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Afine Chemicals Limited

1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of APIs in China

Buy High quality Hot sale 98% Atorvastatin calcium Atorvastatine Calcium Trihydrate supplier price

Cas:134523-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Chinese Manufacturer Supply Reliable Quality 134523-03-8 Cheapest Price

Cas:134523-03-8

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

98% up USP standard GMP certified DMF documents API Atorvastatin Calcium 134523-03-8

Cas:134523-03-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Atorvastatin Calcium supplier in China

Cas:134523-03-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

CASNumber: 134523-03-8 Name: Atorvastatincalcium MolecularStructure: 230)th… Founded in 2014, as a professional international pharmaceutical corporation, headquartered in Xi'an (China), KonoChemCo., Ltd. is a leading producer of standa

Atorvastatin calcium

Cas:134523-03-8

Min.Order:1 Kilogram

FOB Price: $2000.0

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Atorvastatin calcium CAS NO.134523-03-8

Cas:134523-03-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Atorvastatin calcium manufacturer/supplier

Cas:134523-03-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Crystalline Powder Storage:Store at +4°C Package:1kg/fo

Manfacturer supply Atorvastatin calcium CAS 134523-03-8 with competitive price

Cas:134523-03-8

Min.Order:5 Kilogram

FOB Price: $250.0

Type:Trading Company

inquiry

Hefei TNJ chemical industry co.,ltd

Service we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to your requirem

Atorvastatin calcium

Cas:134523-03-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Atorvastatin Calcium

Cas:134523-03-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Atorvastatin calcium 134523-03-8 ISO Producer

Cas:134523-03-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Atorvastatin calcium

Cas:134523-03-8

Min.Order:1 Kilogram

FOB Price: $8.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Atorvastatin calcium

Cas:134523-03-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

GMP factoryFull experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Rich experience for

Atorvastatin calcium

Cas:134523-03-8

Min.Order:0

Negotiable

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

ATORVASTATIN CALCIUM

Cas:134523-03-8

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Atorvastatin calcium 134523-03-8 Atorvastatin calcium Basic information Product Name: Atorvastatin calcium Synonyms: LIPITOR;ATORVASTATIN CALCIUM SALT;ATORVASTATIN CALCIUM;ATORVASTATIN

Atorvastatin calcium 134523-03-8

Cas:134523-03-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Atorvastatin Calcium Powder CAS 134523-03-8

Cas:134523-03-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 134523-03-8 with competitive price

Cas:134523-03-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Atorvastatin calcium CAS134523-03-8

Cas:134523-03-8

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name: [r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrr [r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid calcium sal

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Atorvastatin Calcium Manufacturer For Hypolipidemic Drugs

Cas:134523-03-8

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

China GMP Factory Direct Supply 99% Purity Atorvastatin Calcium Powder CAS: 134523-03-8

Cas:134523-03-8

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Atorvastatin calcium 134523-03-8

Cas:134523-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Purity Pharmaceutical Raw Material Atorvastatin Calcium powder

Cas:134523-03-8

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

Product Name:Atorvastatin Calcium CAS:134523-03-8 Appearance :White powder Molecular formula: C66H68Ca2F2N4O10 Molecular weight :1195.42 Melting Point:176-178 °C Boiling Point:722.2 °C at 760 mmHg Flash Point:390.6 &deg

High quality China Supplier Atorvastatin calcium,CAS:134523-03-8

Cas:134523-03-8

Min.Order:1 Milligram

Negotiable

Type:Other

inquiry

Shanghai Minstar Chemical Co., Ltd

CAS: 134523-03-8 MF: C66H68CaF2N4O10 MW: 1155.36 EINECS: 200-659-6 Mol File: 134523-03-8.mol Atorvastatin calcium Structure Atorvastatin calcium Chemical Properties Melting point 176-178°C storage temp. Store at +4°C

Atorvastatin calcium

Cas:134523-03-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Atorvastatin Calcium CAS 134523-03-8 For research Use only

