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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(R)-(+)-9-(2-Hydroxypropyl)adenine Manufacturer/High quality/Best price/In stock

Cas:14047-28-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity R-(+)-9-(2-Hydroxypropyl)adenine CAS:14047-28-0

Cas:14047-28-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (R)-(+)-9-(2-Hydroxypropyl)Adenine supplier in China

Cas:14047-28-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of (R)-(+)-9-(2-Hydroxypropyl)adenine Cas 14047-28-0 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:25kg/drum Applicat

Manufacturer high quality (R)-(+)-9-(2-Hydroxypropyl)adenine Cas 14047-28-0 with good price

Cas:14047-28-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (R)-(+)-9-(2-Hydroxypropyl)Adenine

Cas:14047-28-0

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% (R)-(+)-9-(2-Hydroxypropyl)adenine 14047-28-0 GMP Manufacturer

Cas:14047-28-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-9-(2-Hydroxypropyl)-adenine

Cas:14047-28-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM (R)-(+)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Details

China Biggest factory Manufacturer Supply High Quality (R)-(+)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0

Cas:14047-28-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(R)-(+)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 14047-28-0 with best quality

Cas:14047-28-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

R)-(+)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Chemical Name: (R)-(+)-9-(2-Hydroxypropyl)adenine CAS No.: 14047-28-0 Molecular Fomula:C8H11N5O Chemical Structure: Molecular weight: 193.21 Appearance:White powder solid Assay:99%Min Appearance: White powder Storage:Store in cool and dry place,

(R)-(+)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 14047-28-0 (R)-(+)-9-(2-Hydroxypropyl)adenine with best price

Cas:14047-28-0

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

9H-Purine-9-ethanol,6-amino-a-methyl-, (aR)- 14047-28-0

Cas:14047-28-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: (R)-(+)-9-(2-Hydroxypropyl)adenine CAS: 14047-28-0 MF: C8H11N5O MW: 193.21 EINECS: 604-188-0 Mol File: 14047-28-0.mol (R)-(+)-9-(2-Hydroxypropyl)adenine Structure (R)-(+)-9-(2-Hydroxypropyl)adenine Chemical Propertie

(R)-(+)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Tenofovir intermediate, (R)-(+)-9-(2-Hydroxypropyl)adenine CAS:14047-28-0

Cas:14047-28-0

Min.Order:1 Kilogram

FOB Price: $78.1 / 84.3

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

(R)-(+)-9-(2-Hydroxypropyl)adenine CAS:14047-28-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

(R)-(+)-9-(2-Hydroxypropyl)adenine CAS:14047-28-0

Cas:14047-28-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

9H-Purine-9-ethanol,6-amino-a-methyl-, (aR)-

Cas:14047-28-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

9H-Purine-9-ethanol,6-amino-a-methyl-, (aR)-/ LIDE PHARMA- Factory supply / Best price

Cas:14047-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Supply (R)-(-)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in carbomer,carbopol,lead acetate,meglumine diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production enterpr

(R) - (+) -9- (2-Hydroxypropyl) Adenine Powder CAS 14047-28-0

Cas:14047-28-0

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

9H-Purine-9-ethanol,6-amino-a-methyl-, (aR)-

Cas:14047-28-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(R)-(+)-9-(2-Hydroxypropyl)

Cas:14047-28-0

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

(R)-9-(2-hydroxypropyl)adenine (HPA)

Cas:14047-28-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(R)-(+)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (R)-(+)-9-(2-Hydroxypropyl)adenine Synonyms: R-9-(2-hydroxypropyl) adenine, 9-HPA;(R)-(+)-9-(2-HYDROXYPROPYL)ADENINE,98%;Tenofovir Impurity 91;D-(-)-9-(2-Hydroxypropyl)adenine;(R)-(+)-9-(2-Hydroxypropyl)adenine;6-Amino-alpha-methyl-

(R)-(+)-9-(2-Hydroxypropyl)adenine Manufactuered in China best quality

Cas:14047-28-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

we are specializing in manufacturing Tenofovir disoproxil fumarate API and its intermediates. Appearance:white powder Storage:Keep dry, stable at room temperature. Package:25kg/barrel Application:Tenofovir disoproxil fumarate Port:hangzhou airport

(R)-(+)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(HPA) (R)-( - )-9-(2-Hydroxypropyl) adenine

Cas:14047-28-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

(R)-(+)-9-(2-Hydroxypropyl)adenine

Cas:14047-28-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(R)-6-acetyl-9-(2-hydroxypropyl)adenine

(R)-6-acetyl-9-(2-hydroxypropyl)adenine

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With sodium hydroxide In water at 93℃; for 2h; Temperature;97.7%
(R)-1-(6-chloro-9H-purin-9-yl) propan-2-ol
180587-74-0

