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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

Cas:161798-03-4

Min.Order:1 Gram

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Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Manufacturer/High quality/Best price/In stock

Cas:161798-03-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/630.html Product Name

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-03-4

Min.Order:1 Gram

FOB Price: $63.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate manufacturer/supplier

Cas:161798-03-4

Min.Order:1 Gram

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Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Febuxostat Impurity Cas 161798-03-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:25kg/drum Application:pharmaceut

Manufacturer high quality Febuxostat Impurity Cas 161798-03-4 with good price

Cas:161798-03-4

Min.Order:1 Kilogram

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Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate CAS No.:161798-03-4 Name: Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Molecular Structure: Molecular Formula: C18H21NO4S M

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-03-4

Min.Order:0

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Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl 2-[3-formyl-4-(2-methylpropoxy)-phenyl]-4-methyl-5-thiazolecarboxylate

Cas:161798-03-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 161798-03-4-- ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China

TIANFUCHEM-- 161798-03-4-- ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE in stock

Cas:161798-03-4

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Premium Factory Supply Febuxostat Impurity 2 CAS 161798-03-4

Cas:161798-03-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 80.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 161798-03-4 with competitive price

Cas:161798-03-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Sale 161798-03-4 Buy Quality 161798-03-4

Cas:161798-03-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

5-Thiazolecarboxylicacid, 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl esterCAS NO.: 161798-03-4

Cas:161798-03-4

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy.

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

Cas:161798-03-4

Min.Order:10 Gram

FOB Price: $1500.0 / 2000.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Thiazolecarboxylicacid, 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester 161798-03-4

Cas:161798-03-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Shanghai Minstar Chemical Co., Ltd

Product Name: ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE CAS: 161798-03-4 MF: C18H21NO4S MW: 347.43 EINECS: 700-743-7 Mol File: 161798-03-4.mol ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBO

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

Cas:161798-03-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE CAS:161798-03-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermed

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE CAS:161798-03-4

Cas:161798-03-4

Min.Order:1 Gram

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Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

Cas:161798-03-4

Min.Order:1 Kilogram

FOB Price: $15.0 / 30.0

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate CAS: 161798-03-4 Specification product name ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate cas no. 161798-03-4 appear

Factory supply ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-03-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 2-(3-Formyl-4-Iso Butoxyphenyl)-4-Methylthiazole-5-Carboxylate

Cas:161798-03-4

Min.Order:0

Negotiable

Type:Manufacturers

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-03-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Buy Febuxostat intermediate cas 161798-03-4 with high quality

Cas:161798-03-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-5-CARBOXYLATE cas no.161798-03-4 0.98

Cas:161798-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-03-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Thiazolecarboxylicacid, 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester

Cas:161798-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

Cas:161798-03-4

Min.Order:1 Gram

Negotiable

Type:Other

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Synthetic route

3-formyl-4-isobutoxythiobenzamide

3-formyl-4-isobutoxythiobenzamide

ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 60℃; for 4h;97%
Isobutyl bromide
78-77-3

Isobutyl bromide

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 75 - 85℃; for 6h;94.7%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h;90%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide90%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

isobutyl p-toluenesulfonate
4873-56-7

isobutyl p-toluenesulfonate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; Temperature;92.7%
isobutyl methanesulfonate
16156-53-9

isobutyl methanesulfonate

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 95 - 100℃; Temperature;85.5%
ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

isobutyl benzenesulfonate
24698-43-9

isobutyl benzenesulfonate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 95 - 100℃;84.4%
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / 40 h / Reflux
2: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C
View Scheme
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / 24 h / 80 °C
1.2: 0.17 h
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5.08 h / 25 - 85 °C
View Scheme
Multi-step reaction with 2 steps
1: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h / Microwave irradiation
2: potassium carbonate / acetonitrile / 0.17 h / Microwave irradiation
View Scheme
ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isopropyl alcohol / 25 - 85 °C
2.1: trifluoroacetic acid / 24 h / 80 °C
2.2: 0.17 h
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5.08 h / 25 - 85 °C
View Scheme
4-hydroxythiobenzamide
25984-63-8