Cas:134523-03-8

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Atorvastatin calcium used for lowering blood cholesterol. Atorvastatin calcium also stabilizes plaque and prevents strokes through anti-inflammation and other mechanisms. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an

Atorvastatin-Ca-D5,Atorvastatin calcium,cas:134523-03-8

Cas:134523-03-8

Min.Order:1 Gram

FOB Price: $2.0 / 3.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Atorvastatin calcium CAS 134523-03-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made i

High quality Atorvastatin calcium CAS 134523-03-8

Cas:134523-03-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful d

cas 134523-03-8 Atorvastatin calcium Chinese manufacturer

Cas:134523-03-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

atorvastatin lysine

atorvastatin lysine

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In ethanol; water at 0 - 40℃;98%
With calcium acetate In water; acetone at 15 - 20℃; for 1h;88%
tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
125971-95-1

tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; methanol; water at 35℃; for 3h;
Stage #2: With calcium hydroxide In methanol; water; toluene at 70℃; for 2h;
Stage #3: In methanol; water at 20 - 78℃; for 24.25h;
96%
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In methanol at 15 - 30℃; for 12h;
Stage #2: With sodium hydroxide In methanol; water at 25 - 30℃; for 6h; pH=12;
Stage #3: With hydrogenchloride; calcium acetate Product distribution / selectivity; more than 3 stages;
93.94%
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In methanol at 15 - 30℃; for 10 - 12h;
Stage #2: With sodium hydroxide In methanol; water at 25 - 30℃; for 4 - 6h; pH=~ 12;
Stage #3: With hydrogenchloride; calcium acetate Product distribution / selectivity; more than 3 stages;
86.5%
atorvastatin lactone
125995-03-1

atorvastatin lactone

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: atorvastatin lactone With calcium hydroxide In tetrahydrofuran; water at 45 - 50℃; for 2h;
Stage #2: In dichloromethane; di-isopropyl ether at 10 - 15℃; for 0.25h; Product distribution / selectivity;
95.1%
Stage #1: atorvastatin lactone With sodium hydroxide In methanol; water at 25 - 50℃; for 2h;
Stage #2: With hydrogenchloride In water pH=7.8 - 8.2;
Stage #3: With calcium acetate In methanol; water at 25 - 30℃; Product distribution / selectivity;
92.21%
Stage #1: atorvastatin lactone With calcium hydroxide In tetrahydrofuran; water at 45 - 50℃; for 2h;
Stage #2: In methanol at 40 - 45℃; Product distribution / selectivity;
91.82%
(3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
1035205-25-4

(3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: (3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate With sodium hydroxide In methanol; water at 50℃; for 1h;
Stage #2: With calcium chloride monohydrate In methanol; water at 20℃; for 1h;
94%
Stage #1: (3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate With sodium hydroxide In methanol; water at 20℃; for 1h;
Stage #2: With calcium chloride In methanol; water at 20℃; for 1h;
90%
atorvastatin sodium
134523-01-6

atorvastatin sodium

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In water at 20℃; for 2h;93%
With calcium acetate In methanol; water at 60 - 65℃; for 2h; Industrial scale;85.4%
With calcium acetate In water at 13 - 63℃;
C33H34FN2O5(1-)*Li(1+)

C33H34FN2O5(1-)*Li(1+)

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In water at 52℃; for 17h; Reagent/catalyst; Solvent;92%
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
345891-62-5

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: (3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate With sodium hydroxide In methanol at 0℃; for 0.5h;
Stage #2: With calcium acetate In methanol at 0℃; for 1h;
91%
2C33H32FN2O4(1-)*Ca(2+)

2C33H32FN2O4(1-)*Ca(2+)

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium hydroxide In water; acetone at 20 - 50℃; Product distribution / selectivity;90%
2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester
1112262-71-1

