Product Name

  • Name

    4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

  • EINECS 604-564-4
  • CAS No. 147118-37-4
  • Article Data29
  • CAS DataBase
  • Density 1.32 g/cm3
  • Solubility
  • Melting Point 178.0 to 182.0 °C
  • Formula C16H18FN3O3S
  • Boiling Point 536.594 °C at 760 mmHg
  • Molecular Weight 351.402
  • Flash Point 278.322 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 147118-37-4 (4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl)
  • Hazard Symbols
  • Synonyms N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide;Methanesulfonamide,N-[4-(4-fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-;Rosuvastatin intermediate Z8;
  • PSA 88.61000
  • LogP 3.69520

Synthetic route

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; [2,2]bipyridinyl; tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; 9-azabicyclo<3.3.1>nonane-N-oxyl In acetonitrile at 20 - 50℃; for 2h; Sealed tube;99%
With fluorosulfonyl fluoride; potassium carbonate; dimethyl sulfoxide at 20℃; for 2h; Sealed tube; chemoselective reaction;99%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(II) nitrate trihydrate In 2-methyltetrahydrofuran at 40℃; for 18h; Temperature; Reagent/catalyst; Solvent;99%
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile
1092844-00-2

4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With formic acid for 2h; Time; Reflux;95%
With diisobutylaluminium hydride In toluene at -5℃; for 1h;81%
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile With diisobutylaluminium hydride In dichloromethane at 0 - 5℃; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water at 0 - 30℃;		80.3%
N-[5-[1,3]dioxolane-2-yl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
916480-94-9

N-[5-[1,3]dioxolane-2-yl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With acetic acid In water at 60 - 70℃; for 0.166667h;93%
N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
799842-07-2

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide With sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide for 25h; Kornblum Oxydation;
Stage #2: With acetic anhydride; dimethyl sulfoxide at 70℃;		93%
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
2: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 2 steps
1: water / tetrahydrofuran / 6 h / Reflux
2: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
C29H40FN3O6S

C29H40FN3O6S

A

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
124752-23-4

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: C29H40FN3O6S With ozone In methanol; dichloromethane at 25℃; for 5h;
Stage #2: With thiourea In methanol; dichloromethane; water Temperature; Time;		A n/a
B 82.2%
ethyl 2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-carboxylic acid
147118-30-7

ethyl 2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-carboxylic acid

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With lithium borohydride In tetrahydrofuran at 0 - 5℃; for 4h;80%
Multi-step reaction with 2 steps
1: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
2: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine
1031246-43-1

4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With trichlorophosphate at 90 - 108℃; Temperature;72%
With trichlorophosphate at 90 - 108℃;72%
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine
1031246-43-1

4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With N,N-dimethyl-formamide; trichlorophosphate at 90 - 108℃; Temperature; Concentration;72%
4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde
147118-41-0

4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: methanesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h;		55%
Stage #1: 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carbaldehyde With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: methanesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 3.5h; Product distribution / selectivity;		55%
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Product distribution / selectivity;30%
N-(4-(4-fluorophenyl)-6-isopropyl-5-(prop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide
1356998-77-0

N-(4-(4-fluorophenyl)-6-isopropyl-5-(prop-1-enyl)pyrimidin-2-yl)-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With oxone; water; sodium hydrogencarbonate; ruthenium(III) trichloride hydrate In acetonitrile at 20℃; for 24h;40%
With Oxone; sodium hydrogencarbonate; ruthenium(III) trichloride hydrate In water; acetonitrile at 20℃; for 24h;40%
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

PhCH2CH2MgHal

PhCH2CH2MgHal

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86.7 percent / piperidine, AcOH / benzene / Heating
2: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min
3: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature
4: 46.9 g / ethanol / 1 h / Ambient temperature
5: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
6: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
7: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester
122930-45-4

