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Huaian Yishu techonology Co.,Ltd

1、Methacide<10%,HPLC>90% 2、甲苯<1.0%,HPLC>98% Application:Tenofovir Disoproxil intermediate

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:0 Metric Ton

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Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Diethyl (tosyloxy)methylphosphonate Manufacturer/High quality/Best price/In stock

Cas:31618-90-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Diethyl P-Tosyloxymethylphosphonate supplier in China

Cas:31618-90-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Light yellow to colorless oily liquid Storage:cool dry place Package:25kg/drum;200kg/drum Application:pharmaceutic

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

diethyl p-toluenesulfonyloxymethy Phosphonate

Cas:31618-90-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name Diethyl (tosyloxy)methylphosphonate CAS number 31618-90-3 Assay ≥98% Appearance Yellowish or colorless transparent liquid Capacity 200mt/year A

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Diethyl P-Tosyloxymethylphosphonate

Cas:31618-90-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Diethyl P-Toluene Sulfonyloxy Methyl Phosphonate

Cas:31618-90-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

{{[(4-Methylphenyl)-sulfonyl]-oxy}-methyl}-phosphonic acid diethyl ester

Cas:31618-90-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me

Diethyl (tosyloxy)methylphosphonate 31618-90-3

Cas:31618-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 31618-90-3 with best quality

Cas:31618-90-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

Diethyl (tosyloxy)methylphosphonateCAS31618-90-3

Cas:31618-90-3

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: Diethyl (tosyloxy)methylphosphonate Synonyms: DIETHYL 4-TOLUENESULFONYLOXYMETHYLPHOSPHONATE;diethyl [[[(4-tolyl)sulfonyl]oxy]methyl]phosphonate;(DIETHOXYPHOSPHORYL)METHYL 4-METHYLBENZENESULFON

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Viscous Liquid Storage:Store in sealed containers at c

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phosphonic acid,P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester 31618-90-3

Cas:31618-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Diethyl (tosyloxy)methylphosphonate CAS:31618-90-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

Diethyl (tosyloxy)methylphosphonate CAS:31618-90-3

Cas:31618-90-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phosphonic acid,P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester

Cas:31618-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:31618-90-3

Cas:31618-90-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Diethyl (Tosyloxy)Methylphosphonate

Cas:31618-90-3

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

Diethyl p-toluene sulfonyl oxymethyl phosphonate (DESMP)

Cas:31618-90-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Synonyms: 2,3-DICHLORO-5,6-DICYANO-1,4-BENZOQUINONE pure;4,5-Dichloro-3,6-dioxo-1,4-cyclohexadiene-1,2-dicarbonitrile, DDQ;2,3-Dicyano-5,6-dichloro-2,5-cyclohexadiene-1,4-dione;3,6-Dihydro-3

Diethyl (tosyloxy)methylphosphonate Manufactuered in China best quality

Cas:31618-90-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DIETHYL (TOSYLOXY)METHYLPHOSPHONATE

Cas:31618-90-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Diethyl (tosyloxy)methylphosphonate

Cas:31618-90-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

diethyl (1-hydroxymethyl)phosphonate
3084-40-0

diethyl (1-hydroxymethyl)phosphonate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

Conditions
ConditionsYield
With triethylamine In diethyl ether97%
In water at 3 - 35℃; for 14.5h; Temperature;95.4%
With triethylamine In dichloromethane at 20℃; for 4h; Inert atmosphere;92%
diethyl (1-hydroxymethyl)phosphonate
3084-40-0

diethyl (1-hydroxymethyl)phosphonate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

A

magnesium para-toluenesulfonate

magnesium para-toluenesulfonate

B

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

Conditions
ConditionsYield
With magnesium carbonate In water at 65℃; for 20h;A n/a
B 91%
hydroxymethyl-phosphonic acid dimethyl ester
24630-67-9

hydroxymethyl-phosphonic acid dimethyl ester

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane at 5 - 10℃; for 3h;86.5%
formaldehyd
50-00-0

formaldehyd

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

Conditions
ConditionsYield
Stage #1: formaldehyd; phosphonic acid diethyl ester With triethylamine In toluene at 85 - 90℃; for 3h; Heating / reflux;
Stage #2: p-toluenesulfonyl chloride With triethylamine at 4 - 20℃; for 14.75h;
77.6%
Stage #1: formaldehyd; phosphonic acid diethyl ester With triethylamine In toluene at 90 - 125℃; for 5h; Inert atmosphere;
Stage #2: p-toluenesulfonyl chloride With triethylamine In toluene at 0 - 20℃;
47%
Stage #1: formaldehyd; phosphonic acid diethyl ester With triethylamine In toluene at 70℃; Inert atmosphere; Reflux;
Stage #2: p-toluenesulfonyl chloride With triethylamine In toluene at 5 - 20℃; Inert atmosphere;
Stage #1: formaldehyd; phosphonic acid diethyl ester With triethylamine In toluene at 87℃; for 2h;
Stage #2: p-toluenesulfonyl chloride In toluene
Stage #1: formaldehyd; phosphonic acid diethyl ester With triethylamine In toluene at 87℃; for 3h; Inert atmosphere; Reflux;
Stage #2: p-toluenesulfonyl chloride With triethylamine In toluene at -2 - 22℃; Inert atmosphere;
formaldehyd
50-00-0