2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester With hydrogenchloride In methanol; water at 25℃; for 3h;
Stage #2: With sodium hydroxide In methanol; water at 25 - 38℃;
Stage #3: With calcium acetate In water at 58℃; for 1h; Product distribution / selectivity;
90%
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester With hydrogenchloride In methanol; water at 25 - 37℃;
Stage #2: With sodium hydroxide In methanol; water at 25 - 30℃; pH=> 12; Product distribution / selectivity;
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester With hydrogenchloride In methanol; water at 25 - 37℃;
Stage #2: With sodium hydroxide In methanol; water at 30℃; for 2h; pH=12.2;
Stage #3: With calcium acetate In tert-butyl methyl ether; water at 45 - 58℃; pH=8.6 - 8.8; Product distribution / selectivity;
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid isopropyl ester With hydrogenchloride; methanol; water at 25 - 27℃; for 2h;
Stage #2: With sodium hydroxide In methanol; water at 25 - 30℃; for 2h; pH=< 12; Further stages;
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid potassium
134523-02-7

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid potassium

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In water at 20℃; for 2h;89%
atorvastatin arginine

atorvastatin arginine

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In water; isopropyl alcohol at 15 - 20℃; for 1h;88%
calcium acetate
62-54-4

calcium acetate

atorvastatin
134523-00-5

atorvastatin

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: calcium acetate; atorvastatin In water; acetonitrile at 44℃; for 1.25h;
Stage #2: With sodium hydroxide In water at 30 - 70℃; for 9.5h; Product distribution / selectivity;
84.35%
2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester
1363896-50-7

2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester With hydrogenchloride; water In methanol at 25 - 30℃; for 3.16667h;
Stage #2: With sodium hydroxide In methanol; water at 25 - 38℃;
Stage #3: With calcium acetate In water at 48 - 58℃; for 2h;
73%
Stage #1: 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid 1-methylpropyl ester With hydrogenchloride In methanol; water at 25℃; for 3.16667h;
Stage #2: With calcium acetate In water at 35 - 58℃; for 5h;
73%
calcium hydroxide

calcium hydroxide

(4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester
697266-20-9

(4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: (4R-cis)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]pyrrol-1-yl]ethyl]-2,2-diisopropyl-1,3-dioxa-2-silacyclohexane-4-acetic acid tert-butyl ester With sodium hydroxide In ethanol at 30 - 55℃; for 25h;
Stage #2: With hydrogenchloride In ethanol; water at 20℃; pH=2 - 2.5;
Stage #3: calcium hydroxide In ethanol; water at 20 - 70℃; for 4h;
56.4%
C49H51FN2O5Si

C49H51FN2O5Si

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium hydroxide In ethanol; water at 70℃; for 5.5h;26%
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
134395-00-9

(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester With sodium hydroxide In methanol; water at 50℃; for 1h;
Stage #2: With calcium acetate In water; ethyl acetate at 50℃; for 1h;
Stage #1: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester With sodium hydroxide; water In acetonitrile at 40 - 45℃; for 2h;
Stage #2: With calcium acetate In water; acetonitrile at 40 - 45℃; for 0.5 - 1h;
Stage #3: With sodium hydroxide In water; acetonitrile at 70 - 80℃; for 7 - 9h;
Stage #1: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester With sodium hydroxide In methanol; water
Stage #2: With calcium chloride In water at 55 - 60℃; Product distribution / selectivity;
(6-{2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2]dioxaborinan-4-yl)-acetic acid ter-butyl ester

(6-{2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2]dioxaborinan-4-yl)-acetic acid ter-butyl ester

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium oxide In methanol; water at 50 - 60℃; for 10h;
With calcium oxide In water; acetonitrile at 50 - 60℃; for 12h;
With calcium oxide In tetrahydrofuran; water at 50 - 60℃; for 8h;
1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate
134394-98-2

