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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Chloropyrazine Manufacturer/High quality/Best price/In stock

Cas:14508-49-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chloropyrazine supplier in China

Cas:14508-49-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 2-Chloropyrazine

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

inquiry

Hefei TNJ chemical industry co.,ltd

ISO Certification Technology: Technology innovation is our eternal pursuit,or we will be left behind.Our technology experts,all from famous universities and institutes,has rich experience and high achievements in chemical research.This makes sure

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:whit

Chloropyrazine

Cas:14508-49-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Chloropyrazine

Cas:14508-49-7

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 2-Chloropyrazine 14508-49-7 Producer

Cas:14508-49-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloropyrazine

Cas:14508-49-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-Chloropyrazine CAS 14508-49-7

Cas:14508-49-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2-Chloropyrazine 14508-49-7

Cas:14508-49-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 14508-49-7 with best quality

Cas:14508-49-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2-Chloropyrazine/ LIDE PHARMA- Factory supply / Best price

Cas:14508-49-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

2-Chloropyrazine

Cas:14508-49-7

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Chloropyrazine 14508-49-7

Cas:14508-49-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2-Chloropyrazine, 99%

Cas:14508-49-7

Min.Order:1 Kilogram

FOB Price: $68.0 / 75.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Chloropyrazine

Cas:14508-49-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloropyrazine

Cas:14508-49-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por

2-Chloropyrazine

Cas:14508-49-7

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Gram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Chloropyrazine

Cas:14508-49-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloropyrazine

Cas:14508-49-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Chlorpyrazin

Cas:14508-49-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:clear colorless to yellowish liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Applicat

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 2-Chloropyrazine CAS No.:14508-49-7 Molecule Formula:C4H3ClN2 Molecule Weight:114.53 Purity: 98.0% Package: 200kg/drum Description:Colorless or light yellow transparent liquid Manufacture Standards:Enterprise Standard

Best Quality 2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Chloropyrazine

Cas:14508-49-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Chloropyrazine

Cas:14508-49-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-hydroxypyrazine sodium salt
24387-68-6

2-hydroxypyrazine sodium salt

2-chloropyrazin
14508-49-7

2-chloropyrazin

Conditions
ConditionsYield
With thionyl chloride; N-ethyl-N,N-diisopropylamine In chloroform at 65℃; for 2h; Reagent/catalyst;95.4%
pyrazin-2-ol
6270-63-9

pyrazin-2-ol

2-chloropyrazin
14508-49-7

2-chloropyrazin

Conditions
ConditionsYield
With dmap; thionyl chloride; bis(trichloromethyl) carbonate for 10.5h; Reflux; Green chemistry;89%
With trichlorophosphate for 0.666667h; Heating;84%
With trichlorophosphate
2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

2-chloropyrazin
14508-49-7

2-chloropyrazin

Conditions
ConditionsYield
With thionyl chloride In pyridine; para-tert-butylphenol; benzene75%
Pyrazin-N-Oxid(PyzNO)
2423-65-6

Pyrazin-N-Oxid(PyzNO)

2-chloropyrazin
14508-49-7

2-chloropyrazin

Conditions
ConditionsYield
With trichlorophosphate at 70℃; for 2h;37%
With trichlorophosphate35%
Pyrazin-N-Oxid(PyzNO)
2423-65-6

Pyrazin-N-Oxid(PyzNO)

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

Pyrazine 1-oxide; hydrochloride

Pyrazine 1-oxide; hydrochloride

C

1-(2-pyrazinyl) pyrazinium salt

1-(2-pyrazinyl) pyrazinium salt

Conditions
ConditionsYield
With trichlorophosphate for 0.5h; Product distribution; Ambient temperature;A 13%
B 30%
C n/a
1,4-pyrazine
290-37-9

1,4-pyrazine

2-chloropyrazin
14508-49-7

2-chloropyrazin

Conditions
ConditionsYield
With chlorine at 500℃;
With water; chlorine at 450℃;
pyrazin-2(1H)-one
6270-63-9

pyrazin-2(1H)-one

2-chloropyrazin
14508-49-7

2-chloropyrazin

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate
With trichlorophosphate
1H-imidazole
288-32-4

