1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of APIs in China
Cas:134523-03-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryThe company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
Cas:134523-03-8
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:134523-03-8
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:134523-03-8
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryCASNumber: 134523-03-8 Name: Atorvastatincalcium MolecularStructure: 230)th… Founded in 2014, as a professional international pharmaceutical corporation, headquartered in Xi'an (China), KonoChemCo., Ltd. is a leading producer of standa
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:134523-03-8
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:134523-03-8
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Crystalline Powder Storage:Store at +4°C Package:1kg/fo
Cas:134523-03-8
Min.Order:5 Kilogram
FOB Price: $250.0
Type:Trading Company
inquiryService we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to your requirem
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:134523-03-8
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:134523-03-8
Min.Order:1 Kilogram
FOB Price: $8.0
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:134523-03-8
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryGMP factoryFull experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Rich experience for
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:134523-03-8
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryAtorvastatin calcium 134523-03-8 Atorvastatin calcium Basic information Product Name: Atorvastatin calcium Synonyms: LIPITOR;ATORVASTATIN CALCIUM SALT;ATORVASTATIN CALCIUM;ATORVASTATIN
Cas:134523-03-8
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:134523-03-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:134523-03-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:134523-03-8
Min.Order:1 Kilogram
FOB Price: $289.0 / 499.0
Type:Trading Company
inquiryProduct name: [r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrr [r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid calcium sal
Cas:134523-03-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:134523-03-8
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:134523-03-8
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:134523-03-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:134523-03-8
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryProduct Name:Atorvastatin Calcium CAS:134523-03-8 Appearance :White powder Molecular formula: C66H68Ca2F2N4O10 Molecular weight :1195.42 Melting Point:176-178 °C Boiling Point:722.2 °C at 760 mmHg Flash Point:390.6 °
Cas:134523-03-8
Min.Order:1 Milligram
Negotiable
Type:Other
inquiryCAS: 134523-03-8 MF: C66H68CaF2N4O10 MW: 1155.36 EINECS: 200-659-6 Mol File: 134523-03-8.mol Atorvastatin calcium Structure Atorvastatin calcium Chemical Properties Melting point 176-178°C storage temp. Store at +4°C
Cas:134523-03-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:134523-03-8
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryAtorvastatin calcium used for lowering blood cholesterol. Atorvastatin calcium also stabilizes plaque and prevents strokes through anti-inflammation and other mechanisms. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an
Cas:134523-03-8
Min.Order:1 Gram
FOB Price: $2.0 / 3.0
Type:Trading Company
inquiryBeluga chemical professional supply High quality Atorvastatin calcium CAS 134523-03-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made i
Cas:134523-03-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful d
Cas:134523-03-8
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquirylipitor
Conditions | Yield |
---|---|
With calcium acetate In ethanol; water at 0 - 40℃; | 98% |
With calcium acetate In water; acetone at 15 - 20℃; for 1h; | 88% |
tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
lipitor
Conditions | Yield |
---|---|
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; methanol; water at 35℃; for 3h; Stage #2: With calcium hydroxide In methanol; water; toluene at 70℃; for 2h; Stage #3: In methanol; water at 20 - 78℃; for 24.25h; | 96% |
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In methanol at 15 - 30℃; for 12h; Stage #2: With sodium hydroxide In methanol; water at 25 - 30℃; for 6h; pH=12; Stage #3: With hydrogenchloride; calcium acetate Product distribution / selectivity; more than 3 stages; | 93.94% |
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In methanol at 15 - 30℃; for 10 - 12h; Stage #2: With sodium hydroxide In methanol; water at 25 - 30℃; for 4 - 6h; pH=~ 12; Stage #3: With hydrogenchloride; calcium acetate Product distribution / selectivity; more than 3 stages; | 86.5% |
atorvastatin lactone
lipitor
Conditions | Yield |
---|---|
Stage #1: atorvastatin lactone With calcium hydroxide In tetrahydrofuran; water at 45 - 50℃; for 2h; Stage #2: In dichloromethane; di-isopropyl ether at 10 - 15℃; for 0.25h; Product distribution / selectivity; | 95.1% |
