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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Manufacturer/High quality/Best price/In stock

Cas:161798-02-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/629.html Product Name

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Cas:161798-02-3

Min.Order:1 Gram

FOB Price: $63.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Light yellow crystalline powder Storage:2-8°C Package:1kg/foi

Good quality Febuxostat intermediate CAS 161798-02-3 with favorable price

Cas:161798-02-3

Min.Order:1 Kilogram

FOB Price: $190.0 / 210.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate CAS No.:161798-02-3 Name: Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Molecular Structure Molecular Formula: C14H12N2O3S

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Cas:161798-02-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 161798-02-3-- Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in Chi

TIANFUCHEM-- 161798-02-3-- Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate in stock

Cas:161798-02-3

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

High purity Febuxostat Impurity 5 CAS 161798-02-3

Cas:161798-02-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 161798-02-3 with competitive price

Cas:161798-02-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

superiority of choosing our company superiority of choosing our company Why choice me: 1, We guarantee deeply analyze and demonstrate, purity more than 99% 2, Factory outlet with priority price & large stock. 3, Special magic vacuum safe packag

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Thiazolecarboxylicacid, 2-(3-cyano-4-hydroxyphenyl)-4-methyl-, ethyl ester 161798-02-3

Cas:161798-02-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate CAS 161798-02-3 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate CAS 161798-02-3

Cas:161798-02-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Thiazolecarboxylicacid, 2-(3-cyano-4-hydroxyphenyl)-4-methyl-, ethyl ester

Cas:161798-02-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate CAS NO.161798-02-3

Cas:161798-02-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate CAS: 161798-02-3 Specification Product Name: Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Synonyms: Ethyl 2-(3-Cyano-4-hydrox

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Synonyms: Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate;2-(3-Cyano-4-hydroxyphenyl)-4-Methyl-1,3-thiazole-5-carboxylicacidethylester;Febu

Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate supplier best quality

Cas:161798-02-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-(3-Cyano-4-Hydroxy-Phenyl)-4-Methyl-Thiazole-5-Carboxilic Acid Ethyl Ester

Cas:161798-02-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-THIAZOLECARBOXYLIC ACID, 2-(3-CYANO-4-HYDROXYPHENYL)-4-METHYLETHYL ESTER

Cas:161798-02-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-(3-Cyano-4-Hydroxy-Phenyl)-4-Methyl-Thiazole-5-Carboxilic Acid Ethyl Ester

Cas:161798-02-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Cas:161798-02-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Cas:161798-02-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Cas:161798-02-3

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5-Thiazolecarboxylicacid, 2-(3-cyano-4-hydroxyphenyl)-4-methyl-, ethyl ester

Cas:161798-02-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Chemical Properties Boiling point 475.3±55.0 °C(Predicted) density 1.38 storage temp. Sealed in dry,Room Temperature pka 5.80±0.20(Predicted)

Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Cas:161798-02-3

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Ethyl 2-(3-Cyano-4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate CAS No.:161798-02-3 Molecule Formula:C14H12N2O3S Molecule Weight:288.32 Purity: 99.0% Package: 25kg/drum Description: White powder Manufacture Standards:En

High Quality Ethyl 2-(3-Cyano-4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate

Cas:161798-02-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate

Cas:161798-02-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Cas:161798-02-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate
161798-01-2

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate With hydroxylamine hydrochloride In N,N-dimethyl-formamide for 0.5h;
Stage #2: With acetyl chloride In N,N-dimethyl-formamide at 90℃;
99%
Stage #1: ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate With hydroxylamine hydrochloride In N,N-dimethyl-formamide for 0.5h;
Stage #2: With acetyl chloride In N,N-dimethyl-formamide at 90℃;
99%
With formic acid; hydroxylamine hydrochloride; sodium acetate at 100 - 105℃; for 10h;97.6%
ethyl 2-[4-(benzyloxy)-3-cyanophenyl]-4-methyl-1,3-thiazole-5-carboxylate
934470-15-2

ethyl 2-[4-(benzyloxy)-3-cyanophenyl]-4-methyl-1,3-thiazole-5-carboxylate

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
palladium-carbon In tetrahydrofuran; ethanol
With hydrogen; palladium on activated charcoal In tetrahydrofuran; ethanol at 20℃;
ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: spirit / 2.5 h / 60 - 65 °C
2: methanesulfonic acid / 10 h / 75 °C
3: hydroxylamine hydrochloride; sodium formate; formic acid / 8 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: ethanol / Reflux
2: phosphorus pentoxide
3: hydroxylamine hydrochloride; sodium acetate; formic acid
View Scheme
(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)
161797-99-5

