2-Chloropyrazine supplier | CasNO.14508-49-7

Name
2-Chloropyrazine
EINECS 238-517-0
CAS No. 14508-49-7
Article Data25
CAS DataBase
Density 1.303 g/cm³
Solubility insoluble in water
Melting Point 153～154℃
Formula C₄H₃ClN₂
Boiling Point 155.3 °C at 760 mmHg
Molecular Weight 114.534
Flash Point 57 °C
Transport Information UN 1993 3/PG 3
Appearance clear colorless to yellowish liquid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Pyrazine,chloro- (6CI,7CI,8CI,9CI);Pyrazine,2-chloro-;Chloropyrazine;Pyrazin-2-ylchloride;
PSA 25.78000
LogP 1.13000

Synthetic route

: 24387-68-6
2-hydroxypyrazine sodium salt

: 14508-49-7
2-chloropyrazin

Conditions

Conditions	Yield
With thionyl chloride; N-ethyl-N,N-diisopropylamine In chloroform at 65℃; for 2h; Reagent/catalyst;	95.4%

: 6270-63-9
pyrazin-2-ol

: 14508-49-7
2-chloropyrazin

Conditions

Conditions	Yield
With dmap; thionyl chloride; bis(trichloromethyl) carbonate for 10.5h; Reflux; Green chemistry;	89%
With trichlorophosphate for 0.666667h; Heating;	84%
With trichlorophosphate

: 98-97-5
2-pyrazylcarboxylic acid

: 14508-49-7
2-chloropyrazin

Conditions

Conditions	Yield
With thionyl chloride In pyridine; para-tert-butylphenol; benzene	75%

: 2423-65-6
Pyrazin-N-Oxid(PyzNO)

: 14508-49-7
2-chloropyrazin

Conditions

Conditions	Yield
With trichlorophosphate at 70℃; for 2h;	37%
With trichlorophosphate	35%

: 2423-65-6
Pyrazin-N-Oxid(PyzNO)

A: 14508-49-7
2-chloropyrazin

B: Pyrazine 1-oxide; hydrochloride

C: 1-(2-pyrazinyl) pyrazinium salt

Conditions

Conditions	Yield
With trichlorophosphate for 0.5h; Product distribution; Ambient temperature;	A 13% B 30% C n/a

...Expand

: 290-37-9
1,4-pyrazine

: 14508-49-7
2-chloropyrazin

Conditions

Conditions	Yield
With chlorine at 500℃;
With water; chlorine at 450℃;

: 6270-63-9
pyrazin-2(1H)-one

: 14508-49-7
2-chloropyrazin

Conditions

Conditions	Yield
With phosphorus pentachloride; trichlorophosphate
With trichlorophosphate

: 288-32-4
1H-imidazole

: 67-66-3
chloroform

A: 14508-49-7
2-chloropyrazin

B: 17180-94-8
5-chloropyrimidine

Conditions

Conditions	Yield
at 550℃; Yield given. Yields of byproduct given;

...Expand

: 616-47-7
1-methyl-1H-imidazole

: 67-66-3
chloroform

A: 14508-49-7
2-chloropyrazin

B: 4513-94-4
1H-pyrrole-2-carbonitrile

C: 17180-94-8
5-chloropyrimidine

D: 51269-82-0
5-chloronicotinonitrile

Conditions

Conditions	Yield
at 550℃; Yield given. Further byproducts given. Yields of byproduct given;

...Expand

: 616-47-7
1-methyl-1H-imidazole

: 67-66-3
chloroform

A: 14508-49-7
2-chloropyrazin

B: 17180-94-8
5-chloropyrimidine

C: 89809-64-3
2-cyano-5-chloropyridine

D: 51269-82-0
5-chloronicotinonitrile

Conditions

Conditions	Yield
at 550℃; Yield given. Further byproducts given. Yields of byproduct given;

...Expand

: 616-47-7
1-methyl-1H-imidazole

: 67-66-3
chloroform

A: 14508-49-7
2-chloropyrazin

B: 17180-94-8
5-chloropyrimidine

C: 51269-82-0
5-chloronicotinonitrile

D: 38180-46-0
3-chloro-2-cyanopyridine

Conditions

Conditions	Yield
at 550℃; Yield given. Further byproducts given. Yields of byproduct given;

