PRODUCT NAME: METHYL PARABEN CHEMICAL NAME: METHYL 4-HYDROXYBENZOATE CAS REGISTRY NUMBER: [ 99-76-3 ] MOLECULAR FORMULA: C8H8O3 MOLECULAR WEIGHT: 152.15 STRUCTURAL FORMULA: Appearance:White Powder Storage:Store in a cool, dry, ventilate
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Analysis tests Standard Results Appearance White crystalline powder Conform Purity(%) 98.0-1
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inquiryProduct description: Product name Methylparaben CAS number 99-76-3 Assay ≥99% Appearance White crystalline powder Capacity 500mt/year Application Antiseptic for food, Cosmeti
Unique advantages for Methylparaben Cas 99-76-3 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White Powder Storage:Store in a dry and cool place Package:1kg/foil b
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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Name:Methyl 4-hydroxybenzoate CAS NO:99-76-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulner
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inquiryMethylparaben Basic information Product Name: Methylparaben Synonyms: NIPAGIN;NIPAGIN PLAIN;P-HYDROXYBENZOIC ACID METHYL ESTER;RARECHEM AL BF 0098;4-hydroxy-benzoicacimethylester;Abiol;A
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inquiryMethyl Paraben Identification: Chemical Name: Methyl P-Hydroxybenzoate Synonyms: Methyl 4-hydroxybenzoate CAS No.: 99-76-3 Structural Formula: Molecular Formula: C8H8O3 E-Code:E218 Properties: White crystalline and easily dis
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inquiryConditions | Yield |
---|---|
With boron trifluoride at 65℃; for 0.333333h; | 100% |
With sulfuric acid for 8h; Heating; | 100% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; Mitsunobu reaction; chemoselective reaction; | 100% |
methyl 4-acetoxybenzoate
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
silica gel; toluene-4-sulfonic acid In water; toluene at 80℃; for 6h; | 100% |
With phosphate buffer In diethyl ether for 2.75h; Ambient temperature; pig liver acetone powder; | 100% |
With ammonium acetate In methanol at 20℃; for 2.5h; | 100% |
Conditions | Yield |
---|---|
With oxygen at 80℃; under 3750.38 Torr; for 4h; Temperature; Reagent/catalyst; Pressure; Sealed tube; | 99.3% |
With perchloric acid; sodium percarbonate; vanadia for 1h; Cooling; | 98% |
With perchloric acid; dihydrogen peroxide; vanadia In water at 5℃; for 2.5h; oxidative esterification; | 97% |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 40℃; | 99% |
Stage #1: 4-hydroxy-benzoic acid With sodium hydrogencarbonate In water at 20℃; for 1h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 0 - 20℃; | 95% |
With potassium hydroxide at 220℃; im geschlossenen Rohr; | |
With N'',N'''''-1,8-naphthalenediyl bis[N,N,N',N'-tetramethyl]guanidine In N,N-dimethyl-formamide at 20℃; Kinetics; |
methyl 4-(cyanomethoxy)benzoate
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With hydrogen; platinum(IV) oxide In ethanol | 99% |
methyl 4-allyloxybenzoate
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With aniline; (ϖ-allyl)palladium triflate based catalyst at 30℃; for 0.333333h; | 99% |
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique; | 95% |
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube; | 95% |
4-(tert-butyldimethylsilanyloxy)benzoic acid methyl ester
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; acetonitrile at 20℃; for 0.166667h; | 99% |
With potassium hydroxide In ethanol at 20℃; for 0.7h; | 95% |
With sodium phosphate dodecahydrate In N,N-dimethyl-formamide at 20℃; for 2h; chemoselective reaction; | 92% |
methanol
carbon monoxide
4-Iodophenol
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With triethylamine at 100℃; under 3750.38 Torr; for 1.5h; Inert atmosphere; | 99% |
With triethylamine at 80℃; under 3750.38 Torr; for 3h; Autoclave; | 75% |
With triethylamine; G0-C2 PAMAM dendrimer*PPh2*PdMe2 at 105℃; under 5171.62 Torr; for 19h; | 100 % Chromat. |