(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min
2: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature
3: 46.9 g / ethanol / 1 h / Ambient temperature
4: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
5: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
6: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
ethyl 4-methyl-3-oxo-pentanoate
7152-15-0

ethyl 4-methyl-3-oxo-pentanoate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86.7 percent / piperidine, AcOH / benzene / Heating
2: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min
3: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature
4: 46.9 g / ethanol / 1 h / Ambient temperature
5: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
6: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
7: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
5-ethoxycarbonyl-6-(4'-fluorophenyl)-4-isopropyl-2-(methylamino)pyrimidine
147118-32-9

5-ethoxycarbonyl-6-(4'-fluorophenyl)-4-isopropyl-2-(methylamino)pyrimidine

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
2: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
3: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate
147118-27-2

ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 95.7 percent / m-CPBA / CHCl3 / Ambient temperature
2: 46.9 g / ethanol / 1 h / Ambient temperature
3: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
4: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
5: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate
147118-28-3

ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 46.9 g / ethanol / 1 h / Ambient temperature
2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h
3: 277 mg / DIBAL-H / toluene / 1 h / -74 °C
4: 71.2 percent / 4-methylmorpholine-N-oxide, tetrapropyl-ammonium perruthenate, molecular sieves 4 Angstroem / CH2Cl2 / 2 h
View Scheme
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione
114433-94-2

1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium carbonate / acetone / 24 h / 20 °C
2: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C
3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
4: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
5: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
6: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 24 h / 20 °C
2.1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C
3.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
4.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
5.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h
5.2: 70 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / acetone / 4.17 h / 20 °C
2: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 25 °C
3: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere
4: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
5: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C
View Scheme
4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine
1207460-34-1

4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
3: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
4: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
3.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h
3.2: 70 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
3: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
3: water / tetrahydrofuran / 6 h / Reflux
4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 26 h / 0 - 20 °C
2: N-Bromosuccinimide / acetonitrile / 68 h / 20 °C / UV-irradiation
3: sodium hydrogencarbonate / acetonitrile / 4 h / Reflux
4: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide
953776-62-0

N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
2: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
3: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
2.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h
2.2: 70 °C
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
2: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
2: water / tetrahydrofuran / 6 h / Reflux
3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / acetonitrile / 68 h / 20 °C / UV-irradiation
2: sodium hydrogencarbonate / acetonitrile / 4 h / Reflux
3: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
2-allyl-1-(4-fluorophenyl)-4-methylpentane-1,3-dione
1356998-74-7

2-allyl-1-(4-fluorophenyl)-4-methylpentane-1,3-dione

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 25 °C
2: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere
3: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
4: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 0.33 h / 20 °C
1.2: 48.16 h / 25 °C
2.1: triethylamine / dichloromethane / 17 h / -5 °C
3.1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
4.1: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C
View Scheme
5-allyl-4-(4-fluorophenyl)-6-isopropyl-N-methylpyrimidin-2-amine
1356998-75-8

5-allyl-4-(4-fluorophenyl)-6-isopropyl-N-methylpyrimidin-2-amine

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere
2: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
3: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 17 h / -5 °C
2: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
3: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C
View Scheme
N-(5-allyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
1356998-76-9

N-(5-allyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
2: oxone; sodium hydrogencarbonate; water / ruthenium(III) trichloride hydrate / acetonitrile / 24 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / Aliquat 336 / toluene / 24 h / 20 °C
2: sodium hydrogencarbonate; Oxone / ruthenium(III) trichloride hydrate / acetonitrile; water / 24 h / 20 °C
View Scheme
1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
1354455-77-8

1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C
2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
4: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux
5: acetic anhydride; dimethyl sulfoxide / 85 °C
View Scheme
Multi-step reaction with 4 steps
1.1: caesium carbonate / 2-methyltetrahydrofuran / 10 h / 40 °C
2.1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3.1: N-Bromosuccinimide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor
4.1: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 25 h
4.2: 70 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C
2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
5: acetic anhydride; dimethyl sulfoxide / 17 h / 85 °C
View Scheme
N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide
953776-62-0