1H-imidazole

chloroform
67-66-3

chloroform

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

5-chloropyrimidine
17180-94-8

5-chloropyrimidine

Conditions
ConditionsYield
at 550℃; Yield given. Yields of byproduct given;
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

chloroform
67-66-3

chloroform

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

1H-pyrrole-2-carbonitrile
4513-94-4

1H-pyrrole-2-carbonitrile

C

5-chloropyrimidine
17180-94-8

5-chloropyrimidine

D

5-chloronicotinonitrile
51269-82-0

5-chloronicotinonitrile

Conditions
ConditionsYield
at 550℃; Yield given. Further byproducts given. Yields of byproduct given;
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

chloroform
67-66-3

chloroform

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

5-chloropyrimidine
17180-94-8

5-chloropyrimidine

C

2-cyano-5-chloropyridine
89809-64-3

2-cyano-5-chloropyridine

D

5-chloronicotinonitrile
51269-82-0

5-chloronicotinonitrile

Conditions
ConditionsYield
at 550℃; Yield given. Further byproducts given. Yields of byproduct given;
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

chloroform
67-66-3

chloroform

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

5-chloropyrimidine
17180-94-8

5-chloropyrimidine

C

5-chloronicotinonitrile
51269-82-0

5-chloronicotinonitrile

D

3-chloro-2-cyanopyridine
38180-46-0

3-chloro-2-cyanopyridine

Conditions
ConditionsYield
at 550℃; Yield given. Further byproducts given. Yields of byproduct given;
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

chloroform
67-66-3

chloroform

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

5-chloropyrimidine
17180-94-8

5-chloropyrimidine

C

5-chloronicotinonitrile
51269-82-0

5-chloronicotinonitrile

D

3-chloro-isonicotinonitrile
68325-15-5

3-chloro-isonicotinonitrile

Conditions
ConditionsYield
at 550℃; Yield given. Further byproducts given. Yields of byproduct given;
Pyrazin-N-Oxid(PyzNO)
2423-65-6

Pyrazin-N-Oxid(PyzNO)

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

2-Aminopyrazine
5049-61-6

2-Aminopyrazine

Conditions
ConditionsYield
With sodium hydroxide; trichlorophosphate 1) 70 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
Pyrazin-N-Oxid(PyzNO)
2423-65-6

Pyrazin-N-Oxid(PyzNO)

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

1-(2-pyrazinyl) pyrazinium chloride

1-(2-pyrazinyl) pyrazinium chloride

Conditions
ConditionsYield
With trichlorophosphate at 70℃; for 2h; Product distribution;A 50 % Spectr.
B 50 % Spectr.
chloroform
67-66-3

chloroform

1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

5-chloropyrimidine
17180-94-8

5-chloropyrimidine

Conditions
ConditionsYield
at 550℃; Yield given. Yields of byproduct given;
3-chloropyrazine 1-oxide
6863-76-9

3-chloropyrazine 1-oxide

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

2,5-dichloropyrazine
19745-07-4

2,5-dichloropyrazine

C

2,3-dichloropyrazine
4858-85-9

2,3-dichloropyrazine

D

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
2-chloropyrazine 1-oxide
16025-16-4

2-chloropyrazine 1-oxide

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

2,3-dichloropyrazine
4858-85-9

2,3-dichloropyrazine

C

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
1,4-pyrazine
290-37-9

1,4-pyrazine

water
7732-18-5

water

chlorine
7782-50-5

chlorine

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

2,5-dichloropyrazine
19745-07-4

2,5-dichloropyrazine

C

2,3-dichloropyrazine
4858-85-9

2,3-dichloropyrazine

D

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
at 350℃; Product distribution;
CuCl(μ-2-chloropyrazine-N,N')
419581-31-0

CuCl(μ-2-chloropyrazine-N,N')

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

copper(l) chloride

copper(l) chloride

Conditions
ConditionsYield
In neat (no solvent) heating in Ar at 220 °C; detected by powder X-ray diffractometry;
CuCl(μ-2-chloropyrazine-N,N')
419581-31-0

CuCl(μ-2-chloropyrazine-N,N')

oxygen
80937-33-3

oxygen

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

copper(II) oxide

copper(II) oxide

Conditions
ConditionsYield
In neat (no solvent) in air, heating at 180 °C, CuCl, 2-chloropyrazine and some CuO were formed, Cu2OCl2 was formed at 392 °C, CuCl was formed again at430 °,C and CuO was formed in the last step at 461 °C; detected by X-ray powder diffractometry;
CuBr(μ-2-chloropyrazine-N,N')
419581-32-1

CuBr(μ-2-chloropyrazine-N,N')