Stage #1: atorvastatin lactone With sodium hydroxide In methanol; water at 25 - 50℃; for 2h; Stage #2: With hydrogenchloride In water pH=7.8 - 8.2; Stage #3: With calcium acetate In methanol; water at 25 - 30℃; Product distribution / selectivity; | 92.21% |
Stage #1: atorvastatin lactone With calcium hydroxide In tetrahydrofuran; water at 45 - 50℃; for 2h; Stage #2: In methanol at 40 - 45℃; Product distribution / selectivity; | 91.82% |
(3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
lipitor
Conditions | Yield |
---|---|
Stage #1: (3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate With sodium hydroxide In methanol; water at 50℃; for 1h; Stage #2: With calcium chloride monohydrate In methanol; water at 20℃; for 1h; | 94% |
Stage #1: (3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate With sodium hydroxide In methanol; water at 20℃; for 1h; Stage #2: With calcium chloride In methanol; water at 20℃; for 1h; | 90% |
atorvastatin sodium
lipitor
Conditions | Yield |
---|---|
With calcium acetate In water at 20℃; for 2h; | 93% |
With calcium acetate In methanol; water at 60 - 65℃; for 2h; Industrial scale; | 85.4% |
With calcium acetate In water at 13 - 63℃; |
lipitor
Conditions | Yield |
---|---|
With calcium acetate In water at 52℃; for 17h; Reagent/catalyst; Solvent; | 92% |
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
lipitor
Conditions | Yield |
---|---|
Stage #1: (3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate With sodium hydroxide In methanol at 0℃; for 0.5h; Stage #2: With calcium acetate In methanol at 0℃; for 1h; | 91% |
lipitor
Conditions | Yield |
---|---|
With calcium hydroxide In water; acetone at 20 - 50℃; Product distribution / selectivity; | 90% |
2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester
lipitor
Conditions | Yield |
---|---|
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester With hydrogenchloride In methanol; water at 25℃; for 3h; Stage #2: With sodium hydroxide In methanol; water at 25 - 38℃; Stage #3: With calcium acetate In water at 58℃; for 1h; Product distribution / selectivity; | 90% |
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester With hydrogenchloride In methanol; water at 25 - 37℃; Stage #2: With sodium hydroxide In methanol; water at 25 - 30℃; pH=> 12; Product distribution / selectivity; | |
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester With hydrogenchloride In methanol; water at 25 - 37℃; Stage #2: With sodium hydroxide In methanol; water at 30℃; for 2h; pH=12.2; Stage #3: With calcium acetate In tert-butyl methyl ether; water at 45 - 58℃; pH=8.6 - 8.8; Product distribution / selectivity; | |
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester With hydrogenchloride; methanol; water at 25 - 27℃; for 2h; Stage #2: With sodium hydroxide In methanol; water at 25 - 30℃; for 2h; pH=< 12; Further stages; |
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid potassium
lipitor
Conditions | Yield |
---|---|
With calcium acetate In water at 20℃; for 2h; | 89% |
lipitor
Conditions | Yield |
---|---|
With calcium acetate In water; isopropyl alcohol at 15 - 20℃; for 1h; | 88% |
Conditions | Yield |
---|---|
Stage #1: calcium acetate; atorvastatin In water; acetonitrile at 44℃; for 1.25h; Stage #2: With sodium hydroxide In water at 30 - 70℃; for 9.5h; Product distribution / selectivity; | 84.35% |
2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester
lipitor
Conditions | Yield |
---|---|
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester With hydrogenchloride; water In methanol at 25 - 30℃; for 3.16667h; Stage #2: With sodium hydroxide In methanol; water at 25 - 38℃; Stage #3: With calcium acetate In water at 48 - 58℃; for 2h; | 73% |
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester With hydrogenchloride In methanol; water at 25℃; for 3.16667h; Stage #2: With calcium acetate In water at 35 - 58℃; for 5h; | 73% |
(4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester
lipitor
Conditions | Yield |
---|---|
Stage #1: (4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester With sodium hydroxide In ethanol at 30 - 55℃; for 25h; Stage #2: With hydrogenchloride In ethanol; water at 20℃; pH=2 - 2.5; Stage #3: calcium hydroxide In ethanol; water at 20 - 70℃; for 4h; | 56.4% |
lipitor
Conditions | Yield |
---|---|
With calcium hydroxide In ethanol; water at 70℃; for 5.5h; | 26% |
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
lipitor
Conditions | Yield |
---|---|
Stage #1: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester With sodium hydroxide In methanol; water at 50℃; for 1h; Stage #2: With calcium acetate In water; ethyl acetate at 50℃; for 1h; | |
Stage #1: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester With sodium hydroxide; water In acetonitrile at 40 - 45℃; for 2h; Stage #2: With calcium acetate In water; acetonitrile at 40 - 45℃; for 0.5 - 1h; Stage #3: With sodium hydroxide In water; acetonitrile at 70 - 80℃; for 7 - 9h; | |
Stage #1: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester With sodium hydroxide In methanol; water Stage #2: With calcium chloride In water at 55 - 60℃; Product distribution / selectivity; |
lipitor
Conditions | Yield |
---|---|
With calcium oxide In methanol; water at 50 - 60℃; for 10h; | |