(2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester)

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanesulfonic acid / 10 h / 75 °C
2: hydroxylamine hydrochloride; sodium formate; formic acid / 8 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: phosphorus pentoxide
2: hydroxylamine hydrochloride; sodium acetate; formic acid
View Scheme
4-hydroxythiobenzamide
25984-63-8

4-hydroxythiobenzamide

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: spirit / 2.5 h / 60 - 65 °C
2: methanesulfonic acid / 10 h / 75 °C
3: hydroxylamine hydrochloride; sodium formate; formic acid / 8 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: ethanol / Reflux
2: phosphorus pentoxide
3: hydroxylamine hydrochloride; sodium acetate; formic acid
View Scheme
C19H18N2O5S

C19H18N2O5S

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
With hydrogen
4-(benzyloxy)-3-cyanobenzenecarbothioamide
934470-14-1

4-(benzyloxy)-3-cyanobenzenecarbothioamide

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / 75 °C
2: hydrogen / palladium on activated charcoal / tetrahydrofuran; ethanol / 20 °C
View Scheme
4-benzyloxyisophthalonitrile
206533-18-8

4-benzyloxyisophthalonitrile

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / 1,4-dioxane; N,N-dimethyl-formamide / 60 °C
2: ethanol / 75 °C
3: hydrogen / palladium on activated charcoal / tetrahydrofuran; ethanol / 20 °C
View Scheme
C14H14N2O3S

C14H14N2O3S

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

Conditions
ConditionsYield
With sodium chlorite In ethanol for 2h; Inert atmosphere; Green chemistry;0.69 g
Isobutyl bromide
78-77-3

Isobutyl bromide

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
160844-75-7

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In ethyl acetate at 65 - 70℃; for 5h; Temperature; Solvent; Reagent/catalyst;98.2%
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 8h;92.9%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 90℃; for 3h;88%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 90℃; for 3h;88%
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 15h;2.28 g
3-bromo-2-methyl propan-1-ol
40145-08-2

3-bromo-2-methyl propan-1-ol

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 0.5h;
Stage #2: 3-bromo-2-methyl propan-1-ol In N,N-dimethyl-formamide at 80℃; for 4h;
63%
2-methyl-1,2-epoxypropane
558-30-5

2-methyl-1,2-epoxypropane

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

ethyl 2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

ethyl 2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

Conditions
ConditionsYield
With sodium dihydrogenphosphate; potassium carbonate In water; acetonitrile at 150℃; for 12h; Sealed tube;48%
ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

febuxostat

febuxostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 3 h / 90 °C
2: sodium hydroxide; water / methanol / 1 h / 45 - 60 °C
View Scheme
ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 80 °C
1.2: 4 h / 80 °C
2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1.5 h / 60 °C
View Scheme
ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; sodium dihydrogenphosphate / water; acetonitrile / 12 h / 150 °C / Sealed tube
2: sodium hydroxide; water / ethanol; tetrahydrofuran / 1.5 h / 60 °C
View Scheme
ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

3-{2-cyano-4-[5-(ethoxycarbonyl)-4-methylthiazol-2-yl]phenoxy}-2-methylpropanoic acid

3-{2-cyano-4-[5-(ethoxycarbonyl)-4-methylthiazol-2-yl]phenoxy}-2-methylpropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 80 °C
1.2: 4 h / 80 °C
2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium chlorite / water; acetonitrile; aq. phosphate buffer / 6 h / 35 °C / pH 6.7
View Scheme
ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

2-[4-(2-carboxypropoxy)-3-cyanophenyl]-4-methylthiazole-5-carboxylic acid

2-[4-(2-carboxypropoxy)-3-cyanophenyl]-4-methylthiazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 80 °C
1.2: 4 h / 80 °C
2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium chlorite / water; acetonitrile; aq. phosphate buffer / 6 h / 35 °C / pH 6.7
3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1.5 h / 60 °C
View Scheme
ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate
161798-02-3

ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate

methyl 2-(bromomethyl)propenoate
4224-69-5

methyl 2-(bromomethyl)propenoate

C19H18N2O5S

C19H18N2O5S

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 80℃;

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