1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

lipitor
134523-03-8

lipitor

calcium (3S,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate

calcium (3S,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate

A

2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid
581772-29-4

2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid

B

C26H24FNO5
887196-28-3

C26H24FNO5

C

5'-deshydroxy atorvastatin
887196-27-2

5'-deshydroxy atorvastatin

D

3'-deshydroxy atorvastatin
887196-26-1

3'-deshydroxy atorvastatin

E

3-oxo atorvastatin
887196-30-7

3-oxo atorvastatin

F

C33H35FN2O7
887470-43-1

C33H35FN2O7

G

C40H48FN3O8
887196-24-9

C40H48FN3O8

H

2C33H35N2O5(1-)*Ca(2+)*3H2O

2C33H35N2O5(1-)*Ca(2+)*3H2O

I

O-methyl atorvastatin calcium

O-methyl atorvastatin calcium

J

lipitor
134523-03-8

lipitor

K

3-<(4-fluorophenyl)carbonyl>-2-(2-methyl-1-oxopropyl)-N,3-diphenyl-2-oxiranecarboxamide

3-<(4-fluorophenyl)carbonyl>-2-(2-methyl-1-oxopropyl)-N,3-diphenyl-2-oxiranecarboxamide

L

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
345891-62-5

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With water In tetrahydrofuran; cyclohexane at 20 - 70℃; for 4.75h; Product distribution / selectivity; Molecular sieve;
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid; ammonium salt
340266-37-7

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid; ammonium salt

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In tetrahydrofuran; water for 12h; Product distribution / selectivity;
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrole-1-heptanoic acid diisopropylamine salt
908852-23-3

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrole-1-heptanoic acid diisopropylamine salt

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In tetrahydrofuran; water for 6h; Product distribution / selectivity;
atorvastatin
134523-00-5

atorvastatin

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In water for 1h; pH=8;
With calcium acetate In water; butanone
With calcium acetate In methanol; water for 1h;
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrole-1-heptanoic acid calcium propylene glycol

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrole-1-heptanoic acid calcium propylene glycol

A

(S)-1,2-Propanediol
4254-15-3

(S)-1,2-Propanediol

B

(2R)-propane-1,2-diol
4254-14-2

(2R)-propane-1,2-diol

C

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
at 130 - 140℃; under 1 - 1.5 Torr; Product distribution / selectivity;
calcium acetate
62-54-4

calcium acetate

atorvastatin sodium
134523-01-6

atorvastatin sodium

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
In methanol; water at 13 - 63℃; Product distribution / selectivity;
(-)-(4S)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1-<(tetrahydro-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-4-carboxamide
134523-07-2

(-)-(4S)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1-<(tetrahydro-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-4-carboxamide

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium hydroxide; tetrabutylammomium bromide In methanol; water at 50℃; for 5h;
C39H45FN2O5

C39H45FN2O5

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: C39H45FN2O5 With hydrogenchloride; water In methanol at 20 - 26℃; for 6h;
Stage #2: With water; sodium hydroxide In methanol at 23 - 40℃; pH=12 - 12.5;
Stage #3: With calcium acetate In water at 47 - 50℃;
calcium(II) acetate dihydrate

calcium(II) acetate dihydrate

atorvastatin sodium

atorvastatin sodium

aqueous calcium acetate dihydrate

aqueous calcium acetate dihydrate

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
In water; ethyl acetate
In water; ethyl acetate
C13H25NO4
1112262-76-6

C13H25NO4

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Trimethylacetic acid / n-heptane; tetrahydrofuran / Reflux
2.1: hydrogenchloride / water; methanol / 3 h / 25 °C
2.2: 25 - 38 °C
2.3: 1 h / 58 °C
View Scheme
Multi-step reaction with 3 steps
1.1: isopropyl alcohol / 25 - 30 °C
2.1: cyclohexane; 1-methyl-pyrrolidin-2-one / 80 - 82 °C
3.1: hydrogenchloride / water; methanol / 3 h / 25 °C
3.2: 25 - 38 °C
3.3: 1 h / 58 °C
View Scheme
C2H2O4*C13H25NO4
1363159-13-0

