Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:161798-03-4
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/630.html Product Name
Cas:161798-03-4
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
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inquiryUnique advantages of Febuxostat Impurity Cas 161798-03-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:25kg/drum Application:pharmaceut
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inquiryEthyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate CAS No.:161798-03-4 Name: Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Molecular Structure: Molecular Formula: C18H21NO4S M
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:161798-03-4
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inquiryTIANFUCHEM-- 161798-03-4-- ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China
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inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:161798-03-4
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inquiryHubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy.
Cas:161798-03-4
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:161798-03-4
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inquiryProduct Name: ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE CAS: 161798-03-4 MF: C18H21NO4S MW: 347.43 EINECS: 700-743-7 Mol File: 161798-03-4.mol ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBO
Cas:161798-03-4
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inquiryETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE CAS:161798-03-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermed
Cas:161798-03-4
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
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inquiryethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate CAS: 161798-03-4 Specification product name ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate cas no. 161798-03-4 appear
Cas:161798-03-4
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:161798-03-4
Min.Order:10 Kilogram
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:161798-03-4
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Cas:161798-03-4
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inquiryethyl 2-chloro-3-oxo-butyrate
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 60℃; for 4h; | 97% |
Isobutyl bromide
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 75 - 85℃; for 6h; | 94.7% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h; | 90% |
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide | 90% |
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
isobutyl p-toluenesulfonate
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; Temperature; | 92.7% |
isobutyl methanesulfonate
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 95 - 100℃; Temperature; | 85.5% |
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
isobutyl benzenesulfonate
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 95 - 100℃; | 84.4% |
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trifluoroacetic acid / 40 h / Reflux 2: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: trifluoroacetic acid / 24 h / 80 °C 1.2: 0.17 h 2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5.08 h / 25 - 85 °C View Scheme | |
Multi-step reaction with 2 steps 1: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h / Microwave irradiation 2: potassium carbonate / acetonitrile / 0.17 h / Microwave irradiation View Scheme |
ethyl 2-chloro-3-oxo-butyrate
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: isopropyl alcohol / 25 - 85 °C 2.1: trifluoroacetic acid / 24 h / 80 °C 2.2: 0.17 h 3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5.08 h / 25 - 85 °C View Scheme |
4-hydroxythiobenzamide
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: isopropyl alcohol / 25 - 85 °C 2.1: trifluoroacetic acid / 24 h / 80 °C 2.2: 0.17 h 3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5.08 h / 25 - 85 °C View Scheme | |
Multi-step reaction with 3 steps 1: phosphoric acid / water; ethanol / 30 - 80 °C 2: sulfuric acid / 60 - 120 °C 3: potassium carbonate / N,N-dimethyl-formamide / 60 - 115 °C View Scheme | |
Multi-step reaction with 3 steps 1: PPA / 0.25 h / Microwave irradiation 2: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h / Microwave irradiation 3: potassium carbonate / acetonitrile / 0.17 h / Microwave irradiation View Scheme | |
Multi-step reaction with 3 steps 1: ethanol / 2 h / Reflux 2: water; trifluoroacetic acid; acetic acid / 2.5 h / 100 °C 3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C 2: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C 3: N,N-dimethyl-formamide / 4 h / 60 °C View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C 2: N,N-dimethyl-formamide / 4 h / 60 °C View Scheme |
4-cyanophenol
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C 2: aluminum (III) chloride / nitromethane / 5.5 h / 0 - 5 °C 3: iron(III) sulfate; water / toluene / 0.7 h / 110 °C 4: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C 5: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C 6: N,N-dimethyl-formamide / 4 h / 60 °C View Scheme | |
Multi-step reaction with 6 steps 1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C 2: aluminum (III) chloride / nitromethane / 5.5 h / 0 °C 3: iron(III) sulfate; water / toluene / 0.7 h / 110 °C 4: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C 5: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C 6: N,N-dimethyl-formamide / 4 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: polyphosphoric acid / water / 40 - 80 °C 2: phosphoric acid / water; ethanol / 30 - 80 °C 3: sulfuric acid / 60 - 120 °C 4: potassium carbonate / N,N-dimethyl-formamide / 60 - 115 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydrogensulfide; magnesium chloride monohydrate / 3 h / 20 °C 2: PPA / 0.25 h / Microwave irradiation 3: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h / Microwave irradiation 4: potassium carbonate / acetonitrile / 0.17 h / Microwave irradiation View Scheme |
4-(2-methylpropoxy)benzonitrile
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: aluminum (III) chloride / nitromethane / 5.5 h / 0 - 5 °C 2: iron(III) sulfate; water / toluene / 0.7 h / 110 °C 3: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C 4: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C 5: N,N-dimethyl-formamide / 4 h / 60 °C View Scheme | |
Multi-step reaction with 5 steps 1: aluminum (III) chloride / nitromethane / 5.5 h / 0 °C 2: iron(III) sulfate; water / toluene / 0.7 h / 110 °C 3: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C 4: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C 5: N,N-dimethyl-formamide / 4 h / 60 °C View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: iron(III) sulfate; water / toluene / 0.7 h / 110 °C 2: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C 3: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C 4: N,N-dimethyl-formamide / 4 h / 60 °C View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phosphoric acid / 70 - 95 °C 2: potassium carbonate / N,N-dimethyl-formamide / 100 - 110 °C View Scheme | |
