CasNo.138112-76-2,CAS NO.138112-76-2 High Quality Agomelatine,(138112-76-2) Suppliers

1 Gram	FOB Price: USD 2.0000

Min.Order :1 Gram
Purity: 99.9%
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Keywords

Agomelatine 138112-76-2 N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide

Quick Details

Appearance:White powder
Application:Dietary supplements, supplements,
PackAge:100 gram/ bag, 1kg/ bag, 25kgs/ drum?
ProductionCapacity:100|Kilogram|Month
Storage:Store in tight, light-resistant containers, avoid exposure to direct sunlight, moisture and excessive heat.
Transportation:by air

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Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

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We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

Details:

Agomelatine is a new type of antidepressant. Its mechanism of action breaks through the traditional monoamine transmitter system. It activates melatonin receptors, MT1 and MT2, and antagonizes 5-HT2C receptors. It can improve sleep quality and restore biological rhythm while having antidepressant effect; among them, by antagonizing the 5-HT2C receptor of the postsynaptic membrane, it can increase the release of DA and NE in the prefrontal cortex and play an antidepressant role. When MT agonism and 5-HT2C receptor antagonism exist at the same time, a unique synergistic effect can be produced to promote the release of more DA and NE in the PFC brain area, further strengthening the antidepressant effect. In addition, agomelatine can also promote the release of brain-derived neurotrophic factor in the PFC and block the stress-induced release of glutamate in the amygdala brain region.

Product name	Agomelatine
Other name	N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide; N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
CAS No.	138112-76-2
Molecular formula	C15H17NO2
Molecular weight	243.3082
Purity	99.0%
Appearance	Off-white powder
Packing	25kg /drum
Application	Raw material of health product

Agomelatine is for antidepressant that is also a melatonin antagonist. It reduces depressive symptoms by modulating levels of melatonin MT1 receptors (to reduce cortical alarm signals) and MT2 receptors (to circadian rhythms of sleep) and serotonin. Taken at night to mimic the natural rhythm of melatonin release, it can significantly improve sleep quality.

(1) Dual regulation: It can not only regulate the release of melatonin, but also regulate the release of 5-hydroxytryptamine and norepinephrine, thus playing a role in regulating mood, sleep, pain and so on.

(2) Improvement of sleep: Agomelatine is that may improve insomnia without causing drowsiness or coma.

(3) Improve cognitive function: Agomelatine can improve cognitive function by improving neuroplasticity in the hippocampus.

(4) High safety: Compared with other antidepressants, the drug has relatively less side effects when treating depression, and will not affect sexual function and body weight.