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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Manufacturer/High quality/Best price/In stock

Cas:161797-99-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxytic Acid Ethyl Ester supplier in China

Cas:161797-99-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/632.html Product Name Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carbo

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161797-99-5

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate manufacturer/supplier

Cas:161797-99-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate CAS NO.:161797-99-5 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business exper

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:W

Ethyl 2-(4-hydroxyphenyl)-4-Methylthiazole-5-carboxylate

Cas:161797-99-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161797-99-5

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylic acid

Cas:161797-99-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 161797-99-5- ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China

TIANFUCHEM-- 161797-99-5- ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate in stock

Cas:161797-99-5

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Manufacturers Supply Top Quality High Purity Pharmaceutical Intermediate Powder

Cas:161797-99-5

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 161797-99-5 with competitive price

Cas:161797-99-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Shandong Hanjiang Chemical Co., Ltd.

Company profile Shandong Hanjiang Chemical Co., Ltd. is located in Qilu Petrochemical Industrial Park, Zibo City, Shandong Province, involving pesticide, medicine, chemical industry, coating, dye, reagent, polyester, petrochemical and other fields.

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS NO 161797-99-5

Cas:161797-99-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Febuxostat Antihyperlipidemic Febuxostat Price CAS: 161797-99-5 with High Purity

Cas:161797-99-5

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Thiazolecarboxylicacid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester 161797-99-5

Cas:161797-99-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

5-Thiazolecarboxylicacid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester/ LIDE PHARMA- Factory supply / Best price

Cas:161797-99-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS: 161797-99-5 MF: C13H13NO3S MW: 263.31 EINECS: 605-268-8 Mol File: 161797-99-5.mol ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Structure eth

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Cas:161797-99-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS:161797-99-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spe

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate CAS:161797-99-5

Cas:161797-99-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:161797-99-5

Cas:161797-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate CAS: 161797-99-5 Specification product name ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate cas no. 161797-99-5 appearance yellowish o

Factory supply Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161797-99-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161797-99-5

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Synonyms: 161797-99-5;ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate;Intermediates of Febuxostat;5-T

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Manufactory best quality

Cas:161797-99-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161797-99-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

ethyl 2-(4-hydroxyphenyl)-5-carboxylate cas no.161797-99-5 0.98

Cas:161797-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161797-99-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Cas:161797-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Cas:161797-99-5

Min.Order:1 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ethyl 2-(4-Hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Cas:161797-99-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Synthetic route

4-hydroxythiobenzamide
25984-63-8

4-hydroxythiobenzamide

ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
In ethanol at 65 - 70℃; for 3h;98%
In spirit at 60 - 65℃; for 2.5h;90.7%
In isopropyl alcohol at 55 - 85℃; for 3h;58%
ethyl 4-methyl-2-[4-(methoxy)phenyl]-1,3-thiazole-5-carboxylate
54032-88-1

ethyl 4-methyl-2-[4-(methoxy)phenyl]-1,3-thiazole-5-carboxylate

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
Stage #1: ethyl 4-methyl-2-[4-(methoxy)phenyl]-1,3-thiazole-5-carboxylate With boron tribromide In dichloromethane at 20℃;
Stage #2: With methanol In dichloromethane
95%
4-hydroxythiobenzamide
25984-63-8

4-hydroxythiobenzamide

ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
In ethanol for 3h; Reflux;91%
In ethanol for 2h; Reflux;84%
ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
Stage #1: 4-cyanophenol With sodium hydroxide; hydrogen sulfide In ethanol at 80℃; under 1551.49 - 3102.97 Torr;
Stage #2: With hydrogenchloride In ethanol pH=3.5;
Stage #3: ethyl 2-chloro-3-oxo-butyrate In ethanol at 70℃; for 2 - 3h; Heating / reflux;
84.2%
ethyl 2-chloroacetoacetate(1.1 eq.)

ethyl 2-chloroacetoacetate(1.1 eq.)

4-cyanophenol
767-00-0

4-cyanophenol

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In ethanol50.50 g (84.2%)
4-hydroxythiobenzamide
25984-63-8

4-hydroxythiobenzamide

C8H11ClO4

C8H11ClO4

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
In isopropyl alcohol at 75℃;
4-cyanophenol
767-00-0

4-cyanophenol

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: O,O-Diethyl hydrogen phosphorodithioate / water / 3 h / 50 °C
2: ethanol / 3 h / 65 - 70 °C
View Scheme
Multi-step reaction with 2 steps
1: tetraphosphorus decasulfide / ethanol / 12 h / 70 °C
2: isopropyl alcohol / 3 h / 55 - 85 °C
View Scheme
Multi-step reaction with 2 steps
1: polyphosphoric acid / water / 40 - 80 °C
2: phosphoric acid / water; ethanol / 30 - 80 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogensulfide; magnesium chloride monohydrate / 3 h / 20 °C
2: PPA / 0.25 h / Microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1.1: ammonium chloride; hydrogen sulfide / N,N-dimethyl-formamide / 50 - 95 °C / 1520.1 - 3040.2 Torr / Autoclave; Inert atmosphere
2.1: ethanol / 60 - 80 °C
2.2: 25 - 30 °C
View Scheme
4-cyanophenol
767-00-0

