1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
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inquiryThe company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryAssay: 99% up; Stable supply with over 50Mt annually; Appearance:white to off-white powder Storage:room temprature Package:25kg/drum Application:Intermediate of Rosuvastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:cool dry place Package:25kg/drum Application:pharmaceutical intermediate Transp
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inquirySleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric
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Min.Order:10000 Gram
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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryGIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod
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inquiryProduct Name: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate Synonyms: tert-butyl (4r-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate;(4r-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-aceti
Cas:154026-95-6
Min.Order:1 Gram
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryProduct name tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2 2-dimethyl-1 3-dioxane-4-acetate Synonyms Rosuvastatin Calcium Impurity 7;(4R-Cis)-6-[(Acetyloxy)Methy]-2,2-diMethyl-1,3-dioxane-4-aceti
Cas:154026-95-6
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Type:Other
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryProduct Name: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate CAS: 154026-95-6 MF: C15H26O6 MW: 302.36 EINECS: 688-142-5 Mol File: 154026-95-6.mol tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquirySuperiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail bes
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Min.Order:100 Kilogram
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inquiryProduct Name: tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate Synonyms: Pitavastatin Impurity 62;Rosuvastatin Calcium Impurity 7;(4R-Cis)-6-[(Acetyloxy)Methy]-2,2-diMethyl-1,3-dioxane-4-acetic acid,1,1-diMenthylethyl
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Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquirytetrabutylammonium acetate
(4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
at 115℃; for 7h; | 99.1% |
In 1-methyl-pyrrolidin-2-one at 25 - 95℃; for 24h; | 7.2 g |
sodium acetate
(4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
With copper(l) chloride In N,N-dimethyl-formamide at 120 - 130℃; for 24h; Reagent/catalyst; Solvent; | 97.6% |
With tetrabutylammomium bromide In N,N-dimethyl-formamide at 120℃; for 4h; Solvent; | 542.97 g |
2,2-dimethoxy-propane
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
With methanesulfonic acid In toluene at 20℃; for 8h; | 95.8% |
With methanesulfonic acid In toluene at 0 - 5℃; for 4h; | 88.1% |
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
acetyl chloride
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate With pyridine In dichloromethane at 20℃; for 0.5h; Stage #2: acetyl chloride In dichloromethane at 20℃; for 1h; | 86% |
With pyridine In dichloromethane at 20℃; for 0.5h; | 15.9 g |
ammonium acetate
(4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 95℃; for 24h; | 80% |
potassium acetate
(4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: potassium acetate; (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester With tetrabutyl phosphonium bromide In toluene at 105℃; for 22h; Stage #2: With pyrographite In n-heptane; toluene at 20℃; | 76% |
Stage #1: (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester; 1-ethyl-3-methylimidazolium acetate at 90℃; for 5h; Stage #2: potassium acetate at 90℃; for 23.5h; Product distribution / selectivity; | |
In 1-ethyl-3-methyl-1H-imidazol-3-ium chloride at 110℃; for 2.5h; |
sodium hydrogencarbonate
2,2-dimethoxy-propane
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane; ethyl acetate |
tetrabutylammonium acetate
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one |
potassium acetate
1-ethyl-3-methylimidazolium acetate
(4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
at 100℃; for 4h; |
1-ethyl-3-methylimidazolium acetate
(4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
at 100℃; for 3h; Product distribution / selectivity; |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water / 1 h / 0 °C 2.1: sodium tetrahydroborate / water / 14 h / 0 °C 3.1: acetone / 0.25 h / 25 °C 3.2: 6 h / 48 - 50 °C 4.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water / 1 h / 0 °C 2.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1 h / 25 °C / Inert atmosphere 2.2: 4 h / -78 °C / Inert atmosphere 3.1: acetone / 0.25 h 3.2: 6 h / 48 - 50 °C 4.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water / 1 h / 0 °C 2.1: sodium tetrahydroborate; sodium dodecyl-sulfate / water / 14 h / 0 °C 3.1: acetone / 0.25 h 3.2: 6 h / 48 - 50 °C 4.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 1 h / 0 °C 2: sodium tetrahydroborate / water / 14 h / 0 °C 3: (R)-10-camphorsulfonic acid / dichloromethane / 3 h / 40 °C 4: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme |
(5S)-tert-butyl 6-chloro-3,5-dihydroxyhexanoate
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetone / 0.25 h / 25 °C 1.2: 6 h / 48 - 50 °C 2.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme | |
Multi-step reaction with 2 steps 1: (R)-10-camphorsulfonic acid / dichloromethane / 3 h / 40 °C 2: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme |
tetrabutylammonium acetate
A
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 25 - 85℃; for 24h; Overall yield = 7.2 %; | A n/a B n/a |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water; dichloromethane / 24 h / 20 °C 2: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme |
Tert-butyl (5S)-6-chloro-5-hydroxy-3-oxohexanoate
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate / water / 14 h / 0 °C 2.1: acetone / 0.25 h / 25 °C 2.2: 6 h / 48 - 50 °C 3.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: diethyl methoxy borane / tetrahydrofuran; methanol / 1 h / 25 °C / Inert atmosphere 1.2: 4 h / -78 °C / Inert atmosphere 2.1: acetone / 0.25 h 2.2: 6 h / 48 - 50 °C 3.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate; sodium dodecyl-sulfate / water / 14 h / 0 °C 2.1: acetone / 0.25 h 2.2: 6 h / 48 - 50 °C 3.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme |
1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetone / 0.25 h 1.2: 6 h / 48 - 50 °C 2.1: 1-methyl-pyrrolidin-2-one / 24 h / 25 - 95 °C View Scheme | |
Multi-step reaction with 2 steps 1: (1S)-10-camphorsulfonic acid / acetone / 6 h / 48 - 50 °C 2: 1-methyl-pyrrolidin-2-one / 24 h / 95 °C View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In dichloromethane; water at 25℃; for 48h; | n/a |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: zinc; methanesulfonic acid / tetrahydrofuran / 0.5 h / Reflux 2: D-glucose; potassium dihydrogenphosphate; dipotassium hydrogenphosphate / 25 - 28 °C 3: methanesulfonic acid / toluene / 4 h / 0 - 5 °C View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: glucose dehydrogenase; nicotinamide adenine dinucleotide phosphate / N,N-dimethyl-formamide / 25 °C / pH 6.5 / Enzymatic reaction 2: methanesulfonic acid / toluene / 8 h / 20 °C View Scheme |
tert-butyl 4-chloroacetoacetate
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: methanesulfonic acid / 6 h / 20 - 60 °C 2.1: ethyl bromide; magnesium; iodine / tetrahydrofuran / 50 - 60 °C 2.2: -10 - 40 °C 3.1: glucose dehydrogenase; nicotinamide adenine dinucleotide phosphate / N,N-dimethyl-formamide / 25 °C / pH 6.5 / Enzymatic reaction 4.1: methanesulfonic acid / toluene / 8 h / 20 °C View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ethyl bromide; magnesium; iodine / tetrahydrofuran / 50 - 60 °C 1.2: -10 - 40 °C 2.1: glucose dehydrogenase; nicotinamide adenine dinucleotide phosphate / N,N-dimethyl-formamide / 25 °C / pH 6.5 / Enzymatic reaction 3.1: methanesulfonic acid / toluene / 8 h / 20 °C View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: zinc; chloro-trimethyl-silane; ethyl bromide / tetrahydrofuran / 60 - 65 °C 1.2: 0 - 40 °C 2.1: glucose dehydrogenase; nicotinamide adenine dinucleotide phosphate / N,N-dimethyl-formamide / 25 °C / pH 6.5 / Enzymatic reaction 3.1: methanesulfonic acid / toluene / 8 h / 20 °C View Scheme |
tert-butyl 4-bromoacetoacetate
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: methanesulfonic acid / 6 h / 20 - 60 °C 2.1: zinc; chloro-trimethyl-silane; ethyl bromide / tetrahydrofuran / 60 - 65 °C 2.2: 0 - 40 °C 3.1: glucose dehydrogenase; nicotinamide adenine dinucleotide phosphate / N,N-dimethyl-formamide / 25 °C / pH 6.5 / Enzymatic reaction 4.1: methanesulfonic acid / toluene / 8 h / 20 °C View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxane-4-yl)acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 60℃; for 20h; | 100% |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Conditions | Yield |
---|---|
With potassium carbonate In methanol; water | 98% |
With methanol; potassium carbonate for 0.5h; | 98% |
With methanol; potassium carbonate at 20℃; | 92% |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
Conditions | Yield |
---|---|
Stage #1: (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester With methanol; potassium carbonate for 3h; Stage #2: With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide In dichloromethane at -5 - 5℃; for 1h; | 96.1% |
Multi-step reaction with 2 steps 1: potassium carbonate; methanol / 0.5 h 2: copper(l) chloride; [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen / acetonitrile; dichloromethane / 25 - 40 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / dichloromethane; methanol 2: triethylamine; oxalyl dichloride / dichloromethane; dimethyl sulfoxide View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
With acetic acid In tetrahydrofuran at 20℃; for 2h; | 90% |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; methanol / 0.5 h 2: potassium carbonate / dimethyl sulfoxide / 3 h / 70 °C View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
1-thiopropane
Conditions | Yield |
---|---|
Stage #1: (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester With sodium hydroxide In methanol; water at 15 - 70℃; Stage #2: 1-thiopropane With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at -2 - 2℃; |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide / methanol; water / 15 - 70 °C 1.2: -2 - 2 °C 2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hydrogencarbonate; sodium hypochlorite / dichloromethane / -2 - 35 °C View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / methanol / -2 - 2 °C 2: triethylamine / dichloromethane View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / methanol / -2 - 2 °C 2: triethylamine / dichloromethane 3: N,N-dimethyl-formamide / 25 - 130 °C View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / methanol / -2 - 2 °C 2: triethylamine / dichloromethane 3: N,N-dimethyl-formamide / 25 - 130 °C 4: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol View Scheme |
(4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / methanol / -2 - 2 °C 2: triethylamine / dichloromethane 3: N,N-dimethyl-formamide / 25 - 130 °C 4: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol 5: sodium hydride / tetrahydrofuran / 0 - 35 °C View Scheme |
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