Multi-step reaction with 2 steps 1: phosphoric acid / 70 - 95 °C 2: potassium carbonate / N,N-dimethyl-formamide / 95 - 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: phosphoric acid / 70 - 95 °C 2: potassium carbonate / N,N-dimethyl-formamide / 95 - 100 °C View Scheme |
ethyl bromide
2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 60℃; for 20h; |
ethyl 2-bromoacetoacetate
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol / 2 h / Reflux 2: water; trifluoroacetic acid; acetic acid / 2.5 h / 100 °C 3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With ammonium hydroxide; sodium persulfate; sodium iodide; iron(II) chloride In 1,2-dichloro-ethane at 20 - 50℃; for 16h; Reagent/catalyst; Solvent; Temperature; | 98% |
With hydroxylamine hydrochloride; sodium formate In formic acid for 3h; Product distribution / selectivity; Reflux; | 96% |
With formic acid; hydroxylamine hydrochloride; sodium formate at 100℃; for 7h; | 95.2% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
aniline
phosphonic acid diethyl ester
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Kabachnik-Fields Reaction; Green chemistry; | 96% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
4-methoxy-aniline
phosphonic acid diethyl ester
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 96% |
4-aminophenyl phenyl sulfide
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
phosphonic acid diethyl ester
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 96% |
4-trifluoromethylphenylamine
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
phosphonic acid diethyl ester
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 95% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
phosphonic acid diethyl ester
4-fluoroaniline
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 94% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
phosphonic acid diethyl ester
2-iodo-4-(trifluoromethyl)aniline
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 94% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
phosphonic acid diethyl ester
3-chloro-aniline
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 92% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
4-nitro-aniline
phosphonic acid diethyl ester
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 92% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-iodophenylamine
phosphonic acid diethyl ester
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 91% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
thiosemicarbazide
para-bromophenacyl bromide
Conditions | Yield |
---|---|
With acetic acid In ethanol for 3h; Reflux; Green chemistry; | 90% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
phosphonic acid diethyl ester
4-bromo-aniline
Conditions | Yield |
---|---|
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry; | 90% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
thiosemicarbazide
4-chlorobenzoylmethyl bromide
Conditions | Yield |
---|---|
With acetic acid In ethanol for 4h; Reflux; Green chemistry; | 88% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
thiosemicarbazide
α-bromoacetophenone
Conditions | Yield |
---|---|
With acetic acid In ethanol for 3h; Reflux; Green chemistry; | 86% |
3-bromoacetylcoumarin
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
thiosemicarbazide
Conditions | Yield |
---|---|
With acetic acid In ethanol for 4h; Reflux; Green chemistry; | 86% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one
thiosemicarbazide
Conditions | Yield |
---|---|
With acetic acid In ethanol for 3h; Reflux; Green chemistry; | 83% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
4-Nitrophenacyl bromide
thiosemicarbazide
Conditions | Yield |
---|---|
With acetic acid In ethanol for 4h; Reflux; Green chemistry; | 81% |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; sodium formate; formic acid / 100 °C 2: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: hydroxylamine hydrochloride / methanol / 65 °C 2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C 2.2: hydrose / 5 h / 25 °C / pH 2 - 3 3.1: sodium formate; formic acid / 100 °C View Scheme | |
With formic acid; hydroxylamine hydrochloride; sodium formate for 5h; Reflux; |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester With water; sodium hydroxide In methanol at 75℃; for 0.5h; Stage #2: With hydrogenchloride In methanol; water at 25℃; for 5h; pH=2 - 3; | |
Stage #1: 2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester With sodium hydroxide In ethanol at 80℃; for 4h; Stage #2: With hydrogenchloride In ethanol; water pH=~ 3; | |
Stage #1: 2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester With water; potassium carbonate In methanol for 3h; Reflux; Stage #2: With hydrogenchloride In water at 40℃; pH=5.3 - 5.7; Product distribution / selectivity; |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
ethyl 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride In methanol at 65℃; | |
With formic acid; hydroxylamine hydrochloride; sodium formate at 100 - 110℃; |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydroxylamine hydrochloride / methanol / 65 °C 2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C 2.2: hydrose / 5 h / 25 °C / pH 2 - 3 View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride; sodium formate; formic acid / 100 °C 2: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C 3: ethyl acetate; cyclohexane; methanol / 3 h View Scheme | |
Multi-step reaction with 4 steps 1.1: hydroxylamine hydrochloride / methanol / 65 °C 2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C 2.2: hydrose / 5 h / 25 °C / pH 2 - 3 3.1: sodium formate; formic acid / 100 °C 4.1: ethyl acetate; cyclohexane; methanol / 3 h View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride; sodium formate; formic acid / 100 °C 2: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C 3: toluene / 10 h View Scheme | |
Multi-step reaction with 4 steps 1.1: hydroxylamine hydrochloride / methanol / 65 °C 2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C 2.2: hydrose / 5 h / 25 °C / pH 2 - 3 3.1: sodium formate; formic acid / 100 °C 4.1: toluene / 10 h View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C 1.2: hydrose / 5 h / 25 °C / pH 2 - 3 2.1: ethyl acetate; cyclohexane; methanol / 3 h View Scheme |
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid n-butylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C 1.2: hydrose / 5 h / 25 °C / pH 2 - 3 2.1: toluene / 10 h View Scheme |
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