4-carbomethoxyphenyl triflate
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h; | 99% |
With caesium carbonate In toluene at 80℃; for 15h; | 87% |
With ammonium acetate; methanol; magnesium; palladium on activated charcoal at 20℃; for 24h; | 51% |
With (1,2-dimethoxyethane)dichloronickel(II); N-isopropyl-N-tert-butylamine; N-tert-butoxycarbonyl-proline; 4,4'-di-tert-butyl-2,2'-bipyridine In dimethyl sulfoxide at 40℃; for 14h; Irradiation; Sealed tube; | 27 %Spectr. |
4-benzyloxy-benzoic acid methyl ester
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With cyclohexa-1,4-diene; 3,6-bis(dimethylamino)-9H-carbazole; caesium carbonate In dimethyl sulfoxide at 23℃; for 44h; Inert atmosphere; Schlenk technique; Irradiation; | 99% |
With pentamethylbenzene,; boron trichloride In dichloromethane at -78℃; for 0.333333h; | 97% |
With thiophene; sodium hydrogen sulfate; silica gel for 6h; Heating; | 96% |
potassium (4-(methoxycarbonyl)phenyl)trifluoroborate
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With Oxone; water In acetone at 20℃; for 0.0333333h; | 99% |
4-methoxycarbonylphenylboronic acid
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃; for 48h; Reagent/catalyst; Irradiation; Green chemistry; | 99% |
With N-ethyl-N,N-diisopropylamine In water; acetonitrile for 28h; Irradiation; | 99% |
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; under 760.051 Torr; for 27h; Irradiation; Green chemistry; | 98% |
Conditions | Yield |
---|---|
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; boric acid; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Catalytic behavior; Solvent; Reagent/catalyst; Schlenk technique; Inert atmosphere; | 98% |
With trans-di(μ-acetato)bis[o-(di-o-tolyl-phosphino)benzyl]dipalladium(II); C29H45Pt; potassium carbonate In water; N,N-dimethyl-formamide at 115℃; for 0.5h; Inert atmosphere; Microwave irradiation; | 92% |
With tris(6,6'-diamino-2,2'-bipyridine); 4,4-diphenyl-1,3,5,7,8-pentamethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene; Br2Ni*3H2O; water; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 24h; Glovebox; Irradiation; Inert atmosphere; | 79% |
dihydrogen peroxide
4-methoxycarbonylphenylboronic acid
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique; | 98% |
carbonic acid dimethyl ester
4-hydroxy-benzoic acid
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With sulfuric acid at 80 - 85℃; for 7.5h; Neat (no solvent); chemoselective reaction; | 97.6% |
With NaY faujasite at 165℃; for 24h; | 87% |
Conditions | Yield |
---|---|
magnesium(II) perchlorate In nitromethane at 40℃; for 16h; | 97% |
methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With water; caesium carbonate; hydrazine hydrate at 80℃; for 24h; | 97% |
With air at 25℃; for 16h; Inert atmosphere; | 25 mg |
With Oxone; potassium phosphate; naphthalene-2-boronic acid In water at 70℃; for 1h; chemoselective reaction; |
4-(tert-butyldimethylsilanyloxy)benzoic acid methyl ester
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 20℃; for 1h; | 96% |
4-(methoxymethoxy)benzoic acid methyl ester
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
sodium hydrogen sulfate; silica gel In dichloromethane at 20℃; for 1h; | 96% |
4-allyloxycarbonyloxybenzoic acid methyl ester
2-propanethiol
A
allylisopropyl sulfide
B
carbon dioxide
C
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With Roussin's red salt ester; tetrabutylammomium bromide; potassium hydride In tetrahydrofuran; ethanol at 40℃; | A n/a B n/a C 96% |
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; oxygen; sodium carbonate at 120℃; under 15001.5 Torr; for 1.5h; Microwave irradiation; Green chemistry; | 96% |
With sodium carbonate; palladium; silver(l) oxide at 80℃; for 48h; Molecular sieve; | 85% |
With oxygen at 79.84℃; under 3750.38 Torr; for 12h; Autoclave; |
3-iodo-4-methoxy-benzoic acid methyl ester