4-hydroxythiobenzamide

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isopropyl alcohol / 25 - 85 °C
2.1: trifluoroacetic acid / 24 h / 80 °C
2.2: 0.17 h
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 5.08 h / 25 - 85 °C
View Scheme
Multi-step reaction with 3 steps
1: phosphoric acid / water; ethanol / 30 - 80 °C
2: sulfuric acid / 60 - 120 °C
3: potassium carbonate / N,N-dimethyl-formamide / 60 - 115 °C
View Scheme
Multi-step reaction with 3 steps
1: PPA / 0.25 h / Microwave irradiation
2: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h / Microwave irradiation
3: potassium carbonate / acetonitrile / 0.17 h / Microwave irradiation
View Scheme
Multi-step reaction with 3 steps
1: ethanol / 2 h / Reflux
2: water; trifluoroacetic acid; acetic acid / 2.5 h / 100 °C
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide
View Scheme
C12H15NO2

C12H15NO2

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C
2: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C
3: N,N-dimethyl-formamide / 4 h / 60 °C
View Scheme
C12H13NO2

C12H13NO2

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C
2: N,N-dimethyl-formamide / 4 h / 60 °C
View Scheme
4-cyanophenol
767-00-0

4-cyanophenol

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C
2: aluminum (III) chloride / nitromethane / 5.5 h / 0 - 5 °C
3: iron(III) sulfate; water / toluene / 0.7 h / 110 °C
4: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C
5: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C
6: N,N-dimethyl-formamide / 4 h / 60 °C
View Scheme
Multi-step reaction with 6 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C
2: aluminum (III) chloride / nitromethane / 5.5 h / 0 °C
3: iron(III) sulfate; water / toluene / 0.7 h / 110 °C
4: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C
5: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C
6: N,N-dimethyl-formamide / 4 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: polyphosphoric acid / water / 40 - 80 °C
2: phosphoric acid / water; ethanol / 30 - 80 °C
3: sulfuric acid / 60 - 120 °C
4: potassium carbonate / N,N-dimethyl-formamide / 60 - 115 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydrogensulfide; magnesium chloride monohydrate / 3 h / 20 °C
2: PPA / 0.25 h / Microwave irradiation
3: magnesium chloride; triethylamine / tetrahydrofuran / 0.17 h / Microwave irradiation
4: potassium carbonate / acetonitrile / 0.17 h / Microwave irradiation
View Scheme
4-(2-methylpropoxy)benzonitrile
5203-15-6

4-(2-methylpropoxy)benzonitrile

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: aluminum (III) chloride / nitromethane / 5.5 h / 0 - 5 °C
2: iron(III) sulfate; water / toluene / 0.7 h / 110 °C
3: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C
4: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C
5: N,N-dimethyl-formamide / 4 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: aluminum (III) chloride / nitromethane / 5.5 h / 0 °C
2: iron(III) sulfate; water / toluene / 0.7 h / 110 °C
3: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C
4: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C
5: N,N-dimethyl-formamide / 4 h / 60 °C
View Scheme
3-chloromethyl-4-isobutoxybenzonitrile

3-chloromethyl-4-isobutoxybenzonitrile

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: iron(III) sulfate; water / toluene / 0.7 h / 110 °C
2: tetrabutylammomium bromide; sodium hypochlorite / ethyl acetate; water / 0 - 5 °C
3: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 4 h / 80 °C
4: N,N-dimethyl-formamide / 4 h / 60 °C
View Scheme
2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester hydrochloride

2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester hydrochloride

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphoric acid / 70 - 95 °C
2: potassium carbonate / N,N-dimethyl-formamide / 100 - 110 °C
View Scheme
Multi-step reaction with 2 steps
1: phosphoric acid / 70 - 95 °C
2: potassium carbonate / N,N-dimethyl-formamide / 95 - 100 °C
View Scheme
Multi-step reaction with 2 steps
1: phosphoric acid / 70 - 95 °C
2: potassium carbonate / N,N-dimethyl-formamide / 95 - 100 °C
View Scheme
ethyl bromide
74-96-4

ethyl bromide

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
144060-62-8

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 60℃; for 20h;
ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / 2 h / Reflux
2: water; trifluoroacetic acid; acetic acid / 2.5 h / 100 °C
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide
View Scheme
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
160844-75-7