formaldehyd

Diethyl phosphonate
762-04-9, 123-22-8

Diethyl phosphonate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

Conditions
ConditionsYield
Stage #1: formaldehyd; Diethyl phosphonate With triethylamine In toluene at 85 - 90℃; for 3h; Heating / reflux;
Stage #2: p-toluenesulfonyl chloride In toluene at 4 - 20℃; for 14.75h;
77.6%
Stage #1: formaldehyd; Diethyl phosphonate With triethylamine In toluene at 85 - 90℃; for 3h; Heating / reflux;
Stage #2: p-toluenesulfonyl chloride With triethylamine In toluene at 4 - 20℃; for 14.75h;
77.6%
diethyl (1-hydroxymethyl)phosphonate
3084-40-0

diethyl (1-hydroxymethyl)phosphonate

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

Conditions
ConditionsYield
With triethylamine In diethyl ether at -10 - 20℃; for 17h;75%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

(R)-9-[3-trityloxy-2-hydroxypropyl]-N6-(4-monomethoxytrityl)adenine
1338605-36-9

(R)-9-[3-trityloxy-2-hydroxypropyl]-N6-(4-monomethoxytrityl)adenine

diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)adenine
1338605-37-0

diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)adenine

Conditions
ConditionsYield
With sodium t-butanolate In N,N-dimethyl-formamide at 80℃;99%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

3-trifluoromethyl-2-mercaptopyridine
104040-74-6

3-trifluoromethyl-2-mercaptopyridine

diethyl (((3-(trifluoromethyl)pyridin-2-yl)thio)methyl)phosphonate

diethyl (((3-(trifluoromethyl)pyridin-2-yl)thio)methyl)phosphonate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;99%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

4-benzyloxybutanal
5470-84-8

4-benzyloxybutanal

(E)-p-tolyl 5-(benzyloxy)pent-1-en-1-yl sulfone

(E)-p-tolyl 5-(benzyloxy)pent-1-en-1-yl sulfone

Conditions
ConditionsYield
With triethylamine; lithium chloride In acetonitrile at 20℃; for 18h; Horner-Wadsworth-Emmons Olefination;98%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

Conditions
ConditionsYield
With trimethylsilyl bromide In acetonitrile at 30℃; for 24h; Solvent; Reagent/catalyst; Temperature; Cooling with ice;98%
With trimethylsilyl bromide In dichloromethane at 20℃; for 12h;97%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

3,5-bis(trifluoromethyl)thiophenol
130783-02-7

3,5-bis(trifluoromethyl)thiophenol

(2-ethyl)bistrifluoromethyl thiophenolmethylphosphoric acid ethyl ester
934177-56-7

(2-ethyl)bistrifluoromethyl thiophenolmethylphosphoric acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 5h;94%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;89%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

S-(((3aS,4S,6R,6aR)-6-(6-chloro-5-cyano-4-(((1S,3S)-3-fluorocyclobutyl)amino)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl) ethanethioate

S-(((3aS,4S,6R,6aR)-6-(6-chloro-5-cyano-4-(((1S,3S)-3-fluorocyclobutyl)amino)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl) ethanethioate

diethyl (((((3aS,4S,6R,6aR)-6-(6-chloro-5-cyano-4-(((1S,3S)-3-fluorocyclobutyl)amino)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)thio)methyl)phosphonate

diethyl (((((3aS,4S,6R,6aR)-6-(6-chloro-5-cyano-4-(((1S,3S)-3-fluorocyclobutyl)amino)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)thio)methyl)phosphonate

Conditions
ConditionsYield
Stage #1: S-(((3aS,4S,6R,6aR)-6-(6-chloro-5-cyano-4-(((1S,3S)-3-fluorocyclobutyl)amino)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl) ethanethioate With sodium ethanolate In ethanol at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In ethanol at 56℃; for 2h; Inert atmosphere;
90%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

bis-(diethoxy)phosphorylmethyl disulfide
70660-09-2

bis-(diethoxy)phosphorylmethyl disulfide

Conditions
ConditionsYield
With sulfur; sodium sulfide In ethanol Heating;89%
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

diethyl (4-fluorophenylthio)methylphosphonate

diethyl (4-fluorophenylthio)methylphosphonate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃;88%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;63%
With caesium carbonate In N,N-dimethyl-formamide at 70℃;
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