(R)-1-(6-chloro-9H-purin-9-yl) propan-2-ol

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With ammonium hydroxide In 1,4-dioxane at 100 - 110℃; Sealed tube; Large scale;96.3%
With ammonia at 65℃;91%
With monomethanolamine In water at 0 - 60℃; for 48h;76%
(Z)-6-amino-9-(prop-1-en-1-yl)-9H-purine

(Z)-6-amino-9-(prop-1-en-1-yl)-9H-purine

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With D-tartaric acid; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; Concentration; Reagent/catalyst; Temperature;95.4%
9-propenyladenine
4121-40-8

9-propenyladenine

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine) In dichloromethane at 15℃; for 5h; Temperature; Concentration;94.7%
(R)-5-amino-1-(2-hydroxypropyl)-1H-imidazole-4-carbonitrile
852954-49-5

(R)-5-amino-1-(2-hydroxypropyl)-1H-imidazole-4-carbonitrile

formamidine acetic acid
3473-63-0

formamidine acetic acid

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With barium hydroxide monohydrate In N,N-dimethyl-formamide for 16h; Solvent; Concentration; Heating;93%
Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 145℃; Temperature; Large scale;89.5%
With sodium hydroxide In N,N-dimethyl-formamide at 90 - 140℃; for 12h; Inert atmosphere;87%
With sodium hydroxide In N,N-dimethyl-formamide at 130 - 140℃; for 12h; Inert atmosphere;87%
(R)-9-<2-(2-tetrahydropyranyloxy)propyl>adenine
160616-02-4

(R)-9-<2-(2-tetrahydropyranyloxy)propyl>adenine

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With sulfuric acid Ambient temperature;85%
7H-purin-6-ylamine
73-24-5

7H-purin-6-ylamine

(R)-1,2-propylene carbonate
16606-55-6

(R)-1,2-propylene carbonate

A

(R)-3-(2′-hydroxyprop-1-yl)adenine

(R)-3-(2′-hydroxyprop-1-yl)adenine

B

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide for 8h; Reflux;A 8%
B 80%
Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 95℃; for 6h; Reagent/catalyst; Temperature;69%
1-(6-amino-9H-purin-9-yl)propan-2-one
105970-02-3

1-(6-amino-9H-purin-9-yl)propan-2-one

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With dichloro(benzene)ruthenium(II) dimer; sodium formate; (R)-α,α-diphenylprolinol In acetonitrile at 20 - 30℃; for 48h; enantioselective reaction;64%
(R)-1-(5-Amino-6-chloro-pyrimidin-4-ylamino)-propan-2-ol
17435-30-2

(R)-1-(5-Amino-6-chloro-pyrimidin-4-ylamino)-propan-2-ol

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / conc. HCl / Ambient temperature
2: 91 percent / NH3 / 65 °C
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine; dmap / N,N-dimethyl-formamide / 10 h / 5 - 85 °C
2.1: 4 h / 130 °C
2.2: 2 h / 20 °C / pH 9 / Cooling
3.1: sodium hydroxide / water / 2 h / 93 °C
View Scheme
Conditions
ConditionsYield
Stage #1: adenine With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: (R)-1,2-propylene carbonate at 120 - 130℃; for 16h;
A 97.9 %Chromat.
B 92.9 %Chromat.
7H-purin-6-ylamine
73-24-5

7H-purin-6-ylamine

(R)-propylene oxide
15448-47-2

(R)-propylene oxide

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Stage #1: 7H-purin-6-ylamine With sodium hydroxide In water at 100 - 110℃; for 5h;
Stage #2: (R)-propylene oxide With ammonium chloride In water at 25℃; Reagent/catalyst; Solvent; Temperature;
5.5 g
6-chloropurine
87-42-3

6-chloropurine

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Cooling with ice
1.2: 1 h / Cooling with ice
2.1: ruthenium; D-Prolin; sodium formate / acetonitrile / 24 h / 20 °C
3.1: monomethanolamine / water / 48 h / 0 - 60 °C
View Scheme
9-propenyladenine
4121-40-8

9-propenyladenine

A

(S)-1-(6-amino-9H-purin-9-yl) propan-2-ol
14047-27-9

(S)-1-(6-amino-9H-purin-9-yl) propan-2-ol

B

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl In dichloromethane at 25℃; for 5h; Temperature; Concentration; Overall yield = 43.8 %; Overall yield = 4.2 g;
N6-acetyladenine
6034-68-0

N6-acetyladenine

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: formic acid ethyl ester / 7 h / Reflux
2: sodium hydroxide / water / 2 h / 70 °C
3: lithium ethoxide / tetrahydrofuran; ethanol / 0.5 h / 20 °C
4: (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 5 h / 15 °C
View Scheme
N6-acetyladenine
6034-68-0