...Expand

: 616-47-7
1-methyl-1H-imidazole

: 67-66-3
chloroform

A: 14508-49-7
2-chloropyrazin

B: 17180-94-8
5-chloropyrimidine

C: 51269-82-0
5-chloronicotinonitrile

D: 68325-15-5
3-chloro-isonicotinonitrile

Conditions

Conditions	Yield
at 550℃; Yield given. Further byproducts given. Yields of byproduct given;

...Expand

: 2423-65-6
Pyrazin-N-Oxid(PyzNO)

A: 14508-49-7
2-chloropyrazin

B: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With sodium hydroxide; trichlorophosphate 1) 70 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;

: 2423-65-6
Pyrazin-N-Oxid(PyzNO)

A: 14508-49-7
2-chloropyrazin

B: 1-(2-pyrazinyl) pyrazinium chloride

Conditions

Conditions	Yield
With trichlorophosphate at 70℃; for 2h; Product distribution;	A 50 % Spectr. B 50 % Spectr.

: 67-66-3
chloroform

: 18156-74-6
1-(Trimethylsilyl)imidazole

A: 14508-49-7
2-chloropyrazin

B: 17180-94-8
5-chloropyrimidine

Conditions

Conditions	Yield
at 550℃; Yield given. Yields of byproduct given;

...Expand

: 6863-76-9
3-chloropyrazine 1-oxide

A: 14508-49-7
2-chloropyrazin

B: 19745-07-4
2,5-dichloropyrazine

C: 4858-85-9
2,3-dichloropyrazine

D: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 16025-16-4
2-chloropyrazine 1-oxide

A: 14508-49-7
2-chloropyrazin

B: 4858-85-9
2,3-dichloropyrazine

C: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 290-37-9
1,4-pyrazine

: 7732-18-5
water

: 7782-50-5
chlorine

A: 14508-49-7
2-chloropyrazin

B: 19745-07-4
2,5-dichloropyrazine

C: 4858-85-9
2,3-dichloropyrazine

D: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
at 350℃; Product distribution;

...Expand

: 419581-31-0
CuCl(μ-2-chloropyrazine-N,N')

A: 14508-49-7
2-chloropyrazin

B: copper(l) chloride

Conditions

Conditions	Yield
In neat (no solvent) heating in Ar at 220 °C; detected by powder X-ray diffractometry;

: 419581-31-0
CuCl(μ-2-chloropyrazine-N,N')

: 80937-33-3
oxygen

A: 14508-49-7
2-chloropyrazin

B: copper(II) oxide

Conditions

Conditions	Yield
In neat (no solvent) in air, heating at 180 °C, CuCl, 2-chloropyrazine and some CuO were formed, Cu2OCl2 was formed at 392 °C, CuCl was formed again at430 °,C and CuO was formed in the last step at 461 °C; detected by X-ray powder diffractometry;

...Expand

: 419581-32-1
CuBr(μ-2-chloropyrazine-N,N')

A: 14508-49-7
2-chloropyrazin

B: 7787-70-4
copper(I) bromide

Conditions

Conditions	Yield
In neat (no solvent) heating in Ar at 200 °C; detected by powder X-ray diffractometry;

: 419581-32-1
CuBr(μ-2-chloropyrazine-N,N')

: 80937-33-3
oxygen

A: 14508-49-7
2-chloropyrazin

B: copper(II) oxide

Conditions

Conditions	Yield
In neat (no solvent) in air, CuBr and 2-chloropyrazine were formed at 171 °C, CuBr wasoxidised during further heating; detected by X-ray powder diffractometry;

...Expand

: 419581-33-2
CuI(μ-2-chloropyrazine-N,N')

A: 14508-49-7
2-chloropyrazin

B: 7681-65-4
copper(l) iodide

Conditions

Conditions	Yield
In neat (no solvent) heating in Ar at 150 °C; detected by powder X-ray diffractometry;

: 419581-33-2
CuI(μ-2-chloropyrazine-N,N')