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

copper(I) bromide
7787-70-4

copper(I) bromide

Conditions
ConditionsYield
In neat (no solvent) heating in Ar at 200 °C; detected by powder X-ray diffractometry;
CuBr(μ-2-chloropyrazine-N,N')
419581-32-1

CuBr(μ-2-chloropyrazine-N,N')

oxygen
80937-33-3

oxygen

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

copper(II) oxide

copper(II) oxide

Conditions
ConditionsYield
In neat (no solvent) in air, CuBr and 2-chloropyrazine were formed at 171 °C, CuBr wasoxidised during further heating; detected by X-ray powder diffractometry;
CuI(μ-2-chloropyrazine-N,N')
419581-33-2

CuI(μ-2-chloropyrazine-N,N')

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

copper(l) iodide
7681-65-4

copper(l) iodide

Conditions
ConditionsYield
In neat (no solvent) heating in Ar at 150 °C; detected by powder X-ray diffractometry;
CuI(μ-2-chloropyrazine-N,N')
419581-33-2

CuI(μ-2-chloropyrazine-N,N')

oxygen
80937-33-3

oxygen

A

2-chloropyrazin
14508-49-7

2-chloropyrazin

B

copper(II) oxide

copper(II) oxide

Conditions
ConditionsYield
In neat (no solvent) in air, heating at 138 °C, Cu2I2(2-chloropyrazine) then CuI and 2-chloropyrazine were formed, CuO was formed in the last step around 340 °C; detected by X-ray powder diffractometry;
2-chloropyrazin
14508-49-7

2-chloropyrazin

phenylboronic acid
98-80-6

phenylboronic acid

2-phenylpyrazine
29460-97-7

2-phenylpyrazine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride; tricyclohexylphosphine; dichloro bis(acetonitrile) palladium(II) at 85 - 90℃; for 5h; Suzuki-Miyaura reaction;100%
With potassium phosphate; C46H52Cl3N3O2Pd In tetrahydrofuran; water at 60℃; for 4h; Suzuki-Miyaura Coupling;99%
With 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; palladium diacetate; potassium carbonate In water at 100℃; for 24h; Suzuki-Miyaura Coupling;95%
2-chloropyrazin
14508-49-7

2-chloropyrazin

2-mercaptopyrazine
38521-06-1

2-mercaptopyrazine

Conditions
ConditionsYield
With thiourea In ethanol for 16h; Reflux;100%
With hydrogen sulfide; sodium methylate In methanol for 1h; Heating;91%
With hydrogen sulfide; sodium ethanolate; N,N-dimethyl-formamide In ethanol at 100℃; for 3h;88%
2-chloropyrazin
14508-49-7

2-chloropyrazin

(2,3-dimethylphenyl)zinc chloride

(2,3-dimethylphenyl)zinc chloride

2-(2,3-dimethylphenyl)pyrazine

2-(2,3-dimethylphenyl)pyrazine

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium (0); ruphos In tetrahydrofuran at 20℃; for 15h; Negishi coupling;100%
2-chloropyrazin
14508-49-7

2-chloropyrazin

methylamine
74-89-5

methylamine

N-methylpyrazin-2-amine
32111-28-7

N-methylpyrazin-2-amine

Conditions
ConditionsYield
at 100℃; for 15h;100%
In ethanol at 95℃; for 1h; Inert atmosphere; Sealed tube;77%
In dimethyl sulfoxide at 130℃;
2-chloropyrazin
14508-49-7

2-chloropyrazin

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

t-butyl 4-[(pyrazin-2-yl)oxy]piperidine-1-carboxylate
442199-08-8

t-butyl 4-[(pyrazin-2-yl)oxy]piperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;100%
In hexane; dimethyl sulfoxide; ethyl acetate
2-chloropyrazin
14508-49-7

2-chloropyrazin

(2,6-dimethylphenyl)magnesium bromide
21450-64-6

(2,6-dimethylphenyl)magnesium bromide

2-(2,6-dimethylphenyl)pyrazine
1157867-58-7

2-(2,6-dimethylphenyl)pyrazine

Conditions
ConditionsYield
Stage #1: (2,6-dimethylphenyl)magnesium bromide With dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II); zinc(II) chloride In tetrahydrofuran at 23℃; for 0.333333h; Inert atmosphere;
Stage #2: 2-chloropyrazin In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 23℃; for 24h; Negishi coupling; Inert atmosphere;
100%
2-chloropyrazin
14508-49-7