N6-acetyladenine

A

(S)-1-(6-amino-9H-purin-9-yl) propan-2-ol
14047-27-9

(S)-1-(6-amino-9H-purin-9-yl) propan-2-ol

B

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: formic acid ethyl ester / 7 h / Reflux
2: sodium hydroxide / water / 2 h / 70 °C
3: lithium ethoxide / tetrahydrofuran; ethanol / 0.5 h / 20 °C
4: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / dichloromethane / 5 h / 25 °C
View Scheme
C8H7N5O2

C8H7N5O2

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / water / 2 h / 70 °C
2: lithium ethoxide / tetrahydrofuran; ethanol / 0.5 h / 20 °C
3: (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 5 h / 15 °C
View Scheme
C8H7N5O2

C8H7N5O2

A

(S)-1-(6-amino-9H-purin-9-yl) propan-2-ol
14047-27-9

(S)-1-(6-amino-9H-purin-9-yl) propan-2-ol

B

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / water / 2 h / 70 °C
2: lithium ethoxide / tetrahydrofuran; ethanol / 0.5 h / 20 °C
3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / dichloromethane / 5 h / 25 °C
View Scheme
9-formyladenine

9-formyladenine

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium ethoxide / tetrahydrofuran; ethanol / 0.5 h / 20 °C
2: (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 5 h / 15 °C
View Scheme
C8H11ClN4O2

C8H11ClN4O2

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride; trimethyl orthoformate / N,N-dimethyl-formamide; water / 20 - 30 °C
2: ammonium hydroxide / 1,4-dioxane / 100 - 110 °C / Sealed tube; Large scale
View Scheme
7H-purin-6-ylamine
73-24-5

7H-purin-6-ylamine

(R)-1,2-propylene carbonate
16606-55-6

(R)-1,2-propylene carbonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 125 - 138℃;
5-amino-1-(2-hydroxypropyl)-1H-imidazole-4-carbonitrile

5-amino-1-(2-hydroxypropyl)-1H-imidazole-4-carbonitrile

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: barium hydroxide monohydrate / acetonitrile; water / 2 h / 25 °C
2: barium hydroxide monohydrate / N,N-dimethyl-formamide / 16 h / Heating
View Scheme
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate
35717-98-7

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine
160616-04-6

bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine

Conditions
ConditionsYield
With magnesium 2-methylpropan-2-olate In water; N,N-dimethyl-formamide at -15 - 20℃; for 44h; Inert atmosphere;91%
With magnesium 2-methylpropan-2-olate In water; N,N-dimethyl-formamide at -15 - 20℃; for 44h; Inert atmosphere;
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

(S)-9-(2-phosphonylmethoxypropyl)adenine
147127-19-3

(S)-9-(2-phosphonylmethoxypropyl)adenine

Conditions
ConditionsYield
Stage #1: (R)-9-(2-hydroxypropyl)adenine With bis(isopropoxy) magnesium In N,N-dimethyl-formamide at 65℃; for 1h; Inert atmosphere;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide at 45 - 55℃; for 10h;
Stage #3: With hydrogenchloride In water at 90℃; for 10h;
88%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
180587-75-1

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

Conditions
ConditionsYield
With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 80℃; for 5h; Solvent;85%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;44%
Stage #1: (R)-9-(2-hydroxypropyl)adenine With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide for 64h;
29%
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C9H14N5O4P

C9H14N5O4P

B

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 0 - 20℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Molecular sieve;A 12%
B 82%
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

C17H23N10O4P

C17H23N10O4P

Conditions
ConditionsYield
With dmap; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 90℃; Inert atmosphere;77.8%
With dmap; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 90℃; Inert atmosphere;55%
(di-tert-butoxyphosphoryl)methyl methanesulfonate

(di-tert-butoxyphosphoryl)methyl methanesulfonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl acetamide at 90℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: (di-tert-butoxyphosphoryl)methyl methanesulfonate In N,N-dimethyl acetamide at 90℃; for 23h; Schlenk technique; Inert atmosphere;
Stage #3: With sulfuric acid at 60℃; Reagent/catalyst; Schlenk technique; Inert atmosphere;
72%
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C10H17N5O7P2

C10H17N5O7P2

B

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With magnesium chloride In 1-methyl-pyrrolidin-2-one at -20 - 20℃; Inert atmosphere;A 6%
B 69%
(di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate

(di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 80℃; Schlenk technique; Inert atmosphere;
Stage #2: (di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate In N,N-dimethyl-formamide at 80℃; for 23h; Schlenk technique; Inert atmosphere;
Stage #3: With sulfuric acid at 60℃; Schlenk technique; Inert atmosphere;
68%
{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C10H17N5O7P2