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With aluminium trichloride In dichloromethane; ethanethiol for 6.5h; temp. 0 deg C -> RT; | 95.1% |
Conditions | Yield |
---|---|
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; boric acid; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Schlenk technique; Inert atmosphere; | 94% |
With tris(6,6'-diamino-2,2'-bipyridine); 4,4-diphenyl-1,3,5,7,8-pentamethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene; Br2Ni*3H2O; water; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 24h; Glovebox; Irradiation; Inert atmosphere; | 89% |
With nickel(II) sulphate; water; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 12h; pH=8.8; UV-irradiation; Inert atmosphere; Glovebox; Enzymatic reaction; | 85% |
methyl 4-acetoxybenzoate
A
4-acetyloxy-benzoic acid
B
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; potassium carbonate; 2-amino-benzenethiol at 100℃; for 0.75h; Hydrolysis; | A 7% B 93% |
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With methanol; carbon tetrabromide; triphenylphosphine for 18h; Reflux; | 93% |
With piperidine In dichloromethane at 20℃; for 4h; | 92% |
Conditions | Yield |
---|---|
With triethanolamine In water at 20℃; for 18h; Sonication; Irradiation; Green chemistry; | 93% |
Conditions | Yield |
---|---|
microwave irradiation; | 92% |
Conditions | Yield |
---|---|
With lanthanum complex grafted upon hydrotalcite for 8h; pH=10; Reflux; | 92% |
scandium tris(trifluoromethanesulfonate) at 64℃; for 168h; | 81% |
With C7H10N2O2*Zn(2+)*2C7H9N2O2(1-)*H2O at 75℃; for 24h; Catalytic behavior; | 54 %Spectr. |
4-benzoyloxybenzoic acid methyl ester
A
4-(benzoyloxy)benzoic acid
B
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; potassium carbonate; 2-amino-benzenethiol at 100℃; for 0.75h; Hydrolysis; debenzoylation; | A 9% B 91% |
benzyl chloride
methyl 4-hydroxylbenzoate
4-benzyloxy-benzoic acid methyl ester
Conditions | Yield |
---|---|
With iodide; potassium carbonate In acetone for 7h; Reflux; | 100% |
With sodium methylate | |
With sodium ethanolate |
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 65℃; for 20h; | 100% |
With potassium carbonate In dimethyl sulfoxide at 20℃; for 8h; | 99% |
With potassium carbonate In acetone Heating; | 89% |
methyl 4-hydroxylbenzoate
methyl 3-bromo-4-hydroxybenzoate
Conditions | Yield |
---|---|
With ammonium metavanadate; aluminum tri-bromide; oxygen In 1,4-dioxane at 80℃; for 18h; | 100% |
With bromine In acetic acid Ambient temperature; | 99% |
With bromine In dichloromethane at 20℃; for 24h; | 95% |
1-undecen-11-ylbromide
methyl 4-hydroxylbenzoate
4-undec-10-enyloxybenzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: methyl 4-hydroxylbenzoate With potassium carbonate In acetonitrile at 70℃; Inert atmosphere; Stage #2: 1-undecen-11-ylbromide In acetonitrile for 12h; Reflux; Inert atmosphere; | 100% |
With potassium carbonate In acetone Etherification; | 94.9% |
With potassium carbonate; potassium iodide In butanone for 12h; Williamson reaction; Reflux; | 77.8% |
With sodium methylate In methanol Heating; |
3,4-dihydro-2H-pyran
methyl 4-hydroxylbenzoate
4-methoxycarbonylphenyl 2-tetrahydropyranyl ether
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In acetone for 15h; Ambient temperature; | 100% |
With pyridinium p-toluenesulfonate In acetone at 20℃; | 99% |
With 1,5-dichloro-9,10-anthraquinone In dichloromethane for 0.5h; UV-irradiation; | 90% |
2-(3-bromopropyl)isoindole-1,3-dione
methyl 4-hydroxylbenzoate
methyl 4-[3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propoxy]benzoate
Conditions | Yield |
---|---|
Stage #1: methyl 4-hydroxylbenzoate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 2h; Inert atmosphere; Stage #2: 2-(3-bromopropyl)isoindole-1,3-dione In dimethyl sulfoxide; mineral oil at 20℃; for 3.5h; Time; Inert atmosphere; | 100% |
Stage #1: methyl 4-hydroxylbenzoate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 3h; Stage #2: 2-(3-bromopropyl)isoindole-1,3-dione In dimethyl sulfoxide; mineral oil at 20℃; for 70h; | 89.3% |