2-chloropyrazin

N,N`-dimethylethylenediamine
110-70-3

N,N`-dimethylethylenediamine

N,N'-dimethyl-N-pyrazin-2-yl-ethane-1,2-diamine

N,N'-dimethyl-N-pyrazin-2-yl-ethane-1,2-diamine

Conditions
ConditionsYield
In ethanol100%
2-chloropyrazin
14508-49-7

2-chloropyrazin

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

methyl pyrazine-2-carboxylate
6164-79-0

methyl pyrazine-2-carboxylate

Conditions
ConditionsYield
With dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); triethylamine at 100℃; under 2585.74 Torr; for 4h;99%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In acetonitrile at 180℃; under 25502.6 Torr; Flow reactor;61%
With triethylamine; palladium bis(dibenzylideneacetone)palladium(0); triphenylphosphine at 120℃; under 29420.3 Torr; for 16h; other chloropyrazines;93 % Chromat.
With ethyl azide; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) at 120℃; under 29420.3 Torr; for 16h;93 % Chromat.
2-chloropyrazin
14508-49-7

2-chloropyrazin

phenylacetylene
536-74-3

phenylacetylene

2-(2-phenylethynyl)pyrazine
96129-41-8

2-(2-phenylethynyl)pyrazine

Conditions
ConditionsYield
With potassium phosphate; bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride In acetonitrile at 90℃; for 6h; Sonogashira Cross-Coupling;99%
With tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; copper(I) oxide at 135 - 140℃; for 24h; Sonogashira coupling;98%
With bis(η3-allyl-μ-chloropalladium(II)); triethylamine; triphenylphosphine; 1-butyl-3-methylimidazolium Tetrafluoroborate at 100℃; for 4h; Heck alkynylation; Inert atmosphere;95%
With dichloro bis(acetonitrile) palladium(II); 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; caesium carbonate In water; acetonitrile at 100℃; for 24h; Sonogashira Cross-Coupling;89%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine at 70℃; for 12h; Sonogashira coupling;76%
2-chloropyrazin
14508-49-7

2-chloropyrazin

2,6-dimethylbenzene boronic acid
100379-00-8

2,6-dimethylbenzene boronic acid

2-(2,6-dimethylphenyl)pyrazine
1157867-58-7

2-(2,6-dimethylphenyl)pyrazine

Conditions
ConditionsYield
With trans-dichloro(1,3-bis-(2,6-diisopentylphenyl)imidazolylidinium)(3-chloro-pyridine); potassium tert-butylate In tert-butyl alcohol at 65℃; Suzuki-Miyaura coupling; Inert atmosphere; Molecular sieve;99%
2-chloropyrazin
14508-49-7

2-chloropyrazin

4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

2-(4-methylphenyl)pyrazine
108030-80-4

2-(4-methylphenyl)pyrazine

Conditions
ConditionsYield
With potassium phosphate tribasic heptahydrate; palladium diacetate In ethylene glycol at 80℃; for 0.333333h; Suzuki coupling;99%
With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; tetrabutylammomium bromide; sodium hydrogencarbonate In water for 1h; Catalytic behavior; Suzuki-Miyaura Coupling; Reflux;98%
Stage #1: 2-chloropyrazin; 4-methylphenylboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere;
Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;
96%
With potassium phosphate tribasic heptahydrate; palladium dichloride In water; N,N-dimethyl-formamide at 20℃; for 24h; Suzuki cross-coupling reaction;88%
With potassium phosphate tribasic heptahydrate; palladium diacetate In isopropyl alcohol at 80℃; for 0.666667h; Suzuki coupling;82%
6-methyl-2-pyridylzinc bromide

6-methyl-2-pyridylzinc bromide

2-chloropyrazin
14508-49-7

2-chloropyrazin

6-Methyl-2-(2-pyrazinyl)pyridine
149775-45-1

6-Methyl-2-(2-pyrazinyl)pyridine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); XPhos In tetrahydrofuran at 65℃; for 3h; Negishi cross-coupling; Inert atmosphere;99%
2-chloropyrazin
14508-49-7

2-chloropyrazin

2-Methoxyphenylboronic acid
5720-06-9

2-Methoxyphenylboronic acid

2-(2-methoxyphenyl)pyrazine
251933-26-3

2-(2-methoxyphenyl)pyrazine

Conditions
ConditionsYield
With (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; palladium diacetate; potassium carbonate In ethanol; water at 80℃; for 3h; Catalytic behavior; Reagent/catalyst; Suzuki-Miyaura Coupling; Inert atmosphere;99%
With 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; palladium diacetate; potassium carbonate In water at 100℃; for 24h; Suzuki-Miyaura Coupling;91%
2-chloropyrazin
14508-49-7