: 80937-33-3
oxygen

A: 14508-49-7
2-chloropyrazin

B: copper(II) oxide

Conditions

Conditions	Yield
In neat (no solvent) in air, heating at 138 °C, Cu2I2(2-chloropyrazine) then CuI and 2-chloropyrazine were formed, CuO was formed in the last step around 340 °C; detected by X-ray powder diffractometry;

...Expand

: 14508-49-7
2-chloropyrazin

: 98-80-6
phenylboronic acid

: 29460-97-7
2-phenylpyrazine

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; tricyclohexylphosphine; dichloro bis(acetonitrile) palladium(II) at 85 - 90℃; for 5h; Suzuki-Miyaura reaction;	100%
With potassium phosphate; C46H52Cl3N3O2Pd In tetrahydrofuran; water at 60℃; for 4h; Suzuki-Miyaura Coupling;	99%
With 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; palladium diacetate; potassium carbonate In water at 100℃; for 24h; Suzuki-Miyaura Coupling;	95%

: 14508-49-7
2-chloropyrazin

: 38521-06-1
2-mercaptopyrazine

Conditions

Conditions	Yield
With thiourea In ethanol for 16h; Reflux;	100%
With hydrogen sulfide; sodium methylate In methanol for 1h; Heating;	91%
With hydrogen sulfide; sodium ethanolate; N,N-dimethyl-formamide In ethanol at 100℃; for 3h;	88%

: 14508-49-7
2-chloropyrazin

: (2,3-dimethylphenyl)zinc chloride

: 2-(2,3-dimethylphenyl)pyrazine

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); ruphos In tetrahydrofuran at 20℃; for 15h; Negishi coupling;	100%

: 14508-49-7
2-chloropyrazin

: 74-89-5
methylamine

: 32111-28-7
N-methylpyrazin-2-amine

Conditions

Conditions	Yield
at 100℃; for 15h;	100%
In ethanol at 95℃; for 1h; Inert atmosphere; Sealed tube;	77%
In dimethyl sulfoxide at 130℃;

: 14508-49-7
2-chloropyrazin

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 442199-08-8
t-butyl 4-[(pyrazin-2-yl)oxy]piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;	100%
In hexane; dimethyl sulfoxide; ethyl acetate

: 14508-49-7
2-chloropyrazin

: 21450-64-6
(2,6-dimethylphenyl)magnesium bromide

: 1157867-58-7
2-(2,6-dimethylphenyl)pyrazine

Conditions

Conditions	Yield
Stage #1: (2,6-dimethylphenyl)magnesium bromide With dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II); zinc(II) chloride In tetrahydrofuran at 23℃; for 0.333333h; Inert atmosphere; Stage #2: 2-chloropyrazin In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 23℃; for 24h; Negishi coupling; Inert atmosphere;	100%

: 14508-49-7
2-chloropyrazin

: 110-70-3
N,N`-dimethylethylenediamine

: N,N'-dimethyl-N-pyrazin-2-yl-ethane-1,2-diamine

Conditions

Conditions	Yield
In ethanol	100%

: 14508-49-7
2-chloropyrazin

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 6164-79-0
methyl pyrazine-2-carboxylate

Conditions

Conditions	Yield
With dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); triethylamine at 100℃; under 2585.74 Torr; for 4h;	99%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In acetonitrile at 180℃; under 25502.6 Torr; Flow reactor;	61%
With triethylamine; palladium bis(dibenzylideneacetone)palladium(0); triphenylphosphine at 120℃; under 29420.3 Torr; for 16h; other chloropyrazines;	93 % Chromat.
With ethyl azide; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) at 120℃; under 29420.3 Torr; for 16h;	93 % Chromat.

...Expand

: 14508-49-7
2-chloropyrazin

: 536-74-3
phenylacetylene

: 96129-41-8
2-(2-phenylethynyl)pyrazine

Conditions

Conditions	Yield
With potassium phosphate; bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride In acetonitrile at 90℃; for 6h; Sonogashira Cross-Coupling;	99%
With tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; copper(I) oxide at 135 - 140℃; for 24h; Sonogashira coupling;	98%
With bis(η3-allyl-μ-chloropalladium(II)); triethylamine; triphenylphosphine; 1-butyl-3-methylimidazolium Tetrafluoroborate at 100℃; for 4h; Heck alkynylation; Inert atmosphere;	95%
With dichloro bis(acetonitrile) palladium(II); 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; caesium carbonate In water; acetonitrile at 100℃; for 24h; Sonogashira Cross-Coupling;	89%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine at 70℃; for 12h; Sonogashira coupling;	76%