N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
2: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
799842-07-2

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide at 20℃; for 71h; Kornblum oxidation; Inert atmosphere;
1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione
1354455-77-8

1-(4-fluorophenyl)-2-methyl-3-isopropylpropan-1,3-dione

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C
2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: caesium carbonate / 2-methyltetrahydrofuran / 24 h / 70 °C
2: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
3: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
4: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine
1207460-34-1

4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
2: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
3: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione
114433-94-2

1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

A

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

B

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere
2: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C
3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
4: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere
2: caesium carbonate / 2-methyltetrahydrofuran / 24 h / 70 °C
3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere
4: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation
5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere
View Scheme
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dmap; ammonia / toluene; water / 0 - 35 °C / Inert atmosphere
2.1: copper(l) chloride; sulfuric acid / methanol / 30 - 70 °C / Inert atmosphere; Reflux
3.1: potassium carbonate; tert.-butylhydroperoxide; copper(II) choride dihydrate / dichloromethane / 25 - 30 °C / Inert atmosphere
4.1: trichlorophosphate / dichloromethane / 0 - 105 °C / Inert atmosphere
5.1: potassium carbonate / toluene / 25 - 115 °C / Inert atmosphere; Reflux
6.1: diisobutylaluminium hydride / dichloromethane / 0 - 5 °C / Inert atmosphere
6.2: 0 - 30 °C
View Scheme
methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
147118-35-2

methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)-pyrimidin-5-yl)-(3R)-3-tert-butyldimethylsiloxy-5-oxo-(E)-6-heptenoic acid methyl ester
147118-38-5

7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)-pyrimidin-5-yl)-(3R)-3-tert-butyldimethylsiloxy-5-oxo-(E)-6-heptenoic acid methyl ester

Conditions
ConditionsYield
In toluene for 30h; Wittig condensation; Heating / reflux;100%
Stage #1: methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate; N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In acetonitrile for 10 - 12h; Heating / reflux;
Stage #2: With acetic acid In di-isopropyl ether; water at 20℃; for 0.25h;
Stage #3: With water; sodium hydrogencarbonate In di-isopropyl ether Product distribution / selectivity;		100%
In acetonitrile for 10 - 12h; Product distribution / selectivity; Heating / reflux;100%
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
147118-36-3

N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate In tetrahydrofuran at 5 - 25℃; for 2h;98%
With methanol; sodium tetrahydroborate In tetrahydrofuran at 5 - 10℃;
With methanol; sodium tetrahydroborate In tetrahydrofuran at 0 - 20℃; for 1h;
methyl (triphenylphosphoranylidene)acetate
21204-67-1

methyl (triphenylphosphoranylidene)acetate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

methyl 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoate
1024024-26-7

methyl 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoate

Conditions
ConditionsYield
In acetonitrile at 20 - 81℃;96%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

allyl halide

allyl halide

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-allylisothiourea

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-allylisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; allyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 5h; Reflux;		93%
...Expand
ethyl 2-((4R,6S)-6-triphenylphosphinomethylidene-2,2-dimethyl-1,3-dioxan-4-yl)acetate

ethyl 2-((4R,6S)-6-triphenylphosphinomethylidene-2,2-dimethyl-1,3-dioxan-4-yl)acetate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

C27H36FN3O6S

C27H36FN3O6S

Conditions
ConditionsYield
In acetonitrile at 50℃; for 3h; Wittig Olefination;92.9%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

isopentyl halide

isopentyl halide

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-isopentylisothiourea

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-isopentylisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; isopentyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux;		92%
...Expand
[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
380460-37-7

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
289042-12-2

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; water at -15 - 42℃; for 1h; Temperature; Inert atmosphere;91%
With sodium hydride In tetrahydrofuran at 0 - 35℃; Solvent; Temperature; Reagent/catalyst;120 g
ethyl 2-((4R,6S)-6-triphenylphosphinemethylidene-2-ethoxycarbonylmethyl-1,3-dioxane-4-yl)acetate

ethyl 2-((4R,6S)-6-triphenylphosphinemethylidene-2-ethoxycarbonylmethyl-1,3-dioxane-4-yl)acetate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