2-chloropyrazin

3-methoxyphenylboronic acid
10365-98-7

3-methoxyphenylboronic acid

2-(3-methoxyphenyl)-pyrazine
912771-38-1

2-(3-methoxyphenyl)-pyrazine

Conditions
ConditionsYield
Stage #1: 2-chloropyrazin; 3-methoxyphenylboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere;
Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;
99%
2-chloropyrazin
14508-49-7

2-chloropyrazin

4-fluoro-2-methylphenylboronic acid
139911-29-8

4-fluoro-2-methylphenylboronic acid

2-(4-fluoro-2-methylphenyl)pyrazine
334476-87-8

2-(4-fluoro-2-methylphenyl)pyrazine

Conditions
ConditionsYield
Stage #1: 2-chloropyrazin; 4-fluoro-2-methylphenylboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere;
Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;
99%
2-chloropyrazin
14508-49-7

2-chloropyrazin

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

2-(4-methoxybenzyloxy)pyrazine

2-(4-methoxybenzyloxy)pyrazine

Conditions
ConditionsYield
Stage #1: 4-Methoxybenzyl alcohol With sodium hydride In 1,2-dimethoxyethane at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: 2-chloropyrazin In 1,2-dimethoxyethane at 0 - 45℃; Inert atmosphere;
99%
2-chloropyrazin
14508-49-7

2-chloropyrazin

ferrous(II) sulfate heptahydrate

ferrous(II) sulfate heptahydrate

potassium thioacyanate
333-20-0

potassium thioacyanate

Fe(NCS)2(2-chloropyrazine)4

Fe(NCS)2(2-chloropyrazine)4

Conditions
ConditionsYield
In water at 20℃; for 24h;98.6%
2-chloropyrazin
14508-49-7

2-chloropyrazin

nickel(II) thiocyanate
13689-92-4

nickel(II) thiocyanate

Ni(NCS)2(2-chloropyrazine)4·2-chloropyrazine solvate

Ni(NCS)2(2-chloropyrazine)4·2-chloropyrazine solvate

Conditions
ConditionsYield
at 20℃; for 72h;98.5%
2-chloropyrazin
14508-49-7

2-chloropyrazin

nickel(II) thiocyanate
13689-92-4

nickel(II) thiocyanate

[Ni(NCS)2(2-chloropyrazine)2]n

[Ni(NCS)2(2-chloropyrazine)2]n

Conditions
ConditionsYield
In acetonitrile at 20℃; for 168h;98.3%
2-chloropyrazin
14508-49-7

2-chloropyrazin

potassium enolate of acetone
128190-66-9, 25088-58-8

potassium enolate of acetone

1-(pyrazin-2-yl)propan-2-one
6784-62-9

1-(pyrazin-2-yl)propan-2-one

Conditions
ConditionsYield
In diethyl ether; ammonia for 0.25h; Mechanism; Product distribution; effect of inhibitor (di-tert-butyl-nitroxide);98%
2-chloropyrazin
14508-49-7

2-chloropyrazin

3-(Tributylstannyl)pyridine N-oxide

3-(Tributylstannyl)pyridine N-oxide

3-(2-Pyrazinyl)pyridine N-oxide

3-(2-Pyrazinyl)pyridine N-oxide

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 36h; Heating;98%
2-chloropyrazin
14508-49-7

2-chloropyrazin

thiophene boronic acid
6165-68-0

thiophene boronic acid

2-(thiophen-2-yl)pyrazine
56421-72-8

2-(thiophen-2-yl)pyrazine

Conditions
ConditionsYield
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;98%
With tetrabutyl ammonium fluoride; tricyclohexylphosphine; dichloro bis(acetonitrile) palladium(II) at 85 - 90℃; for 5h; Suzuki-Miyaura reaction;95%
With 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; palladium diacetate; potassium carbonate In water at 100℃; for 24h; Suzuki-Miyaura Coupling;87%
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 160℃; for 0.5h; Suzuki Coupling; Microwave irradiation;71%
With 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; palladium diacetate In N,N-dimethyl-formamide at 110℃; for 38h; Suzuki-Miyaura cross-coupling;50%
2-chloropyrazin
14508-49-7