: 14508-49-7
2-chloropyrazin

: 100379-00-8
2,6-dimethylbenzene boronic acid

: 1157867-58-7
2-(2,6-dimethylphenyl)pyrazine

Conditions

Conditions	Yield
With trans-dichloro(1,3-bis-(2,6-diisopentylphenyl)imidazolylidinium)(3-chloro-pyridine); potassium tert-butylate In tert-butyl alcohol at 65℃; Suzuki-Miyaura coupling; Inert atmosphere; Molecular sieve;	99%

: 14508-49-7
2-chloropyrazin

: 5720-05-8
4-methylphenylboronic acid

: 108030-80-4
2-(4-methylphenyl)pyrazine

Conditions

Conditions	Yield
With potassium phosphate tribasic heptahydrate; palladium diacetate In ethylene glycol at 80℃; for 0.333333h; Suzuki coupling;	99%
With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; tetrabutylammomium bromide; sodium hydrogencarbonate In water for 1h; Catalytic behavior; Suzuki-Miyaura Coupling; Reflux;	98%
Stage #1: 2-chloropyrazin; 4-methylphenylboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere; Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;	96%
With potassium phosphate tribasic heptahydrate; palladium dichloride In water; N,N-dimethyl-formamide at 20℃; for 24h; Suzuki cross-coupling reaction;	88%
With potassium phosphate tribasic heptahydrate; palladium diacetate In isopropyl alcohol at 80℃; for 0.666667h; Suzuki coupling;	82%

: 6-methyl-2-pyridylzinc bromide

: 14508-49-7
2-chloropyrazin

: 149775-45-1
6-Methyl-2-(2-pyrazinyl)pyridine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); XPhos In tetrahydrofuran at 65℃; for 3h; Negishi cross-coupling; Inert atmosphere;	99%

: 14508-49-7
2-chloropyrazin

: 5720-06-9
2-Methoxyphenylboronic acid

: 251933-26-3
2-(2-methoxyphenyl)pyrazine

Conditions

Conditions	Yield
With (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; palladium diacetate; potassium carbonate In ethanol; water at 80℃; for 3h; Catalytic behavior; Reagent/catalyst; Suzuki-Miyaura Coupling; Inert atmosphere;	99%
With 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; palladium diacetate; potassium carbonate In water at 100℃; for 24h; Suzuki-Miyaura Coupling;	91%

: 14508-49-7
2-chloropyrazin

: 10365-98-7
3-methoxyphenylboronic acid

: 912771-38-1
2-(3-methoxyphenyl)-pyrazine

Conditions

Conditions	Yield
Stage #1: 2-chloropyrazin; 3-methoxyphenylboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere; Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;	99%

: 14508-49-7
2-chloropyrazin

: 139911-29-8
4-fluoro-2-methylphenylboronic acid

: 334476-87-8
2-(4-fluoro-2-methylphenyl)pyrazine

Conditions

Conditions	Yield
Stage #1: 2-chloropyrazin; 4-fluoro-2-methylphenylboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere; Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;	99%

: 14508-49-7
2-chloropyrazin

: 105-13-5
4-Methoxybenzyl alcohol

: 2-(4-methoxybenzyloxy)pyrazine

Conditions

Conditions	Yield
Stage #1: 4-Methoxybenzyl alcohol With sodium hydride In 1,2-dimethoxyethane at 0℃; for 0.333333h; Inert atmosphere; Stage #2: 2-chloropyrazin In 1,2-dimethoxyethane at 0 - 45℃; Inert atmosphere;	99%