4-cyanophenol

ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
Stage #1: 4-cyanophenol With hydrogen sulfide; sodium hydroxide In ethanol at 80℃;
Stage #2: ethyl 2-chloro-3-oxo-butyrate In ethanol at 70℃; Reflux;
4-hydroxythiobenzamide
25984-63-8

4-hydroxythiobenzamide

ethyl (2-chloroaceto)acetate
638-07-3

ethyl (2-chloroaceto)acetate

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
In isopropyl alcohol at 85℃; for 2h;
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; formic acid; sodium formate / 2 h / 105 °C / Green chemistry
2: hydrogenchloride / water / 2 h / 60 °C / Green chemistry
3: ethanol / 3 h / 80 °C / Green chemistry
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide; hydroxylamine hydrochloride / water; methanol / 20 - 25 °C
2.1: tetraphosphorus decasulfide / toluene / 80 - 85 °C
3.1: ethanol / 60 - 80 °C
3.2: 25 - 30 °C
View Scheme
4-hydroxybenzaldehyde oxime
699-06-9, 60221-52-5, 60221-53-6

4-hydroxybenzaldehyde oxime

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetraphosphorus decasulfide / toluene / 80 - 85 °C
2.1: ethanol / 60 - 80 °C
2.2: 25 - 30 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Stage #1: (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) With n-butyllithium In tetrahydrofuran; hexane at -10℃; for 0.2h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -10℃; for 0.5h; Inert atmosphere;
Stage #3: With acetic acid In tetrahydrofuran; hexane at 10℃; for 0.166667h; Time; Inert atmosphere;
96.6%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

hexamethylenetetramine
100-97-0

hexamethylenetetramine

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
With methanesulfonic acid; boric acid In cyclohexane at 75 - 100℃; for 7h; Temperature; Reagent/catalyst; Solvent; Duff Aldehyde Synthesis;91.2%
Stage #1: (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) With methanesulfonic acid; boric acid In cyclohexane at 80℃;
Stage #2: hexamethylenetetramine In cyclohexane at 75℃; for 7h; Temperature;
91.2%
With water; acetic acid; trifluoroacetic acid at 100℃; for 2.5h;90%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Isobutyl bromide
78-77-3

Isobutyl bromide

ethyl 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
144060-97-9

ethyl 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 85℃; for 2h;83%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

Isobutyl bromide
78-77-3

Isobutyl bromide

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
160844-75-7

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester); Isobutyl bromide; N,N-dimethyl-formamide With potassium carbonate at 90 - 95℃;
Stage #2: With trichlorophosphate at 0 - 60℃; for 2h;
Stage #3: With ammonia; iodine at 10 - 20℃; for 2h; Temperature; Solvent;
83%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

3-(2-bromobutyl)-4-hydroxy-2H-chromen-2-one

3-(2-bromobutyl)-4-hydroxy-2H-chromen-2-one

C26H25NO6S

C26H25NO6S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 6h;77%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

3-(2-bromoethyl)-4-hydroxy-2H-chromen-2-one

3-(2-bromoethyl)-4-hydroxy-2H-chromen-2-one

C24H21NO6S

C24H21NO6S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 6h;72%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

acetic acid
64-19-7

acetic acid

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Conditions
ConditionsYield
Stage #1: (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester); acetic acid With hexamethylenetetramine at 90℃; for 12h;
Stage #2: With hydrogenchloride In water at 75℃; for 0.5h;
29%
With hydrogenchloride; hexamethylenetetramine In water at 90℃; for 12h;
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

ethyl 4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazole-5-carboxylate
929693-89-0

ethyl 4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With triethylamine In acetone; toluene at 20℃; for 24h;
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid
929693-90-3

4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / toluene; acetone / 24 h / 20 °C
2: 50 percent / NaOH / ethanol; H2O / 1.5 h / 85 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-[4-({[2-(4-hydroxy-phenyl)-4-methyl-thiazole-5-carbonyl]-amino}-methyl)-phenoxy]-2-methyl-propionic acid

2-[4-({[2-(4-hydroxy-phenyl)-4-methyl-thiazole-5-carbonyl]-amino}-methyl)-phenoxy]-2-methyl-propionic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Et3N / toluene; acetone / 24 h / 20 °C
2: 50 percent / NaOH / ethanol; H2O / 1.5 h / 85 °C
3: 73 percent / HOBT; EDCI; Et3N / dimethylformamide / 20 °C
4: 74 percent / aq. NaOH / tetrahydrofuran; ethanol / 4 h / 70 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-[4-({[2-(4-methanesulfonyloxy-phenyl)-4-methyl-thiazole-5-carbonyl]-amino}-methyl)-phenoxy]-2-methyl-propionic acid

