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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/631.html Product Name Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-01-2

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Shanghai Sutong Biotechnology Co.,Ltd

Appearance:Light yellow to off-white powder

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-01-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Manufacturer/High quality/Best price/In stock

Cas:161798-01-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl 2-(3-Formyl-4-Hydroxyphenyl)-4-Methyl Thiazole-5-Carboxylate supplier in China

Cas:161798-01-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate manufacturer/supplier

Cas:161798-01-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

1) Specialized in pharmaceutical industry since from 1987 2) ISO 9001:2015 & SGS audited supplier 3) Accept better payment terms : T.T 30-60 days.on the basic of pass SINOSURE credit investigation. 5) We have warehouse in USA with quickly shi

Febuxostat intermediate Cas:161798-01-2

Cas:161798-01-2

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate CAS No.:161798-01-2 Name: Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Molecular Structure Molecular Formula: C14H13NO4S

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Ethyl 2-(3-forMyl-4-hydroxyphenyl)-4-Methylthiazole-5-carboxylate

Cas:161798-01-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-01-2

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Cas:161798-01-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 161798-01-2-- ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China

TIANFUCHEM-- 161798-01-2-- ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate in stock

Cas:161798-01-2

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate manufacturer/supplier

Cas:161798-01-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 161798-01-2 with competitive price

Cas:161798-01-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Buy Quality Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161798-01-2 Factory Supply

Cas:161798-01-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS161798-01-2

Cas:161798-01-2

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Thiazolecarboxylicacid, 2-(3-formyl-4-hydroxyphenyl)-4-methyl-, ethyl ester 161798-01-2

Cas:161798-01-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS: 161798-01-2 MF: C14H13NO4S MW: 291.32 EINECS: 692-179-2 Mol File: 161798-01-2.mol ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxy

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Cas:161798-01-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

organic intermediates, ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS:161798-01-2

Cas:161798-01-2

Min.Order:1 Kilogram

FOB Price: $72.0 / 78.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS:161798-01-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermedi

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS:161798-01-2

Cas:161798-01-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:161798-01-2

Cas:161798-01-2

Min.Order:0

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Type:Lab/Research institutions

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Lonwin Chemical Group Limited

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS: 161798-01-2 Specification Product Name: Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Synonyms: Ethyl 2-

Factory supply ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Cas:161798-01-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Hangzhou Yunuo Chemical Co., Ltd is located in Hangzhou city China. As a global supplier in the chemical industry, Yunuochem is to create added value for customers around the world. Sticking to such business idea of "Good faith wins the busin

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-01-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Synonyms: 161798-01-2;Febuxostat intermediate3;ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate;2-(3-Formyl-4-hydroxy-phenyl)-4-methyl-thiazole-5-

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Manufactory best quality

Cas:161798-01-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 2-(3-Formyy-4-Hydroxy Phenyl)-4-Methyl Thiazole-5-Carboxylate

Cas:161798-01-2

Min.Order:0

Negotiable

Type:Manufacturers

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-01-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:Pale Yellow to Yellow solid Storage:under inert gas (nitrogen or Argon) at 2-8°C Application:Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a product prepared via reaction 4-Hydroxybenzene-1-benzothiomide w

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Cas:161798-01-2

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Stage #1: (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) With n-butyllithium In tetrahydrofuran; hexane at -10℃; for 0.2h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -10℃; for 0.5h; Inert atmosphere;
Stage #3: With acetic acid In tetrahydrofuran; hexane at 10℃; for 0.166667h; Time; Inert atmosphere;
96.6%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

hexamethylenetetramine
100-97-0

hexamethylenetetramine

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
With methanesulfonic acid; boric acid In cyclohexane at 75 - 100℃; for 7h; Temperature; Reagent/catalyst; Solvent; Duff Aldehyde Synthesis;91.2%
Stage #1: (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) With methanesulfonic acid; boric acid In cyclohexane at 80℃;
Stage #2: hexamethylenetetramine In cyclohexane at 75℃; for 7h; Temperature;
91.2%
With water; acetic acid; trifluoroacetic acid at 100℃; for 2.5h;90%
ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

hexamethylenetetramine
100-97-0

hexamethylenetetramine

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid for 20h; Reflux;80%
hexamethylenetetramine
100-97-0

hexamethylenetetramine

2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester hydrochloride

2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester hydrochloride

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
With phosphoric acid at 70 - 95℃;75.2%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

acetic acid
64-19-7

acetic acid

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Stage #1: (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester); acetic acid With hexamethylenetetramine at 90℃; for 12h;
Stage #2: With hydrogenchloride In water at 75℃; for 0.5h;
29%
With hydrogenchloride; hexamethylenetetramine In water at 90℃; for 12h;
ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: spirit / 2.5 h / 60 - 65 °C
2: methanesulfonic acid / 10 h / 75 °C
View Scheme
Multi-step reaction with 2 steps
1.1: isopropyl alcohol / 25 - 85 °C
2.1: trifluoroacetic acid / 24 h / 80 °C
2.2: 0.17 h
View Scheme
4-hydroxythiobenzamide
25984-63-8