: 14508-49-7
2-chloropyrazin

: ferrous(II) sulfate heptahydrate

: 333-20-0
potassium thioacyanate

: Fe(NCS)2(2-chloropyrazine)4

Conditions

Conditions	Yield
In water at 20℃; for 24h;	98.6%

...Expand

: 14508-49-7
2-chloropyrazin

: 13689-92-4
nickel(II) thiocyanate

: Ni(NCS)2(2-chloropyrazine)4·2-chloropyrazine solvate

Conditions

Conditions	Yield
at 20℃; for 72h;	98.5%

: 14508-49-7
2-chloropyrazin

: 13689-92-4
nickel(II) thiocyanate

: [Ni(NCS)2(2-chloropyrazine)2]n

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 168h;	98.3%

: 14508-49-7
2-chloropyrazin

: 128190-66-9, 25088-58-8
potassium enolate of acetone

: 6784-62-9
1-(pyrazin-2-yl)propan-2-one

Conditions

Conditions	Yield
In diethyl ether; ammonia for 0.25h; Mechanism; Product distribution; effect of inhibitor (di-tert-butyl-nitroxide);	98%

: 14508-49-7
2-chloropyrazin

: 3-(Tributylstannyl)pyridine N-oxide

: 3-(2-Pyrazinyl)pyridine N-oxide

Conditions

Conditions	Yield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 36h; Heating;	98%

: 14508-49-7
2-chloropyrazin

: 6165-68-0
thiophene boronic acid

: 56421-72-8
2-(thiophen-2-yl)pyrazine

Conditions

Conditions	Yield
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;	98%
With tetrabutyl ammonium fluoride; tricyclohexylphosphine; dichloro bis(acetonitrile) palladium(II) at 85 - 90℃; for 5h; Suzuki-Miyaura reaction;	95%
With 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; palladium diacetate; potassium carbonate In water at 100℃; for 24h; Suzuki-Miyaura Coupling;	87%
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 160℃; for 0.5h; Suzuki Coupling; Microwave irradiation;	71%
With 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; palladium diacetate In N,N-dimethyl-formamide at 110℃; for 38h; Suzuki-Miyaura cross-coupling;	50%

: 14508-49-7
2-chloropyrazin

: 121359-48-6
2-(tri-n-butylstannyl)thiazole

: 2-(2'-pyrazinyl)thiazole

Conditions

Conditions	Yield
With trans-dichloro(1,3-bis-(2,6-diisopentylphenyl)imidazolylidinium)(3-chloro-pyridine); cesium fluoride In 1,4-dioxane at 20 - 80℃; for 32h; Stille-Migita cross-coupling; Molecular sieve; Inert atmosphere;	98%

: 14508-49-7
2-chloropyrazin

: 1765-93-1
4-fluoroboronic acid

: 939975-25-4
2-(4-fluorophenyl)pyrazine

Conditions

Conditions	Yield
Stage #1: 2-chloropyrazin; 4-fluoroboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere; Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;	98%
With palladium diacetate; potassium carbonate In ethanol; water at 80℃; for 0.5h; Suzuki Coupling;	90%
With potassium phosphate tribasic heptahydrate; palladium diacetate In ethylene glycol at 80℃; for 1.58333h; Suzuki coupling;	88%

: 14508-49-7
2-chloropyrazin

: 16419-60-6
2-Methylphenylboronic acid

: 87537-41-5
2-(2-methylphenyl)pyrazine

Conditions

Conditions	Yield
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;	98%
With 2-((3-sulfonatomesityl)-5-sulfonatoindenyl)dicyclohexylphosphinehydrate sodium salt; palladium diacetate; potassium carbonate In water at 100℃; for 24h; Suzuki-Miyaura Coupling;	90%

: 14508-49-7
2-chloropyrazin

: 17933-03-8
m-tolylboronic acid

: 1142346-68-6
2-(3-methylphenyl)pyrazine

Conditions

Conditions	Yield
Stage #1: 2-chloropyrazin; m-tolylboronic acid With tetrakis(triphenylphosphine) palladium(0) In water; toluene at 95℃; for 0.166667h; Suzuki Coupling; Inert atmosphere; Stage #2: With potassium fluoride dihydrate In water; toluene at 95℃; Suzuki Coupling; Inert atmosphere;	98%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol at 80℃; for 2.5h; Inert atmosphere;	95%
With potassium phosphate tribasic trihydrate; C30H39P; palladium diacetate In tetrahydrofuran at 110℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere;	93%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol at 80℃; for 2.5h;