With sodium hydride 1.) DMF, 40 deg C, 1 h, 2.) DMF, 90 deg C, 5 h; Yield given. Multistep reaction; |
benzyl bromide
methyl 4-hydroxylbenzoate
4-benzyloxy-benzoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: methyl 4-hydroxylbenzoate With potassium carbonate In acetone at 50℃; for 1h; Stage #2: benzyl bromide In acetone at 80℃; for 5h; | 100% |
Stage #1: methyl 4-hydroxylbenzoate With potassium carbonate In acetone at 50℃; for 1h; Stage #2: benzyl bromide In acetone at 80℃; for 5h; | 100% |
With potassium carbonate In acetone at 60℃; | 100% |
1-dodecylbromide
methyl 4-hydroxylbenzoate
methyl 4-(dodecyloxy)benzoate
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In acetonitrile for 24h; Heating; | 100% |
With potassium carbonate In N,N-dimethyl-formamide for 20h; Inert atmosphere; Reflux; | 98% |
Stage #1: methyl 4-hydroxylbenzoate With potassium carbonate In acetonitrile at 70℃; Inert atmosphere; Stage #2: 1-dodecylbromide In acetonitrile for 12h; Reflux; Inert atmosphere; | 96% |
trifluoromethylsulfonic anhydride
methyl 4-hydroxylbenzoate
4-carbomethoxyphenyl triflate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere; | 100% |
With pyridine In dichloromethane at 0 - 20℃; for 1h; | 98% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at -78 - 0℃; | 96% |
methyl 4-hydroxylbenzoate
propargyl bromide
methyl 4-(2-propynoxy)benzoate
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium carbonate In acetone; toluene for 72h; Reflux; | 100% |
With potassium carbonate In acetone Inert atmosphere; | 99% |
With potassium carbonate In acetone at 65℃; for 18h; Inert atmosphere; | 98% |
methyl 4-hydroxylbenzoate
cyanomethyl bromide
methyl 4-(cyanomethoxy)benzoate
Conditions | Yield |
---|---|
With potassium carbonate In acetone Heating; | 100% |
With potassium carbonate In acetone at 20℃; | 95.8% |
methyl 4-hydroxylbenzoate
methyl 4-hydroxycyclohexanecarboxylate
Conditions | Yield |
---|---|
With hydrogen; rhodium on aluminium In ethanol under 2327.2 Torr; for 96h; | 100% |
With hydrogen; Rh/Al2O3 In methanol under 2844.3 Torr; for 18h; | 98% |
With hydrogen; Rh on carbon In tetrahydrofuran under 76000 Torr; for 18h; | 98% |
Conditions | Yield |
---|---|
Stage #1: methyl 4-hydroxylbenzoate With potassium carbonate In acetonitrile at 70℃; Inert atmosphere; Stage #2: 1-bromo dodecane In acetonitrile for 12h; Reflux; Inert atmosphere; | 100% |
With potassium carbonate In N,N-dimethyl-formamide for 20h; Inert atmosphere; Reflux; | 96% |
With potassium carbonate In acetonitrile for 12h; Reflux; | 96% |
2-(N-tert-butoxycarbonylamino)ethanol
methyl 4-hydroxylbenzoate
4-(2-tert-butoxycarbonylaminoethoxy)benzoic acid methyl ester
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 20℃; for 20h; Condensation; | 100% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 5h; | |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 5.16h; | |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 20℃; for 17h; Cooling with ice; | 0.45 g |
methyl 4-hydroxylbenzoate
4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester
methyl 4-(2-N-BOC-piperidin-4-ylethoxy)benzoate
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 20℃; for 20h; Condensation; | 100% |
With triphenylphosphine tagged with poly-(ethyleneglycol)-ω-monomethyl ether; diethyl azodicarboxylate tagged with poly-(ethyleneglycol)-ω-monomethyl ether In tetrahydrofuran for 20h; Mitsunobu reaction; Inert atmosphere; |
methyl 4-hydroxylbenzoate
3-(4-nitro)-benzoyl-2(3H)-benzothiazolone
4-(4-nitro-benzoyloxy)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 2h; | 100% |
(S)-1-bromo-3,7-dimethyloctane
methyl 4-hydroxylbenzoate
methyl 4-((S)-3,7-dimethyloctyloxy) benzoate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 4h; Inert atmosphere; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 4h; Inert atmosphere; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 13h; | 94% |