4-hydroxythiobenzamide

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: spirit / 2.5 h / 60 - 65 °C
2: methanesulfonic acid / 10 h / 75 °C
View Scheme
Multi-step reaction with 2 steps
1.1: isopropyl alcohol / 25 - 85 °C
2.1: trifluoroacetic acid / 24 h / 80 °C
2.2: 0.17 h
View Scheme
Multi-step reaction with 2 steps
1: ethanol / Reflux
2: phosphorus pentoxide
View Scheme
C8H11ClO4

C8H11ClO4

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: isopropyl alcohol / 75 °C
2.1: PPA / 75 °C
2.2: 20 °C
View Scheme
4-cyanophenol
767-00-0

4-cyanophenol

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetraphosphorus decasulfide / ethanol / 12 h / 70 °C
2.1: isopropyl alcohol / 3 h / 55 - 85 °C
3.1: hexamethylenetetramine / 12 h / 90 °C
3.2: 0.5 h / 75 °C
View Scheme
Multi-step reaction with 3 steps
1: polyphosphoric acid / water / 40 - 80 °C
2: phosphoric acid / water; ethanol / 30 - 80 °C
3: sulfuric acid / 60 - 120 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydrogensulfide; magnesium chloride monohydrate / 3 h / 20 °C
2: PPA / 0.25 h / Microwave irradiation
3: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h / Microwave irradiation
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

formaldehyd
50-00-0

formaldehyd

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
With triethylamine; magnesium chloride In tetrahydrofuran for 0.166667h; Microwave irradiation;
ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / 2 h / Reflux
2: water; trifluoroacetic acid; acetic acid / 2.5 h / 100 °C
View Scheme
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate With hydroxylamine hydrochloride In N,N-dimethyl-formamide for 0.5h;
Stage #2: With acetyl chloride In N,N-dimethyl-formamide at 90℃;
99%
Stage #1: ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate With hydroxylamine hydrochloride In N,N-dimethyl-formamide for 0.5h;
Stage #2: With acetyl chloride In N,N-dimethyl-formamide at 90℃;
99%
With formic acid; hydroxylamine hydrochloride; sodium acetate at 100 - 105℃; for 10h;97.6%
Isobutyl bromide
78-77-3

Isobutyl bromide

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

febuxostat

febuxostat

Conditions
ConditionsYield
With potassium carbonate; N,N-dimethyl-formamide In toluene at 105℃; for 4h;98.71%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

allyl bromide
106-95-6

allyl bromide

ethyl 2-[4-(allyloxy)-3-formylphenyl]-4-methyl-1,3-thiazole-5-carboxylate

ethyl 2-[4-(allyloxy)-3-formylphenyl]-4-methyl-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With potassium carbonate In ethanol at 70℃; for 10h; regioselective reaction;97%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

2-methylpropyl phenylphosphinate
13336-52-2

2-methylpropyl phenylphosphinate

C24H28NO6PS

C24H28NO6PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;95%
2-amino-benzthiazole
136-95-8

2-amino-benzthiazole

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

C21H17N3O3S2

C21H17N3O3S2

Conditions
ConditionsYield
With acetic acid In methanol Reflux;95%
Isobutyl bromide
78-77-3

Isobutyl bromide

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 75 - 85℃; for 6h;94.7%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h;90%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide90%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

propyl phenyl-H-phosphinate
6911-99-5

propyl phenyl-H-phosphinate

C23H26NO6PS

C23H26NO6PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;94%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

isobutyl p-toluenesulfonate
4873-56-7

isobutyl p-toluenesulfonate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; Temperature;92.7%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

C18H24NO7PS

C18H24NO7PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;92%
1-bromo-butane
109-65-9

1-bromo-butane

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

C18H21NO4S

C18H21NO4S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80 - 100℃; for 8h;92%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

