In toluene99%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

phenylboronic acid
98-80-6

phenylboronic acid

phenyl[4-(trifluoromethyl)phenyl]methanone
728-86-9

phenyl[4-(trifluoromethyl)phenyl]methanone

Conditions
ConditionsYield
With dimethyl dicarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 80℃; for 6h;99%
Stage #1: 4-trifluoromethylbenzoic acid With di(succinimido) carbonate; sodium carbonate; tricyclohexylphosphine; palladium(II) hexafluoroacetylacetonate In tetrahydrofuran at 60℃;
Stage #2: phenylboronic acid In tetrahydrofuran at 60℃; for 20h; Further stages.;
89%
Stage #1: 4-trifluoromethylbenzoic acid With potassium phosphate In 1,4-dioxane at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: With 2-chloro-1,3-dimethylimidazolinium chloride In 1,4-dioxane at 20℃; for 2h; Inert atmosphere;
Stage #3: phenylboronic acid With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 90℃; for 16h; Inert atmosphere; Sealed tube;
62%
With 2,2-dimethylpropanoic anhydride; tricyclohexylphosphine In tetrahydrofuran; water at 60℃; for 16h;40%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

benzyl alcohol
100-51-6

benzyl alcohol

4-trifluoromethyl-benzoic acid benzyl ester

4-trifluoromethyl-benzoic acid benzyl ester

Conditions
ConditionsYield
With [Cl(C6F13C2H4)2SnOSn(C2H4C6F13)2Cl]2 In various solvent(s) at 150℃; for 10h;99%
With 2-butyl-1,3-diphenyl-1,3,2-diazaphospholidine; 1,1'-azodicarbonyl-dipiperidine In 1,2-dichloro-ethane at 40℃; under 760.051 Torr; Mitsunobu Displacement;89%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

benzylamine
100-46-9

benzylamine

N-benzyl-4-trifluoromethylbenzamide

N-benzyl-4-trifluoromethylbenzamide

Conditions
ConditionsYield
With 14C2H2F3O(1-)*6C4H8O*La2Na8(14+) at 80℃; for 6h; Inert atmosphere;99%
With borane-ammonia complex In 5,5-dimethyl-1,3-cyclohexadiene for 6h; Reflux;99%
With tetrachloromethane; Bis(p-nitrophenyl) phosphate; 3-Methyl-1-phenyl-2-phospholene 1-oxide In toluene at 110℃; for 20h; Green chemistry;98%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

aniline
62-53-3

aniline

N-phenyl 4-trifluoromethylbenzamide
347-80-8

N-phenyl 4-trifluoromethylbenzamide

Conditions
ConditionsYield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;99%
With 2,4,6-trimethyl-pyridine; dmap; carbon tetrabromide In N,N-dimethyl-formamide for 0.5h; UV-irradiation;94 %Spectr.
para-iodoanisole
696-62-8

para-iodoanisole

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

2,6-bis(4-methoxyphenyl)-4-(trifluoromethyl)benzoic acid

2,6-bis(4-methoxyphenyl)-4-(trifluoromethyl)benzoic acid

Conditions
ConditionsYield
With C30H54N6Ru(2+)*2BF4(1-); potassium perfluoro-tert-butoxide; potassium carbonate at 140℃; for 24h; Glovebox; Inert atmosphere;99%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

methyl 5-amino-4'-carbamoyl-[1,1'-biphenyl]-3-carboxylate

methyl 5-amino-4'-carbamoyl-[1,1'-biphenyl]-3-carboxylate

methyl 4'-carbamoyl-5-(4-(trifluoromethyl)benzamido)-[1,1'-biphenyl]-3-carboxylate

methyl 4'-carbamoyl-5-(4-(trifluoromethyl)benzamido)-[1,1'-biphenyl]-3-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 15h;99%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 15h;99%
10-Undecen-1-ol
112-43-6

10-Undecen-1-ol

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

undec-10-en-1-yl 4-(trifluoromethyl)benzoate

undec-10-en-1-yl 4-(trifluoromethyl)benzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere;99%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

potassium 4-(trifluoromethyl)benzoate
1195761-03-5

potassium 4-(trifluoromethyl)benzoate

Conditions
ConditionsYield
With potassium tert-butylate In ethanol at 20℃; Inert atmosphere;98%
With potassium tert-butylate In ethanol at 20℃; for 3h;98%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

benzyl azide
622-79-7

benzyl azide

N-benzyl-4-trifluoromethylbenzamide

N-benzyl-4-trifluoromethylbenzamide

Conditions
ConditionsYield
With phenylsilane; triphenylphosphine In toluene at 20 - 60℃; for 21h; Reagent/catalyst; Staudinger Azide Reduction; Inert atmosphere; chemoselective reaction;98%
With 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; triethylamine In chlorobenzene at 20 - 130℃; for 14h;85%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

ethyl 4-(4-(trifluoromethyl)benzamido)benzoate

ethyl 4-(4-(trifluoromethyl)benzamido)benzoate

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylbenzoic acid With dichlorotriphenylphosphorane In chloroform at 20℃; for 0.25h; Inert atmosphere;
Stage #2: p-aminoethylbenzoate In chloroform at 100℃; Inert atmosphere; Irradiation;
98%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

phenyl[4-(trifluoromethyl)phenyl]methanone
728-86-9

phenyl[4-(trifluoromethyl)phenyl]methanone

Conditions
ConditionsYield
Stage #1: 4-trifluoromethylbenzoic acid With tert-butylmagnesium chloride In tetrahydrofuran; toluene at 0℃; for 0.25h; Inert atmosphere;
Stage #2: phenylmagnesium bromide With diisopropylaminomagnesium chloride lithium chloride In tetrahydrofuran; toluene at 0 - 20℃; for 3.25h; Inert atmosphere; Sonication;
98%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

2,5-dioxopyrrolidin-1-yl 4-(trifluoromethyl)benzoate

2,5-dioxopyrrolidin-1-yl 4-(trifluoromethyl)benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;97%
With dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃; for 3h; Inert atmosphere;67%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 25℃; for 2h;
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(4-(trifluoromethyl)benzoyl)piperazine-1-carboxylate
1327712-44-6

tert-butyl 4-(4-(trifluoromethyl)benzoyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h;97%
Stage #1: 4-trifluoromethylbenzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1-t-Butoxycarbonylpiperazine In N,N-dimethyl-formamide at 20℃; for 16h;
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Propargylamine
2450-71-7

Propargylamine

4-(trifluoromethyl)-N-(prop-2-yn-1-yl)benzamide
1250690-13-1

4-(trifluoromethyl)-N-(prop-2-yn-1-yl)benzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane97%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; Concentration; Inert atmosphere;93.2%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;70.5%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

4-trifluoromethylphenylboronic acid pinacol ester
214360-65-3

4-trifluoromethylphenylboronic acid pinacol ester

Conditions
ConditionsYield
With palladium diacetate; 2,2-dimethylpropanoic anhydride; triethylamine; 1,4-di(diphenylphosphino)-butane In 1,4-dioxane at 160℃; for 15h;97%
With biphenyl; naphthalene-1,4-dicarbonitrile In water; acetonitrile at 30℃; for 6h; Inert atmosphere; UV-irradiation;34%
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Benzhydrylamine
91-00-9

Benzhydrylamine

N-benzhydryl-4-(trifluoromethyl)benzamide

N-benzhydryl-4-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h; Inert atmosphere; Schlenk technique;97%

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