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With ammonium hydroxide; sodium persulfate; sodium iodide; iron(II) chloride In 1,2-dichloro-ethane at 20 - 50℃; for 16h; Reagent/catalyst; Solvent; Temperature;98%
With hydroxylamine hydrochloride; sodium formate In formic acid for 3h; Product distribution / selectivity; Reflux;96%
With formic acid; hydroxylamine hydrochloride; sodium formate at 100℃; for 7h;95.2%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

aniline
62-53-3

aniline

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

ethyl 2-(3-((diethoxyphosphoryl)(phenylamino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((diethoxyphosphoryl)(phenylamino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Kabachnik-Fields Reaction; Green chemistry;96%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

4-methoxy-aniline
104-94-9

4-methoxy-aniline

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

ethyl 2-(3-((diethoxyphosphoryl)((4-methoxyphenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((diethoxyphosphoryl)((4-methoxyphenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;96%
4-aminophenyl phenyl sulfide
1135-14-4

4-aminophenyl phenyl sulfide

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

ethyl 2-(3-((diethoxyphosphoryl)((4-(phenylthio)phenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((diethoxyphosphoryl)((4-(phenylthio)phenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;96%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

ethyl 2-(3-((diethoxyphosphoryl)((4-(trifluoromethyl)phenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((diethoxyphosphoryl)((4-(trifluoromethyl)phenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;95%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

4-fluoroaniline
371-40-4

4-fluoroaniline

ethyl 2-(3-((diethoxyphosphoryl)((4-fluorophenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((diethoxyphosphoryl)((4-fluorophenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;94%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

2-iodo-4-(trifluoromethyl)aniline
163444-17-5

2-iodo-4-(trifluoromethyl)aniline

ethyl 2-(3-((diethoxyphosphoryl)((2-iodo-4-(trifluoromethyl)phenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((diethoxyphosphoryl)((2-iodo-4-(trifluoromethyl)phenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;94%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

3-chloro-aniline
108-42-9

3-chloro-aniline

ethyl 2-(3-(((3-chlorophenyl)amino)(diethoxyphosphoryl)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-(((3-chlorophenyl)amino)(diethoxyphosphoryl)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;92%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

4-nitro-aniline
100-01-6

4-nitro-aniline

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

ethyl 2-(3-((diethoxyphosphoryl)((4-nitrophenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((diethoxyphosphoryl)((4-nitrophenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;92%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-iodophenylamine
615-43-0

2-iodophenylamine

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

ethyl 2-(3-((diethoxyphosphoryl)((2-iodophenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((diethoxyphosphoryl)((2-iodophenyl)amino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;91%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

thiosemicarbazide
79-19-6

thiosemicarbazide

para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

ethyl 2-(3-((2-(4-(4-bromophenyl)thiazol-2-yl)hydrazono)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((2-(4-(4-bromophenyl)thiazol-2-yl)hydrazono)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Reflux; Green chemistry;90%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

4-bromo-aniline
106-40-1

4-bromo-aniline

ethyl 2-(3-(((4-bromophenyl)amino)(diethoxyphosphoryl)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-(((4-bromophenyl)amino)(diethoxyphosphoryl)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With β-cyclodextrin supported sulfonic acid In neat (no solvent) at 50℃; for 0.5h; Kabachnik-Fields Reaction; Green chemistry;90%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

thiosemicarbazide
79-19-6

thiosemicarbazide

4-chlorobenzoylmethyl bromide
536-38-9

4-chlorobenzoylmethyl bromide

ethyl 2-(3-((2-(4-(4-chlorophenyl)thiazol-2-yl)hydrazono)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(3-((2-(4-(4-chlorophenyl)thiazol-2-yl)hydrazono)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 4h; Reflux; Green chemistry;88%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

thiosemicarbazide
79-19-6

thiosemicarbazide

α-bromoacetophenone
70-11-1

α-bromoacetophenone

ethyl 2-(4-isobutoxy-3-((2-(4-phenylthiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(4-isobutoxy-3-((2-(4-phenylthiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Reflux; Green chemistry;86%
3-bromoacetylcoumarin
29310-88-1