2-[4-({[2-(4-methanesulfonyloxy-phenyl)-4-methyl-thiazole-5-carbonyl]-amino}-methyl)-phenoxy]-2-methyl-propionic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Et3N / toluene; acetone / 24 h / 20 °C
2: 50 percent / NaOH / ethanol; H2O / 1.5 h / 85 °C
3: 73 percent / HOBT; EDCI; Et3N / dimethylformamide / 20 °C
4: 15 percent / aq. LiOH / tetrahydrofuran / 24 h / 20 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate
929693-91-4

ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Et3N / toluene; acetone / 24 h / 20 °C
2: 50 percent / NaOH / ethanol; H2O / 1.5 h / 85 °C
3: 73 percent / HOBT; EDCI; Et3N / dimethylformamide / 20 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

febuxostat

febuxostat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: methanesulfonic acid / 10 h / 75 °C
2.1: hydroxylamine hydrochloride; sodium formate; formic acid / 8 h / 100 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 75 °C
4.1: water; barium hydroxide octahydrate / tetrahydrofuran; spirit / 60 °C
4.2: 35 °C / pH 0.5 - 0.8
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 40 h / Reflux
2: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C
3: hydroxylamine hydrochloride; sodium formate; formic acid / 5 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / 40 h / Reflux
2.1: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C
3.1: hydroxylamine hydrochloride; sodium formate; formic acid / 5 h / Reflux
4.1: potassium carbonate; water / methanol / 3 h / Reflux
4.2: 40 °C / pH 2.3 - 2.7
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanesulfonic acid / 10 h / 75 °C
2: hydroxylamine hydrochloride; sodium formate; formic acid / 8 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: phosphorus pentoxide
2: hydroxylamine hydrochloride; sodium acetate; formic acid
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
160844-75-7

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanesulfonic acid / 10 h / 75 °C
2: hydroxylamine hydrochloride; sodium formate; formic acid / 8 h / 100 °C
3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 75 °C
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 40 h / Reflux
2: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C
3: hydroxylamine hydrochloride; sodium formate; formic acid / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / 24 h / 80 °C
1.2: 0.17 h
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5.08 h / 25 - 85 °C
3.1: sodium formate; formic acid; hydroxylamine / 2.17 h / 25 - 100 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
144060-62-8

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / 40 h / Reflux
2.1: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C
3.1: potassium carbonate; water / methanol / 3 h / Reflux
3.2: 40 °C / pH 5.3 - 5.7
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / 40 h / Reflux
2: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C
View Scheme
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / 24 h / 80 °C
1.2: 0.17 h
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5.08 h / 25 - 85 °C
View Scheme
Multi-step reaction with 2 steps
1: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h / Microwave irradiation
2: potassium carbonate / acetonitrile / 0.17 h / Microwave irradiation
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

C16H16NO4S(1-)*K(1+)

C16H16NO4S(1-)*K(1+)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 40 h / Reflux
2: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C
3: potassium carbonate / water; methanol / 4 h / Reflux
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: phosphorus pentoxide
2.1: hydroxylamine hydrochloride; sodium acetate; formic acid
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 80 °C
3.2: 4 h / 80 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: phosphorus pentoxide
2.1: hydroxylamine hydrochloride; sodium acetate; formic acid
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 80 °C
3.2: 4 h / 80 °C
4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1.5 h / 60 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

ethyl 2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

ethyl 2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentoxide
2: hydroxylamine hydrochloride; sodium acetate; formic acid
3: potassium carbonate; sodium dihydrogenphosphate / water; acetonitrile / 12 h / 150 °C / Sealed tube
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: phosphorus pentoxide
2: hydroxylamine hydrochloride; sodium acetate; formic acid
3: potassium carbonate; sodium dihydrogenphosphate / water; acetonitrile / 12 h / 150 °C / Sealed tube
4: sodium hydroxide; water / ethanol; tetrahydrofuran / 1.5 h / 60 °C
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

3-{2-cyano-4-[5-(ethoxycarbonyl)-4-methylthiazol-2-yl]phenoxy}-2-methylpropanoic acid

3-{2-cyano-4-[5-(ethoxycarbonyl)-4-methylthiazol-2-yl]phenoxy}-2-methylpropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: phosphorus pentoxide
2.1: hydroxylamine hydrochloride; sodium acetate; formic acid
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 80 °C
3.2: 4 h / 80 °C
4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium chlorite / water; acetonitrile; aq. phosphate buffer / 6 h / 35 °C / pH 6.7
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-[4-(2-carboxypropoxy)-3-cyanophenyl]-4-methylthiazole-5-carboxylic acid

2-[4-(2-carboxypropoxy)-3-cyanophenyl]-4-methylthiazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: phosphorus pentoxide
2.1: hydroxylamine hydrochloride; sodium acetate; formic acid
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 80 °C
3.2: 4 h / 80 °C
4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium chlorite / water; acetonitrile; aq. phosphate buffer / 6 h / 35 °C / pH 6.7
5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1.5 h / 60 °C
View Scheme
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