C10H17N5O7P2

B

C9H14N5O4P

C9H14N5O4P

C

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;A 8%
B 11%
C 64%
diethyl (p-toluenesulfonyloxymethane)phosphonate
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
With bis(isopropoxy) magnesium In N,N-dimethyl-formamide at 45 - 65℃; for 11h; Autoclave; Inert atmosphere; Large scale;59.2%
Stage #1: diethyl (p-toluenesulfonyloxymethane)phosphonate; (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In 1-methyl-pyrrolidin-2-one; toluene at 25 - 75℃; for 6h;
Stage #2: With water; acetic acid In 1-methyl-pyrrolidin-2-one; water; acetic acid; toluene for 1h;
Stage #3: With hydrogen bromide In 1-methyl-pyrrolidin-2-one; water; toluene at 90 - 95℃;
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 20 - 35℃; for 0.5h;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide at 75 - 80℃; for 2h;
Stage #3: With hydrogenchloride In N,N-dimethyl-formamide at 0 - 95℃; for 9h; Temperature; Reagent/catalyst;
82 g
With trimethylsilyl bromide; water; sodium hydroxide In dichloromethane at 0 - 5℃; for 3h; pH=2.5 - 3;
Stage #1: diethyl (p-toluenesulfonyloxymethane)phosphonate; (R)-9-(2-hydroxypropyl)adenine With alumina-supported potassium hydroxide In N,N-dimethyl-formamide at 40 - 130℃; for 18h;
Stage #2: With water at 100 - 105℃; for 18h; Reagent/catalyst; Temperature; Solvent;
2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate
62921-74-8

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

C15H25N5O4

C15H25N5O4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 7h;49.4%
benzoyl chloride
98-88-4

benzoyl chloride

(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

(R)-9-(2-hydroxypropyl)-N6-benzoyladenine
160616-03-5

(R)-9-(2-hydroxypropyl)-N6-benzoyladenine

Conditions
ConditionsYield
With chloro-trimethyl-silane 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h; Yield given. Multistep reaction;
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

(R)-9-[2-(phosphanylmethoxy)propyl]adenine
919512-64-4

(R)-9-[2-(phosphanylmethoxy)propyl]adenine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium tert-butoxide / dimethylformamide / 1 h / 20 °C
1.2: 740 mg / dimethylformamide / 64 h / 20 °C
2.1: 65 percent / TMSCl; LiAlH4 / tetrahydrofuran / 2 h / 20 °C
View Scheme
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphinic acid
919512-65-5

({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium tert-butoxide / dimethylformamide / 1 h / 20 °C
1.2: 740 mg / dimethylformamide / 64 h / 20 °C
2.1: 65 percent / TMSCl; LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3.1: 100 percent / aq. H2O2 / tetrahydrofuran / 1 h / 20 °C
View Scheme
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

C15H30N5O3PSi2

C15H30N5O3PSi2

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tert-butoxide / dimethylformamide / 1 h / 20 °C
1.2: 740 mg / dimethylformamide / 64 h / 20 °C
2.1: 65 percent / TMSCl; LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3.1: 100 percent / aq. H2O2 / tetrahydrofuran / 1 h / 20 °C
4.1: tetrahydrofuran / 1 h / 20 °C
View Scheme
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

tenofovir
147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiOt-Bu / dimethylformamide; tetrahydrofuran / 1 h / 30 - 35 °C
2: 1.) bromotrimethylsilane, 2.) NaOH / 1.) acetonitrile, reflux, 2.) H2O, pH 3
View Scheme
Multi-step reaction with 2 steps
1: 44 percent / NaH / dimethylformamide / 0 - 20 °C
2: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C
View Scheme
Multi-step reaction with 4 steps
1: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h
2: sodium hydride / dimethylformamide / 48 h / Ambient temperature
3: sodium methoxide / dimethylformamide / Ambient temperature
4: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine
160616-04-6

bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h
2: sodium hydride / dimethylformamide / 48 h / Ambient temperature
3: sodium methoxide / dimethylformamide / Ambient temperature
View Scheme
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

[(R)-2-(6-Benzoylamino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropyl ester
627510-49-0

[(R)-2-(6-Benzoylamino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h
2: sodium hydride / dimethylformamide / 48 h / Ambient temperature
View Scheme
(R)-9-(2-hydroxypropyl)adenine
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C15H24N5O8P
1244022-55-6

C15H24N5O8P

B

C20H32N5O11P
1244022-53-4

C20H32N5O11P

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium 2-methylpropan-2-olate / 1-methyl-pyrrolidin-2-one / 70 - 74 °C
2.1: chloro-trimethyl-silane; sodium bromide / 1-methyl-pyrrolidin-2-one / 0 - 75 °C
3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 45 °C
3.2: 5.5 h / 45 - 50 °C
View Scheme
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