2-mercapto-5-(trifluoromethyl)benzothiazole
23420-87-3

2-mercapto-5-(trifluoromethyl)benzothiazole

(2-ethyl)-5-trifluoromethyl-thiophenethiol-methylphosphoric acid ethyl ester

(2-ethyl)-5-trifluoromethyl-thiophenethiol-methylphosphoric acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;88%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

(±)-2-fluoro-4-(6-methoxy-9H-purin-9-yl)-2-cyclopenten-1-ol

(±)-2-fluoro-4-(6-methoxy-9H-purin-9-yl)-2-cyclopenten-1-ol

(±)-diethyl {[-2-fluoro-4-(6-methoxy-9H-purin-9-yl)-2-cyclopenten-1-yl]oxy}methylphosphonate

(±)-diethyl {[-2-fluoro-4-(6-methoxy-9H-purin-9-yl)-2-cyclopenten-1-yl]oxy}methylphosphonate

Conditions
ConditionsYield
Stage #1: (±)-2-fluoro-4-(6-methoxy-9H-purin-9-yl)-2-cyclopenten-1-ol With lithium tert-butoxide In tetrahydrofuran at 0℃; for 1h; Inert atmosphere;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In tetrahydrofuran at 30℃; for 192h; Inert atmosphere;
88%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

(S)-9-(2-phosphonylmethoxypropyl)adenine
147127-19-3

(S)-9-(2-phosphonylmethoxypropyl)adenine

Conditions
ConditionsYield
Stage #1: (R)-9-(2-hydroxypropyl)adenine With bis(isopropoxy) magnesium In N,N-dimethyl-formamide at 65℃; for 1h; Inert atmosphere;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide at 45 - 55℃; for 10h;
Stage #3: With hydrogenchloride In water at 90℃; for 10h;
88%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

1-((diphenylmethylamino)methyl)cyclopropan-1-ol
428855-17-8

1-((diphenylmethylamino)methyl)cyclopropan-1-ol

diethyl ({1-[(dibenzylamino)methyl]cyclopropoxy}methyl)phosphonate

diethyl ({1-[(dibenzylamino)methyl]cyclopropoxy}methyl)phosphonate

Conditions
ConditionsYield
With lithium tert-butoxide In tetrahydrofuran at 60℃; Inert atmosphere;87.5%
3-mercaptophenol
40248-84-8

3-mercaptophenol

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

diethyl (((3-hydroxyphenyl)thio)methyl)phosphonate

diethyl (((3-hydroxyphenyl)thio)methyl)phosphonate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;87%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

1-(6-chloro-9H-purin-9-yl)propan-2-ol
75166-59-5

1-(6-chloro-9H-purin-9-yl)propan-2-ol

diethyl (((1-(6-chloro-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

diethyl (((1-(6-chloro-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

Conditions
ConditionsYield
Stage #1: 1-(6-chloro-9H-purin-9-yl)propan-2-ol With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 70℃; for 0.5h;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide at 70℃; for 7h; Inert atmosphere;
87%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

fluconazole
86386-73-4

fluconazole

C18H23F2N6O4P

C18H23F2N6O4P

Conditions
ConditionsYield
Stage #1: fluconazole With sodium hydride In tetrahydrofuran at 20℃; for 1.08333h; Inert atmosphere;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In tetrahydrofuran at 50℃; for 4h; Inert atmosphere;
86.5%
3-methoxybenzenethiol
15570-12-4

3-methoxybenzenethiol

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

diethyl (((3-methoxyphenyl)thio)methyl)phosphonate
1478586-07-0

diethyl (((3-methoxyphenyl)thio)methyl)phosphonate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃;86%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;86%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

4(5)-(3-bromophenyl)-1H-imidazole

4(5)-(3-bromophenyl)-1H-imidazole

C14H18BrN2O3P

C14H18BrN2O3P

Conditions
ConditionsYield
Stage #1: 4(5)-(3-bromophenyl)-1H-imidazole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; pH=1; Inert atmosphere;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide at 80℃; Inert atmosphere;
86%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
180587-75-1

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

Conditions
ConditionsYield
With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 80℃; for 5h; Solvent;85%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;44%
Stage #1: (R)-9-(2-hydroxypropyl)adenine With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide for 64h;
29%
2-chlorothiphenol
6320-03-2

2-chlorothiphenol

diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

diethyl (((2-chlorophenyl)thio)methyl)phosphonate

diethyl (((2-chlorophenyl)thio)methyl)phosphonate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;85%
With caesium carbonate In N,N-dimethyl-formamide at 70℃;
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