C9H11O3P

C9H11O3P

C23H24NO7PS

C23H24NO7PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;91%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Dimethyl phosphite
868-85-9

Dimethyl phosphite

C16H20NO7PS

C16H20NO7PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;89%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

C13H12ClO2P

C13H12ClO2P

C27H25ClNO6PS

C27H25ClNO6PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;89%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one
88735-43-7

2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one

thiosemicarbazide
79-19-6

thiosemicarbazide

ethyl 2-(4-hydroxy-3-((2-(4-(3-oxo-3H-benzo[f]chromen-2-yl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(4-hydroxy-3-((2-(4-(3-oxo-3H-benzo[f]chromen-2-yl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Reflux; Green chemistry;87%
diphenyl hydrogen phosphite
4712-55-4

diphenyl hydrogen phosphite

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

C26H24NO7PS

C26H24NO7PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;86%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

C13H12NO4P

C13H12NO4P

C27H25N2O8PS

C27H25N2O8PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;86%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

thiosemicarbazide
79-19-6

thiosemicarbazide

para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

ethyl 2-(3-((2-(4-(4-bromophenyl)thiazol-2-yl)hydrazono)methyl)-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((2-(4-(4-bromophenyl)thiazol-2-yl)hydrazono)methyl)-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Reflux; Green chemistry;86%
isobutyl methanesulfonate
16156-53-9

isobutyl methanesulfonate

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 95 - 100℃; Temperature;85.5%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

thiosemicarbazide
79-19-6

thiosemicarbazide

4-chlorobenzoylmethyl bromide
536-38-9

4-chlorobenzoylmethyl bromide

ethyl 2-(3-((2-(4-(4-chlorophenyl)thiazol-2-yl)hydrazono)methyl)-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((2-(4-(4-chlorophenyl)thiazol-2-yl)hydrazono)methyl)-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Reflux; Green chemistry;85%
3-bromoacetylcoumarin
29310-88-1

3-bromoacetylcoumarin

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

thiosemicarbazide
79-19-6

thiosemicarbazide

ethyl 2-(4-hydroxy-3-((2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(4-hydroxy-3-((2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Reflux; Green chemistry;85%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

isobutyl benzenesulfonate
24698-43-9

isobutyl benzenesulfonate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 95 - 100℃;84.4%
Isobutyl bromide
78-77-3

Isobutyl bromide

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
160844-75-7

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate With hydroxylamine hydrochloride In dimethyl sulfoxide at 40℃; for 0.5h;
Stage #2: With acetyl chloride In dimethyl sulfoxide at 70 - 80℃;
Stage #3: Isobutyl bromide With potassium carbonate In dimethyl sulfoxide at 20 - 80℃;
84%
Stage #1: ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate With hydroxylamine hydrochloride In dimethyl sulfoxide for 0.5h;
Stage #2: With acetyl chloride In dimethyl sulfoxide at 70 - 80℃;
Stage #3: Isobutyl bromide With potassium carbonate In dimethyl sulfoxide at 70 - 80℃; for 5h;
84%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

p-benzoquinone
106-51-4

p-benzoquinone

ethyl 2-(5,8-dihydroxy-9-oxo-9H-xanthen-2-yl)-4-methylthiazole-5-carboxylate

ethyl 2-(5,8-dihydroxy-9-oxo-9H-xanthen-2-yl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate In 1,2-dichloro-ethane at 90℃; for 16h;84%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

thiosemicarbazide
79-19-6

thiosemicarbazide

α-bromoacetophenone
70-11-1

α-bromoacetophenone

ethyl 2-(4-hydroxy-3-((2-(4-phenylthiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(4-hydroxy-3-((2-(4-phenylthiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 2h; Reflux; Green chemistry;83%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

ethyl Phenylphosphinate
172487-18-2

ethyl Phenylphosphinate

C22H24NO6PS

C22H24NO6PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;81%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

4-Nitrophenacyl bromide
99-81-0

4-Nitrophenacyl bromide

thiosemicarbazide
79-19-6

thiosemicarbazide

ethyl 2-(3-((2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazono)methyl)-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazono)methyl)-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 4h; Reflux; Green chemistry;80%
dibutyl hydrogen phosphite
1809-19-4

dibutyl hydrogen phosphite

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

C22H32NO7PS

C22H32NO7PS

Conditions
ConditionsYield
With N,N'-dimethylpiperazine In tetrahydrofuran at 60℃; for 3h;78%
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