3-bromoacetylcoumarin

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

thiosemicarbazide
79-19-6

thiosemicarbazide

ethyl 2-(4-isobutoxy-3-((2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(4-isobutoxy-3-((2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 4h; Reflux; Green chemistry;86%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one
88735-43-7

2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one

thiosemicarbazide
79-19-6

thiosemicarbazide

ethyl 2-(4-isobutoxy-3-((2-(4-(3-oxo-3H-benzo[f]chromen-2-yl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(4-isobutoxy-3-((2-(4-(3-oxo-3H-benzo[f]chromen-2-yl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Reflux; Green chemistry;83%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

4-Nitrophenacyl bromide
99-81-0

4-Nitrophenacyl bromide

thiosemicarbazide
79-19-6

thiosemicarbazide

ethyl 2-(4-isobutoxy-3-((2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

ethyl 2-(4-isobutoxy-3-((2-(4-(4-nitrophenyl)thiazol-2-yl)hydrazono)methyl)phenyl)-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol for 4h; Reflux; Green chemistry;81%
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

febuxostat

febuxostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; sodium formate; formic acid / 100 °C
2: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride / methanol / 65 °C
2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C
2.2: hydrose / 5 h / 25 °C / pH 2 - 3
3.1: sodium formate; formic acid / 100 °C
View Scheme
With formic acid; hydroxylamine hydrochloride; sodium formate for 5h; Reflux;
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
144060-62-8

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid

Conditions
ConditionsYield
Stage #1: 2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester With water; sodium hydroxide In methanol at 75℃; for 0.5h;
Stage #2: With hydrogenchloride In methanol; water at 25℃; for 5h; pH=2 - 3;
Stage #1: 2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester With sodium hydroxide In ethanol at 80℃; for 4h;
Stage #2: With hydrogenchloride In ethanol; water pH=~ 3;
Stage #1: 2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester With water; potassium carbonate In methanol for 3h; Reflux;
Stage #2: With hydrogenchloride In water at 40℃; pH=5.3 - 5.7; Product distribution / selectivity;
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

ethyl 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
1271738-74-9

ethyl 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With hydroxylamine hydrochloride In methanol at 65℃;
With formic acid; hydroxylamine hydrochloride; sodium formate at 100 - 110℃;
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid
1350352-70-3

2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydroxylamine hydrochloride / methanol / 65 °C
2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C
2.2: hydrose / 5 h / 25 °C / pH 2 - 3
View Scheme
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine
1350352-71-4

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; sodium formate; formic acid / 100 °C
2: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C
3: ethyl acetate; cyclohexane; methanol / 3 h
View Scheme
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride / methanol / 65 °C
2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C
2.2: hydrose / 5 h / 25 °C / pH 2 - 3
3.1: sodium formate; formic acid / 100 °C
4.1: ethyl acetate; cyclohexane; methanol / 3 h
View Scheme
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine
1350352-72-5

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid tert-butylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; sodium formate; formic acid / 100 °C
2: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C
3: toluene / 10 h
View Scheme
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride / methanol / 65 °C
2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C
2.2: hydrose / 5 h / 25 °C / pH 2 - 3
3.1: sodium formate; formic acid / 100 °C
4.1: toluene / 10 h
View Scheme
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine
1350352-73-6

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C
1.2: hydrose / 5 h / 25 °C / pH 2 - 3
2.1: ethyl acetate; cyclohexane; methanol / 3 h
View Scheme
2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
161798-03-4

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid n-butylamine
1350352-74-7

2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid n-butylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C
1.2: hydrose / 5 h / 25 °C / pH 2 - 3
2.1: toluene / 10 h
View Scheme

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