C2H2O4*C13H25NO4

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium pivalate / tert-butyl methyl ether; tetrahydrofuran / 140 h / Reflux
2.1: hydrogenchloride / water; methanol / 3 h / 25 °C
2.2: 25 - 38 °C
2.3: 1 h / 58 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium carbonate / water / 25 °C / pH 10.9
2.1: Trimethylacetic acid / n-heptane; tetrahydrofuran / Reflux
3.1: hydrogenchloride / water; methanol / 3 h / 25 °C
3.2: 25 - 38 °C
3.3: 1 h / 58 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium carbonate / water / 25 °C / pH 10.9
2.1: isopropyl alcohol / 25 - 30 °C
3.1: cyclohexane; 1-methyl-pyrrolidin-2-one / 80 - 82 °C
4.1: hydrogenchloride / water; methanol / 3 h / 25 °C
4.2: 25 - 38 °C
4.3: 1 h / 58 °C
View Scheme
pentan-1-ol
71-41-0

pentan-1-ol

lipitor
134523-03-8

lipitor

A

pentyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

pentyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 96%
B n/a
lipitor
134523-03-8

lipitor

(1S,5R)-9-(4-fluorophenyl)-11-isopropyl-10-phenyl-1,2,6,7-tetrahydro-3H,5H-1,5-methanopyrrolo[1,2-e][1,5]oxazonin-3-one

(1S,5R)-9-(4-fluorophenyl)-11-isopropyl-10-phenyl-1,2,6,7-tetrahydro-3H,5H-1,5-methanopyrrolo[1,2-e][1,5]oxazonin-3-one

Conditions
ConditionsYield
With hydrogenchloride In water for 5h; Reflux;96%
lipitor
134523-03-8

lipitor

(S)-5-(4-fluorophenyl)-2-isopropyl-1-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
442851-50-5

(S)-5-(4-fluorophenyl)-2-isopropyl-1-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 5h; Reagent/catalyst; Reflux;95%
lipitor
134523-03-8

lipitor

butan-1-ol
71-36-3

butan-1-ol

butyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

butyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.5h;93%
lipitor
134523-03-8

lipitor

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
With hydrogenchloride In tert-butyl methyl ether; water92%
With hydrogenchloride In water; acetonitrile at 20℃; for 0.25h; pH=2.35 - 7;
With sodium hydrogen sulfate In water; ethyl acetate
methanol
67-56-1

methanol

lipitor
134523-03-8

lipitor

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
345891-62-5

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.5h;90%
lipitor
134523-03-8

lipitor

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Stage #1: lipitor With hydrogenchloride In water; ethyl acetate at 4 - 20℃;
Stage #2: In toluene for 2.5h; Reflux; Dean-Stark;
88%
With hydrogenchloride In water at 20℃; for 2h;55%
Stage #1: lipitor With hydrogenchloride In dichloromethane; water
Stage #2: With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Cooling with ice;
2.78 g
lipitor
134523-03-8

lipitor

atorvastatin hemicalcium salt trihydrate

atorvastatin hemicalcium salt trihydrate

Conditions
ConditionsYield
With water In methanol; dichloromethane at 20 - 30℃; for 2h;85%
lipitor
134523-03-8

lipitor

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt monohydrate

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt monohydrate

Conditions
ConditionsYield
With water In tetrahydrofuran; methanol at 30 - 50℃; for 9h;80%
ethanol
64-17-5

ethanol

lipitor
134523-03-8

lipitor

ethyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
1146977-93-6

ethyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.5h;77%
C9H6Cl2N4O2

C9H6Cl2N4O2

lipitor
134523-03-8

lipitor

C42H40ClFN6O7

C42H40ClFN6O7

Conditions
ConditionsYield
With potassium iodide In N,N-dimethyl-formamide for 50h;76.7%
1-Decanol
112-30-1

1-Decanol

lipitor
134523-03-8

lipitor

decyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

decyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.5h;75%
lipitor
134523-03-8

lipitor

allyl alcohol
107-18-6

allyl alcohol

allyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
915092-85-2

allyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.5h;74%
2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

lipitor
134523-03-8

lipitor

A

isobutyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

isobutyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 74%
B n/a
octanol
111-87-5

octanol

lipitor
134523-03-8

lipitor

octyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

octyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.5h;73%
propan-1-ol
71-23-8

propan-1-ol

lipitor
134523-03-8

lipitor

A

propyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

propyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 70%
B n/a
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