: 14508-49-7
2-chloropyrazin

: 6165-69-1
Thien-3-ylboronic acid

: 56421-87-5
2-(thiophen-3-yl)pyrazine

Conditions

Conditions	Yield
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;	98%
With potassium phosphate; C46H52Cl3N3O2Pd In tetrahydrofuran; water at 60℃; for 4h; Suzuki-Miyaura Coupling;	91%

: 14508-49-7
2-chloropyrazin

: 13689-92-4
nickel(II) thiocyanate

: Ni(NCS)2(2-chloropyrazine)4

Conditions

Conditions	Yield
In water at 20℃; for 48h;	97.6%

: 14508-49-7
2-chloropyrazin

: 108-98-5
thiophenol

: 107697-83-6
2-(phenylsulfanyl)pyrazine

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); 1,1',3,3'-tetrakis(diphenylphosphino)ferrocene; sodium t-butanolate In toluene for 17h; Catalytic behavior; Inert atmosphere; Schlenk technique; Heating;	97%
at 28℃; for 12h;	94%
Stage #1: 2-chloropyrazin With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Schlenk technique; Inert atmosphere; Stage #2: thiophenol With potassium phosphate In N,N-dimethyl-formamide at 50℃; for 2h; Catalytic behavior; Temperature; Solvent; Reagent/catalyst; Schlenk technique; Inert atmosphere;	88%
With 1,1'-bis-(diphenylphosphino)ferrocene; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate In toluene at 120℃; for 17h;	86%
With sodium hydride In dimethyl sulfoxide for 5h; Heating;	70%

: 14508-49-7
2-chloropyrazin

: 10199-00-5
2,2'-bipyrazine

Conditions

Conditions	Yield
With palladium diacetate; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine In isopropyl alcohol; toluene at 105℃; for 24h;	97%
With potassium hydroxide In water; N,N-dimethyl-formamide at 35℃; for 12h; Ullmann Condensation; Inert atmosphere;	94%
With nickel diacetate; triphenylphosphine; sodium t-butanolate In 1,2-dimethoxyethane at 45℃; for 0.00277778h;	48%
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 140℃; for 16h;	42%
With palladium diacetate; potassium carbonate In isopropyl alcohol; toluene at 100℃; for 5h; Reagent/catalyst; Inert atmosphere;	3%

2-Chloropyrazine Chemical Properties

Molecular Structure of 2-Chloropyrazine (CAS NO.14508-49-7):

IUPAC Name: 2-Chloropyrazine
Molecular Formula: C₄H₃ClN₂
Molecular Weight: 114.53 g/mol
Density: 1.303 g/cm³
Flash Point: 57.8 °C
Boiling Point: 155.3 °C at 760 mmHg
Water Solubility: insoluble
Index of Refraction: 1.534
Molar Refractivity: 27.33 cm³
Molar Volume: 87.8 cm³
Surface Tension: 48.2 dyne/cm
XLogP3: 0.7
H-Bond Acceptor: 2
Exact Mass: 113.998476
MonoIsotopic Mass: 113.998476
Topological Polar Surface Area: 25.8
Heavy Atom Count: 7
Canonical SMILES: C1=CN=C(C=N1)Cl
InChI: InChI=1S/C4H3ClN2/c5-4-3-6-1-2-7-4/h1-3H
InChIKey: GELVZYOEQVJIRR-UHFFFAOYSA-N
EINECS: 238-517-0
Product Categories: Halides; Heterocycles; Pyrazines; Pyrazine; Chloropyrazines, etc.; Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks; PyrazinesHeterocyclic Building Blocks

2-Chloropyrazine Uses

2-Chloropyrazine (CAS NO.14508-49-7) is used as intermediates of medicine and pesticide.

2-Chloropyrazine Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Irritant
TSCA: T
HazardClass: 3
PackingGroup: III
HS Code: 29339990

2-Chloropyrazine Specification

2-Chloropyrazine (CAS NO.14508-49-7) is also named as Chloropyrazine ; Pyrazine, 2-chloro- ; Pyrazine, chloro- . 2-Chloropyrazine (CAS NO.14508-49-7) is clear colorless to yellowish liquid.

Product Name

2-Chloropyrazine

Synthetic route

2-Chloropyrazine Chemical Properties

2-Chloropyrazine Uses

2-Chloropyrazine Safety Profile

2-Chloropyrazine Specification

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