C29H38FN3O8S

C29H38FN3O8S

Conditions
ConditionsYield
In acetonitrile at 50℃; for 3h; Wittig Olefination;90.6%
(R)-methyl 3-(tert-butyldimethylsilyloxy)-5-oxohexanoate
1622874-01-4

(R)-methyl 3-(tert-butyldimethylsilyloxy)-5-oxohexanoate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

methyl (3R,6E)-3-[[(1,1-dimethylethyl)dimethylsilyl]-oxo]-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidyl]-5-oxo-6-heptenoate

methyl (3R,6E)-3-[[(1,1-dimethylethyl)dimethylsilyl]-oxo]-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidyl]-5-oxo-6-heptenoate

Conditions
ConditionsYield
Stage #1: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide With tin(IV) chloride In tetrahydrofuran; dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #2: (R)-methyl 3-(tert-butyldimethylsilyloxy)-5-oxohexanoate With 4-methyl-morpholine In tetrahydrofuran; dichloromethane at 0℃; for 3h; Reagent/catalyst; Inert atmosphere;		87%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

benzyl halide

benzyl halide

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-benzylisothiourea

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-benzylisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; benzyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux;		85%
...Expand
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

n-heptyl halide

n-heptyl halide

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-hepteneisothiourea

2-[N-methyl (methylsulphanamid)]-4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-hepteneisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; n-heptyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 6h; Reflux;		85%
...Expand
C19H23N5O7S

C19H23N5O7S

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

C28H35FN4O7S

C28H35FN4O7S

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol at -40℃; for 4h;85%
1,1-dimethylethyl 2,4,6-trideoxy-3,5-O-(1-methylethylidene)-6-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]-D-erythro-hexonate

1,1-dimethylethyl 2,4,6-trideoxy-3,5-O-(1-methylethylidene)-6-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]-D-erythro-hexonate

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester
289042-12-2

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 42℃; Inert atmosphere;84.5%
thiosemicarbazide
79-19-6

thiosemicarbazide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

isopropyl halide

isopropyl halide

2-[N-methyl(methylsulphanamid)] - 4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-isopropylisothiourea

2-[N-methyl(methylsulphanamid)] - 4-[(4-fluorophenyl)-6-isopropylpyrimidine-5-yl] methyleneamino-2-isopropylisothiourea

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; isopropyl halide In ethanol for 3h; Reflux;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In ethanol for 5.5h; Reflux;		83%
...Expand
allyl bromide
106-95-6

allyl bromide

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
147118-37-4

N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[4-(4-fluorophenyl)-5-(1-hydroxybut-3-enyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
1352138-41-0

N-[4-(4-fluorophenyl)-5-(1-hydroxybut-3-enyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: allyl bromide With magnesium In diethyl ether for 0.5h; Inert atmosphere;
Stage #2: N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide In tetrahydrofuran; diethyl ether at -5 - 5℃;
Stage #3: With hydrogenchloride; water In tetrahydrofuran; diethyl ether for 0.5h;		81%

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Chemical Properties

Molecular structure of 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl (CAS NO.147118-37-4) is:

Product Name: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl
CAS Registry Number: 147118-37-4
Molecular Formula: C16H18FN3O3S
Molecular Weight: 351.39 
Surface Tension: 53.975 dyne/cm
Density: 1.32 g/cm3
Flash Point: 278.322 °C
Enthalpy of Vaporization: 81.332 kJ/mol
Boiling Point: 536.594 °C at 760 mmHg
Product Categories: Rosuvastatin Calcium and its intermediates

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl Specification

 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl , its cas register number is 147118-37-4. It also can be called Methanesulfonamide,N-[4-(4-fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl- ; N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl-N-methyl-methanesulfonamide .

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