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 110℃; Williamson etherification; |
4-(2-chloroethyl)morpholine hydrochride
methyl 4-hydroxylbenzoate
methyl 4-(2-morpholinoethoxy)benzoate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 50℃; | 100% |
With caesium carbonate In acetonitrile at 80 - 85℃; for 4h; Inert atmosphere; | 92% |
With potassium carbonate In acetone Heating; |
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 72h; Inert atmosphere; Reflux; | 100% |
With potassium carbonate In acetone for 72h; Inert atmosphere; Reflux; | 100% |
With potassium carbonate In acetone at 85℃; for 72h; Sealed tube; | 94.7% |
With sodium hydride In N,N-dimethyl-formamide at 60℃; | 80% |
chloroacetonitrile
methyl 4-hydroxylbenzoate
methyl 4-(cyanomethoxy)benzoate
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In acetone at 20 - 60℃; for 88h; | 100% |
With potassium carbonate; sodium iodide In acetone at 20 - 60℃; for 88h; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 4h; | 98% |
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With diisopropyl (E)-azodicarboxylate; triphenylphosphine In tetrahydrofuran; hexane; ethyl acetate | 100% |
4-(2-chloroethyl)morpholine hydrochride
methyl 4-hydroxylbenzoate
4-(2-morpholin-4-yl-ethoxy)-benzoic acid
Conditions | Yield |
---|---|
Stage #1: methyl 4-hydroxylbenzoate With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃; Stage #2: 4-(2-chloroethyl)morpholine hydrochride In DMF (N,N-dimethyl-formamide) at 100℃; for 2h; | 100% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50℃; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; | 99% |
Stage #1: methyl 4-hydroxylbenzoate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.333333h; Inert atmosphere; Stage #2: 3-chloroprop-1-ene In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; | 87% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; | 85.7% |
10-bromodec-1-ene
methyl 4-hydroxylbenzoate
methyl 4-(dec-9-enyloxy)benzoate
Conditions | Yield |
---|---|
Stage #1: methyl 4-hydroxylbenzoate With potassium carbonate In acetonitrile at 70℃; Inert atmosphere; Stage #2: 10-bromodec-1-ene In acetonitrile for 12h; Reflux; Inert atmosphere; | 100% |
methyl 4-hydroxylbenzoate
1-Bromo-2-butyne
methyl 4-(but-2-yn-1-yloxy)benzoate
Conditions | Yield |
---|---|
With potassium carbonate In butanone at 20℃; for 23h; Reflux; | 100% |
With potassium carbonate In butanone at 20℃; for 23h; Reflux; | 100% |
Stage #1: methyl 4-hydroxylbenzoate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h; Inert atmosphere; Stage #2: 1-Bromo-2-butyne In N,N-dimethyl-formamide; mineral oil at 19℃; for 20h; Inert atmosphere; | 79% |
2-Methoxyethoxymethyl chloride
methyl 4-hydroxylbenzoate
methyl 4-((2-methoxyethoxy)methoxy)benzoate
Conditions | Yield |
---|---|
Stage #1: methyl 4-hydroxylbenzoate With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 2-Methoxyethoxymethyl chloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 24h; | 100% |
Stage #1: methyl 4-hydroxylbenzoate With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 2-Methoxyethoxymethyl chloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 24h; | 100% |
methyl 4-hydroxylbenzoate
3,4-dichlorobenzyl bromide
4-(3,4-dichloro-benzyloxy)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 48h; | 100% |
With potassium carbonate In acetone at 65 - 80℃; for 5h; | |
With potassium carbonate In acetone at 80℃; for 5h; |
2,3,4,6-tetra-O-acetyl-d-glucopyranosyl trichloroacetimidate
methyl 4-hydroxylbenzoate
4-(Methoxycarbonyl)phenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside
Conditions | Yield |
---|---|
Stage #1: 2,3,4,6-tetra-O-acetyl-d-glucopyranosyl trichloroacetimidate; methyl 4-hydroxylbenzoate In dichloromethane at 0℃; for 0.166667h; Molecular sieve; Inert atmosphere; Stage #2: With boron trifluoride diethyl etherate In dichloromethane for 3h; Molecular sieve; Inert atmosphere; | 100% |
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