With calcium oxide In water; acetonitrile at 50 - 60℃; for 12h; | |
With calcium oxide In tetrahydrofuran; water at 50 - 60℃; for 8h; |
1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate
lipitor
A
2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid
B
C26H24FNO5
C
5'-deshydroxy atorvastatin
D
3'-deshydroxy atorvastatin
E
3-oxo atorvastatin
F
C33H35FN2O7
G
C40H48FN3O8
J
lipitor
L
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
Conditions | Yield |
---|---|
With water In tetrahydrofuran; cyclohexane at 20 - 70℃; for 4.75h; Product distribution / selectivity; Molecular sieve; |
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid; ammonium salt
lipitor
Conditions | Yield |
---|---|
With calcium acetate In tetrahydrofuran; water for 12h; Product distribution / selectivity; |
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrole-1-heptanoic acid diisopropylamine salt
lipitor
Conditions | Yield |
---|---|
With calcium acetate In tetrahydrofuran; water for 6h; Product distribution / selectivity; |
atorvastatin
lipitor
Conditions | Yield |
---|---|
With calcium acetate In water for 1h; pH=8; | |
With calcium acetate In water; butanone | |
With calcium acetate In methanol; water for 1h; |
Conditions | Yield |
---|---|
at 130 - 140℃; under 1 - 1.5 Torr; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In methanol; water at 13 - 63℃; Product distribution / selectivity; |
(-)-(4S)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1-<(tetrahydro-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-4-carboxamide
lipitor
Conditions | Yield |
---|---|
With calcium hydroxide; tetrabutylammomium bromide In methanol; water at 50℃; for 5h; |
lipitor
Conditions | Yield |
---|---|
Stage #1: C39H45FN2O5 With hydrogenchloride; water In methanol at 20 - 26℃; for 6h; Stage #2: With water; sodium hydroxide In methanol at 23 - 40℃; pH=12 - 12.5; Stage #3: With calcium acetate In water at 47 - 50℃; |
lipitor
Conditions | Yield |
---|---|
In water; ethyl acetate | |
In water; ethyl acetate |
C13H25NO4
lipitor
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: Trimethylacetic acid / n-heptane; tetrahydrofuran / Reflux 2.1: hydrogenchloride / water; methanol / 3 h / 25 °C 2.2: 25 - 38 °C 2.3: 1 h / 58 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: isopropyl alcohol / 25 - 30 °C 2.1: cyclohexane; 1-methyl-pyrrolidin-2-one / 80 - 82 °C 3.1: hydrogenchloride / water; methanol / 3 h / 25 °C 3.2: 25 - 38 °C 3.3: 1 h / 58 °C View Scheme |
C2H2O4*C13H25NO4
lipitor
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium pivalate / tert-butyl methyl ether; tetrahydrofuran / 140 h / Reflux 2.1: hydrogenchloride / water; methanol / 3 h / 25 °C 2.2: 25 - 38 °C 2.3: 1 h / 58 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium carbonate / water / 25 °C / pH 10.9 2.1: Trimethylacetic acid / n-heptane; tetrahydrofuran / Reflux 3.1: hydrogenchloride / water; methanol / 3 h / 25 °C 3.2: 25 - 38 °C 3.3: 1 h / 58 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium carbonate / water / 25 °C / pH 10.9 2.1: isopropyl alcohol / 25 - 30 °C 3.1: cyclohexane; 1-methyl-pyrrolidin-2-one / 80 - 82 °C 4.1: hydrogenchloride / water; methanol / 3 h / 25 °C 4.2: 25 - 38 °C 4.3: 1 h / 58 °C View Scheme |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 96% B n/a |
lipitor
Conditions | Yield |
---|---|
With hydrogenchloride In water for 5h; Reflux; | 96% |
lipitor
(S)-5-(4-fluorophenyl)-2-isopropyl-1-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 5h; Reagent/catalyst; Reflux; | 95% |
lipitor
butan-1-ol
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.5h; | 93% |
lipitor
atorvastatin
Conditions | Yield |
---|---|
With hydrogenchloride In tert-butyl methyl ether; water | 92% |
With hydrogenchloride In water; acetonitrile at 20℃; for 0.25h; pH=2.35 - 7; | |
With sodium hydrogen sulfate In water; ethyl acetate |
methanol
lipitor
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.5h; | 90% |
lipitor
atorvastatin lactone
Conditions | Yield |
---|---|
Stage #1: lipitor With hydrogenchloride In water; ethyl acetate at 4 - 20℃; Stage #2: In toluene for 2.5h; Reflux; Dean-Stark; | 88% |
With hydrogenchloride In water at 20℃; for 2h; | 55% |
Stage #1: lipitor With hydrogenchloride In dichloromethane; water Stage #2: With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Cooling with ice; | 2.78 g |
lipitor
Conditions | Yield |
---|---|
With water In methanol; dichloromethane at 20 - 30℃; for 2h; | 85% |
lipitor
Conditions | Yield |
---|---|
With water In tetrahydrofuran; methanol at 30 - 50℃; for 9h; | 80% |
ethanol
lipitor
ethyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.5h; | 77% |
Conditions | Yield |
---|---|
With potassium iodide In N,N-dimethyl-formamide for 50h; | 76.7% |
1-Decanol
lipitor
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.5h; | 75% |
lipitor
allyl alcohol
allyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.5h; | 74% |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 74% B n/a |
octanol
lipitor
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.5h; | 73% |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 70% B n/a |
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