2-chloropyrazin

2-(tri-n-butylstannyl)thiazole
121359-48-6

2-(tri-n-butylstannyl)thiazole

2-(2'-pyrazinyl)thiazole

2-(2'-pyrazinyl)thiazole

Conditions
ConditionsYield
With trans-dichloro(1,3-bis-(2,6-diisopentylphenyl)imidazolylidinium)(3-chloro-pyridine); cesium fluoride In 1,4-dioxane at 20 - 80℃; for 32h; Stille-Migita cross-coupling; Molecular sieve; Inert atmosphere;98%
2-chloropyrazin
14508-49-7

2-chloropyrazin

4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

2-(4-fluorophenyl)pyrazine
939975-25-4

2-(4-fluorophenyl)pyrazine

Conditions
ConditionsYield
Stage #1: 2-chloropyrazin; 4-fluoroboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere;
Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;
98%
With palladium diacetate; potassium carbonate In ethanol; water at 80℃; for 0.5h; Suzuki Coupling;90%
With potassium phosphate tribasic heptahydrate; palladium diacetate In ethylene glycol at 80℃; for 1.58333h; Suzuki coupling;88%
2-chloropyrazin
14508-49-7

2-chloropyrazin

2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

2-(2-methylphenyl)pyrazine
87537-41-5

2-(2-methylphenyl)pyrazine

Conditions
ConditionsYield
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;98%
With 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; palladium diacetate; potassium carbonate In water at 100℃; for 24h; Suzuki-Miyaura Coupling;90%
2-chloropyrazin
14508-49-7

2-chloropyrazin

m-tolylboronic acid
17933-03-8

m-tolylboronic acid

2-(3-methylphenyl)pyrazine
1142346-68-6

2-(3-methylphenyl)pyrazine

Conditions
ConditionsYield
Stage #1: 2-chloropyrazin; m-tolylboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere;
Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;
98%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol at 80℃; for 2.5h; Inert atmosphere;95%
With potassium phosphate tribasic trihydrate; C30H39P; palladium diacetate In tetrahydrofuran at 110℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere;93%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol at 80℃; for 2.5h;
2-chloropyrazin
14508-49-7

2-chloropyrazin

Thien-3-ylboronic acid
6165-69-1

Thien-3-ylboronic acid

2-(thiophen-3-yl)pyrazine
56421-87-5

2-(thiophen-3-yl)pyrazine

Conditions
ConditionsYield
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;98%
With potassium phosphate; C46H52Cl3N3O2Pd In tetrahydrofuran; water at 60℃; for 4h; Suzuki-Miyaura Coupling;91%
2-chloropyrazin
14508-49-7

2-chloropyrazin

nickel(II) thiocyanate
13689-92-4

nickel(II) thiocyanate

Ni(NCS)2(2-chloropyrazine)4

Ni(NCS)2(2-chloropyrazine)4

Conditions
ConditionsYield
In water at 20℃; for 48h;97.6%
2-chloropyrazin
14508-49-7

2-chloropyrazin

thiophenol
108-98-5

thiophenol

2-(phenylsulfanyl)pyrazine
107697-83-6

2-(phenylsulfanyl)pyrazine

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 1,1',3,3'-tetrakis(diphenylphosphino)ferrocene; sodium t-butanolate In toluene for 17h; Catalytic behavior; Inert atmosphere; Schlenk technique; Heating;97%
at 28℃; for 12h;94%
Stage #1: 2-chloropyrazin With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: thiophenol With potassium phosphate In N,N-dimethyl-formamide at 50℃; for 2h; Catalytic behavior; Temperature; Solvent; Reagent/catalyst; Schlenk technique; Inert atmosphere;
88%
With 1,1'-bis-(diphenylphosphino)ferrocene; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate In toluene at 120℃; for 17h;86%
With sodium hydride In dimethyl sulfoxide for 5h; Heating;70%
2-chloropyrazin
14508-49-7

2-chloropyrazin

2,2'-bipyrazine
10199-00-5

2,2'-bipyrazine

Conditions
ConditionsYield
With palladium diacetate; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine In isopropyl alcohol; toluene at 105℃; for 24h;97%
With potassium hydroxide In water; N,N-dimethyl-formamide at 35℃; for 12h; Ullmann Condensation; Inert atmosphere;94%
With nickel diacetate; triphenylphosphine; sodium t-butanolate In 1,2-dimethoxyethane at 45℃; for 0.00277778h;48%
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 140℃; for 16h;42%
With palladium diacetate; potassium carbonate In isopropyl alcohol; toluene at 100℃; for 5h; Reagent/catalyst; Inert atmosphere;3%
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